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舒胃汤对功能性消化不良肝郁脾虚证模型大鼠胃窦组织中ENS-PDGFRα^(+)细胞-SMC网络超微结构的影响

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中医杂志 2024年第12期65卷 1269-1278页

作者：梁俊尧郭璇张德旭周曼肖婕唐楚森封慧徐寅湖南中医药大学第一附属医院湖南省长沙市410000

目的基于肠神经系统(ENS)-血小板衍生的生长因子受体α阳性(PDGFRα^(+))细胞-平滑肌细胞(SMC)网络超微结构探讨舒胃汤治疗功能性消化不良(FD)肝郁脾虚证的可能作用机制。方法将50只SD大鼠随机分为空白组、模型组及舒胃汤低、中、高剂量... 详细信息

目的基于肠神经系统(ENS)-血小板衍生的生长因子受体α阳性(PDGFRα^(+))细胞-平滑肌细胞(SMC)网络超微结构探讨舒胃汤治疗功能性消化不良(FD)肝郁脾虚证的可能作用机制。方法将50只SD大鼠随机分为空白组、模型组及舒胃汤低、中、高剂量组,每组10只。空白组不予造模,其余大鼠采用改良复合病因造模法(慢性束缚应激+夹尾激怒+过度疲劳+饮食失节)建立FD肝郁脾虚证大鼠模型,持续21天。造模完成后舒胃汤低、中、高剂量组大鼠分别给予舒胃汤药液3.78、7.56、15.12 g/(kg·d)灌胃,空白组和模型组大鼠给予生理盐水10 ml/(kg·d)灌胃,均每日灌胃1次,持续14天。实验结束后比较各组大鼠灌胃前后体质量增长值,进行高架十字迷宫实验观察大鼠开臂停留时间百分比和进入开臂次数百分比;黑色半固体糊灌胃法检测大鼠胃排空率、小肠推进率;HE染色法观察胃窦组织病理情况;Western Blot法和RT-qPCR法分别检测胃窦组织血小板衍生的生长因子受体α(PDGFRα)、小电导钙激活钾通道3(Sk3)、嘌呤能P2Y1受体(P2Y1)蛋白及mRNA表达;免疫荧光双染检测胃窦组织中PDGFRα与酪氨酸激酶受体(C-kit)、蛋白基因产物9.5(PGP9.5)、Sk3、平滑肌细胞(SMC)的共定位情况;透射电镜观察ENS-PDGFRα^(+)细胞-SMC网络的超微结构。结果HE染色结果显示,各组大鼠胃组织黏膜皱襞清晰,未见出血、溃疡、肿胀等器质性病变,模型组及舒胃汤低剂量组胃窦组织固有层内部分区域胃腺排列较为紊乱,舒胃汤中、高剂量组固有层内胃腺排列较为整齐,病变程度轻于模型组及舒胃汤低剂量组。与空白组比较,模型组大鼠灌胃前后体质量增长值、开臂停留时间百分比、进入开臂次数百分比、小肠推进率、胃排空率均明显降低,胃窦组织中PDGFRα、Sk3、P2Y1蛋白及mRNA表达降低,PDGFRα与C-kit、Sk3、SMC、PGP9.5共定位表达明显降低(P<0.05或P<0.01),ENS-PDGFRα^(+)细胞-SMC网络超微结构破坏,未见缝隙连接。与模型组和舒胃汤低剂量组比较,舒胃汤中、高剂量组大鼠灌胃前后体质量增长值、开臂停留时间百分比、进入开臂次数百分比、小肠推进率、胃排空率均升高,胃窦组织中PDGFRα、Sk3、P2Y1蛋白及mRNA表达升高,舒胃汤高剂量组PDGFRα与C-kit、Sk3、SMC、PGP9.5共定位表达明显升高(P<0.05或P<0.01),ENS-PDGFRα^(+)细胞-SMC网络超微结构完整。与舒胃汤中剂量组比较,舒胃汤高剂量组PDGFRα、Sk3、P2Y1蛋白表达,PDGFRα、Sk3 mRNA表达,以及PDGFRα与C-kit、Sk3、SMC、PGP9.5共定位表达均升高(P<0.05或P<0.01)。结论舒胃汤可有效改善FD肝郁脾虚证模型大鼠胃窦组织的病理损伤,提高大鼠胃排空率、小肠推进率,其可能作用机制与保护ENS-PDGFRα^(+)细胞-SMC网络超微结构完整性有关。

