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The Value of Excipients and the Required Understanding of the Biological System in Product Development: An Impactful Example of Curaderm, a Topical Skin Cancer Treatment

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International Journal of Clinical Medicine 2024年第2期15卷 68-87页

作者： tania Robyn Chase Kai Elliot Cham Bill Elliot Cham Australasian Medical Research Port Vila Republic of Vanuatu

The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.

关键词： Curaderm BEC Solasodine Glycosides Solamargine Apoptosis Skin Cancer Actinic Keratosis Keratoacanthoma Basal Cell Carcinoma Squamous Cell Carcinoma

Chemical Profile of the Sulphated Saponins from the Starfish Luidia senegalensis Collected as by-Catch Fauna in Brazilian Coast

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Natural Products and Bioprospecting 2018年第2期8卷 83-89页

作者： Marcelo Marucci Pereira Tangerina Julia Pizarro Cesario Gerson Rodrigues Raggi Pereira tania Marcia Costa Wagner Cotroni Valenti Wagner Vilegas UNESP-Univ Estadual Paulista Coastal campus of Sao VicentePraca Infante Dom Henrique s/nSao VicenteSP 11330-900Brazil Chemistry Institute Sao Paulo State University-UNESPAraraquara CampusProf.Francisco Degni55SPAraraquara 14800-060Brazil

The by-catch fauna of the shrimp fishery includes a number of marine invertebrates that are discarded because they do not have commercial *** order to try to add some value to these materials,we analyzed the chemical composition of the starfish Luidia senegalensis collected in the Brazilian coast as a consequence of the trawling fishery *** order to access their chemical composition,we used a combination of solid phase extraction(SPE)followed by ultra-high performance liquid chromatography coupled to electrospray ionization ion trap tandem mass spectrometry(UPLC-ESI-IT-MSn).Luidia sene-galensis contains asterosaponins,which are sulphated glycosilated steroids,containing five and six sugar moieties,in addition to *** study helped us to support the presence of important and potentially bioactive compounds in invertebrates associated to the by-catch fauna of the shrimp fishery,using a fast and efficient method.

关键词： Luidia senegalensis By-catch fauna Asterosaponins UPLC-MS

Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 555-560页

作者： Evandro de Oliveira Souza Elbio Antonio D’Amico tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias Division of Gastroenterology and Hepatology University of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2559th flooroffice 9159Sao PauloSP 05403-000Brazil Hemostasis Laboratory Hematology ServiceUniversity of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2552nd floorSao PauloSP 05403-000Brazil

Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal ***,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this *** objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to ***:Totally 111 patients were divided into three groups according to platelet count:(1)100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ***-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function ***:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding.

关键词： Cirrhosis Hemostasis Thrombocytopenia Platelet aggregation Endoscopy Hemorrage

Are Family Table Foods Appropriate for Infants? Comparing the Nutritional Quality of Homemade Meals Adapted from the Family’s Table Foods and Those Specially Prepared for Infants

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Food and Nutrition Sciences 2014年第13期5卷 1247-1254页

作者： Pérola Ribeiro Dirce Maria Sigulem tania Beninga Morais Nutrition Course Universidade Nove de JulhoSao PauloBrazil Postgraduate Program in Nutrition Universidade Federal de Sao Paulo/UNIFESPSao PauloBrazil Food Quality Control Laboratory Universidade Federal de Sao Paulo/UNIFESPSao PauloBrazil

The Brazilian Ministry of Health recommends that by 8 months of age, children should eat the same types of foods consumed by the other members of the family. Thus, this study sought to evaluate whether the nutritional composition of meals specially prepared (SM) for children aged 7 to 18 months in low-income families was superior to that of meals adapted (AM) from the family’s table foods. Protein, fat, carbohydrate, energy, dietary fiber, iron, sodium and sodium chloride values, were determined by chemical analyses and compared to dietetic guidelines. The infants’ hemoglobin levels were also investigated. In total, sixty samples of the infants’ lunch meal (51 AM and 9 SM) were taken for during a home visit. The values of protein, fat, carbohydrate, dietary fiber and energy of the AM were significantly lower, while the sodium and sodium chloride values were significantly higher, compared to those of the SM. The AM also contained significantly more water. No differences were seen with regard to iron values. Sodium chloride amounted for most of the sodium content. Neither the SM nor AM was adequate in terms of iron and sodium. All SM were adequate for protein and fat, whereas AM showed significantly more samples with inadequate energy levels. SM fell within the Acceptable Macronutrient Distribution Range, while AM fell below the lower value for fat and slightly above the upper value for carbohydrate. The prevalence of anemia was 60% in the study population (36/60). In conclusion, meals adapted from the family’s table foods showed a lower nutrient density and a less balanced macronutrient range when compared to meals specially prepared for infants. The main nutritional shortcomings, for both AM and SM, were the extremely low content of iron and the high content of sodium.

