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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang Gang Shen Yina Wang Fuyan Hong xiumei tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang Anton Gao Weiwei Qi Xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic damage.Hyperlipidemia(HLP)is the leading risk factor for NAFLD.This study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were enrolled.The plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver injury.Further,KAL levels of NAFLD patients were significantly up-regulated.KAL transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)mice.In contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD rats.Mechanistically,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),respectively.CGl-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa induction.Meanwhile,hepatic CGl-58-overexpress reverses NASH in KAL transgenic mice.Further,free fatty acids up-regulated KAL against thyroid hormone in hepatocytes.Moreover,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating KAL.These results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

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Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin Luo Jiadi Gan Zhu Luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng xiumei tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui Zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in China.In this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster injection.Neither group reported any severe adverse events.Following the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p<0.001).In the Sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 folds.Similarly,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of diverse SARS-CoV-2 variants of concern,while causing

关键词： protective vaccine boost

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The contribution of cultivated land occupation by construction to China＇s economic growth

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Journal of Geographical Sciences 2011年第5期21卷 897-908页

作者： YANG Ke CHEN Baiming DU Hongliang tang xiumei Institute of Urban Development of Pan-China Construction Group Beijing 100070 China Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China Institute of Scientific and Technical Information of China Beijing 100038 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The paper applies Cobb-Douglas Production Function and Solow-Swan Model to constructing the calculation model of the contribution rate of cultivated land occupation by construction （CLOC） to China＇s economic growth,and analyzes the contribution change of CLOC to China＇s economic growth qualitatively and quantitatively.The main conclusions are as follows：1） From 1989 to 2007,the contribution rates of capital,labor,and CLOC to China＇s economic growth were 45.76%,8.47%,and 6.19% respectively.2） From the period 1989-1996 to the period 1997-2007 the contribution rate of CLOC to China＇s economic growth increased from 5.40% to 5.87%.The degree of contribution was enhanced significantly.3） The contribution of CLOC to China＇s economic growth had a spatial distribution characteristic that the contribution rate of eastern coastal regions was the highest,that of central regions came second,and that of western regions the lowest.The paper indicates that in order to enhance the contribution of CLOC to China＇s economic growth,some relevant economic and administrative measures might be taken,and land might be used intensively and economically to increase land economic density.The cost of promoting gross domestic product （GDP） growth might be reduced as much as possible to achieve higher GDP growth and lower land resource consumption.

关键词： cultivated land occupation by construction economic growth contribution production function

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Decoupling Relationship Between Cultivated Land Occupation by Construction and Economic Growth in China During 1998-2007

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Chinese Journal of Population,Resources and Environment 2010年第1期8卷 38-46页

作者： Yang Ke Chen Baiming tang xiumei Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

With the rapid development of economy,the conversion of cultivated land into nonagricultural land occurs more frequently and makes cultivated land sparser.This article based on the decoupling theory takes the situations of cultivated land occupation by construction and economic growth in China from 1998 to 2007 as an example to evaluate and analyze the decoupling.The conclusions are drawn as follows.First,the article applies IU curve and gross method.The decoupling status by gross method,in contrast to that by IU curve,can express the pressure from cultivated land occupation better and is similar to the decoupling status based on the model of decoupling in this article.Second,in most provinces of China,the relationship between the cultivated land occupation by construction and economic growth has transformed from expansive negative decoupling to strong decoupling.In general,the transformation was firstly from economically advanced eastern municipalities under the central government directly,then to economically advanced eastern coastal provinces,and lastly to central,western and northeastern regions.Third,the decoupling status was relative to contemporaneous policies and laws on cultivated land protection and regional development planning.Their effect is obvious and positive.

关键词：保护耕地土地占用经济增长解耦理论中国国际单位解耦模型经济发展

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GIS-Supported Precision Agricultural Fertilization Management at Small Scale

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Chinese Journal of Population,Resources and Environment 2010年第3期8卷 67-72页

作者： tang xiumei Chen Baiming Gao Hong Lu Qingbin Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Gradate University of Chinese Academy of Science Beijing 100049 China Shandong Normal University Jinan Shandong 250014 China Chinese Research Academy of Environmental Sciences Beijing 100012 China

Precision agricultural fertilization technique at small scale is the key for regional cultivated land protection and management. Taking Dingzhuang Town (located in Guangrao County, Shandong Province) as a case study, this article explores the precision agricultural fertilization technique at small scale. First, three main cropping systems are identified via field investigation, namely "wheat–maize–soybean", "garlic–maize" and "cotton". Then, application amount of fertilizer N, P and K under the three cropping systems is calculated on the parameters acquired through field experiment, using nutrient balance approach on the support of geographic information system technique. The results indicate that, precision agricultural fertilization technique at small scale take on different characteristics compared with that at larger scale. The spatial distribution of soil nutrients in Dingzhuang Town is out of equilibrium, and huge amount fertilizer is needed to satisfy local agricultural production. There is huge distinction of fertilizer ap- plication amount under different cropping systems. The demand of fertilizer amount under "wheat–maize–soybean" system is larger than that under "garlic–maize" and "cotton" systems. This study can provide theories and principles for regional precision agricul- tural fertilization management.

