检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

人工智能体执法并承担执法责任的可能性

学习与实践 2024年第4期 34-43+2页

作者：宋华琳唐曼南开大学法学院南开大学医药卫生法研究中心

人工智能体执法正成为数字法治政府建设的重要表现，将会对以人的行为作为逻辑底色而建构的法律秩序形成冲击。人工智能体或许可以拥有有限的法律人格及有限的责任能力，并为一般行为承担法律责任，但却可能面临执法权行使正当性与执法... 详细信息

人工智能体执法正成为数字法治政府建设的重要表现，将会对以人的行为作为逻辑底色而建构的法律秩序形成冲击。人工智能体或许可以拥有有限的法律人格及有限的责任能力，并为一般行为承担法律责任，但却可能面临执法权行使正当性与执法能力不足的困境。因此，人工智能体不适宜执法或行使公权力，只能承担事务性公务，其执行公务引起的责任可由人工智能体自身、供应商以及行政机关共同承担。

关键词：人工智能体执法主体执法责任

来源：博看期刊

基于摩擦角修正的异性岩石结构面抗剪强度准则

在线全文

学校读者我要写书评

暂无评论

地球科学 2024年第8期49卷 2826-2838页

作者：张志飞黄曼唐志成中国地质大学工程学院湖北武汉430074 绍兴文理学院土木工程学院浙江绍兴312000

异性岩石结构面在三峡库区广泛发育,准确评估其峰值剪切强度对库区岩体稳定性评价至关重要.采用类岩石材料浇筑若干具有相同形貌、不同壁岩强度组合的异性结构面试块,在0.3~3.0 MPa常法向应力下开展直剪试验,并引入“壁岩强度组合系数... 详细信息

异性岩石结构面在三峡库区广泛发育,准确评估其峰值剪切强度对库区岩体稳定性评价至关重要.采用类岩石材料浇筑若干具有相同形貌、不同壁岩强度组合的异性结构面试块,在0.3~3.0 MPa常法向应力下开展直剪试验,并引入“壁岩强度组合系数λ”来表征岩石抗压强度和基本摩擦角对异性结构面峰值剪切强度的综合影响.结果表明,异性结构面的峰值剪切强度随λ的增加而呈非线性降低,降低程度主要受粗糙度控制,而与法向应力关系不明显.采用简单幂函数分析了峰值摩擦角与λ之间的关系,并在此基础上建立含三维形貌参数的异性岩石结构面抗剪强度经验准则.最后,利用在三峡库区采集的天然样品进一步验证了新准则对天然异性岩石结构面峰值剪切强度评估的可靠性.新准则可在一定程度上为三峡库区含异性结构面的岩体稳定性评价提供理论依据.

关键词：异性岩石结构面抗剪强度准则三维形貌参数壁岩强度组合系数工程地质

Distribution and influencing factors of acoustic characteristics of seafloor sediment in the Sunda Shelf

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第5期42卷 1486-1492页

作者： Zhengyu HOU Danling tang Jianguo LIU Zhenglin LI Peng XIAO School of Ocean Engineering and Technology Sun Yat-sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519000China Key Laboratory of Comprehensive Observation of Polar Environment(Sun yat-sen University) Ministry of EducationZhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)&South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 511458China

To understand the acoustic and physical properties of piston core samples collected from the Sunda continental shelf and analyze their distribution patterns,the samples were analyzed in laboratory,from which three provinces were divided in sound speed,sound speed ratio,porosity,wet bulk density,and maximum shear ***Ⅰhad lower sound speed and sound speed ratio(1.04),low porosity,and high wet bulk ***Ⅲhad the lowest sound speed and sound speed ratio(0.99),highest porosity(81%),and lowest wet bulk density(1.34 g/cm^(3)).The distribution pattern indicates that sediment movement,sediment source,topography,and hydrodynamic conditions influenced the distribution of acoustic and physical ***,we investigated the relationship of the maximum shear strength to the porosity and wet bulk density,and found that the maximum shear strength was proportional to both the porosity and wet bulk *** finding has significant implications for ocean engineering applications.

关键词： seafloor sediment acoustic property Sunda Shelf

Unraveling the mechanism of potassium metal capacitor for highly efficient charge storage

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第5期67卷 1578-1588页

作者： Qianqian Yao Pei tang Kunyao Peng Zhenyuan Miao Yuecong Chen Qingyun Dou Xingbin Yan Department of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China South China Academy of Advanced Optoelectronics South China Normal UniversityGuangzhou 510006China

Although hybrid metal ion capacitors(MICs) are highly desired to achieve both high power density of supercapacitors and high energy density of rechargeable batteries, the mismatch problem of electrochemical kinetics of negative and positive electrodes in MICs hampers the realization of this goal. Here, a new hybrid capacitor concept-potassium metal capacitor(PMC) is proposed for the first time, where potassium metal and commercial activated carbon(AC) without any modification are applied as negative and positive electrodes, respectively, and the electrolyte is the same as that of non-aqueous potassium ion batteries. The simplest PMC prototype exhibits a good combination of high energy density(184.9 Wh kg^(-1)) and power density(12.4 kW kg^(-1)), which benefits from the synergistic effect of potassium metal and AC electrode. The former experiences fast potassium plating/striping during charging and discharging, and the later possesses complex multiple charge behaviors driven by low potential of potassium metal. Specifically, below open-circuit voltage, transportation of solvated cations in AC pores plays an important role;beyond this voltage, synergy actions of cations and anions, including adsorption/desorption of solvated cations and anions, and ions exchange between them, dominate the capacitance contribution. This work enriches the types of MICs, and deepens the understanding of the energy storage mechanism of non-aqueous hybrid metal capacitors.

