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Extracorporeal blood purification strategies in sepsis and septic shock:An insight into recent advancements

World Journal of Critical Care Medicine 2023年第2期12卷 71-88页

作者： Yatin Mehta Rajib Paul Abdul Samad Ansari tanmay banerjee Serdar Gunaydin Amir Ahmad Nassiri Federico Pappalardo Vedran Premužić Prachee Sathe Vinod Singh Emilio Rey Vela Institute of Critical Care and Anesthesiology Medanta the MedicityGurugram 12201India Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Internal Medicine&Critical Care Medica Institute of Critical Care MedicineMedica Superspecialty HospitalKolkata 700099India Department of Cardiovascular Surgery University of Health SciencesAnkara City Hospital CampusAnkara 06933Turkey Department of Nephrology Shahid Beheshti University of Medical SciencesTehran 19839-63113Iran Cardiothoracic and Vascular Anesthesia and Intensive Care AO SS Antonio e Biagio e Cesare ArrigoAlessandria 15121Italy Department of Nephrology Clinical Hospital ZagrebClinic for internal diseasesZagreb 10000Croatia Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Institute of critical care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Cardiac Surgery Intensive Care Unit Samaritan University HospitalBogotá11Colombia

BACKGROUND Despite various therapies to treat sepsis,it is one of the leading causes of mortality in the intensive care unit patients *** about the pathophysiology of sepsis has sparked interest in extracorporeal therapies(ECT)which are intended to balance the dysregulation of the immune system by removing excessive levels of inflammatory *** To review recent data on the use of ECT in sepsis and to assess their effects on various inflammatory and clinical *** In this review,an extensive English literature search was conducted from the last two decades to identify the use of ECT in sepsis.A total of 68 articles from peer-reviewed and indexed journals were selected excluding publications with only *** Results showed that ECT techniques such as high-volume hemofiltration,coupled plasma adsorption/filtration,resin or polymer adsorbers,and CytoSorb®are emerging as adjunct therapies to improve hemodynamic stability in ***®has the most published data in regard to the use in the field of septic shock with reports on improved survival rates and lowered sequential organ failure assessment scores,lactate levels,total leucocyte count,platelet count,interleukin-IL-6,IL-10,and TNF *** Clinical acceptance of ECT in sepsis and septic shock is currently still limited due to a lack of large random clinical *** addition to patient-tailored therapies,future research developments with therapies targeting the cellular level of the immune response are expected.

关键词： CytoSorb® Hemadsorbers Inflammatory mediators Extracorporeal therapies Sepsis

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A Chicken's Egg as a Reaction Vessel to Explore Biomineralization

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Journal of Bionic Engineering 2007年第3期4卷 133-141页

作者： tanmay Bera P. Ramachandrarao Department of Metallurgical Engineering Institute of TechnologyBanaras Hindu UniversityVaranasi 221005India International Advanced Research Centre for Powder Metallurgy and other New Materials(ARCI)-Balapur Hyderabad 500005India

Natural composites, formed through biomineralization, have highly ordered structures which have been aptly explored for functional applications. Though the role of organic phases has been well understood in biomineralization, not enough attention has been paid to the role of bio-membranes which are often found encapsulating the chamber in which mineralization occurs. We have used the natural protein and semi-permeable membrane of chicken eggs to grow different materials such as ceramics, semi-metals and metals to understand the role of bio-membranes in biomineralization. We here report the successful biomimetic synthesis of calcite, cadmium sulphide, and silver having homogeneous morphologies. We have found that the membrane operates like a tuned gateway, playing a significant role in controlling the morphology of the inorganic crystals formed during biomineralization.

关键词： biomimetics biomineralization bio-membranes proteins organic-inorganic interface eggs

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Augmentation of situational awareness by fault passage indicators in distribution network incorporating network reconfiguration

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Protection and Control of Modern Power Systems 2019年第1期4卷 281-294页

作者： tanmay Jain Debomita Ghosh Dusmanta Kumar Mohanta Department of Electrical and Electronics Engineering Birla Institute of TechnologyMesraRanchiIndia

Power distribution systems are profoundly inclined to disturbances like untimely switching of breakers & relays, sympathetic tripping, and uncertainties regarding fault location. Thus, system stability and reliability are greatly affected. In this way, situational awareness and system integrity are the crucial factors in developing power system security, as it empowers successful decision making & timely reaction by the operators to any disturbance and also maintaining continuity of power supply. This paper focuses on the enhancement of situational awareness by fault location through fault passage indicators (FPI) to improve nominal impedance-based methods in distribution networks. Also, the proposed method is validated by comparing it with Intelligent Electronic Device (IED) based fault location method. Further, simultaneous reconfiguration of the system is incorporated to maintain the continuity of supply. The analysis has been tested on IEEE 33 bus distribution system.