关键词：地理信息系统精准农业施肥管理小规模精度施肥技术种植制度营养平衡

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基于多源数据的北京生态涵养区生态产品供给与经济发展耦合协调度研究

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北京大学学报（自然科学版） 2024年第4期60卷 713-722页

作者：梁丽娜王洪佳冯慧懿唐秀美北京市农林科学院植物营养与资源环境研究所北京100097 北京市农林科学院信息技术研究中心北京100097 国家农业信息化工程技术研究中心北京100097

结合生态涵养区的特点,构建生态产品供给与经济发展两个系统评价指标体系,采用综合评价法评估生态产品供给和经济发展状况,采用耦合协调度模型分析北京市生态涵养区2019年生态产品供给与经济发展的耦合协调度及其耦合协调类型。结果表明... 详细信息

结合生态涵养区的特点,构建生态产品供给与经济发展两个系统评价指标体系,采用综合评价法评估生态产品供给和经济发展状况,采用耦合协调度模型分析北京市生态涵养区2019年生态产品供给与经济发展的耦合协调度及其耦合协调类型。结果表明,2019年北京市生态涵养区各乡镇生态产品供给和经济发展差距较大,生态产品供给能力的高值和较高值区域主要分布在怀柔区、密云区和延庆区,经济发展水平较高的区域主要分布在各区的城镇以及靠近北京市近郊的乡镇。北京市生态涵养区各乡镇生态产品供给与经济发展的耦合度介于0.648~0.999之间,处于高水平耦合阶段。耦合协调度值介于0.312~0.600之间,耦合协调度内部差异较大,整体耦合协调水平不高,呈现较弱的耦合协调关系。北京市生态涵养区各乡镇生态产品供给与经济没有实现同步发展,生态产品供给滞后型和经济发展滞后型的乡镇大约各占一半。建议北京生态涵养区应立足于不同的资源优势,根据生态产品供给和经济发展状况采取不同的策略,实现两者的互补和相互促进。

关键词：生态涵养区生态产品供给经济发展耦合协调

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施氮量对花生结瘤特性的影响

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中国农学通报 2024年第14期40卷 32-38页

作者：黄志鹏吴海宁唐秀梅钟瑞春贺梁琼蒋菁韩柱强刘菁熊发前唐荣华广西农业科学院经济作物研究所南宁530007 广西农业科学院甘蔗研究所南宁530007

为了探明施氮量对田间栽培花生结瘤特性的影响,以‘桂花36’为研究材料,设置6个氮用量处理:施氮量0%(N0,不施氮)、施氮量25%(N1,少量施氮)、施氮量50%(N2,中量施氮)、施氮量75%(N3,少量减施氮)、施氮量100%(N4,常规施氮67.50 kg/hm^(2)... 详细信息

为了探明施氮量对田间栽培花生结瘤特性的影响,以‘桂花36’为研究材料,设置6个氮用量处理:施氮量0%(N0,不施氮)、施氮量25%(N1,少量施氮)、施氮量50%(N2,中量施氮)、施氮量75%(N3,少量减施氮)、施氮量100%(N4,常规施氮67.50 kg/hm^(2))、施氮量150%(N5,大量施氮),大田试验采用随机区组设计,田间取样共33次,研究了不同施氮量对结瘤特性观测值和变化规律的影响。结果表明:在采样前期,根瘤数量与直径的观测值平均数随施氮量的上升而下降;在采样中、后期,根瘤平均数量的最小值都出现在N4处理,平均直径的最小值则均出现在N5处理,既氮对数量的抑制在常规施氮条件下达到最强,对直径的抑制随用量的增加而增强;从N0到N4,以其中任一处理为参照时,参照处理与相邻处理间的变化差异显著概率在各采样期均未达到很可能级别,既当施氮量小于67.50 kg/hm^(2)时,25%幅度的氮用量增减不会导致根瘤数量和直径观测值产生差异显著的变化;相比常规施氮,大量施氮时根瘤直径观测值在采样中、后期很可能显著下降,数量观测值在采样后期很可能显著上升。

关键词：花生施氮量根瘤数量根瘤直径

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国土空间生态修复规划的理论认知与实践指导——《国土空间生态修复规划概论》评介

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中国土地科学 2023年第12期37卷 139-143页

