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中药红花的化学成分及色素提取工艺研究进展

中国中药杂志 2024年第7期49卷 1725-1740页

作者：张喜妹肖江鸿王玉唐于平乐世俊陕西中医药大学、陕西省中医药管理局中药配伍重点实验室陕西西安712046 河北中医药大学、河北省中药资源利用与质量评价国际联合研究中心河北石家庄050200

红花具有活血通经、散瘀止痛的功效,是临床常用的活血化瘀类中药之一。迄今,红花中已分离并报道的化合物有210多种,包括醌式查尔酮类(红花黄色素和红色素)、黄酮类、亚精胺类、生物碱类、聚炔类、有机酸类等。红花黄色素作为红花主要的... 详细信息

红花具有活血通经、散瘀止痛的功效,是临床常用的活血化瘀类中药之一。迄今,红花中已分离并报道的化合物有210多种,包括醌式查尔酮类(红花黄色素和红色素)、黄酮类、亚精胺类、生物碱类、聚炔类、有机酸类等。红花黄色素作为红花主要的水溶性活性成分,常用水提法进行提取分离,而红色素常用碱提酸沉法进行提取。近年,天然深共熔溶剂作为一种绿色溶剂在红花的色素提取分离中呈现出较好的应用前景。该文针对红花的化学成分进行系统地归纳,并对红花中色素类成分的提取工艺进行分析,以期为进一步合理利用红花资源提供参考。

关键词：红花红花黄色素红花苷化学成分提取工艺

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Potential Medicinal Value of Rhein for Diabetic Kidney Disease

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中国结合医学杂志:英文版 2023年第10期29卷 951-960页

作者： MAO Xi XU Ding-qiao yuE Shi-jun FU Rui-jia ZHANG Sai tang yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi’an712046China

Diabetic kidney disease(DKD)is the primary cause of mortality among diabetic *** the increasing prevalence of diabetes,it has become a major concern around the *** therapeutic effect of clinical use of drugs is far from expected,and therapy choices to slow the progression of DKD remain ***,research on new drugs and treatments for DKD has been a hot topic in the medical *** has been found that rhein has the potential to target the pathogenesis of DKD and has a wide range of pharmacological effects on DKD,such as anti-nephritis,decreasing blood glucose,controlling blood lipids and renal *** recent years,the medical value of rhein in the treatment of diabetes,DKD and renal disease has gradually attracted worldwide attention,especially its potential in the treatment of ***,DKD can only be treated with medications from a single symptom and are accompanied by adverse effects,while rhein improves DKD with a multi-pathway and multi-target ***,this paper reviews the therapeutic effects of rhein on DKD,and proposes solutions to the limitations of rhein itself,in order to provide valuable references for the clinical application of rhein in DKD and the development of new drugs.

关键词： rhein diabetic kidney disease rhein derivatives toxicity bioavailability

Modern research thoughts and methods on bio-active components of TCM formulae

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Chinese Journal of Natural Medicines 2022年第7期20卷 481-493页

作者： tang yu-ping XU Ding-Qiao yuE Shi-Jun CHEN Yan-Yan FU Rui-Jia BAI Xue Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drug ResearchShaanxi Collaborative Innovation Center of Chinese Medicinal Resource IndustrializationShaanxi University of Chinese MedicineXi’an 712046China

TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in *** the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese *** the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of TCM formulae into a higher *** when the medicinal efficacy,bio-active components,function mechanism of TCM formulae are understood,we can guarantee TCM safety and quality *** this paper,we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of TCM in the future.

关键词： Chinese medicine TCM formulae Bio-active component Morden research methods

Efficacy and Safety of Lianhua Qingwen for Patients with COVID-19: A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2022年第7期28卷 650-660页

作者： SUN Xiao-hu ZHANG Shuo YANG Zhen CHEN Zhen-lin yuE Shi-jun ZHANG Sai tang yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Compatibility Shaanxi University of Chinese MedicineXi'an 712046China Nanjing Bestform Pharmaceutical Technology Co. Ltd.Nanjing 210032China Cardiovascular Department Guang'anmen HospitalSchool of Clinical MedicineBeijing University of Chinese MedicineBeijing 100029China School of Public Health Shaanxi University of Chinese MedicineXi'an 712046China International Programs Office Shaanxi University of Chinese MedicineXi'an 712046China