关键词：功能性消化不良肝郁脾虚证舒胃汤胃肠动力肠神经系统血小板衍生的生长因子受体α 平滑肌细胞超微结构

基于措施优先级的失效模式和效应分析在结直肠术手术部位感染防控中的应用

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中国感染控制杂志 2024年第7期23卷 881-888页

作者：吴红曼赖静敏陈乐陶付陈超汤紫媛周凤曾翠曾烂漫任南黄勋中南大学湘雅医院医院感染控制中心湖南长沙410008 国家老年疾病临床医学研究中心(湘雅医院) 湖南长沙410008 中南大学湘雅医院临床护理学教研室湖南长沙410008

目的评估结直肠手术后手术部位感染(SSI)防控措施执行的过程风险,探讨基于措施优先级的失效模式和效应分析(FMEA)的应用效果。方法应用基于措施优先级的FMEA评估结直肠手术后SSI防控措施执行的整个流程,对是否采取优化措施进行优先级排... 详细信息

目的评估结直肠手术后手术部位感染(SSI)防控措施执行的过程风险,探讨基于措施优先级的失效模式和效应分析(FMEA)的应用效果。方法应用基于措施优先级的FMEA评估结直肠手术后SSI防控措施执行的整个流程,对是否采取优化措施进行优先级排序,比较FMEA实施前后结直肠手术SSI防控措施依从项达标率、SSI发病率。结果评估后SSI高优先级防控措施7项,中优先级22项,对中优先级措施加强控制,重点对高优先级措施制定进一步的预防和可探测措施。改进后再评价结果显示,7项高优先级措施降至中优先级;16项中优先级措施降至低优先级。SSI防控措施执行达标率由77.15%(2566/3326)提高至92.47%(3096/3348),SSI发病率由6.04%(58/960)降至2.54%(60/2364)。结论运用基于措施优先级的FMEA可对结直肠手术SSI防控过程进行有效风险评估,并结合现状针对性采用预防性风险控制措施,可降低结直肠手术SSI发病率。

关键词：手术部位感染感染预防与控制措施优先级失效模式和效应分析风险管理

Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng Yu Yiqi tang Sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng Yu Tingting Ai Wei Zhao Vicky Yau Chufeng Liu Liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

Design concept of the Twin River Bridges in Chongqing,China

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Frontiers of Structural and Civil Engineering 2011年第4期5卷 427-431页

作者： man-Chung tang T.Y.Lin International Corporate Headquarters Two Harrison StreetSuite 500San FranciscoCA 94105USA

The Dongshuimen Bridge over the Yangtze River and the Qiansimen Bridge over the Jialing River in Chongqing,China are located at the tip of the Yuzhong ***,they are called the Twin River *** are double deck structures carrying four lanes of traffic on their upper decks and two transit tracks on their lower *** girders are steel truss structures with orthotropic plates and the towers are made of *** were carefully considered for the design of these bridges because of their visibility in the city and their neighboring landmarks.

