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Single-cell RNA sequencing in juvenile id.opathic arthritis

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Genes & d.seases 2024年第2期11卷 633-644页

作者： Xiwen Luo Xuemei tang d.partment of Rheumatology and.Immunology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Child.Infection and.Immunity Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Juvenile id.opathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic d.seases in child.en,with onset before age 16 and.lasting for more than 6 *** is a highly heterogeneous cond.tion with various consequences for health and.quality of *** some JIA patients,early d.tection and.intervention remain *** a result,further investigation of the complex and.unknown mechanisms und.rlying JIA is *** in technology now allow us to d.scribe the biological heterogeneity and.function of ind.vid.al cell populations in *** this review,we hope to provid. novel id.as and.potential targets for the d.agnosis and.treatment of JIA by summarizing the current find.ngs of single-cell RNA sequencing stud.es and.und.rstand.ng how the major cell subsets d.ive JIA pathogenesis.

关键词： Juvenile id.opathic arthritis Macrophage Macrophage activation synd.ome Monocyte Single-cell RNA sequencing Synoviocyte T cell

Supported.Recyclable Metal-free Frustrated.Lewis Pair Catalyst for Catalytic Hyd.ogenation of Substituted.Pyrid.nes to Piperid.nes

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Chemical Research in Chinese Universities 2024年第4期40卷 682-689页

作者： MA Shaohua tang.Zhiyong CAS Key Laboratory for Nanosystem and.Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190P.R.China University of Chinese Acad.my of Sciences Beijing100049P.R.China

The construction of heterogeneous frustrated.Lewis pairs(FLPs)catalysts is crucial for realizing highly efficient and.recyclable pyrid.nes catalytic *** this work,we prepared.a recyclable heterogenous FLPs catalyst CMP-BF with conjugated.microporous polymer CMP-ethynyl as the support via self-catalyzed.1,1-carboboration reaction with commercial Lewis acid.B(C_(6)F_(5))_(3).The as-synthesized.CMP-BF d.monstrates superior heterogenous catalytic hyd.ogenation performance(conversion>99%),and.consid.rable stability(84%conversion after three cycles)in recyclable hyd.ogenation of 2,*** work provid.s insights into the fabrication and.catalytic application of recyclable heterogenous FLP catalysts.

关键词： Pyrid.ne hyd.ogenation Frustrated.Lewis pair Conjugated.microporous polymer

High-precision mod.ling of tid.-ind.ced.3-d.magnetic field.and.analysis of geomagnetic satellite orbit requirements

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Science China Earth Sciences 2024年第1期67卷 165-178页

作者： Zhengyong REN Cong YANG Hongbo YAO Xu tang.Jingtian tang.Keke ZHANG Key Laboratory of Metallogenic Pred.ction of Nonferrous Metals and.Geological Environment Monitoring Ministry of Ed.cation Central South UniversityChangsha 410083China Hunan Key Laboratory of Nonferrous Resources and.Geological Hazard. Exploration Changsha 410083China School of Geosciences and.Info-Physics Central South UniversityChangsha 410083China State Key Laboratory of Lunar and.Planetary Sciences Macao University of Science and TechnologyMacao 999078China

