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Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition

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Cancer Biology & Medicine 2018年第2期15卷 137-156页

作者： Aniket V.mali Asavari A.Joshi Mahabaleshwar V.Hegde Shivajirao S.Kadam Center for Innovation in Nutrition Health and Disease (CINHD) Interactive Research School for Health Affairs (IRSHA)Bharati Vidyapeeth Deemed to be University (BVDU) Pharmaceutical Sciences Poona College of PharmacyBharati Vidyapeeth Deemed to be University (BVDU)

Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against *** transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EMT)via the ERK/NF-κB/Snail signaling pathway,leading to breast cancer *** this pathway to revert the EMT would be an attractive,novel therapeutic strategy to halt breast cancer ***:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELISA),*** of TGF-βinduction and EL treatment on the functional malignancy of MDA-MB-231 breast cancer cells were investigated using migration and chemo-invasion *** effects of EL on EMT markers and the ERK/NF-κB/Snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow ***:Herein,we report that EL exhibits a significant antimetastatic effect on MDA-MB-231 cells by almost reverting the TGF-β-induced EMT in *** downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and *** represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(MAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and Snail at the m RNA and protein ***:Briefly,EL was found to inhibit TGF-β-induced EMT by blocking the ERK/NF-κB/Snail signaling pathway,which is a promising target for breast cancer metastasis therapy.

关键词： Enterolactone breast cancer metastasis EMT invasion migration

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Effect of electron acceptors H_2O_2 and O_2 on the generated reactive oxygen species ~1O_2 and OH~· in TiO_2-catalyzed photocatalytic oxidation of glycerol

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Chinese Journal of Catalysis 2016年第11期37卷 1975-1981页

作者： Trin Jedsukontorn Vissanu Meeyoo Nagahiro Saito mali Hunsom 朱拉隆功大学科学学院化工系燃料研究中心马汉科理工大学高级材料与环境研究中心名古屋大学大学院工学研究科与智能移动协作研究中心朱拉隆功大学石油化学与材料工程卓越中心(PETRO-MAT)

The effect of the electron acceptors H2O2 and O2 on the type of generated reactive oxygen species（ROS）,and glycerol conversion and product distribution in the TiO2-catalyzed photocatalytic oxidation of glycerol was studied at ambient *** the absence of an electron acceptor,only HO^·radicals were generated by irradiated UV light and ***,in the presence of the two electron acceptors,both HO^· radical and ^1O2 were produced by irradiated UV light and TiO2 in different concentrations that depended on the concentration of the electron *** use of H2O2 as an electron acceptor enhanced glycerol conversion more than *** type of generated value-added compounds depended on the concentration of the generated ROS.

关键词： Glycerol oxidation Titanium dioxide Photocatalyst Electron acceptor

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Ovarian cancer recurrence:“is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?”

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Cancer Drug Resistance 2022年第2期5卷 451-458页

作者： tanja Pejovic Katherine Fitch Gordon Mills Knight Cancer Institute Oregon Health&Science UniversityPortlandOR 97239USA. Department of Obstetrics&Gynecology Oregon Health&Science UniversityPortlandOR 97239USA.

PolyADP ribose polymerase inhibitors(PARPi)have transformed the treatment of ovarian *** in high-grade serous ovarian cancer(HGSOC),a disease characterized by homologous recombination deficiency(HRD),PARPi have had a rapid and profound impact on the disease course,as well as biologic and biomarker definitions of HGSOC,thereby creating a paradigm shift in the approach to *** this review,we discuss the role of PARPi in the maintenance treatment of HGSOC,its effect on platinum sensitivity,and cross-resistance between platinum and PARP inhibitors.

关键词： PARP inhibitors olaparib niraparib ovarian cancer maintenance therapy

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Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions

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Cell Research 2007年第1期17卷 62-72页

作者： Betty Ying Zhou Prashant mali USA. Whitehead institute for Biomedical Research CambridgeMA 02142USAThe Institute for Cell EngineeringDepartment of Gynecology & Obstetricsthe Johns Hopkins University School of MedicineBaltimoreMD Program of Biomedical Engineeringthe Johns Hopkins UniversiOSchool of MedicineBaltimoreMD 21205USA

We previously showed that Wnt3a could stimulate human embryonic stem (hES) cell proliferation and affect cell *** the absence of feeder cell-derived factors,hES cells cultured under a feeder-free condition survivedand proliferated *** recombinant Wnt3a in the absence of feeder cell derived-factors stimulated hES cellproliferation but also *** the present study,we further extended our analysis to other Wnt ligands such asWntl and *** Wntl displayed a similar effect on hES cells as Wnt3a,Wnt5a had little effect in this ***3a and Wntl enhanced proliferation of undifferentiated hES cells when feeder-derived self-renewal factors andbFGF are also *** explore the possibility to promote the proliferation of undifferentiated hES cells by activatingthe Wnt signaling,we overexpressed Wnt3a or Wntl gene in immortalized human adult fibroblast (HAFi) cells that aresuperior in supporting long-term growth of undifferentiated hES cells than primary mouse embryonic *** with or without a Wnt transgene can be propagated ***-expression of the Wnt3a gene significantlyenhanced the ability of HAFi feeder cells to support the undifferentiated growth of 3 different hES cell lines we ***-expression of three commonly-used drug selection genes in Wnt3a-overpressing HAFi cells further enabled us toselect rare hES clones after stable transfection or *** immortalized engineered feeder cells (W3R) thatco-express growth-promoting genes such as Wnt3a and three drug selection genes should empower us to efficiently makegenetic modified hES cell lines for basic and translational research.