关键词： long span bridges partially cable-supported girder bridge cable-stayed bridge extradosed steel truss bridge aesthetics Chongqing China

Semiparametric Quantile Modelling of Hierarchical Data

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Acta Mathematica Sinica,English Series 2009年第4期25卷 597-616页

作者： Mao Zai TIAN man Lai tang Ping Shing CHAN School of Statistics Renmin University of China Beijing 100872 P. R. China Center for Applied Statistics Renmin University of China Beijing 100872 P. R. China Department of Mathematics Hong Kong Baptist University Kowloon Hong Kong Department of Statistics The Chinese University of Hong Kong Shatin N.T. Hong Kong

The classic hierarchical linear model formulation provides a considerable flexibility for modelling the random effects structure and a powerful tool for analyzing nested data that arise in various areas such as biology, economics and education. However, it assumes the within-group errors to be independently and identically distributed （i.i.d.） and models at all levels to be linear. Most importantly, traditional hierarchical models （just like other ordinary mean regression methods） cannot characterize the entire conditional distribution of a dependent variable given a set of covariates and fail to yield robust estimators. In this article, we relax the aforementioned and normality assumptions, and develop a so-called Hierarchical Semiparametric Quantile Regression Models in which the within-group errors could be heteroscedastic and models at some levels are allowed to be nonparametric. We present the ideas with a 2-level model. The level-1 model is specified as a nonparametric model whereas level-2 model is set as a parametric model. Under the proposed semiparametric setting the vector of partial derivatives of the nonparametric function in level-1 becomes the response variable vector in level 2. The proposed method allows us to model the fixed effects in the innermost level （i.e., level 2） as a function of the covariates instead of a constant effect. We outline some mild regularity conditions required for convergence and asymptotic normality for our estimators. We illustrate our methodology with a real hierarchical data set from a laboratory study and some simulation studies.

关键词： hierarchical models quantile regression robustness

Kernel Quantile Estimator with ICI Adaptive Bandwidth Selection Technique

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Acta Mathematica Sinica,English Series 2014年第4期30卷 710-722页

作者： Jie Yu FAN man Lai tang Mao Zai TIAN Department of Statistics University of Pittsburgh Department of Mathematics and Statistics Hang Seng Management College School of Statistics Lanzhou University of Finance and Economics Center for Applied Statistics School of StatisticsRenmin University of China

In this article, we consider a class of kernel quantile estimators which is the linear combi- nation of order statistics. This class of kernel quantile estimators can be regarded as an extension of some existing estimators. The exact mean square error expression for this class of estimators will be provided when data are uniformly distributed. The implementation of these estimators depends mostly on the bandwidth selection. We then develop an adaptive method for bandwidth selection based on the intersection confidence intervals （ICI） principle. Monte Carlo studies demonstrate that our proposed approach is comparatively remarkable. We illustrate our method with a real data set.

关键词： Adaptive bandwidth selection ICI principle kernel estimator quantiles

基于Sentinel-2和3D多源域自注意力模型的湿地分类

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遥感学报 2024年第1期28卷 266-279页

作者：楼桉君贺智肖曼李心媛中山大学地理科学与规划学院广州510275 南方海洋科学与工程广东省实验室(珠海) 珠海519082

准确的湿地分类可掌握湿地时空分异特征,在湿地研究中占据重要地位。针对现有基于小样本学习的湿地分类方法仅局限于利用目标域或单源域数据的问题,本文提出一种3D多源域自注意力小样本学习模型3DMDAFSL(3D Multi-source Domain self-At... 详细信息

准确的湿地分类可掌握湿地时空分异特征,在湿地研究中占据重要地位。针对现有基于小样本学习的湿地分类方法仅局限于利用目标域或单源域数据的问题,本文提出一种3D多源域自注意力小样本学习模型3DMDAFSL(3D Multi-source Domain self-Attention Few-Shot Learning)。首先,结合卷积和注意力机制的优势,设计基于自注意力机制和深度残差卷积的3D特征提取器;然后,采用对抗域自适应策略实现多源域特征对齐,在每个域分别进行小样本学习;最后,利用训练好的模型提取特征,并将特征输入至K近邻(K-nearest Neighbor)分类器以获取分类结果。结果表明,3D特征提取器相比无特征提取框架的湿地总体分类精度提升约6.79%;当使用多源域数据集时,3D-MDAFSL模型对中山市Sentinel-2湿地数据集的总体分类精度能达到93.52%,相比于现有算法有明显提升。本文所提出的3D-MDAFSL模型在湿地地物高精度提取和分类中有较好的应用价值。

