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Stimulatory Effect of Whole Coffee Fruit Concentrate Powder on Plasma Levels of Total and Exosomal Brain-Derived Neurotrophic Factor in Healthy Subjects: An Acute Within-Subject Clinical Study

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Food and Nutrition Sciences 2013年第9期4卷 984-990页

作者： tania reyes-izquierdo Ruby Argumedo Cynthia Shu Boris Nemzer Zb Pietrzkowski Applied BioClinical Inc. Irvine USA FutureCeuticals Inc. Momence USA.

A pilot study by reyes [1] previously showed that ingestion of single dose of whole coffee fruit concentrate (WCFC) powder increased blood levels of brain derived neurotrophic factor (BDNF) during the first 60 minutes after ingestion. In the present report, we performed a single dose, placebo-controlled, within-subject study to confirm and further investigate this effect. Twenty healthy subjects with ages ranging from 25 to 35 participated in this study. All fasted and resting subjects received placebo on Day 1, WCFC on Day 2, and a cup of freshly brewed coffee on Day 3. Treatment with WCFC resulted in a statistically significant increase in plasma BDNF compared to placebo (p = 0.0073) or coffee (p = 0.0219) during first 60 minutes. In addition, e isolated exosomes from serum and found that they contained BDNF. Furthermore, oral WCFC consumption acutely increased BDNF levels in serum exosomes. In summary, all presented results justify further clinical investigation of WCFC as a tool to manage BDNF-dependent health conditions.

关键词： Brain-Derived Neurotrophic Factor Whole Coffee Fruit Concentrate Coffee Exosomes Acute Effect

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Effects of the support material addition on the hydrodynamic behavior of an anaerobic expanded granular sludge bed reactor

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Journal of Environmental Sciences 2017年第4期29卷 224-230页

作者： tania Pérez-Pérez Gleyce Teixeira Correia Wu Hong Kwong Ileana Pereda-reyes Deny Oliva-Merencio Marcelo Zaiat Institute of Animal Science San Jose de las Lajas Mayabeque Cuba Department of Chemical Engineering Federal University of Sao Carlos Brazil Process Engineering Centre Instituto Superior Politecnico Jose Antonio Echeverria (Cujae) 11901 114 Street Marianao Havana Cuba Study Centre of Renevaable Energy Technologies Instituto Superior Politecnico rose Antonio Echeverria (Cujae) 11901 114 Street Marianao Havana Cuba Biological Processes Laboratory Center for Research Development and Innovation in Environmental Engineering Sao Carlos School of Engineering University of Sao Paulo Engenharia Ambiental - Bloco 4-F Av. Joao Dagnone 17.00 - Santa Angelina 13.563-120 Sao Carlos SP Brazil

As a support material, zeolite can be used to promote the granulation process due to its high settable property and the ability to retain biomass on its surface. The present paper reports on the influence of zeolite addition on the hydrodynamic behavior of an expanded granular sludge bed reactor（EGSB）. Different models were applied to fit the flow pattern and to compare EGSB hydrodynamic performance with and without the addition of zeolite. The experimental data fit the tanks in a series model for zeolite bed height of 5 cm and upflow velocity of 6 m/*** axial dispersion degree（D/uL） was obtained at lower heights of zeolite. The real hydraulic retention time（HRTr） was increased with both increased zeolite bed height and increased upflow velocity. The short-circuit results for 5 cm of zeolite bed and 6, 8 and 10 m/hr upflow velocity were 0.3, 0.24 and 0.19 respectively, demonstrating the feasibility of using zeolite for a proper hydrodynamic environment to operate the EGSB reactor. The presence of zeolite resulted in the higher percentage values of dead zones, ranging from 12% to 24%.Zeolite addition exerted a positive effect on the hydrodynamics pattern for this technology being advantageous for the anaerobic process because of its possible contribution to better biofilm agglomeration, granule formation and substrate-microorganism contact.

关键词： Anaerobic digestion Axial dispersion degree EGSB reactor Hydrodynamics Upflow velocity Zeolite

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Mathematical Modeling of the Hydrodynamics of an EGSB Reactor

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Journal of Chemistry and Chemical Engineering 2014年第6期8卷 602-610页

作者： Gleyce Teixeira Correia tania Pérez-Pérez Ileana Pereda-reyes Deny Oliva Merencio Marcelo Zaiat Wu Hong Kwong Department of Chemical Engineering Federal University of Sao Carlos Sao Carlos 13565-905 Brazil Institute of Animal Science Mayabeque 32700 Cuba Study Center of Process Engineering Instituto Superior Politécnico "José Antonio Eeheverria " Havana 19390 Cuba Study Center of Renewable Energy Technologies lnstituto Superior Politécnico "José Antonio Echeverria " Havana 19390 Cuba Department of Hydraulic and Sanitation School of Engineering of Sao Carlos University of Sao Paulo Sao Carlos 13563-120 Brazil

Generally, in the literature, the hydrodynamic behavior of an EGSB （expanded granular sludge bed） reactor is considered as a complete mix reactor. Few works study in detail the flow of such reactors. The aim of this work was to study, in detail, the hydrodynamics of an EGSB reactor and to propose a mathematical model to describe its flow. A 3.04 L reactor was used with HRT （hydraulic retention time） of 12 h, affluent flowrate of 4 mL·min^-1, and the recirculation flow rate was changed to study three different upflow velocities in the tube （6, 8 and 10 m·h^-1. The pulse input method was used, with the use of blue dextran as tracer. In order to consider the dimensional differences between the tube and the separator, the reactor was divided into two regions （tube and separator）. Initially, a model with two tubular reactors with dispersion in series was proposed and the Peclet number was adjusted for the two regions. It was observed that the region of the tube shows the behavior of a tubular reactor with high dispersion, whereas the region of the separator shows the behavior of a complete mix reactor. In order to simplify the equation, and by knowing that the concentration profile along the reactor was almost constant, a model of two CSTRs （continuous stirred tank reactors） was proposed in series and the number of reactors （N） was set. The best combination was five CSTRs, three in the tube region and two in the separator region. The presented models were equivalent and can be used to describe the hydrodynamic behavior of the EGSB reactor.

关键词： EGSB reactor hydrodynamics mathematical modeling.

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The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo Martínez Ávila Lliset Álvarez Pérez Gisselle Martínez Rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano Margarita De Quesada Amigó Rafael I. reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza tania A. Agrelo Ramos Rosa María Muñoz reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David Marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical Pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-Psychology INOR La Habana Cuba Clinical Laboratory Department INOR La Habana Cuba Clinical Trials Pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care

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