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miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino M.Reimold E.Beyreuther F.-E.Brack F.Kroll J.Pawelke J.D.Schilz M.Schneider U.Schramm M.E.P.Umlandt K.Zeil T.ziegler J.Metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

德国科隆ORGATEC展Brunner展厅

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现代装饰 2015年第4期 50-57页

作者： tanja ziegler Gunter Fleitz Peter Ippolito Katja Heinemann Alexander Fehre Anne-Laure Minvielle Brunner GmbH Andreas Korner 姜敏华(译) 不详 Ippolito Fleitz Group建筑事务所

本案是2014德国科隆国际办公家具及管理设施展（ORGAETEC）上的Brunner展厅。Ippolito Fleitz Group建筑设计事务所受Brunner公司委托设计了该展厅。项目设计的目标是借众多创新之力展示Brunner公司充满活力的开放企业形象,同时为其产... 详细信息

本案是2014德国科隆国际办公家具及管理设施展（ORGAETEC）上的Brunner展厅。Ippolito Fleitz Group建筑设计事务所受Brunner公司委托设计了该展厅。项目设计的目标是借众多创新之力展示Brunner公司充满活力的开放企业形象,同时为其产品提供一个易于解读的、恰当的展示舞台。另外展厅中还展示了Brunner公司特别为办公空间所设计的桌椅系列。

关键词：德国科隆 Brunner ORGATEC 建筑设计事务所办公空间办公家具企业形象管理设施产品色彩荧光灯管

Swelling-Based Chemical Sensing With Unmodified Optical Fibers

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Photonic Sensors 2022年第2期12卷 99-104页

作者： Alin JDERU Dorel DOROBANTU Dominik ziegler Marius ENACHESCU S.C.NanoPro START MC S.R.L. Bucharest 033091Romania Center for Surface Science and Nanotechnology University Politehnica of BucharestBucharest 060042Romania Academy of Romanian Scientists Bucharest 050094Romania

We use distributed fiber optic strain sensing to examine swelling of the fiber’s polymer *** distributed sensing technique that uses unmodified low-cost telecom fibers opens a new dimension of applications that include leak detection,monitoring of water quality,and waste *** a short-range length scale,the technology enables“lab-on-a-fiber”applications for food processing,medicine,and biosensing for *** chemical sensing is realized with unmodified low-cost telecom optical fibers,namely,by using swelling in the coating material of the fiber to detect specific *** generic and able to work in various areas such as environmental monitoring,food analysis,agriculture or security,the proposed chemical sensors can be targeted for water quality monitoring,or medical diagnostics where they present the most groundbreaking ***,the technique is without restrictions applicable to longer range installations.

关键词： Chemical sensing distributed fiber optic strain short range sensing Brillouin optical time domain analysis

Current practices regarding middle turbinate resection among otolaryngologists

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 183-188页

作者： Andrea ziegler Monica Patadia Chirag Patel Department of Otolaryngology Loyola UniversityMedical CenterMaywoodIlinoisUSA

Objectives:Resection of the middle turbinate(MT)during endoscopic sinus surgery(ESS)has been a controversial topic among otolaryngologists for many *** studies advocate resection and have shown improved outcomes postoperatively,while studies favoring preservation show a decreased incidence of postoperative *** current practice pattern regarding this subject is *** goal of this study was to learn the current practice of MT resection during ESS among ***:We performed an electronic anonymous survey of practicing ***:We found that the majority of the 252 responders stated that they will perform an MT resection in certain clinical situations,while there is a small subset that advocates never resecting the MT for inflammatory sinus disease(n=6,2.4%).Participants were significantly more likely to perform MT resection in patients undergoing revision compared to primary ESS for all conditions *** complication of greatest concern among participants was iatrogenic frontal sinus obstruction,while empty nose was of the least *** majority of participants responded that MT resection was of extreme or moderate benefit for improved visualization and drug delivery *** compared to general otolaryngologists,fellowship-trained rhinologists were less concerned about potential complications following MT resection and were more likely to perceive an extreme or moderate benefit from turbinate resection ***:There remains debate over MT resection among otolaryngologists,but the results of this study show that the majority of participating otolaryngologists will perform a resection in certain clinical situations.

