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Iron metabolism and arthritis: Exploring connections and therapeutic avenues

中华医学杂志(英文版) 2024年第14期137卷 2024 Jun 12页

作者： Zhuo Dachun Xiao Wenze tang yulong Jiang Shuai Geng Chengchun Xie Jiangnan Ma Xiaobei Zhang Qing tang Kunhai Yu Yuexin Bai Lu Zou Hejian Liu Jing Wang Jiucun Department of Rheumatology Shanghai Pudong Hospital Human Phenome Institute Zhangjiang Fudan International Innovation Center Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Science Fudan University Shanghai China Department of Vascular Surgery Shanghai Pudong Hospital Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling Fudan University Pudong Medical Center Shanghai China Department of Anthropology and Human Genetics School of Life Sciences Ministry of Education Key Laboratory of Contemporary Anthropology Fudan University Shanghai China Division of Rheumatology Huashan Hospital State Key Laboratory of Genetic Engineering School of Life Science Fudan University Shanghai China Institute of Rheumatology Immunology and Allergy Allergy and Disease Research Center Fudan University Shanghai China Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences Beijing China

Iron is indispensable for the viablility of nearly all living organisms, and it is imperative for cells, tissues, and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival. Disruption of iron homeostasis can lead to the development of various diseases. There is a robust connection between iron metabolism and infection, immunity, inflammation, and aging, suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis. Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy. Targeting iron metabolism offers a promising approach for individualized treatment of arthritis. Therefore, this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis. Furthermore, this review aimed to identify potential therapeutic targets and active substances related to iron metabolism, which could provide promising research directions in this field.

关键词： Iron metabolism Arthritis Inflammation Immunity Rheumatoid arthritis Psoriatic arthritis Gouty arthritis

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High-peak-power random Yb-fiber laser with intracavity Raman-frequency comb generation

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High Power Laser Science and Engineering 2023年第1期11卷 82-89页

作者： Xinxing Liu Wenhui Hao Zhihui Yang yulong tang Key Laboratory for Laser Plasmas(MOE) School of Physics and AstronomyCollaborative Innovation Center of IFSAShanghai Jiao Tong UniversityShanghaiChina

The random fiber laser(RFL)has been an excellent platform for exploring novel optical dynamics and developing new functional optoelectronic ***,it is challenging for RFLs to regulate their emission into regular narrow pulses due to their intrinsic ***,through engineering the laser configuration(cavity Q value,gain distribution and nonlinearity),we demonstrate that narrow(~2.5 ns)pulses with record peak power as high as 64.3 kW are achieved from a self-Q-switched random ytterbium fiber *** on high intracavity intensity and efficient interplay of multiple nonlinear processes(stimulated Brillouin scattering,stimulated Raman scattering and four-wave mixing),an over-one-octave visible-near-infrared(NIR)Raman-frequency comb is generated from single-mode silica fibers for the first *** spectrally filtering the Raman peaks,wavelength-tunable pulses with durations of several hundreds of picoseconds are *** a high-peak-power random Q-switched fiber laser and wide frequency comb in the visible-NIR region can find applications in diverse areas,such as spectroscopy,biomedical imaging and quantum information.

关键词： high peak power Q-switched fiber laser Raman-frequency comb random laser visible-near-infrared

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Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model

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中国科学:生命科学英文版 2023年第9期66卷 2086-2098页

作者： Zhenglin Dong Shuan Liu Qingqing Deng Guanya Li yulong tang Xin Wu Dan Wan yulong Yin Key Laboratory of Agro-Ecological Processes in Subtropical Region Hunan Research Center of Livestock&Poultry SciencesSouth-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China

Iron is an essential trace element for both the host and resident microbes in the gut. In this study, iron was administered orally and parenterally to anemic piglets to investigate the role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity. We found that oral iron administration easily increased the abundance of Proteobacteria and Escherichia-Shigella, and decreased the abundance of Lactobacillus in the ileum. Furthermore, similar bacterial changes, namely an increase in Proteobacteria, Escherichia-Shigella, and Fusobacterium and a reduction in the Christensenellaceae_R-7_group,were observed in the colon of both iron-supplemented groups. Spearman's correlation analysis indicated that the changed Fusobacterium, Fusobacteria and Proteobacteria in the colon were positively correlated with hemoglobin, colon and spleen iron levels. Nevertheless, it was found that activated m TOR1 signaling, improved villous height and crypt depth in the ileum,enhanced immune communication, and increased protein expression of IL-22 and IL-10 in the colon of both iron-supplemented groups. In conclusion, the benefits of improved host iron outweigh the risks of altered gut microbiota for intestinal mucosal growth and immune regulation in treating iron deficiency anemia.