Background: Corona virus disease 2019(COVID-19) has spread around the world since its outbreak, and there is no ascertained effective drug up to now. Lianhua Qingwen(LHQW) has been widely used in China and overseas Chinese, which had some advantages in the treatment of COVID-19. Objective: To evaluate the efficacy and safety of LHQW for COVID-19 by conducting a systematic review with meta-analysis. Methods: A comprehensive literature search was conducted in 12 electronic databases from their establishment to October 30, 2021. Note Express 3.2.0 was used for screening of trials, and the data was independently extracted in duplicate by 2 researchers. The risk of bias of randomized controlled trials(RCTs) and retrospective studies were assessed by using the Cochrane collaboration tool and Newcastle Ottawa Scale, respectively, followed by data analysis using RevMan 5.3. The RCTs or retrospective studies to treat COVID-19 using LHQW were included. The intervention measures in the experimental group were LHQW alone or combined with chemical drugs(LCWC), and that in the control group were chemical drugs(CDs). Outcome measures included computed tomography(CT) recovery rate, disappearance rates of primary(fever, cough, fatigue), respiratory, gastrointestinal and other symptoms, exacerbation rate and adverse reaction. Subgroup analysis was conducted according to whether LHQW was combined with CDs and the different treatment methods in the control group. Results: Nine trials with 1,152 participants with COVID-19 were included. The CT recovery rates of LHQW and LCWC were 1.36 and 1.32 times of CDs, respectively(P0.05). Conclusions: LHQW was more

关键词： Lianhua Qingwen COVID-19 2019-nCoV systematic review meta-analysis Chinese medicine

Anti-obesity and Gut Microbiota Modulation Effect of Astragalus Polysaccharides Combined with Berberine on High-Fat Diet-Fed Obese Mice

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Chinese Journal of Integrative Medicine 2023年第7期29卷 617-625页

作者： yuE Shi-jun WANG Wen-xiao ZHANG Lei LIU Juan FENG Wu-wen GAO Huan tang yu-ping YAN Dan Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing Shijitan HospitalCapital Medical UniversityBeijing100038China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi’an712046China Department of Pharmacy Beijing Friendship HospitalCaptical UniversityBeijing Institute of Clinical PharmacyBeijing100050China

Objective To investigate whether astragalus polysaccharides(APS)combined with berberine(BBR)can reduce high-fat diet(HFD)-induced obesity in *** Except for normal mice,32 HFD-induced obese mice were randomized into HFD,APS(1,000 mg/kg APS),BBR(200 mg/kg BBR),and APS plus BBR(1,000 mg/kg APS plus 200 mg/kg BBR)groups,*** 6-week treatment(once daily by gavage),the obesity phenotype and pharmacodynamic effects were evaluated by histopathological examination of epididymal fat,liver,and colon using hematoxylin-eosin staining and serum biochemical analyses by an automated chemistry *** feces were collected at the 12 th week,and taxonomic and functional profiles of gut microbiota were analyzed by 16S ribosomal ribonucleic acid(16S rRNA)*** Compared with HFD group,the average body weight of APS plus BBR group was decreased(P<0.01),accompanied with the reduced fat accumulation,enhanced colonic integrity,insulin sensitivity and glucose homeostasis(P<0.05 or P<0.01).Importantly,APS combined with BBR treatment was more effective than APS or BBR alone in improving HFD-induced insulin resistance(P<0.05 or P<0.01).16S rRNA sequence-based analysis of fecal samples demonstrated that APS combined with BBR treatment exhibited a better impact on HFD-induced gut microbiota dysbiosis,exclusively via the enriched abundances of Bacteroides,which corresponded to the large increase of predicted bacterial genes involved in carbohydrate *** APS combined with BBR may synergistically reduce obesity and modulate the gut microbiota in HFD-fed mice.