关键词： current practice trends endoscopic sinus surgery middle turbinate resection survey

The total amount of fluid administered is associated with postoperative complications in head and neck cancer surgery

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第4期9卷 288-294页

作者： Andrea ziegler Erin Carollo Wiliam Adams Carol Bier-Laning Department of Otolaryngology Loyola University Medical CenterMaywoodIlinoisUSA Department of Otolaryngology Stritch School of MedicineLoyola University Medical CenterIllinoisMaywoodUSA Department of Public Health Sciences Loyola University Medical CenterMaywoodIllinoisUSA

Objective:Patients with head and neck cancer often undergo extensive ablative and reconstructive *** risk factors are unalterable,but some operative variables are possible to *** goal of this study was to estimate the association between operative variables and the incidence of perioperative complications in a contemporary tertiary care university‐based head and neck patient population and a Veteran Administration hospital head and neck patient population from an earlier time ***:We retrospectively reviewed all patients who underwent major head and neck ***:Two‐hundred‐two university patients and 122 veteran patients were *** multivariable analysis,the total amount of intravenous(IV)fluid received during the procedure was associated with postoperative complications as were patients’weight,American Society of Anesthesiologists(ASA)score,and adult comorbidity evaluation‐27(ACE‐27)*** associations did not depend on whether the patient was treated at the university or veteran ***:Our study suggests that the odds of a postoperative complication increase as the total amount of IV fluid increases.

关键词： ACE‐27 score ASA complications head and neck cancer intraoperative fluids

Forest Restoration Potential in China:Implications for Carbon Capture

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Journal of Remote Sensing 2022年第1期2022卷 33-45页

作者： Xin Jiang Alan D ziegler Shijing Liang Dashan Wang Zhenzhong Zeng School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Faculty of Fisheries Technology and Aquatic Resources Mae Jo UniversityChiang MaiThailand

Reforestation is an eco-friendly strategy for countering rising carbon dioxide concentrations in the atmosphere and the negative effects of forest loss and ***,with one of the world’s most considerable afforestation rates,has increased its forest cover from 16.6%20 years ago to 23.0%by ***,the maximum potential forest coverage achieved via tree planting and restoration is *** map potential tree coverage across China,we developed a random forest regression model relating environmental factors and appropriate forest *** estimate 67.2 million hectares of land currently available for tree restoration after excluding existing forested areas,urban areas,and agriculture land covers/uses,which is 50%higher than the current *** these lands to the forest would generate 3.99 gigatons of new above-and belowground carbon stocks,representing an important contribution to achieving carbon *** potential is spatially imbalanced,with the largest restorable carbon potential being located in the southwest(29.5%),followed by the northeast(17.2%)and northwest(16.8%).Our study highlights the need to align tree restoration areas with the uneven distribution of carbon sequestration *** addition to being a biological mitigation strategy to partially offset carbon dioxide emissions from fossil fuel burning,reforestation should provide other environmental services such as the restoration of degraded soils,conservation of biological diversity,revitalization of hydrological integrity,localized cooling,and improvement in air *** of the collective benefits of forest restoration,we encourage that such activities be ecosystem focused as opposed to solely focusing on tree planting.

关键词： forest Forest collective

二甲双胍在慢性高胰岛素处理的Hep G2细胞对胰岛素受体后信号转导的调节作用(英文)

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Acta Pharmacologica Sinica 2003年第1期24卷 57-62页

作者：袁莉,Reinhard ziegler,Andreas HAMANN 德国海德堡大学医院内分泌代谢科德国海德堡大学医院内分泌代谢科德国海德堡大学医院内分泌代谢科海德堡 69115 德国 Department of Endocrindlogy in Union Hospital of tongji Medical Colege Huazhong University of Science and Technology Wuhan 430022 China 海德堡 69115 德国海德堡 69115 德国