关键词： iron deficiency iron-microbial interactions m TOR signaling immune regulation

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汉语阅读障碍儿童认知缺陷干预的方法、挑战与启示(综述)

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中国健康心理学杂志 2024年第2期32卷 167-171页

作者：季雨竹赵佳欣汤玉龙浙江工业大学教育科学与技术学院应用心理研究所杭州310023

本文基于阅读障碍认知缺陷亚类型的分类框架,从语言、非语言以及整合的训练3个层面系统回顾了当前国内外公开发表的汉语阅读障碍儿童干预训练的研究成果。总体而言,目前干预研究仍以短期干预为主,且对象主要为小学生,干预效果仍待进一... 详细信息

本文基于阅读障碍认知缺陷亚类型的分类框架,从语言、非语言以及整合的训练3个层面系统回顾了当前国内外公开发表的汉语阅读障碍儿童干预训练的研究成果。总体而言,目前干预研究仍以短期干预为主,且对象主要为小学生,干预效果仍待进一步检验。未来在教育实践中,应当提升干预的针对性、整体性、专业性与多元化。

关键词：阅读障碍儿童干预小学生认知缺陷

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模拟降雨条件下城市污泥养分和重金属的淋出特征

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广东化工 2024年第7期51卷 110-114页

作者：杨秋蕴唐宇龙吴启堂华南农业大学资源环境学院广东省农业农村污染治理与环境安全重点实验室广东广州510642

通过探明城市污泥养分和重金属的淋洗释放特征,可以用某一地区和时段内的降雨量预测污泥养分或重金属的释放量,指导污泥合理间接施用。采用人工模拟降雨淋洗3种城市污泥,得到养分和重金属的释放浓度和累计释放量。结果表明,东莞深度脱... 详细信息

通过探明城市污泥养分和重金属的淋洗释放特征,可以用某一地区和时段内的降雨量预测污泥养分或重金属的释放量,指导污泥合理间接施用。采用人工模拟降雨淋洗3种城市污泥,得到养分和重金属的释放浓度和累计释放量。结果表明,东莞深度脱水污泥比江门普通脱水污泥释放更高浓度的N和COD;江门干燥污泥与原始污泥相比,降低了P、K和Cu的淋出量,表现出一定的老化作用。东莞污泥淋滤液Cu、Zn、Pb、Cd浓度始终未超过农田灌溉水质标准,而Cu超标的江门污泥其淋滤液Cu浓度也超过农田灌溉水质标准。污泥养分或重金属累计淋出量与模拟累计降雨量的对数呈显著正相关关系。根据广州的年降雨量和青枣作物养分需要量,推算得出满足青枣一年生长所需要的N养分而需要间接施用的东莞污泥(含水率455 g/kg)为46.7 kg/株或43240 kg/hm^(2)。

关键词：间接利用淋滤液模拟降雨释放特征

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LEPREL1是特发性肺纤维化的潜在治疗靶点

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复旦学报（自然科学版） 2024年第2期63卷 257-267,275,I0002页

作者：凡志婷唐宇龙陈雅慧孔祥贞杨婧漪王久存姜帅复旦大学生命科学学院上海200438 上海市浦东医院上海201200

为了寻找特发性肺纤维化(IPF)的潜在治疗靶点,从GEO获取IPF基因芯片数据,用R分析差异表达基因和通路;用STRING和Cytoscape筛选枢纽(HUB)基因;RNA-Seq和单细胞数据验证,肺纤维化小鼠实验验证,筛选具有相关性的基因,分析潜在通路。结果显... 详细信息

