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Are liver nested stromal epithelial tumors always low aggressive?

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World Journal of Gastroenterology 2017年第46期23卷 8248-8255页

作者： tania meletani Luca Cantini Andrea Lanese Daniele Nicolini Alessia Cimadamore Andrea Agostini Giulia Ricci Stefania Antognoli Alessandra Mandolesi Maria Guido Rita Alaggio Gian Marco Giuseppetti Marina Scarpelli Marco Vivarelli Rossana Berardi Medical Oncology University Hospital and Polytechnic University Ancona Hepatobiliary and Trans-plantation Surgery Department of Clinical and Experimental MedicineUniversity Hospital and Polytechnic University Ancona Section of Pathological Anatomy Department of Biomedical Sciences and Public HealthUniversity Hospital and Polytechnic University Ancona Department of Radiology University Hospital and Polytechnic University Ancona Pathology Department Padova University

Nested stromal-epithelial tumor(NSET) is a nonhepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver. The histological exam confirmed the diagnosis of NSET. After 6 mo from surgery, a liver recurrence was described and a chemoembolization was performed. After a further disease progression, based on the correlation between the histological features of the disease and those of the hepatoblastoma, a similar chemotherapy regimen(with cisplatin and ifosfamide/mesna chemotherapy, omitting doxorubicin due to liver impairment) was administered. However, infection of the biliary catheter required a dose modification of the treatment. No benefit was noted and a progression of disease was radiologically assessed after only four cycles. The worsening of the clinical status prevented further treatments, and the patient died a few months later. This case report documents how the NSET might have an aggressive and non-preventable behavior. No chemotherapy schedules with a proved efficacy are available, and new data are needed to shed light on this rare neoplasm.

关键词： Nested stromal epithelial tumor Liver Rare Chemotherapy Aggressive Metastatic

Is Burn-Out the Main Issue？ Impact of Aggressiveness and Depression in Burn-Out Among Operators in Oncology

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Psychology Research 2017年第9期7卷 509-514页

作者： Romeo Marco Anna Vespa Maria Velia Giulietti Riccardo Giampieri tania meletani Ilaria Fiordoliva Mafia Giuditta Baleani Sofia Formentini Rossana Berardi Universita Politecnica delle Marche Ancona Italy Fondazione Rossetti Fedecostante Ancona Italy INRCA-IRCCS-National Institute of Science and Health for Aging Ancona Italy Universita Politecnica delle Marche Ancona Italy

The astrophysical gravitational wave stochastic background

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Research in Astronomy and Astrophysics 2011年第4期11卷 369-390页

作者： tania Regimbau UMR ARTEMIS CNRS University of Nice Sophia-Antipolis Observatoire de la Cte d'AzurBP 422906304Nice Cedex 4France

A stochastic background of gravitational waves with astrophysical origins may have＇resulted from the superposition of a large number of unresolved sources since the beginning of stellar activity. Its detection would put very strong constraints on the physical properties of compact objects, the initial mass function and star for- marion history. On the other hand, it could be a ＇noise＇ that would mask the stochastic background of its cosmological origin. We review the main astrophysical processes which are able to produce a stochastic background and discuss how they may differ from the primordial contribution in terms of statistical properties. Current detection methods are also presented.

关键词： gravitational waves -- stochastic background: neutron stars -- blackholes

Retinoid receptor-related orphan receptor alpha： a key gene setting brain circuits

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Neural Regeneration Research 2018年第5期13卷 791-794页

作者： tania Vitalis Jean Mariani PROTECT Institut National de la Santé et de la Recherche Médicale Université Paris Diderot Paris France Université Pierre et Marie Curie Sorbonne Université Paris France Centre National de la Recherche Scientifique Unité Mixte de Recherche 8256 Institut de Biologie de Paris Seine (IBPS) Biological adaptation and ageing (B2A) Team Brain Development Repair and Ageing Paris France Assistance Publique - Hopitaux de Paris Départements Hospitalo-Universitaires FAST Institut de la Longévité Ivry-Sur-Seine France