关键词： Astragalus polysaccharides berberine obesity gut microbiota Bacteroides

Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-Peng Song Lu-ping Zhou Jing-yu tang Zhi-Hao Zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

基于“化学学习共同体”理念的医学基础化学课程思政教学探索与实践

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化学教育（中英文） 2024年第6期45卷 66-75页

作者：李佳佳李卓宁唐于平刘欢孟庆华张光辉史亚军段金伟王其召陕西中医药大学药学院陕西咸阳712046 长安大学水利与环境学院陕西西安710054 西安科技大学材料学院陕西西安710054

通过构建师师、师生、生生化学学习共同体,在课程教学中紧密结合化学知识点引入课程思政,从医德、哲学等方面深度培养医学生大爱情怀、处理问题、敬业奉献等精神,同时培养教师创新思维、强化课程教育能力。并从过程性考核、课程思政成... 详细信息

通过构建师师、师生、生生化学学习共同体,在课程教学中紧密结合化学知识点引入课程思政,从医德、哲学等方面深度培养医学生大爱情怀、处理问题、敬业奉献等精神,同时培养教师创新思维、强化课程教育能力。并从过程性考核、课程思政成效、调查问卷和主观反馈等方面对课程思政实施效果进行多角度全方位评价,为其他课程融入思政元素、践行“立德树人”根本任务提供借鉴和参考。

关键词：基础化学课程思政化学学习共同体探索与实践

经典名方升陷汤的研究进展及质量标志物的预测分析

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中国现代中药 2024年第3期26卷 550-565页

作者：周浩明乐世俊刘文娟崔东晓付瑞嘉唐于平陕西中医药大学陕西省中医药管理局中药配伍重点实验室陕西西安712046 河北中医药大学河北省中药资源利用与质量评价国际联合研究中心河北石家庄050200

经典名方升陷汤由黄芪、知母、柴胡、升麻和桔梗组成,主治大气下陷证,现代临床主要用于治疗循环和呼吸系统的疾病。对近年来升陷汤化学成分、药理作用和临床应用的研究进展进行整理归纳和分析,并从质量传递与溯源、成分可测性、成分有... 详细信息

经典名方升陷汤由黄芪、知母、柴胡、升麻和桔梗组成,主治大气下陷证,现代临床主要用于治疗循环和呼吸系统的疾病。对近年来升陷汤化学成分、药理作用和临床应用的研究进展进行整理归纳和分析,并从质量传递与溯源、成分可测性、成分有效性、成分特有性及复方配伍环境5个方面对升陷汤质量标志物(Q-marker)进行预测,分析发现黄芪甲苷、毛蕊异黄酮苷、毛蕊异黄酮、芒柄花苷、芒柄花素、柴胡皂苷A、柴胡皂苷D、芒果苷、知母皂苷B-Ⅱ、阿魏酸、异阿魏酸和桔梗皂苷D可作为升陷汤的Q-marker,为经典名方升陷汤质量控制体系和全过程质量溯源体系建立提供科学依据。

关键词：升陷汤质量标志物化学成分药理作用临床应用

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Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella(MMAF)and ICSI outcomes

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Asian Journal of Andrology 2024年第1期26卷 91-98页

作者： Zhong-Mei Shao yu-Tong Zhu Meng Gu Sen-Chao Guo Hui yu Kuo-Kuo Li Dong-Dong tang yu-ping Xu Ming-Rong Lv Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Obstetrics and Gynecology Fuyang Hospital of Anhui Medical UniversityFuyang 236112China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People'sRepublicof ChinaHefei 230032China

Variations in the dynein axonemal heavy chain gene,dynein axonemal heavy chain 6(DNAH6),lead to multiple morphological abnormalities of the *** studies have reported that these deficiencies may result in sperm head ***,whether DNAH6 is also involved in human acrosome biogenesis remains *** purpose of this study was to investigate DNAH6 gene variants and their potential functions in the formation of defective sperm heads and ***-exome sequencing was performed on a cohort of 375 patients with asthenoteratozoospermia from the First Affiliated Hospital of Anhui Medical University(Hefei,China).Hematoxylin and eosin staining,scanning electron microscopy,and transmission electron microscopy were performed to analyze the sperm morphology and *** staining and Western blot analysis were conducted to examine the effects of genetic *** identified three novel deleterious variants in DNAH6 among three unrelated *** absence of inner dynein arms and radial spokes was observed in the sperm of patients with DNAH6 ***,deficiencies in the acrosome,abnormal chromatin compaction,and vacuole-containing sperm heads were observed in these patients with DNAH6 *** decreased levels of the component proteins in these defective structures were further confirmed in sperm from patients with DNAH6 variants using Western *** intracytoplasmic sperm injection(ICSl)treatment,the partner of one patient with a DNAH6 variant achieved successful ***,novel variants in DNAH6 genes that contribute to defects in the sperm head and flagella were identified,and the findings indicated Icsl as an effective clinical treatment for such patients.

关键词： asthenoteratospermia DNAH6 intracytoplasmic sperm injection male infertility