为了寻找特发性肺纤维化(IPF)的潜在治疗靶点,从GEO获取IPF基因芯片数据,用R分析差异表达基因和通路;用STRING和Cytoscape筛选枢纽(HUB)基因;RNA-Seq和单细胞数据验证,肺纤维化小鼠实验验证,筛选具有相关性的基因,分析潜在通路。结果显示:基因芯片数据集GSE10667、GSE53845、GSE48149共116例样本,差异基因132个,主要富集在细胞外基质、胶原等通路。STRING和Cytoscape筛选HUB基因,主要为COL1A1、CXCL12、LEPREL1等基因,其中LEPREL1表达显著下调(GSE10667,P_(adj)=0.00096;GSE53845,P_(adj)=0.0001048;GSE48149,P_(adj)=0.01517)。LEPREL1在RNA-Seq数据集GSE92592(P_(adj)=0.0288)、GSE83717(P_(adj)=0.006268)、GSE150910(P_(adj)=1.9528e-30)中均显著下调;在单细胞数据(GSE135893)中主要在AT2细胞中表达并有下调趋势;在肺纤维化小鼠的RT-qPCR和IHC中也表达显著下调。差异表达基因中有81个与LEPREL1具相关性的基因,主要与细胞黏附、钙离子、胶原形成、Wnt等通路相关。IPF的差异基因主要富集在胶原和细胞外基质通路,且AT2细胞中下调的LEPREL1可能是其潜在治疗靶点。

关键词：生物信息学特发性肺纤维化 LEPREL1

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Dietary zero-dimensional fullerene supplementation improves the meat quality,lipid metabolism,muscle fiber characteristics,and antioxidative status in finishing pigs

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Animal Nutrition 2022年第4期11卷 171-180页

作者： Simeng Liao Guang Liu Bie Tan Ming Qi Xin Wu Jianjun Li Xiaoqing Li Changfeng Zhu Jiamei Huang Shuo Zhang yulong tang yulong Yin Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China University of Chinese Academy of Sciences Beijing100008China College of Animal Science and Technology Hunan Agricultural UniversityChangsha410128China Xiamen Funano New Material Technology Company LtdXiamen361005China Yunnan Southwest Agriculture and Animal Husbandry Group Kunming650217China

With the increasing demand for high-quality pork,more nutritional substances have been studied for the regulation of meat ***-dimensional fullerenes(C60)can modulate the biological behavior of a variety of cell lines and *** this study,we report the biological effects of C60 on finishing pigs at different concentrations.A total of 24 barrows(Duroc×Large White×Landrace),with an average body weight of 21.01±0.98 kg,were divided into 3 groups and each treated daily with C60(100 or 200 mg per kg feed)or a control diet until the end of the *** results showed that dietary C60 supplementation improved flesh color,marbling scores,and flavor amino acid contents of longissimus dorsi(LD)of growing-finishing pigs(P<0.05).C60 improved meat quality by regulating lipid metabolism and muscle fiber morphology by mediating the expression of genes,L-lactic dehydrogenase(LDH),myosin heavy chain(MyHC)IIa,MyHCIIb,peroxisome proliferator-activated receptor γ(PPARγ),and fatty acid transport protein 1(FATP1)(P<0.05).Moreover,C60 substantially promoted the mRNA expression of antioxidant enzyme genes(P<0.05),which also contributed to improving meat *** findings have important implications for the application of C60 in the livestock industry,especially for improving the meat quality of fattening pigs.

关键词： Zero-dimensional fullerenes Lipid metabolism Meat quality Muscle fiber Antioxidative

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Origin of the Yueguang gold deposit in Xinhua, Hunan Province, South China: insights from fl uid inclusion and hydrogen–oxygen stable isotope analysis

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Acta Geochimica 2024年第2期43卷 235-254页

作者： Hongxin Fan Qiang Wang yulong Yang Yao tang Hao Zou College of Earth Sciences Chengdu University of TechnologyChengdu 610059China College of Earth Sciences Jilin UniversityJilin 130061China