The retinoid receptor-related orphan receptor alpha（RORα） is thought to act as a constitutive activator of transcription by binding to the ROR response element（RORE） of target genes. Several mouse models in which RORα is defective have revealed the decisive roles of RORα on the development, maturation and neuroprotection of various cerebral regions including the cerebellar and somatosensory systems. We have recently shown that RORα is needed for accurate thalamic sensory system organization and somatosensory cortex development. The phenotype of various RORα deficient mice models（staggerer mutant or mouse lacking RORα in specific somatosensory regions） is, in part, reminiscent of what has been described in mice lacking thyroid hormone triiodothyronine（T3）. As in in vitro studies or in other models, our studies strongly suggest that the T3/RORα-pathway, among others, is in part responsible for the staggerer phenotype. We have indeed identified some genes that were both regulated by T3 and RORα and that are known to be implicated in the cerebellar or somatosensory system development. Moreover, several groups have shown that RORα is at the crossroad of many biological processes and pathologies, including psychiatric and degenerative disorders. In particular, defective RORα-signalling has been demonstrated in humans to be associated with the emergence of autistic-like disorders. We believe that determining the appropriate amount of RORα activity could be crucial in detecting and preventing the emergence of specific brain diseases.

关键词： cerebellum cerebral cortex development maturation neuroprotection psychiatric disorders somatosensory system

Reflections on the importance of built heritage inventory as a tool for preservation in Karachi-a case study of Wadhumal Odharam(Jail)Quarter in Karachi,Sindh,Pakistan

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Built Heritage 2024年第1期8卷 29-45页

作者： tania Ali Soomro Department of Architecture and Urban Studies Politecnico Di MilanoMilanoItaly

The cultural heritage inventory is an alternate tool to document historic buildings to establish a protected enlistment *** the importance of inventories for developing knowledge of historical and cultural patterns,multiple attempts are being made to record Karachi's historic buildings in the form of inventory *** research investigates the various approaches used for inventorying Karachi's cultural heritage and their potential impact on the survival of the city's historical *** literature,this research provides a brief overview of Karachi's architectural development before and after its annexation to the British Raj(Term used by scholars to represent the British Crown in *** term'The Raj'is also sometimes used.)(1843-1947),which is now considered the historic core of the city of Karachi,together with the systems of inventorying the built heritage over *** Odharam(Jail)Quarter is shortlisted as a case study for this research,which will be examined from the perspective of inventory making in relation to its specific physical and sociocultural context as documented through the inventorying *** Quarter is also referred to as'Jail Quarter'because of the presence of the Jail building within the Quarter precinct,which was demolished during the British era;it is discussed in further detail later in this *** research approach follows a survey of the quarter conducted between August and September 2022,followed by a mapping of the historic *** inventory mapping of the Quarter is performed by using an available database(Database of various historic Quarters of Karachi by Heritage Cell-DAPNED).The data for inventory also helps provide an understanding of the history and development of the *** other aspects of the research methodology include intreating questions and collecting data about various aspects of the Quarter,such as the building information,photographic documentation of the properties,an

关键词： inventorying inventory making heritage conservation commercialisation pressure

Current status of esophageal cancer treatment

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Chinese Journal of Cancer Research 2020年第3期32卷 271-286页

作者： tania Triantafyllou Bas P L Wijnhoven Department of Surgery Hippocration General Hospital of AthensNational and Kapodistrian University of AthensAthens 11527Greece Department of Surgery Erasmus University Medical CenterRotterdam 3000the Netherlands

Esophageal cancer(EC) remains one of the most common and aggressive diseases *** review discusses some debates in the modern management of the *** procedures for early cancer(T1a-b) are now embedded in routine care and the challenge will be to more accurately select patients for endoscopic resection with or without adjuvant *** multimodal therapies are associated with improved survival compared to surgery alone for locally advanced esophageal ***, there is no global consensus on the optimal ***, histological subtype(adenocarcinoma *** cell cancer) plays a role in the choice for *** studies are underway to resolve some *** extent of the lymphadenectomy during esophagectomy remains controversial especially after neoadjuvant *** ideal operation balances between limiting surgical trauma and optimizing *** invasive esophagectomy and enhanced recovery pathways are associated with decreased morbidity and faster recovery albeit there is no consensus yet what approach should be ***, immune checkpoint inhibitors present promising preliminary results in the novel treatment of advanced or metastatic EC but their widespread application in clinical practice is still awaited.

