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脂肪间充质干细胞在纤维化疾病治疗中的作用

南京医科大学学报（自然科学版） 2024年第3期44卷 429-434页

作者：王扶凝代会博唐蕾单云盛梅笑南京中医药大学附属医院肾内科江苏南京210029

纤维化疾病由于其广泛性和复杂性带来了重大临床挑战,探究纤维化的发生机制并寻求更有效的治疗方法势在必行。脂肪间充质干细胞(adipose⁃derived stem cell,ADSC)是适用于再生医学的理想干细胞,可作为许多疾病的替代治疗方案。近年来研... 详细信息

纤维化疾病由于其广泛性和复杂性带来了重大临床挑战,探究纤维化的发生机制并寻求更有效的治疗方法势在必行。脂肪间充质干细胞(adipose⁃derived stem cell,ADSC)是适用于再生医学的理想干细胞,可作为许多疾病的替代治疗方案。近年来研究表明,ADSC有显著的抗纤维化潜力。本文就ADSC抗组织纤维化过程中涉及的上皮⁃间充质转变、成纤维细胞活化、抗炎及免疫调节等潜在干预靶点进行综述,旨在为防治纤维化提供新思路。

关键词：脂肪间充质干细胞纤维化治疗机制

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang lei tang Qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision medicine.These updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer patients.Key revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric cancer.For advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)patients.Additionally,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric cancer.The 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Migration characteristics and profile control capabilities of preformed particle gel in porous media

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Petroleum 2022年第4期8卷 483-498页

作者： Nanjun Lai Shufang Chen lei tang Yuaojie Huang Hongwei Xu School of Chemistry and Chemical Engineering Southwest Petroleum UniversityChengdu610500China

Inspired by the viscoelastic displacement theory,a product called preformed particle gel(PPG)is developed as conformance control agent to enhance oil recovery and control excess water production.The migration law of PPG suspension in porous media is related to its deep profile control and displacement capability.Laboratory experiments indicate that PPG suspension has good viscosity increasing,and the apparent viscosity decreases with the increase of shear rate.PPG suspension is mainly elastic,and its network structure makes it have certain shear stability.PPG particles realize migration in porous media in the way of“accumulation and blockage/pressure increase/deformation and migration”.When the ratio of the PPG particle size to the pore throat diameter d ranges from 35.52 to 53.38,the particles can match through the porous medium.When the permeability difference of the parallel model is 5,PPG suspension has the highest profile improvement rate,69.10%.PPG suspension can adjust the planar heterogeneity,and increase the oil recovery rate by 20.75%.The PPG suspension can effectively start“cluster"、“film”and“blind end residual oil”,and has a high oil washing efficiency.The core NMR T2 spectrum shows that PPG suspension mainly reduces oil saturation in mesopores and macropores.After PPG flooding,the EOR capacity of small pores is the highest,39.11%.

关键词： Preformed particle gel(PPG) Migration law Profile control Flow characteristics Microscopic oil displacement

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航空发动机叶片表面损伤与检测研究进展

航空发动机 2024年第2期50卷 32-44页

作者：程亚茹李湉薛辉黎红英王丹唐鋆磊西南石油大学化学化工学院成都610500 中国航发航空科技股份有限公司成都610503 常熟理工学院电气与自动化工程学院江苏常熟215500 西南石油大学碳中和研究院成都610500

航空发动机叶片的工作环境极其恶劣,表面会出现各种类型的损伤。在损伤早期进行表面检测能够有效预防因损伤扩展导致的叶片失效断裂。发动机叶片表面损伤的检测和评估主要由人工操作,严重依赖工作经验,但人工检测不仅效率低下,而且检测... 详细信息

航空发动机叶片的工作环境极其恶劣,表面会出现各种类型的损伤。在损伤早期进行表面检测能够有效预防因损伤扩展导致的叶片失效断裂。发动机叶片表面损伤的检测和评估主要由人工操作,严重依赖工作经验,但人工检测不仅效率低下,而且检测结果容易受到人为因素的影响。为了高效、高精度地检测发动机叶片表面损伤,从叶片失效形式出发,综述了发动机叶片在停放和运行2种状态下的损伤机理,并重点阐述了涡流检测、渗透检测等常用于叶片表面损伤检测的方法。总结了基于机器视觉的检测技术,分析机器视觉检测面临数据集稀缺和单一性的挑战,认为收集大量数据并进一步完善评估标准是未来发动机叶片表面损伤检测系统研究的重点方向。