作者：唐秀美北京市农林科学院信息技术研究中心北京100097 国家农业信息化工程技术研究中心北京100097

随着我国经济发展和城镇化的快速推进,高强度的国土空间开发利用等活动引发了生态环境破坏、生态系统功能退化等问题。国土空间生态修复是推进生态文明建设的重大举措,是关系国家生态安全和民生福祉的重要战略任务[1-2]。中共十九大报... 详细信息

随着我国经济发展和城镇化的快速推进,高强度的国土空间开发利用等活动引发了生态环境破坏、生态系统功能退化等问题。国土空间生态修复是推进生态文明建设的重大举措,是关系国家生态安全和民生福祉的重要战略任务[1-2]。中共十九大报告将生态保护修复上升到了国家战略的高度[3]。近年来,国土空间生态修复也成为学者的研究重点[4],研究领域包括生态修复分区研究[5-8]、生态修复政策实施与效益评价[9-12]、生态修复技术方法[13-15]等。基于健全国土空间规划体系、统筹协调生态修复工作、引领生态修复资金投入等工作需要,自然资源部成立后着手组织编制国土空间生态修复规划。

关键词：重要战略任务我国经济发展生态环境破坏国家生态安全自然资源部国土空间生态文明建设生态保护修复

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生态涵养区农村居民点内部用地结构特征研究

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农业机械学报 2022年第3期53卷 189-196页

作者：唐秀美刘玉任艳敏杨亚楠北京市农林科学院信息技术研究中心北京100097 农业农村部农业遥感机理与定量遥感重点实验室北京100097

科学划分农村居民点内部用地土地利用类型,并对其结构进行系统分析,是编制村庄发展规划和实施差异化整治措施的基础。以北京市密云区为例,基于细化分类的农村居民点内部用地数据和密云水库保护区范围,综合运用Weaver-Thomas组合系数法... 详细信息

科学划分农村居民点内部用地土地利用类型,并对其结构进行系统分析,是编制村庄发展规划和实施差异化整治措施的基础。以北京市密云区为例,基于细化分类的农村居民点内部用地数据和密云水库保护区范围,综合运用Weaver-Thomas组合系数法、洛伦兹曲线、基尼系数和景观格局分析等方法,分析农村居民点内部用地结构特征。结果表明:密云区农村居民点以生活空间为主,生产空间和生态空间为辅,居住、农业生产、工业生产和商旅服务是主要的用地类型;农村居民点内部生活空间的分布最均衡,其次是生产空间,生态空间用地类型最不均衡,水源保护区内的农村居民点用地生态空间面积比例高于区外。农村居民点内部用地类型较为混合,景观破碎;比较而言,水源保护区内的景观相对聚集和规则,说明水源保护区的划定和管理对农村居民点内部用地结构有一定影响。研究结果可为村庄用地的有序整治与高效利用提供依据。

关键词：农村居民点内部用地结构水源保护区均衡度密云区

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生态安全格局视角下村庄用地减量地块识别与分区

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农业工程学报 2022年第17期38卷 254-263页

作者：冯惠懿赵春江唐文正唐秀美孙宁乔晓东北京市农林科学院信息技术研究中心北京100097 国家农业信息化工程技术研究中心北京100097 黑龙江省自然资源生态保护修复监测中心哈尔滨150090

村庄用地减量地块的科学识别和类型分区是编制村庄规划和建设用地减量规划的基础。该研究以北京市密云区为例,基于土地利用、兴趣点和社会经济统计等多源数据,在构建区域生态安全格局的基础上,从生态安全性、空间稳定性、发展适宜性3个... 详细信息

村庄用地减量地块的科学识别和类型分区是编制村庄规划和建设用地减量规划的基础。该研究以北京市密云区为例,基于土地利用、兴趣点和社会经济统计等多源数据,在构建区域生态安全格局的基础上,从生态安全性、空间稳定性、发展适宜性3个维度,构建村庄用地减量地块识别评价指标体系并对其进行评价,根据评价结果确定减量地块,借助三维魔方图解法对减量地块进行类型划分与分区,并提出减量策略。结果表明:1)密云区生境质量的分布具有明显的区域性聚集分布特征,筛选出生态源地781.65km^(2)和15条生态廊道,综合构建密云区生态安全格局;2)密云区村庄用地减量地块识别评价分值内部差异较大,空间上呈现出东北高、西南低的特点。通过综合评价法确定密云区减量地块面积789.84hm^(2);3)采用三维魔方图解法将村庄用地减量地块划分为近期减量区(生态-空间减量型、生态-发展减量型、空间-发展减量型)、中期减量区(生态安全减量型、空间稳定减量型、发展适宜减量型)、远期减量区(综合减量型)共3区7类减量类型,并对不同类型减量地块提出对应的减量措施。研究结果可以为生态涵养区村庄用地减量地块的识别提供科学依据,并为生态涵养区减量、生态保护和区域可持续发展服务。

关键词：土地利用村庄用地减量生态安全格局三维魔方图解法密云区

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