关键词： Infant Food Infant Nutrition Food Composition Food Analysis

A Preliminary Comparison of Convergent IP Networks and Future Internet Approaches

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通讯和计算机（中英文版） 2011年第11期8卷 978-987页

作者： Antonio Marcos Alberti tania Regina Tronco Christian Esteve Rothenberg Instituto Nacional de Telecomunicacoes （INATEL） Santa Rita do Sapucal CEP 37540-000 Minas Gerais Brazil Centro de Pesquisa e Desenvolvimento em Telecomunicacoes （CPqD Foundation） Campinas CEP 13086-902 Sao Paulo Brazil

Trends in Corporate Social Responsibility Among Public Service Media in Europe

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Economics World 2017年第6期5卷 560-565页

作者： tania Femandez-Lombao Andrea Valencia-Bermudez Francisco Campos-Freire University of Santiago de Compostela Santiago Spain

Corporate Social Responsibility （CSR） is the voluntary commitment taken over by companies in social, economic, and environmental terms. The aim is to counteract impacts generated by their activity. While the concept is genuinely linked to the private sector, this self-regulated system has been steadily introduced in some European public service media. Indeed, CSR is one of the mechanisms to face the challenges of the sector, both the financial crisis and the lack of trust. Seven public service media from the European Union are reporting--via their websites--on their CSR strategies. Annual reports on their performance are issued by the German ZDF, the Spanish RTVE, the Portuguese RTP, the British BBC, the Irish RTI~, the Finnish YLE, and the Italian RAI. Also, four other corporations--VRT and RTBF from Belgium, FT from France, and DR from Denmark include a section on corporate social responsibility on their annual reports. The aim of this paper is to know which of the trends in CSR are dominant among public service media in Europe, namely economy, environment, and society. The content analysis of corporate reports is the method used for the research.

关键词： corporate social responsibility public service media accountability European Union

Fisheries resources of Bangladesh:Present status and future direction

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Aquaculture and Fisheries 2017年第4期2卷 145-156页

作者： Md.Mostafa Shamsuzzaman Mohammad Mahmudul Islam Nusrat Jahan tania Md.Abdullah Al-Mamun Partho Protim Barman Xiangmin Xu Environmental&Resources Protection Law Ocean University of ChinaQingdao 266100China Department of Coastal and Marine Fisheries Sylhet Agricultural UniversitySylhet 3100Bangladesh Department of Fisheries Marine Fisheries OfficeChittagong 4100Bangladesh

Bangladesh is considered one of the most suitable regions for fisheries in the world,with the world's largest flooded wetland and the third largest aquatic biodiversity in Asia after China and *** paper reviews the performance of fisheries in Bangladesh using data collected from the Bangladesh Department of Fisheries,and related un-published grey *** findings within describe recent growth within Bangladeshi inland fisheries,primarily in the inland aquaculture sector(2014e2015).This increase in the aquaculture production has been made possible with the implementation of scientific and technological *** 2000 and 2016,aquaculture production increased from 712,640 and 2,060,408 metric t,a much larger quantity than wild capture production(1.023 million t)in *** has also been a recent increase in the value of fishery exports,with more than US$34.08 billion in 2010 rising to more than US$46.60 billion in ***,fisheries production is well below production targets despite the large gains seen in the aquaculture sector.

关键词： Inland fishery Aquaculture Coastal and marine Export and import Regulations Bangladesh

Experience with postmortem computed tomography in the forensic analysis of the November 2015 Paris attacks

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Forensic Sciences Research 2020年第3期5卷 242-247页

作者： Laura W.de Jong Laurence Legrand tania Delabarde Ghazi Hmeydia Myriam Edjlali Lilia Hamza Joseph Benzakoun Catherine Oppenheim Bertrand Ludes Jean-Francois Meder Department of Neuroradiology GHU Paris Psychiatrie et Neurosciences-Sainte-Anne HospitalUniversite de ParisParisFrance Inserm U1266 IMA-BrainInstitut de Psychiatrie et Neurosciences de ParisParisFrance Pole Universitaire d’Imagerie Post-Mortem Universite de ParisParisFrance Institut Medico-Legal de Paris ParisFrance Service d’Accueil des Urgences Hopital AvicenneBobignyFrance Universite de Paris BABELCNRSParisFrance

Several reports discuss the added value of postmortem computed tomography(PMCT)in the forensic analysis of mass fatality incidents(MFIs),such as the 2009 Victorian bushfires,the Grenfell tower disaster and the MH17 plane crash[1–5].In France,the first deployment of PMCT in an MFI took place during the forensic analysis of the November 2015 Paris terrorist attacks.

关键词： postmortem analysis disaster

一个中国先天性有汗性外胚层发育不良家系的GJB6基因筛查（英文）

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中南大学学报（医学版） 2013年第8期38卷 761-765页

作者： tania Mousumi 熊志敏鹿丽娜刘双琳夏昆胡正茂中南大学医学遗传学国家重点实验室长沙410078 浏阳市妇幼保健院长沙410300

目的:先天性有汗性外胚层发育不良是一种常染色体显性遗传病,GJB6基因突变与之相关。调查一个来自中国的先天性有汗性外胚层发育不良家系与GJB6基因的关系。方法:收集一个共有17个家系成员(患者8人,5男3女)的先天性有汗性外胚层发育不... 详细信息

目的:先天性有汗性外胚层发育不良是一种常染色体显性遗传病,GJB6基因突变与之相关。调查一个来自中国的先天性有汗性外胚层发育不良家系与GJB6基因的关系。方法:收集一个共有17个家系成员(患者8人,5男3女)的先天性有汗性外胚层发育不良家系,采集家系成员的外周血,抽提DNA。然后针对GJB6基因的每个外显子设计引物,应用聚合酶链式反应(PCR)方法扩增GJB6基因的整个编码区,测序、筛查突变。结果:通过对家系患者的GJB6基因筛查,发现了一个杂合错义突变c.31G>A(p.G11R)。结论:GJB6基因错义突变c.31G>A(p.G11R)导致该家系先天性有汗性外胚层发育不良。

关键词：毛发缺陷先天性杵状指错义突变掌跖角化过度