关键词：叶片损伤无损检测机器视觉深度学习航空发动机

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基于增强采样构建的隐式马尔可夫状态模型分析GLP-1R激动剂对GLP-1R激活机制

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山东医药 2024年第3期64卷 44-50页

作者：刘一卜汤磊范菊娣贵州医科大学药学院药物化学教研室贵阳550004 贵州省化学合成药物研发利用工程技术研究中心

目的基于增强采样构建的隐式马尔可夫状态模型,分析胰高血糖素样肽1受体(GLP-1R)激动剂PF-06882961激活GLP-1R的机制。方法从PDB数据库中下载GLP-1R晶体结构(PDBID:6X1A),基于该晶体结构构建PF06882961与GLP-1R结合的高斯加速动力学(G... 详细信息

目的基于增强采样构建的隐式马尔可夫状态模型,分析胰高血糖素样肽1受体(GLP-1R)激动剂PF-06882961激活GLP-1R的机制。方法从PDB数据库中下载GLP-1R晶体结构(PDBID:6X1A),基于该晶体结构构建PF06882961与GLP-1R结合的高斯加速动力学(GaMD)体系,模拟PF06882961与GLP-1R结合的动力学轨迹。使用工具包Pyemma读取PF06882961与GLP-1R结合的GaMD动力学轨迹,构建马尔可夫模型。然后分别从一级结构[关键氨基酸残基间的αC间距(Glu247-His180;Glu364-Arg190)]和二级结构[关键α螺旋间扭转角(Val365-Pro358-Ala350;Arg380-Phe390-Met397)]两个层面对构建的马尔可夫模型中PF-06882961与GLP-1R复合物若干构象进行聚类分析,得出5个结构具有差异的PF-06882961与GLP-1R复合物宏观态构象(S1、2、3、4、5),将其可视化后分析各个宏观态构象之间的结构差异,以明确PF-06882961激活GLP-1R的结构基础。结果从二级结构层面进行聚类分析时,PF06882961与GLP-1R结合后,GLP-1R细胞外结构域部分与跨膜结构域间距离减小,GLP-1R下游的G蛋白发生了重要构象转变。从一级结构及二级结构层面进行聚类分析时,PF-06882961结合GLP-1R后,GLP-1R的跨膜结构域内关键氨基酸残基重排出新的极性网络(Glu364-Tyr241-His180-Glu247),细胞外结构域内由Phe385-Tyr203-Tyr148组成π-π堆叠网络。结论 PF-06882961与GLP-1R结合后,通过由Phe385-Tyr203-Tyr148组成的π-π堆叠网络、由Glu364-Tyr241-His180-Glu247重排而成的新极性网络分别稳定GLP-1R的细胞外结构域及跨膜结构域,从而激活GLP-1R。

关键词：胰高血糖素样肽1受体激动剂 PF-06882961 胰高血糖素样肽1受体马尔可夫状态模型高斯加速动力学分子动力学模拟

多种炎症标志物与急性缺血性脑卒中患者血管内治疗近中期预后的相关性

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国际老年医学杂志 2024年第2期45卷 152-156页

作者：唐蕾毛晶王天璐魏然哈尔滨医科大学附属第一医院神经内科哈尔滨150001

目的探究多种炎症标志物在急性缺血性脑卒中患者血管内治疗后近中期预后中的预测作用。方法选取2020年1月—2022年12月哈尔滨医科大学附属第一医院神经内科接受血管内治疗的376例急性缺血性脑卒中患者进行回顾性分析。根据术后90 d的... 详细信息

目的探究多种炎症标志物在急性缺血性脑卒中患者血管内治疗后近中期预后中的预测作用。方法选取2020年1月—2022年12月哈尔滨医科大学附属第一医院神经内科接受血管内治疗的376例急性缺血性脑卒中患者进行回顾性分析。根据术后90 d的改良Rankin量表(mRS)评分,将其分为预后不良组184例(mRS≤2分)和预后良好组192例(mRS>2分)。通过电子病历系统收集所有患者的临床资料,采用多因素logistic回归模型筛选老年急性缺血性脑卒中患者预后不良的危险因素,采用ROC曲线评估术前各炎症指标对其预后不良的预测价值。结果单因素分析显示,预后不良组年龄>75岁的比例和伴糖尿病比例均高于预后良好组(P75岁、NLR、SII、FAR是老年急性缺血性脑卒中患者近中期预后不良的独立危险因素(P<0.05),mTICI分级≥2b级是其保护因素(P<0.05)。ROC曲线显示,SII预测预后不良的曲线下面积最大,其次为NLR、FAR。结论术前NLR、SII、FAR均是老年急性缺血性脑卒中患者血管内治疗后近中期预后不良的危险因素,这些指标可预测预后不良的风险,尤以SII的预测价值最高。