关键词： hybrid capacitor potassium metal activated carbon charge storage mechanism

Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO Quan LI Lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang JIN Li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren tang Chinese Medicine Co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(P<0.05). Furthermore, our research revealed that monotropein induced cell apoptosis by inhibiting Bcl-2 and increasing Bax, induced G_1–S cycle arrest in colorectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(P<0.05), and might play an anticancer role through Akt signaling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase SpeF and P450 monooxygenase SpeG, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, SpeF/SpeG metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-mA with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

Bronchoalveolar lavage fluid metagenomic next-generation sequencing assay for identifying pathogens in lung cancer patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第4期48卷 623-637页

作者： JIYU WANG HUIXIA LI DEYUAN ZHOU LIHONG BAI KEJING tang Division of Pulmonary and Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Institute of Pulmonary Diseases Sun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Background:For patients with lung cancer,timely identiﬁcation of new lung lesions as infectious or non-infectious,and accurate identiﬁcation of pathogens is very important in improving OS of *** a new auxiliary examination,metagenomic next-generation sequencing(mNGS)is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases,compared with conventional microbial tests(CMTs).We designed this study toﬁnd out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavageﬂuid(BALF).Materials and Methods:This study was a real-world retrospective review based on electronic medical records of lung cancer patients with bronchoalveolar lavage(BAL)and BALF commercial mNGS testing as part of clinical care from 1 April 2019 through 30 April 2022 at The First Afﬁliated Hospital of Sun yat-sen University.164 patients were included in this *** were categorized into the pulmonary non-infectious disease(PNID)group(n=64)and the pulmonary infectious disease(PID)group(n=100)groups based onﬁnal ***:BALF mNGS increased the sensitivity rate by 60%compared to CMTs(81%vs.21%,p0.1).Among the patients with PID,bacteria were the most common cause of *** infections occurred in 32%of patients,and Pneumocystis Yersini was most *** with Tyrosine kinase inhibitors(TKIs)therapy possess longer overall survival(OS)than other anti-cancer agents,the difference between TKIs and immuno-checkpoint inhibitors(ICIs)was insigniﬁcant(median OS TKIs *** ***-angiogenic *** ***=76 vs.84 vs.61 vs.58 vs.60).Conclusions:our study indicates that BALF mNGS can add value by improving overall sensitivity in lung cancer patients with potential pulmonary infection,and was outstanding in identifying Pneumocystis *** could be able

关键词： Lung cancer Bronchoalveolar lavage fluid Metagenomic next-generation sequencing Infectious diseases

Circular RNAs in breast cancer diagnosis,treatment and prognosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第2期32卷 241-249页

作者： XIAOJIA HUANG CAILU SONG JINHUI ZHANG LEWEI ZHU HAILIN tang Department of Breast Oncology Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou510095China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Breast Surgery The First People’s Hospital of FoshanFoshan528000China

Breast cancer has surpassed lung cancer to become the most common malignancy *** incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public *** RNAs(circRNAs),a new class of noncoding RNAs(ncRNAs),have been recognized as important oncogenes or suppressors in regulating cancer initiation and *** breast cancer,circRNAs have significant roles in tumorigenesis,recurrence and multidrug resistance that are mediated by various ***,circRNAs may serve as promising targets of therapeutic strategies for breast cancer *** study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis,treatment and prognosis evaluation,as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast *** the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment.

关键词： CircRNA Breast cancer Diagnosis Treatment Biomarker

浅析基于体育核心素养的小学校园足球评价体系构建

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

冰雪体育创新研究 2024年第7期 101-103页

作者：汤曼南京市火瓦巷小学江苏南京210000

基于体育核心素养的小学校园足球评价体系构建是指通过评价体系的建立,将体育核心素养贯穿于小学校园足球的教学和训练中,以培养学生的全面发展和综合能力。该评价体系旨在建立科学、客观、全面的评价指标和方法,以评估学生在足球技术... 详细信息

基于体育核心素养的小学校园足球评价体系构建是指通过评价体系的建立,将体育核心素养贯穿于小学校园足球的教学和训练中,以培养学生的全面发展和综合能力。该评价体系旨在建立科学、客观、全面的评价指标和方法,以评估学生在足球技术、体能、意识、合作精神等方面的表现,为学生的个性发展和素质教育提供有效的指导。

关键词：体育核心素养校园足球小学评价体系