The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South *** represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,west of the Baimashan granitic *** order to discern the characteristics of the ore-formingﬂuids,the underlying mineralization processes,and establish a foundation for the origin of the Yueguang gold depositﬂuid inclusion micro-thermometry,as well as quartz hydrogen and oxygen isotope analysis,have been carried out on samples obtained from various stages of *** hydrothermal miner-alization stages within the Yueguang gold deposit can be categorized into three stages:(i)the barren,pre-ore quartz-pyrite stage(Stage Ⅰ),the quartz-pyrite-gold stage(Stage Ⅱ),and the post-ore quartz-carbonate stage(Stage Ⅲ),with the second stage being the main mineralization ***ﬂuid inclusions identiﬁed in samples from the main min-eralization stage can predominantly be described with the NaCl–H_(2)O and CO_(2)–NaCl–H_(2)O *** inclusions display homogenization temperatures ranging from 158.8 to 334.9℃,and theﬂuid salinity ranges from 0.3%to 4.0%(wt.%NaCl equiv.).Laser Raman spectroscopy analysis of individual inclusions further reveals the presence of gas-phases such as CO_(2),CH_(4),and N_(2).Isotopic analysis indicatesδ^(18)Oﬂuid values ranging from 3.95 to 6.7‰ and δDH_(2)O values ranging from-71.9 to-55.7‰.These results indi-cate that the ore-formingﬂuid of the Yueguang gold deposit belongs to metamorphic hydrothermalﬂuids of middle-low temperature and low *** the process of ore formation,gold is transported in the form of Au(HS)2-complexes,with gold deposition being driven byﬂuid ***,the Yueguang gold deposit is categorized as an orogenic gold deposit dominated by metamorphic hydrother-malﬂ*** may become a new target for gold exploration in the Baimashan region,central Hunan Province.

关键词： Hunan province Yueguang gold deposit Fluid inclusions Hydrogen–oxygen isotopes Laser Raman Fluid immiscibility Orogenic gold deposit

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基于云服务的工业机器人状态监测系统设计

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辽宁科技学院学报 2024年第2期26卷 34-38页

作者：张林泓李文义杨礼京曲颖刘森唐宇龙辽宁科技学院电气与自动化工程学院辽宁本溪117004

随着智能制造技术的推广,工业机器人在各行业得到了广泛应用。这不仅极大提升了企业的生产效率,也改善了劳动人员的工作环境。但专业维护技术人员缺乏导致维护质量不高的问题也日益凸显。为此,文章提出了一种采用工业控制器作为数据采集... 详细信息

随着智能制造技术的推广,工业机器人在各行业得到了广泛应用。这不仅极大提升了企业的生产效率,也改善了劳动人员的工作环境。但专业维护技术人员缺乏导致维护质量不高的问题也日益凸显。为此,文章提出了一种采用工业控制器作为数据采集器,经由工业互联网上传云服务器,最终通过微信小程序进行工业机器人远程监测的技术方案。该方案可对工业机器人进行有效的状态监测和故障诊断,显著提升机器人工作站的运维质量和工作效率。

关键词：工业机器人工业数据采集机电设备状态监测

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Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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Animal Nutrition 2024年第1期16卷 23-33页

作者： Wenjie tang Xuan Xiang Houfu Wang Wentao Zhou Liuqin He yulong Yin Tiejun Li College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China College of Advanced Agricultural Science University of Chinese Academy of SciencesBeijing 100049China Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China Livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co.LtdChengdu 610000China

This study aimed to determine the regulatory mechanism of dietary zinc lactate(ZL)supplementation on intestinal oxidative stress damage in a paraquat(PQ)-induced piglet ***-eight piglets(mean body weight 9.51±0.23 kg)weaned at 28 d of age were randomly divided into control,ZL,PQ,and ZL+PQ groups(n=7 in each group).The ZL-supplemented diet had little effect on growth performance under normal physiological ***,under PQ challenge,ZL supplementation significantly improved average daily gain(P<0.05)and reduced the frequency of *** improved intestinal morphology and ultrastructure by significantly increasing the expression level of the jejunal tight junction protein,zonula occludens-1(ZO-1)(P<0.05),and intestinal zinc transport and absorption in PQ-induced piglets,which reduced intestinal *** supplementation also enhanced the expression of antioxidant and antiinflammatory factor-related genes and decreased inflammatory cytokine expression and secretion in PQinduced ***,ZL treatment significantly inhibited the activation of constitutive androstane receptor(CAR)signaling(P<0.01)in PQ-induced piglets and altered the structure of the gut microbiota,especially by significantly increasing the abundance of beneficial gut microbes,including UCG_002,Ruminococcus,Rikenellaceae_RC9_gut_group,Christensenellaceae_R_7_group,Treponema,unclassified_Christensenellaceae,and unclassified_Erysipelotrichaceae(P<0.05).These data reveal that pre-administration of ZL to piglets can suppress intestinal oxidative stress by improving antioxidant and anti-inflammatory capacity and regulating the crosstalk between CAR signaling and gut microbiota.

关键词： Zinc lactate Intestinal barrier Oxidative stress Inflammation Constitutive androstane receptor Gut microbiota

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