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The effect of progesterone and synthetic progestins on the proliferation of human breast cancer cells expressing a membrane-bound progesterone receptor

The effect of progesterone and synthetic progestins on the p...

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中华医学会第三次全国绝经学术会议暨绝经相关问题学习班

作者： Hans Neubauer Harald Seeger tanja fehm Alfred O Mueck Michael A Cahill University Women’s Hospital TuebingenGermany School of Biomedical Sciences Charles Sturt UniversityWagga WaggaNSWAustralia

Objectives:Evidence is accumulating that progestogens may play a crucial role in the development of breast cancer under contraception and hormone therapy in the *** receptor membrane component 1(PGRMC1) expressed in breast cancer may be important in tumorigenesis and thus may increase breast cancer *** aim of this project was to investigate the influence of progesterone and nine synthetic progestins on MCF-7 breast cancer cells overexpressing ***: MCF-7 cells were stably transfected with PGRMC1 expression plasmid(MCF-7/PGRMC1-3HA).To test the effects of progestogerone(P) and the synthetic progestins chlormadinone acetate(CMA), desogestrel(DSG),dienogest(DNG),drospirenone(DRSP),dydrogesterone(DYD),levonorgestrel (LNG),medroxyprogesterone acetate(MPA),nomegestrol(NOM) and norethisterone(NET) on cell proliferation MCF-7 and MCF-7/PGRMC1-3HA(WT-12) cells were stimulated with different concentrations (10-9 M to 10-7 M).Results:In MCF-7 cells DNG,DSG,DYD,LNG and NET increased the proliferation at 10-7 M,the effect being highest for NET with about 20%.In WT-12 cells the same progestins, but additionally DRSP and MPA showed a significant increase,which was much higher(30- 245%) than in MCF-7 *** again NET showed the highest proliferative *** effect was found for CMA,NOM and ***:Synthetic progestins trigger a proliferative response of PGRMC1 overexpressed MCF-7 cancer *** effect of progestogens on breast cancer tumorigenesis may clearly depend on the specific pharmacology of the various synthetic progestins.

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Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice

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Light(Science & Applications) 2016年第1期5卷 104-111页

作者： X Luís Deán-Ben Thomas F fehm Steven J Ford Sven Gottschalk Daniel Razansky Institute for Biological and Medical Imaging(IBMI) Helmholtz Center Munich85764 NeuherbergGermany School of Medicine and School of Bioengineering Technical University of Munich81675 MunichGermany

Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms,disease state and *** imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue ***,efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of ***,we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched highresolution contrast across multiple spatiotemporal *** vivo experiments in mice demonstrate a wide range of dynamic imaging capabilities,from three-dimensional high-frame-rate visualization of moving organs and contrast agent kinetics in selected areas to whole-body longitudinal studies with unprecedented image *** newly introduced paradigm shift in imaging of multi-scale dynamics adds to the multifarious advantages provided by the optoacoustic technology for structural,functional and molecular imaging.

关键词： multi-scale dynamics multi-spectral imaging optoacoustic tomography real-time imaging whole-body imaging

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Oral but not written test anxiety is related to social anxiety

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World Journal of Psychiatry 2016年第3期6卷 351-357页

作者： Lisa Laurin-Barantke Jürgen Hoyer Lydia fehm Susanne Knappe Institute of Clinical Psychology and Psychotherapy Technische Universitat Dresden Center for Psychotherapy (ZPHU) Humboldt-Universitat zu Berlin Institute of Clinical Psychology and Psychotherapy Center for Preventive Intervention StudiesTechnische Universitat Dresden

AIM To examine the associations of test anxiety(TA) in written vs oral exam situations with social anxiety(SA).METHODS A convenience sample of 204 students was recruited at the Technische Universit?t Dresden(TU Dresden,Germany) and contacted via e-mail asking to complete a cross-sectional online survey based on established *** study protocol was approved by the ethics committee of the TU *** data of n = 96 students were available for dependent t-tests and correlation analyses on the associations of SA and TA respectively with trigger events,cognitions,safety behaviors,physical symptoms and *** were run using *** Levels of TA were higher for fear in oral exams than for fear in written exams(M = 48.1,SD = 11.5 vs M = 43.7,SD = 10.1 P 0.05;Pearson's r = 0.223,P > 0.05).Compared to written TA,triggerevents were more often reported for oral TA(18.2% vs 30.3%,P = 0.007);which was also accompanied more often by test-anxious cognitions(7.9% vs 8.5%,P = 0.001),safety behavior(8.9% vs 10.3%,P < 0.001) and physical symptoms(for all,P < 0.001).CONCLUSION Written,but not oral TA emerged being unrelated to SA and may rather not be considered as a typical facet of SA disorder.