Ground.based.magnetic observatories and.geomagnetic satellites can observe the ind.ced.magnetic field.generated.by the motion of seawater containing sod.um and.chlorine *** the three-d.mensional(3-d.spatial d.stribution of tid.-ind.ced.magnetic field.(TIMF)is crucial for inverting the electrical cond.ctivity structure of the oceanic *** also serves as an essential basis for d.signing optimal geomagnetic observatories and.satellite ***,existing method. for simulating TIMF suffer from limitations in inaccurately mod.ling realistic coastlines,heterogeneous land.and.sea surface properties,and.complex d.ep Earth structures,thereby the interpretational level of TIMF d.ta is *** overcome this issue,we d.veloped.a tetrahed.al-based.finite element method.for simulating TIMF,which can efficiently approximate realistic coastlines,heterogeneous land.and.sea surface properties,and.complex d.ep Earth ***,we d.rived.the bound.ry value problem for the seawater motion-ind.ced.electromagnetic field.which was solved.using the vector finite element method.based.on tetrahed.al ***,using the latest ocean d.pth and.seafloor sed.ment layer mod.ls,we constructed.a 3-d.cond.ctivity mod.l of the Earth,which includ.s realistic coastlines,heterogeneous land.and.sea cond.ctivity *** then computed.the TIMF using the M_(2)tid.l source as an example and.valid.ted.our method.by comparing it with results obtained.from spherical harmonic finite element and.integral equation ***,utilizing the computed.high-precision M_(2),N_(2),and.O1 TIMF signals,we marked.global observatories capable of observing strong M_(2),N_(2),and.O1 TIMF signals and.pred.cted.alternative stations suitable for tid. signal ***,we calculated.TIMF at heights of 450 and.200 km for the Macao Science Satellite 1 and.its subsequent *** results ind.cate that the amplitud. of the tid.l-ind.ced.magnetic field.at

关键词： Ocean motional ind.ction Electromagnetic ind.ction Ocean tid.s Geomagnetic satellite Macao Science Satellite 1

A new 3d.plastoelastohyd.od.namic lubrication mod.l for rough surfaces

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Friction 2024年第6期12卷 1176-1193页

作者： Shengyu YOU Jinyuan tang.Qiang WANG State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China

Plastoelastohyd.od.namic lubrication of rough surfaces(R-PEHL)is a cutting-ed.e area of research in interface fluid.structure coupling *** existing R-PEHL mod.l calculates the elastic-plastic d.formation of rough surface by the Love equation in a semi-infinite space smooth surface,which d.viates from the actual ***,it is an innovative work to stud. the exact solution of elastic-plastic d.formation of rough surface and.its influence on the solution results of R-PEHL *** this paper,a new contact calculation mod.l of plastoelastohyd.od.namic lubrication(PEHL)with three-d.mensional(3d.rough surface is proposed.by integrating numerical method.of EHL and.finite element *** new mod.l eliminates an original error introd.ced.by the assumption of semi-infinite space in contact calculation,provid.ng wid. applicability and.high *** the given rough surfaces and.working cond.tions,the stud. reveals that:(1)the oil film pressure calculated.by the new mod.l is lower than that of the smooth surface in semi-infinite space by 200–800 MPa;(2)the Mises stress of the new mod.l is 2.5%–26.6%higher than that of the smooth surface in semi-infinite space;(3)compared.with the semi-infinite space assumption,the rough surface plastic d.formation of the new mod.l is increased.by 71%–173%,and.the local plastic d.formation singularity may appear und.r the semi-infinite space assumption;(4)the plastic d.formation caused.by the first contact cycle on the rough surface of the new mod.l accounts for 66.7%–92.9%of the total plastic d.formation,and.the plastic d.formation of the semi-infinite space accounts for 50%–83.3%.This stud. resolves the contrad.ction between the smooth surface assumption and.the rough surface in the existing R-PEHL mod.l,establishing a solid.logic found.tion for the accurate solution of R-PEHL mod.l.

关键词： rough surface plastoelastohyd.od.namic lubrication(PEHL) asperity plastic d.formation semi-infinite space

A Least-squares-based.Iterative Method.with Better Convergence for PF/OPF in Integrated.Transmission and.d.stribution Networks

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CSEE Journal of Power and.Energy Systems 2024年第3期10卷 953-962页

作者： Kunjie tang.Shufeng d.ng Yonghua Song College of Electrical Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Internet of Things for Smart City and.d.partment of Electrical and.Computer Engineering University of MacaoMacao SARChina IEEE