关键词： Situational awareness Fault passage Indicator Tie switching Reconfiguration

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Factors Affecting Vulnerability of Ready-Made Garment Factory Buildings in Bangladesh: An Assessment Under Vertical and Earthquake Loads

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International Journal of Disaster Risk Science 2018年第2期9卷 207-223页

作者： tanmay Das Uttama Barua Mehedi Ahmed Ansary Department of Civil Engineering Pabna University of Science and Technology Department of Urban and Regional Planning Bangladesh University of Engineering and Technology (BUET) Department of Civil Engineering Bangladesh University of Engineering and Technology (BUET)

The importance of workplace safety in the ready-made garment(RMG) industry in Bangladesh came to the forefront after a series of disastrous events in recent years. In order to reduce the loss of lives and to ensure sustainable development, an in-depth understanding of the determining factors governing structural vulnerability in the RMG industry is needed. This research explores the key factors influencing the vulnerability of factory buildings under both vertical and earthquake loads. For this purpose,an ordered probit model was applied to 3746 RMG factory buildings to determine the key factors that influenced their vertical load vulnerability. A smaller subset of the original sample, 478 buildings, was examined by the same modeling method in greater detail to assess the key factors that influenced their earthquake load vulnerability. This research reveals that column capacity, structural system,and construction materials are the most influential factors for both types of vulnerabilities. Among other factors, soil liquefaction and irregular internal frame affect earthquake load vulnerability significantly. These findings are expected to enable factory owners and designers to better weigh the appropriate vulnerability factors in order to make informed decision that increase workplace safety. Theresearch findings will also help the designated authorities to conduct successful inspections of factory buildings and take actions that reduce vulnerability to both vertical and earthquake loads.

关键词： Bangladesh Building vulnerability factors Earthquake load vulnerability Ordered probit model Ready-made garment industry Vertical load vulnerability

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Ankol plant(Alangium salvifolium)-The treasure trove of bioactives and medicinal potential

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Food Bioscience 2023年第1期51卷 14-29页

作者： Susmita Ghosh tanmay Sarkar Runu Chakraborty Department of Food Technology and Biochemical Engineering Jadavpur UniversityKolkata700032India Department of Food Processing Technology Malda PolytechnicWest Bengal State Council of Technical EducationGovt.of West BengalMalda732102India

The food industry is vigorously searching for bioactive compounds with therapeutic potential that are derived from unexplored natural *** plant(Alangium salvifolium)is an underutilized small deciduous shrub that reaches a height of 10 m and is underutilized as a culinary *** can be found largely in the plains and lower mountain regions throughout India and elsewhere in East Africa to China,New Guinea,Indonesia,and *** plant is a vital source of high value-added ingredients,including anthocyanin and flavonoid pigments,alkaloid,tannin,and phenols that can be of great interest to the food industry as functional colorants and *** present review highlights the potential of Ankol plant(***)as valuable source of bioactive compounds for the development of functional *** is an important source of structurally varied bioactive compounds with distinct anti-diabetic,anti-cancer,anti-spasmodic,anti-inflammatory,analgesic,anti-arthritic,anti-protozoal,anti-hypertensive and cardio-protective *** results of molecular tests indicate the presence of numerous novel phytochemicals and biochemical substances,paving the way for future scientific discoveries for various aspects.

关键词： Ankol plant Underutilized plant Bioactives Health benefits Bioprospecting

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Impact of the penetration of distributed generation on optimal reactive power dispatch

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Protection and Control of Modern Power Systems 2020年第1期5卷 352-377页

作者： tanmay Das Ranjit Roy Kamal Krishna Mandal Department of Power Engineering Jadavpur UniversityKolkataIndia Department of Electrical Engineering Chaibasa Engineering CollegeChaibasaJharkhandIndia

Optimal reactive power dispatch(ORPD)is a complex and non-linear problem,and is one of the sub-problems of optimal power flow(OPF)in a power *** is formulated as a single-objective problem to minimize the active power loss in a transmission *** this work,power from distributed generation(DG)is integrated into a conventional power system and the ORPD problem is solved to minimize transmission line power *** proves that the application of DG not only contributes to power loss minimization and improvement of system stability but also reduces energy consumption from the conventional sources.A recently proposed meta-heuristic algorithm known as the JAYA algorithm is applied to the standard IEEE 14,30,57 and 118 bus systems to solve the newly developed ORPD problem with the incorporation of *** simulation results prove the superiority of the JAYA algorithm over *** respective optimal values of DG power that should be injected into the four IEEE test systems to obtain the minimum transmission line power losses are also provided.

关键词： Active power loss Distributed generation DG penetration JAYA algorithm Optimization problem ORPD Particle swarm optimization Variants of PSO Transmission line losses

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Do tensile and shear forces exerted on cells influence mechanotransduction through stored energy considerations?