关键词： Social anxiety Derealization Test anxiety Depersonalization Safety behavior

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跟腱移植修复全髋关节置换术后外展肌肌力不足

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中华骨科杂志 2011年第3期31卷 I0006-I0011页

作者： Michael N. fehm, MD James I. Huddleston, MD Dennis W. Burke, MD Jeffrey A. Geller, MD Henrik Malchau, MD, PhD 王韶进(译) Investigation performed at the Harris Orthopaedic Laboratory Department of Orthopaedic S.rgery. Massachusetts General HospitalBostonMassachusetts 山东大学第二医院关节外科济南250033

背景：全髋关节置换术后的外展肌力不足是个罕见但易导致功能不佳的问题。其诊断困难，而且即使诊断明确也几乎没有有效的治疗方法。，本文旨在旧顾我们采用带跟骨止点的新鲜冰冻跟腱移植进行全髋关节置换术后的外展肌重建的一些经验。... 详细信息

背景：全髋关节置换术后的外展肌力不足是个罕见但易导致功能不佳的问题。其诊断困难，而且即使诊断明确也几乎没有有效的治疗方法。，本文旨在旧顾我们采用带跟骨止点的新鲜冰冻跟腱移植进行全髋关节置换术后的外展肌重建的一些经验。方法：2003年至2006年间，我们采用新鲜冰冻跟腱移植治疗7例全髋关节置换术后的外展肌肌力不足患者。所有7例患者，平均在全髋关节置换术后29个月，多出现髋外侧疼痛，并通过Trendelenburg征表明为外展肌力软弱。外展肌腱断裂的诊断建直在关节造影摄片上并在手术中得到确认。结果：重建前Harris评分平均为34．7分，疼痛评分平均为11．4分。，重建后至少随访24个月，Harris评分平均为85．9分，疼痛评分平均为38．9分。结论：采用将带跟骨止点的跟腱固定于大转子上重建外展肌，可以有效缓解疼痛，增加外展肌力，减少跛行，在早期随访叶JTrendelenburg征及髋关节功能得到改善。可信水平：治疗性研究Ⅳ级。关于证据等级的完整描述详见投稿须知。

关键词：全髋关节置换术后外展肌力移植修复跟腱 Harris评分疼痛评分髋关节功能治疗方法

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妊娠前、妊娠期及产后1年体重指数的变化

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 37-38页

作者： Becker S. Fedtke M. fehm T. 赵秀敏 Universitats-Frauenklinik Tubingen Calwer Strafle 7 72076T¨ubingen Germany Dr.

Purpose: Obesity is a problem that affects almost one third of all preg nant wo men. To establish a data base for further studies we looked at the evolution of weight and body mass index before, during and one year after pregnancy. Material and Methods: Out of 2220 women who gave birth at the Womens University Hospit al Tübingen in 2001, 1000 were selected for further evaluation in accordance wi th our inclusion and exclusion criteria. Data regarding pregnancy and delivery w ere collected retrospectively. One year after delivery, the women were contacted by phone and interviewed regarding their weight development. Results: Out of 10 00 women, 713 women were successfully contacted. Average age was 31.7 years. Ave rage weight before pregnancy was 65.9 kg, average weight-gain during pregnancy was 13.2 kg. Average weight one year postpartum was 66.5 kg. Before pregnancy, 2 3.3%of all women were overweight or obese. One year after delivery, 27.0%fell into these two categories (p<0.01). Only about one third of all pregnant women g ained weight within the recommended limits. Conclusion: Almost one third of wome n are overweight or obese before and one year after pregnancy and delivery. Weig ht changes during and after pregnancy varied widely. Overweight status before pregnancy and -for normal-weight wom en -weight gain in excess of the recommended maximal 16 kg during pregnancy wer e important risk factors for weight retention one year after delivery. The proba bility of a normal-weight woman to be overweight or obese one year after pregna ncy is 10%.

关键词：附属医院肥胖问题排除标准女子大学前约限制范围

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输卵管癌:罕见的妇科恶性肿瘤报道及文献回顾

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 40-40页

作者： Krmer B. fehm T. Schauf B. 朱国栋 Universitaetsfrauenklinik Tuebingen Calwer Strasse 7 72076 Tuebingen Germany

Background: Primary fallopian tube carcinoma is the rarest of all gynaecological malignancies. It comprises only 0.1-1.0%of all neoplasms of the female genital tract, although it is a common site of metastases. This carcinoma is rarely diagnosed preoperatively; most often patients undergo surgery for other reasons. Case: We report the case of a 56-year-old postmenopausal woman with primary fallopian tube carcinoma third stage confined to the right tube involving one positive retroperitoneal lymph node. Adjuvant chemotherapy with six cycles of Carboplatin/Taxol was advised after surgical resection. Conclusion: The rarity of the condition makes it difficult to perform randomised studies which could determine the treatment of choice. Our work adds further information to the relatively small body of literature available on fallopian tube carcinoma.

关键词：输卵管癌妇科恶性肿瘤文献回顾生殖道肿瘤辅助化疗肿瘤转移右侧输卵管绝经期妇女

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