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Aceclofenac-Soluplus&reg Nanocomposites for Increased Bioavailability

Soft Nanoscience Letters 2015年第2期5卷 13-20页

作者： Sandeep Patnaik Sai Kiran Aditha tanu rattan Venkataramaniah Kamisetti Department of Physics Sri SathyaSai Institute of Higher Learning Prasanthi Nilayam India

Aceclofenac is a new generational Non-Steroidal Anti-Inflammatory Drug (NSAID), and is considered a better alternative to the popular pain-killer diclofenac, as it overcomes some of the adverse gastrointestinal and cardiac side effects associated with the latter. However, the bioavailability of the drug remains limited due to low aqueous solubility (0.058 μg/mL) and poor dissolution characteristics. Hence, improving its dissolution characteristics is of prime significance in order to establish its optimal therapeutic efficacy. In an effort to tackle this issue, we report the use of novel Soluplus®-based nanocomposites, prepared from emulsion templates, as effective drug loading agent for aceclofenac. Nanoemulsion templates were prepared by high-shear homogenization using a probe sonicator. The emulsions were subsequently lyophilized to obtain free flowing powders. The amorphization of the drug with increasing polymer content was clearly observed from powder X-ray diffractogram, while the drug-polymer interaction was explored by FTIR spectroscopy. The phase purity and homogeneity of the formulation was characterized using Differential Scanning Calorimetry. The dissolution profiles of the formulations were established by an USP paddle apparatus. Phase solubility study was conducted to evaluate the effect of polymer concentration on aqueous solubility of aceclofenac. The values of Gibbs-free energy (ΔG°tr) associated with the aqueous solubility of aceclofenac in the presence of Soluplus was used to optimize the polymer content. The in vitro dissolution rates of aceclofenac from the nanoparticles were significantly higher compared to the pure drug. Thus, Soluplus nanoparticles provide promising formulations for the improvement of the dissolution profiles and thus, the bioavailability, of aceclofenac.

关键词： Aceclofenac Soluplus Nanocomposites Dissolution Emulsion

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Detection of Cd<sup>2+</sup>Ions Using Surface Plasmon Coupled Emission on Engineered Silver-α Nano Alumina Thin Film Hybrids

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Soft Nanoscience Letters 2013年第4期3卷 27-31页

作者： Pradyumna Mulpur Sandeep Patnaik Avinash Chunduri tanu Mimani rattan Apparao M. Rao Venkataramaniah Kamisetti Department of Physics and Astronomy 202C Kinard Laboratory Clemson University Clemson USA. Department of Physics Sri SathyaSai Institute of Higher Learning Prasanthi Nilayam Puttaparthi India

We report the first time fabrication of a silver-α nano alumina thin film hybrid and the observation of the Surface Plasmon Coupled Emission (SPCE) phenomenon in these substrates. We report an “8” fold enhancement in the intensity of the coupled emission signal with respect to the isotropic fluorescence signal. The coupled emission signal displayed a strong p-polarized (92%, p-polarized) output and directionality, which is in accordance with the theory of SPCE. The directionality of emission was found to have strong correlation with the theoretical modeling of minimum reflectivity calculations based on the theory of Surface Plasmon Resonance (SPR). We also report the novel extension of the fabricated substrates towards the economical and sensitive detection of toxic Cd2+ ions from aqueous solutions, which are of immense social relevance.

关键词： Cd2+ Ions Surface Plasmon

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