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BIOCELL 2024年第4期48卷 525-540页

作者： FREDERICK H.SILVER tanmay DESHMUKH Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical SchoolRutgersThe State University of New JerseyPiscatawayNJ 08854USA OptoVibronex LLC.Ben Franklin Tech PartnersBethlehemPA 18015USA

All tissues in the body are subjected externally to gravity and internally by collagenﬁbril and cellular retractive forces that create stress and energy equilibrium required for *** involves mechanical work(force through a distance)and energy storage as kinetic and potential *** leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue *** involves the application of energy directly to cells through integrin-mediated processes,cell-cell connections,stretching of the cell cytoplasm,and activation of the cell nucleus via yes-associated protein(YAP)and transcriptional coactivator with PDZ-motif(TAZ).These processes involve numerous complexes,intermediate molecules,and multiple *** pathways have been identiﬁed from research studies on vertebrate cell culture and from studies in *** pathways involve mechanosensors and other molecules that activate the *** review discusses the mitogen-activated protein kinase(MAPK)family,Hippo,Hedgehog,and Wingless-related integration site(WNT)/βcatenin signaling *** mediators covered includeβcatenin,ion channels,growth factors,hormone receptors,members of the Ras superfamily,and components of the linker of nucleoskeleton and cytoskeleton(LINC)***,the interrelationship among the different pathways remains to be clariﬁ***-mediated mechanotransduction involves direct tensile loading and energy applied to the cell membrane via collagenﬁbril *** energy is transferred between cells by stretching the cell-cell connections involving cadherins and the WNT/βcatenin *** alterations induce changes in intracellular events in the cytoskeleton and nuclear skeleton caused by the release of YAP and *** coactivators then penetrate through the nuclear pores and inﬂuence nuclear cell *** in the balance of forces and energy applied to cells and tissues is hypothesized to shift th

关键词： MAPK family Hippo Hedgehog WNT pathway βcatenin Ion channels Growth factor receptors Hormone receptors Ras superfamily LINC complex Collagen Cadherins

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Underutilized plant sources: A hidden treasure of natural colors

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Food Bioscience 2023年第2期52卷 52-65页

Pigments,which are naturally found in a variety of fruits and are categorized as natural dyes,are compounds that impart color to a variety of products in the food *** colorants are being used in the food industry to broaden the color *** and long-term use of underutilized crops(also known as minor or neglected)are critical for dietary diversification as well as fulfilling the nutritional needs of an ever-increasing human *** recent years,the potential for underutilized crops as an emerging source of natural colorants has gained traction in the scientific *** predominant factors behind the exploration of unconventional plants are sustainable production,local availability,technological feasibility,cultural importance,specialty food production,and new fundamental *** is an urgent need to uncover and explore underutilized plants in the changing world where unfavorable climatic and human conditions endanger natural vegetation around the *** have been using plant-based pigments since ancient *** vegetal resources and the re-discovery of underutilized plants should be prioritized in the hunt for important natural *** review demonstrates the potential of this underutilized natural resource to extract promising natural colorants,which can be utilized in the food industry in the future.A scientific approach as well as research regarding the investigation,utilization,the discovery of new plant species having valuable natural pigments,their actions safety,and nutritional properties,is still needed around the world.

关键词： Underutilized plants Neglected plants Natural pigments Food colorants Food safety

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Asymmetric Aldol Reaction Catalyzed by Modularly Designed Organocatalysts

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Chinese Journal of Chemistry 2012年第11期30卷 2624-2630页

作者： Sinha, Debarshi Mandal, tanmay Gogoi, Sanjib Goldman, Joshua J. 赵从贵 Department of Chemistry University of Texas at San Antonio One UTSA Circle San Antonio Texas 78249-0698 USA

The self-assembly of the precatalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to the direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts （MDOs） may be used for catalyzed asymmetric aldol reaction the corresponding aldol products may be obtained in mediocre diastereoselectivities （up to 79 ： 21 dr）. Depending on structure of the aldehyde substrates, to excellent ee values （up to 92% ee） with moderate

关键词： modularly designed organocatalysts aldol reaction asymmetric catalysis amino acid cinchona alka-loid thiourea

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Photocatalytic Degradation of 4-chlorophenol by CuMoO<sub>4</sub>-doped TiO<sub>2</sub>Nanoparticles Synthesized by Chemical Route

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Open Journal of Physical Chemistry 2011年第2期1卷 28-36页

作者： tanmay K Ghorai Department of Chemistry West Bengal State University Barasat North 24 Pgs Kolkata-700126 India

The photocatalytic degradation of 4-chlorophenol (4-CP) in aqueous solution was studied using Cu-MoO4- doped TiO2 nanoparticles under Visible light radiation. The photocatalysts were synthesized by chemical route from TiO2 with different concentration of CuMoO4 (CuxMoxTi1-xO6;where, x values ranged from 0.05 to 0.5). The prepared nanoparticles are characterized by XRD, BET surface area, TEM, UV-vis diffuse reflectance spectra, Raman spectroscopy, XPS and EDAX spectroscopy were used to investigate the nanoparticles structure, size distribution, and qualitative elemental analysis of the composition. The CuxMoxTi1-xO6 (x = 0.05) showed high activity for degradation of 4-CP under visible light. The surface area of the catalyst was found to be 101 m2/g. The photodegradation process was optimized by using CuxMoxTi1-xO6 (x = 0.05) catalyst at a concentration level of 1 g/l. A maximum photocatalytic efficiency of 96.9% was reached at pH = 9 after irradiation for 3 hours. Parameters affecting the photocatalytic process such as catalyst loading, concentration of the catalyst and the dopant concentration, solution pH, and concentration of 4-CP have been investigated.

关键词： Inorganic Compounds Chemical Synthesis Nanostructures Optical Properties

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