关键词： WNT human embryonic stem cells stem cell renewal stem cell differentiation transgene

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Brewing Up A Business

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Beijing Review 2015年第19期58卷 28-29页

作者： mali The story of a Tibetan tea maker's particularly palatable plateau produce

Jamyang Lotan gets up early every day to make Tibetan tea for his 76-year-old mother. It has been a tradition in his ram-ily for almost a century.

关键词：商业商品品牌市场

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Grids for the dynamic image

Grids for the dynamic image

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1000年

作者： Diezmann tanja

来源：畅想之星图书光盘版（南... 评论

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Semaglutide might be a key for breaking the vicious cycle of metabolically associated fatty liver disease spectrum?

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World Journal of Clinical Cases 2022年第20期10卷 6759-6768页

作者： Maja Cigrovski Berkovic tanja Rezic Ines Bilic-Curcic Anna Mrzljak Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Endocrinology and Diabetes Clinical Hospital DubravaZagreb 10000Croatia Department of Endocrinology and Diabetes University Hospital Centre OsijekOsijek 31000Croatia Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Metabolically associated fatty liver disease(MAFLD)is a liver manifestation of metabolic syndrome potentially related to unfavorable hepatic and extrahepatic outcomes and progression to *** to date,there are no approved pharmacotherapies for the treatment of MAFLD,so management focused on lifestyle interventions to encourage weight loss,and treatment of coexisting conditions is the only available ***,the aforementioned is often not potent enough to offer reversal or slow down hepatic inflammation and ***-like peptide-1 receptor agonists have a favorable effect on glycemic management and weight loss of patients with type 2 diabetes mellitus and recently published data suggest their potential in MAFLD *** addition,some of the agents have proven cardiovascular and renal benefits in dedicated cardiovascular outcome trials,making them an interesting therapeutic *** this opinion review,we discuss the role of semaglutide in MAFLD.

关键词： Semaglutide Non-alcoholic fatty liver disease Glucagon-like peptide-1 receptor agonists Metabolically associated fatty liver disease

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OBSTACLE PROBLEMS FOR SCALAR GINZBURG-LANDAU EQUATIONS

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Journal of Partial Differential Equations 2004年第1期17卷 49-56页

作者： mali SuNing DepartmentofMathematicalSciences TsinghuaUniversityBeijing100084China

In this note, we establish some estimates of solutions of the scalar Ginzburg-Landau equation and other nonlinear Laplacian equation △u =f(x, u). This will give an estimate of the Hausdorff dimension for the free bou... 详细信息

关键词：障碍问题标量GINZBURG-LANDAU方程非线性Laplacian方程 Hausdorff维数

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Range estimation by Doppler of multi-line in radiated noise spectrum

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Chinese Journal of Acoustics 2005年第3期24卷 212-221页

作者： WUGuoqing mali InstituteofAcoustics ChineseAcademyofSciencesBeijing100080

A method by applying Doppler frequency shift of multi-line in radiated noise spectrum to estimate the vertical range from a receiver to a moving vessel, which is supposed to move along a straight line at a constant velocity, is developed. This method is based on passive ranging by a single sensor and the depth of the sea and other environment parameters are not necessarily known. First the Wigner-Ville distribution is used as the instantaneous frequency estimator to find out the instantaneous frequencies of the muti-lines as a signal. Then define Doppler frequency shift basis functions, based on an algorithm called matching pursuit, by a searching strategy of variable span, and explore the minimum spatial distance between the signal and the Doppler frequency shift basis functions in a five-dimension space. The basis function of the obtained minimum spatial distance corresponds to the estimation of range and speed of the moving vessel. Computer simulations yield statistics errors in the range and speed estimates with differing intensities of noise. If the white noise deviation is less than 10% of the maximum Doppler frequency shift and time-window width is 1.47 times of reference-duration, relative error of range estimate is less than 5.4% and relative error of speed estimate is less than 1.4%. This estimation method has been tested and the result conforms to data collected during an experiment on the sea, the estimated speed is 52 knots and the estimated range is 42 m. The single point passive ranging method can be used for ranging purposes in sonar-buoys, mines, movement analysis of an underwater object in underwater acoustics experiment, and sound source level measurements.

关键词： line Range estimation by Doppler of multi-line in radiated noise spectrum

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Instabilities in Coaxial Rotating Jets

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Journal of Thermal Science 2000年第4期9卷 322-326页

作者： tanja Ivanic Eric Foucault Jean Pecheux Virginie Gilard Laboratoire d’Etudes Aérodynamiques (L.E.A. CNRS UMR 6609) Poitiers France

The aim of this study is the characterization of the cylindrical "mixing layer resulting from the interaction of two coaxial swirling jets. The experimental part of this study was performed in a cylindrical water tunnel, permitting an independent rotation of two coaxial jets. The rotations are generated by means of 2×36 blades localized in two swirling chambers. As expected, the evolution of the main instability modes presents certain differences compared to the plane-mixing-layer case. Experimental results obtained by tomography showed the existence of vortex rings and streamwise vortex pairs in the near field region. This method also permitted the observation of the evolution and interaction of different modes. PIV velocity measurements realized in the meridian plans and the plans perpendicular to the jet axis show that rotation distorts the typical top-hat axial velocity profile. The transition of the axial velocity profile from jet-like into wake-like is also observed.

关键词： rotation swirl mixing layer instabilities.

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