关键词： Esophageal cancer endoscopic resection minimally invasive esophagectomy multimodal treatment fast-track protocols

Optical neuroimaging of executive function impairments in food addiction

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 141-155页

作者： tania Alexandra Couto Meng-Yun Wang Zhen Yuan Centre for Cognitive and Brain Sciences University of Macao TaipaMacao SARP.R.China Faculty of Health SciencesUniversity of MacaoTaipaMacao SARP.R.China

This study investigated the neural mechanisms located in the prefrontal cortex(PFC)involved in maintaining addictive-like eating ***,we aimed toll a gap in the existing literature and help clarify the food addiction(FA)cycle by inspecting the relationship between the executive control and psychopathology involved in the FA ***-three students recruited from the University of Macao participated in this *** investigated a hemodynamic response captured by NIRS recordings,activated during n-back,set-shifting,and go/nogo ***,we investigated the FA symptoms through the YFAS clinical inventory to better understand the relationship between hemodynamic response and clinical symptomatology in college ***,the hemodynamicndings conrm that altered cognitive control in executive function performance appears to be linked to addictive-like eating behaviors,which in turn conrms a circuit similarity between FA and the substance abuse population(SUD)as reported in previous fMRI ***,the psychologicalndings conrm the signicant association between the working memory decits and symptoms severity which suggest the role of self-control and regulation in limiting the storage resources as a potential trigger to develop overconsumption episodes in the FA *** highlight how disrupted self-control and regulation of craving and negative a®ect induced by mental imagery might shape and overload the working memory storage as a potential trigger to develop binge eating episodes to maintain the FA *** conclusion,the use of fNIRS in the context of eating disorders studies represents a valuable application,noninvasive,and patientfriendly tool,providing new insights into understanding the addiction cycle and treatment guidelines.

关键词： Food addiction executive functions working memory self-control optical neuroimaging.

Tunnel geometry of the subterranean termite Reticulitermes grassei （Isoptera： Rhinotermitidae）in response to sand bulk density and the presence of food

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Insect Science 2007年第6期14卷 511-518页

作者： tania NOBRE LINA NUNES DAVID E. BIGNELL Laboratorio Nacional de Engenharia Civil Nucleo de Estruturas de Madeira Lisboa Portugal Queen Mary University of London School of Biological and Chemical Sciences London UK Institute of Tropical Biology and Conservation Universiti Malaysia Sabah Kota Kinabalu Sabah Malaysia

The cryptic habits of subterranean termites restricts detailed analysis of their foraging patterns in situ, but the process is evidently dominated by tunnel constructions connecting the nest with woody resources discovered within the territory of each colony. In this study, tunnel formation and orientation were studied experimentally in the termite Reticulitermes grassei （Clement）, using 2-dimensional laboratory foraging arenas con- taining fine sand as the substratum. The building of exploratory tunnels over a 10-day period and the geometry of the resulting network are described. Fractal analysis showed that tunnel geometry had a fractal dimension, regardless of the total length tunnelled whether foragers encountered the food source or not. The bulk density of the sand in the arenas affected the distances tunnelled, with higher density reducing construction, but did not affect tunnel geometry. Tunnels were not discernibly orientated with respect to the positioning of the food source, even in a situation where termites had failed to find the food source at a distance of less than 50 mm, suggesting that volatiles from wood are not attractants.

关键词： foraging gallery fractal analysis Reticulitermes grassei search pattern,subterranean termites tunnel geometry

Feeding on clean food?Potential effects of electric organ discharges by Torpedo spp.(Torpediniformes:Torpedinidae)on their trophically transmitted parasites

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Integrative Zoology 2022年第2期17卷 234-245页

作者： Jaime PENADÉS-SUAY tania REGACHO Francisco Javier AZNAR Marine Zoology Unit Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of ValenciaValènciaSpain LAMNA Association for the study of elasmobranchs from the Valencian Community ValènciaSpain

Members of the Torpedinidae(torpedoes)and Hypnidae(coffin ray)use electric organ discharges(EOD)to stun or kill their prey before *** investigated whether EOD could also negatively affect the helminth larvae infecting these preys through a surrogate model:we applied electric discharges to individuals of blue whiting,Micromesistius poutassou,that harbored live larvae of *** mortality throughout a 6-h period was significantly higher in the treatment group,suggesting that EODs could significantly hamper helminth *** then tested whether torpedinids and hypnids(“strong-EOD”families)harbored species-poor helminth(cestode)assemblages compared with“weak-EOD”Torpediniformes(Narcidae and Narkidae)and other *** on comparisons on estimated species diversity and mean species richness of tapeworms at host individual level we found that(i)Torpediniformes had the lowest tapeworm diversity of all Batoidea orders;(ii)Torpedo *** had the lowest mean cestode richness at host individual level,and this could not be related to other host factors influencing cestode diversity in chondrichthyans,that is body size,trophic level or dietary ***,a preliminary comparison between“strong-EOD”and“weak-EOD”Torpediniformes did not detect clear differences of cestode ***,evidence supporting an unambiguous contribution of EODs to depauperate cestode assemblages requires further research.

关键词： Anisakis Batoidea cestode EOD behavior Torpediniform Torpedo