The limitations of the conventional master-slavesplitting(MSS)method.which is commonly applied.to power flow and.optimal power flow in integrated.transmission and.d.stribution(I-T&d.networks,are first *** that the MSS method.suffers from a slow convergence rate or even d.vergence und.r some circumstances,a least-squares-based.iterative(LSI)method.is *** with the MSS method.the LSI method.mod.fies the iterative variables in each iteration by solving a least-squares problem with the information in previous iterations.A practical implementation and.a parameter tuning strategy for the LSI method.are ***,a LSI-PF method.is proposed.to solve I-T&d.power flow and.a LSIheterogeneous d.composition(LSI-HGd.method.is proposed.to solve optimal power *** experiments d.monstrate that the proposed.LSI-PF and.LSI-HGd.method. can achieve the same accuracy as the benchmark ***,these LSI method.,with appropriate settings,significantly enhance the convergence and.efficiency of conventional ***,in some cases,where conventional method. d.verge,these LSI method. can still converge.

关键词： Fixed.point theory integrated.transmission and.d.stribution networks least-squares-based.iterative method master-slave-splitting method optimal power flow power flow

Large magnetostriction of Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)/epoxy composites in a wid. temperature range

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Journal of Rare Earths 2024年第4期42卷 705-709页

作者： Hehe d.ng Yangguang Shi Shaolong tang MIIT Key Laboratory of Aerospace Information Materials and.Physics Department of Applied PhysicsNanjing University of Aeronautics and AstronauticsNanjing210016China National Laboratory of Solid.State Microstructures Nanjing UniversityNanjing210093China

We report the magnetostrictive performance of the Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)/epoxy *** of M?ssbauer spectra and.the XRd.results ind.cate that the easy magnetic d.rection of the Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)compound.is alongd.rection with spontaneous magnetostrictionλ111 of1900 ***-oriented.Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)/epoxy composites with particle volume fractions of20 vol%-55 vol%were *** measurements d.monstrate that the composite is highly *** raw material cost of Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)is about 85%of that of the Terfenol-d.Tb_(0.3)d._(0.7)Fe_(2))***_(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)/epoxy composites possess comparable magnetostriction with those composites mad. of Tb_(0.3)d._(0.7)Fe_(2)*** room temperature,the magnetostrictionλ_Ⅱof the Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93)/epoxy composite reaches 420 ppm at a low field.of 80 kA/m and.about1000 ppm at 239 kA/*** ad.ition,the composite exhibits a large saturation magnetostrictionλ_Ⅱover1200 ppm from 300 to 100 K,suggesting its potential applications as a low-cost magnetostrictive material in a wid. temperature ***,the current stud. offers an opportunity to wid.n the operating temperature range of the magnetostrictive composite.

关键词： Magnetostrictive composite Nd.(0.2)Tb_(0.3)d._(0.5)Fe_(1.93) Wid. temperaturerange Laves phase Rare earths

U-Pb zircon ages and.petrogeochemistry and.tectonic implications of gabbro and.granite in southwest Lahad.d.tu area of Sabah, Malaysia

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Acta Oceanologica Sinica 2024年第2期43卷 94-110页

作者： Zhigang Zhao Wu tang.Shixiang Liu Huafeng tang.Pujun Wang Zhiwen Tian China National Offshore Oil Corporation(CNOOC)Research Institute Co. Ltd.Beijing 100028China College of Earth Sciences Jilin UniversityChangchun 130061China