关键词：遥感小样本湿地分类多源域自注意力

Reduction mechanism of high-chromium vanadium–titanium magnetite pellets by H_2–CO–CO_2 gas mixtures

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International Journal of Minerals,Metallurgy and Materials 2015年第6期22卷 562-572页

作者： Jue tang man-sheng Chu Feng Li Ya-ting tang Zheng-gen Liu Xiang-xin Xue School of Material and Metallurgy Northeastern University

The reduction of high-chromium vanadium–titanium magnetite as a typical titanomagnetite containing 0.95wt% V2O5 and 0.61wt% Cr2O3 by H2–CO–CO2 gas mixtures was investigated from 1223 to 1373 K. Both the reduction degree and reduction rate increase with increasing temperature and increasing hydrogen content. At a temperature of 1373 K, an H2/CO ratio of 5/2 by volume, and a reduction time of 40 min, the degree of reduction reaches 95%. The phase transformation during reduction is hypothesized to proceed as follows： Fe2O3 → Fe3O4 → FeO → Fe; Fe9 TiO 15 ＋ Fe2Ti3O9 → Fe2.75Ti0.25O4 → FeT iO 3 → TiO 2;（Cr0.15V0.85）2O3 → Fe2VO4; and Cr1.3Fe0.7O3 → FeC r2O4. The reduction is controlled by the mixed internal diffusion and interfacial reaction at the initial stage; however, the interfacial reaction is dominant. As the reduction proceeds, the internal diffusion becomes the controlling step.

关键词： magnetite ore reduction phase transformation reaction mechanism kinetics

Association between glucose levels of children with type 1 diabetes and parental economic status in mobile health application

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World Journal of Diabetes 2024年第7期15卷 1477-1488页

作者： Wen-Hao Zhang Chao-Fan Wang Hao Wang Jie tang Hong-Qiang Zhang Jiang-Yu Zhu Xue-Ying Zheng Si-Hui Luo Yu Ding Department of Endocrinology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510000Guangdong ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND The glycemic control of children with type 1 diabetes(T1D)may be influenced by the economic status of their *** To investigate the association between parental economic status and blood glucose levels of children with T1D using a mobile health *** Data from children with T1D in China's largest T1D online community,tang-tangQuan■.Blood glucose levels were uploaded every three months and parental economic status was evaluated based on annual household *** were divided into three groups:Low-income(100000 yuan)(1 Yuan=0.145 United States Dollar approximately).Blood glucose levels were compared among the groups and associations were explored using Spearman’s correlation analysis and multivariable logistic *** From September 2015 to August 2022,1406 eligible children with T1D were included(779 female,55.4%).Median age was 8.1 years(Q1-Q3:4.6-11.6)and duration of T1D was 0.06 years(0.02-0.44).Participants were divided into three groups:Low-income(n=320),middle-income(n=724),and high-income(n=362).Baseline hemoglobin A1c(HbA1c)levels were comparable among the three groups(P=0.072).However,at month 36,the low-income group had the highest HbA1c levels(P=0.036).Within three years after registration,glucose levels increased significantly in the low-income group but not in the middle-income and high-income *** economic status was negatively correlated with pre-dinner glucose(r=-0.272,P=0.012).After adjustment for confounders,parental economic status remained a significant factor related to pre-dinner glucose levels(odds ratio=13.02,95%CI:1.99 to 126.05,P=0.002).CONCLUSION The blood glucose levels of children with T1D were negatively associated with parental economic *** is suggested that parental economic status should be taken into consideration in the management of T1D for children.

关键词： Type 1 diabetes Children and adolescents Glycemic control Economic status Mobile health application