关键词：急性缺血性脑卒中炎症反应血管内治疗

如何更早发现“灰犀牛”?基于压力指数法的票据市场风险测度

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金融市场研究 2024年第4期 53-59页

作者：唐磊赵诗棋杨扬李莹上海票据交易所

如何更早发现和处置金融市场苗头性风险,对单个金融子市场风险的准确测度和识别提出了更高要求。本文对票据市场风险情况进行全面梳理,建立涵盖信用风险、流动性风险、市场风险及合规风险的11项评价指标体系,借鉴金融市场系统性风险测... 详细信息

如何更早发现和处置金融市场苗头性风险,对单个金融子市场风险的准确测度和识别提出了更高要求。本文对票据市场风险情况进行全面梳理,建立涵盖信用风险、流动性风险、市场风险及合规风险的11项评价指标体系,借鉴金融市场系统性风险测度相关方法,构建票据市场压力指数,并采用MS-AR马尔科夫区制转移模型对票据市场压力状态进行识别。研究结果表明:票据市场高压状态与近年来票据市场发生的风险事件时间相吻合,能够快速反映事件的冲击,且在设置合理的观测阈值后,能够进一步提升风险事件识别的准确性,为识别和监测票据市场风险提供工具和数据参考,也为其他金融子市场提供借鉴。

关键词：票据市场压力指数风险测度识别 MS-AR模型

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全球变暖加剧新疆森林火情

第四纪研究 2024年第1期44卷 226-239页

作者：江来安成邦张永汤蕾谈波张文胜卢超张彦臻郑力源兰州大学资源环境学院西部环境教育部重点实验室甘肃兰州730000

新疆稀缺的森林资源承担着重要的生态服务功能,林火作为森林生态系统中重要的干扰因子,与当前全球变暖关系密切,明确全球变暖对新疆森林火灾的影响及二者关系对于保护新疆森林资源及生态具有重要意义。本研究选取新疆维吾尔自治区1988~2... 详细信息

新疆稀缺的森林资源承担着重要的生态服务功能,林火作为森林生态系统中重要的干扰因子,与当前全球变暖关系密切,明确全球变暖对新疆森林火灾的影响及二者关系对于保护新疆森林资源及生态具有重要意义。本研究选取新疆维吾尔自治区1988~2020年森林火灾数据及气候数据,对二者采用M-K检验、距平分析法、异常度分析法和相关性分析后发现,1988~2020年期间新疆森林覆盖区域气候显著变暖,生长季及夏季气温影响当年森林火灾,而4月降水与6月气温变化对第二年火灾产生重要影响,气候变化改变燃料湿度、堆积量等燃料条件可能为导致这一现象发生的主要原因。这一研究为全球变暖下新疆林火预警提供重要参考。

关键词：森林火灾全球变暖趋势分析滞后效应新疆

Experimental study on 3D internal penny-shaped crack propagation in brittle materials under uniaxial compression

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Deep Underground Science and Engineering 2023年第1期2卷 37-51页

作者： Jiyun Xu Hanzhang Li Haijun Wang lei tang State Key Laboratory of Hydrology‐Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjingChina College of Civil Engineering Tongji UniversityShanghaiChina

Fractures are widely present in geomaterials of civil engineering and deep underground engineering.Given that geomaterials are usually brittle,the fractures can significantly affect the evaluation of underground engineering construction safety and the early warning of rock failure.However,the crack initiation and propagation in brittle materials under composite loading remain unknown so far.In this study,a three-dimensional internal laser-engraved cracking technique was applied to produce internal cracks without causing damage to the surfaces.The uniaxial compression tests were performed on a brittle material with internal cracks to investigate the propagation of these internal cracks at different dip angles under compression and shear.The test results show that the wing crack propagation mainly occurs in the specimen with an inclined internal crack,which is a mixed-ModeⅠ–Ⅱ–Ⅲfracture;in contrast,ModeⅠfracture is present in the specimen with a vertical internal crack.The fractography characteristics of ModeⅢfracture display a lance-like pattern.The fracture mechanism in the brittle material under compression is that the internal wing cracks propagate to the ends of the whole sample and cause the final failure.The initial deflection angle of the wing crack is determined by the participation ratio of stress intensity factors KII to KI at the tip of the internal crack.

关键词： 3D-ILC brittle materials internal crack penny-shaped crack rock fracture uniaxial compression