目的:研究慢性高胰岛素对胰岛素受体后信号转导的影响及其与胰岛素抵抗的关系,并探讨二甲双胍治疗胰岛素抵抗是否通过胰岛素信号转导途径的介导。方法:人类肝癌细胞系(Hep G2)在无血清条件下首先与100nmol/L高浓度胰岛素预温育16h以产... 详细信息

目的:研究慢性高胰岛素对胰岛素受体后信号转导的影响及其与胰岛素抵抗的关系,并探讨二甲双胍治疗胰岛素抵抗是否通过胰岛素信号转导途径的介导。方法:人类肝癌细胞系(Hep G2)在无血清条件下首先与100nmol/L高浓度胰岛素预温育16h以产生胰岛素抵抗细胞模型,并观察不同浓度(0.01-10mmol/L)的二甲双胍对胰岛素受体后磷酯酰肌醇3激酶(PI3K)途径信号转导的影响。结果:高浓度胰岛素100nmol/L慢性处理引起了IRβ、IRS1和IRS2的酪氨酸磷酸化和蛋白表达水平的下调,p85与IRS的相互作用也有显著降低。生理治疗浓度的(0.01-0.1mmol/L)二甲双胍逆转了这种慢性高胰岛素引起的信号下调,细胞用0.1mmol/L二甲双胍预温育后,IRB、IRS1和IRS2的磷酸化反应水平分别增加了2.7倍(P<0.01),6.8倍(P<0.01)和2.3倍(P<0.01),p85与IRS1的相互作用从34％增加至86％(P<0.01),与IRS2的相互作用从30％增加至92％(P<0.01)。相反,药物浓度(1-10mmol/L)的二甲双胍进一步抑制了IRB、IRS的磷酸化及IRS与p85的相互作用。结论:高浓度胰岛素慢性处理可引起胰岛素受体后PI3K途径信号转导的下调,二甲双胍对胰岛素信号转导的作用可能是其治疗胰岛素抵抗的主要分子机制。

关键词：二甲双胍胰岛素受体信号传递

Nano-Morphology of a Polymer Electrolyte Fuel Cell Catalyst Layer Imaging, Reconstruction and Analysis

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纳米研究：英文版 2011年第9期4卷 849-860页

作者： Simon Thiele Roland Zengerle Christoph ziegler Laboratory for MEMS Applications Department of Microsystems Engineering--IMTEK University of Freiburg Georges-Koehler-Allee106 79110 Freiburg Germany

在聚合物电解质燃料房间(PEFC ) 的阴极催化剂层(CCL ) 的氧减小反应(ORR ) 在操作期间是表演损失的主要原因之一。另外， CCL 由于磅催化剂的使用是最昂贵的部件。除了 ORR 本身，种类运输到并且从反应地点决定 PEFC 的表演。在 CCL ... 详细信息

在聚合物电解质燃料房间(PEFC ) 的阴极催化剂层(CCL ) 的氧减小反应(ORR ) 在操作期间是表演损失的主要原因之一。另外， CCL 由于磅催化剂的使用是最昂贵的部件。除了 ORR 本身，种类运输到并且从反应地点决定 PEFC 的表演。在 CCL 的种类的有效运输性质取决于它的 nanostructure。因此， CCL 的三维的重建被要求。一系列二维的图象从集中的离子横梁扫描被获得为二维的图象的电子显微镜(FIB-SEM ) 成像和一个分割方法被开发了。毛孔尺寸分发(PSD ) 为三维的几何学被计算。PSD 上的排列和各向异性的象素尺寸的影响被调查了。毛孔在在 5 nm 和 205 nm 之间的范围被发现。Knudsen 数字的评估证明在 CCL 的那煤气的运输被转变流动政体管理。液体水运输能被包括在连续统水动力学以内描述合适滑动流动边界条件。

关键词：聚合物电解质燃料电池纳米结构催化剂层成像 Knudsen数扫描电子显微镜氧还原反应天然气运输

College Algebra with Trigonometry Raymond A. Barnett, Michael R. ziegler, Karl E. Byleen 7th ed.

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