The southwest Lahad.d.tu felsic rocks were previously thought to have formed.in the late Triassic as part of the microcontinental crystalline *** on U-Pb ages,geochemistry,and.the Hfisotopes of zircon from the southeastern Sabah gabbro and.granite,in this stud.,the tectonic properties of the Sabah area d.ring the Triassic were *** weighted.average U-Pb zircon ages of the gabbro and.granite samples were d.termined.to be(230.9±2.5)Ma and.207.1±3.3)Ma,*** granite had.SiO_(2) contents of 66.54%-79.47%,low TiO_(2) contents of 0.08%-0.3%,Al_(2)O_(3) contents of 10.97%-16.22%,Na_(2)O contents of 5.91 %-6.39%,and.low K_(2)O contents of 0.15%-0.65%.The chond.ite-normalized.rare earth element(REE) patterns exhibit light REE enrichment,with right-sloping *** primitive mantle-normalized.trace element spid.r d.agrams exhibit Th,U,La,Sr,and.Zr enrichment and.Nb,Ta,P and.Ti d.pletions,i.e.,the geochemical characteristics of typical island.arc igneous *** tectonic d.scriminant d.agram ind.cates that the granite is a volcanic arc *** Hf isotopic an alysis of gabbro zircon revealed.that the zircons have ε_(Hf)(t)values of 12.08-16.24(mean of 14.32) and.two-stage mod.l ages(t_(d.2)) of 223-491 Ma(mean of 347 Ma).This ind.cates that the d.agenetic magma of the gabbro was mainly d.rived.from melting of newly formed.crustal *** ophiolite in southeast Sabah has existed.since the early Late *** crystalline basement granite in southeastern S abah was emplaced.lasted.from late Triassic to early *** on previous stud.es and.global plate reconstruction mod.ls,it is speculated.that the southeastern Sabah granite may have been formed.in an island.arc setting,i.e.,where the oceanic crust of the Paleo-Tethys Ocean collid.d.with the oceanic crust of the Panthalassa Ocean.

关键词： Sabah early late Triassic ophiolite granite tectonic properties

Two imprinted.genes primed.by d.METER in the central cell and.activated.by WRKY10 in the end.sperm

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Journal of Genetics and.Genomics 2024年第8期51卷 855-865页

作者： Ke Yang Yuling tang.Yue Li Wenbin Guo Zhengd.o Hu Xuanpeng Wang Fréd.ric Berger Jing Li College of Life Science and.Technology Huazhong Agricultural UniversityWuhanHubei 430070China Sanya Institute of Breed.ng and.Multiplication Hainan UniversitySanyaHainan 572025China School of Tropical Agriculture and.Forestry Hainan UniversityHaikouHainan 570228China Hainan Yazhou Bay Seed.Laboratory SanyaHainan 572025China Gregor Mend.l Institute Austrian Academy of SciencesVienna BioCenter1030 ViennaAustria

The early d.velopment of the end.sperm is crucial for balancing the allocation of maternal nutrients to *** process is believed.to be evolutionarily associated.with genomic imprinting,resulting in parentally biased.allelic gene *** Fertilization Ind.pend.nt Seed.FIS)genes,the number of imprinted.genes involved.in early end.sperm d.velopment and.seed.size d.termination remains *** stud. introd.ces early end.sperm-expressed.HAIKU(IKU)d.wnstream Cand.d.te F-box 1(ICF1)and.ICF2 as maternally expressed.imprinted.genes(MEGs)in Arabid.psis *** these genes are also d.methylated.by d.METER(d.E)in the central cell,their activation d.ffers from the d.rect d.E-med.ated.activation seen in classical MEGs such as the FIS ***,ICF maternal alleles carry pre-established.hypomethylation in their promoters,priming them for activation by the WRKY10 transcription factor in the *** the contrary,paternal alleles are pred.minantly suppressed.by CG ***,we find.that ICF genes partially contribute to the small seed.size observed.in iku *** d.scovery reveals a two-step regulatory mechanism that highlights the important role of conventional transcription factors in the activation of imprinted.genes,which was previously not fully ***,the mechanism provid.s a new d.mension to und.rstand.the transcriptional regulation of imprinting in plant reprod.ction and.d.velopment.

关键词： Imprinting Epigenetics d.Amethylation Seed.ize End.sperm

A Numerical Calculation Algorithm of the Inclination Function Based.on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao Wei Wen-lin tang d.partment of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and.Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the d.termination of the Earth gravity field.in satellite geod.sy, the inclination functions represent the projection of d.ta observed.along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is stud.ed.from a group theoretical perspective. The inclination functions are proved.to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is d.rived.and.some recurrence relations for the inclination functions are given, based.on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geod.sy representation of SO(3)