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In situ synthesis of red fluorescent gold nanoclusters with enzyme-like activity for oxidative stress amplification in chemodynamic therapy

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Chinese Chemical Letters 2022年第3期33卷 1331-1336页

作者： Wenying Mi shuang tang Shaoshi Guo Hejing Li Na Shao College of Chemistry Beijing Normal UniversityBeijing 100875China

Chemodynamic therapy (CDT) has attracted tremendous interest in cancer therapy because it is independent of oxygen and photoirradiation. However, the therapeutic efficacy of CDT is restricted by insufficient H_(2)O_(2) levels in tumor cells. Herein, employing endogenous GSH as a template and cationic polymeric chitosan (CS) as crosslinker and stabilizer exhibiting easy cell uptake, red luminescent gold nanoclusters (denoted CS-GSH@AuNCs) were successfully synthesized in HeLa cells. The in situ synthesized CS-GSH@AuNCs exhibited both superoxidase dismutase (SOD) and peroxidase (POD)-like activity, which could promote the production of H_(2)O_(2) from superoxide anion radicals (O_(2)^(·-)) and then ^(·)OH. The combination of GSH elimination and H_(2)O_(2) elevation boosted the generation of ^(·)OH, which could trigger cancer cell apoptosis and death. The enzyme-like activity of CS-GSH@AuNCs could be effectively activated under acidic conditions, and showed a high killing effect on tumor cells but minimal toxicity to normal cells. The developed GSH consumption and ^(·)OH promotion theranostic platform is an innovative route for enhanced CDT by the amplification of oxidative stress.

关键词： Chemodynamic therapy In situ synthesis Gold nanoclusters Superoxidase dismutase and peroxidase(POD)-like activity Oxidative stress amplification

SQoE KQIs Anomaly Detection in Cellular Networks: Fast Online Detection Framework with Hourglass Clustering

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China Communications 2018年第10期15卷 25-37页

作者： Xiaowei Qin shuang tang Xiaohui Chen DANDan Miao Guo Wei Key Laboratory of Wireless-Optical Communications Chinese Academy of Sciences School of Information Science and TechnologyUniversity of Science and Technology of China

The explosive growth of data volume in mobile networks makes fast online diagnose a pressing search problem. In this paper, an object-oriented detection framework with a two-step clustering, named as Hourglass Clustering, is given. Where three object parameters are chosen as Synthetical Quality of Experience（SQo E） Key Quality Indicators（KQIs） to reflect accessibility, integrality, and maintainability of networks. Then, we choose represented Key Performance Indicators（r KPIs） as cause parameters with correlation analysis. For these two kinds of parameters, a hybrid algorithm combining the self-organizing map（SOM） and

关键词： big data SQoE anomaly detection hourglass clustering codebook.

The response of key ecosystem services to land use and climate change in Chongqing:Time,space,and altitude

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Journal of Geographical Sciences 2022年第2期32卷 317-332页

作者： GAO Jie BIAN Hongyan ZHU Chongjing tang shuang Chongqing Jinfo Mountain Karst Ecosystem National Observation and Research Station School of Geographical SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Karst Environment School of Geographical SciencesSouthwest UniversityChongqing 400715China School of Geographical Sciences State Cultivation Base of Eco-agriculture for Southwest Mountainous LandChongqing 400715China

Mountainous landscapes are particularly vulnerable and sensitive to climate change and human activities,and a clear understanding of how ecosystem services(ES)and their relationships continuously change over time,across space,and along altitude is therefore essential for ecosystem ***,a typical mountainous region,was selected to assess the long-term changes in its key ES and their *** 1992 to 2018,the temporal variation in water yield(WY)revealed that the maximum and minimum WYs occurred in 1998 and 2006,which coincided with El Ni?o-Southern Oscillation and severe drought events,*** export(SE)and WY were consistent with precipitation,which reached their highest values in *** this period,carbon storage(CS)and habitat quality(HQ)both decreased *** in Chongqing showed large variations in ***,WY and SE decreased with increasing altitude,while CS and HQ *** spatial distribution,WY and SE showed positive trends in the west and negative trends in the *** regard to CS and HQ,negative trends dominated the *** tradeoffs between WY and soil conservation(SC)were found at all altitude *** strong synergies between CS and HQ were maintained over time.

关键词： ecosystem services InVEST model Mann-Kendall tradeoffs synergies mountainous region

New mechanism of partial duplication and deletion of chromosome 8:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7139-7145页

作者： Yan Jiang shuang tang Fang He Jue-Xin Yuan Zhu Zhang Office of Prenatal Diagnosis Mianyang People’s HospitalMianyang 621000Sichuan ProvinceChina Department of Obstetrics Mianyang People’s HospitalMianyang 621000Sichuan ProvinceChina Office of Prenatal Diagnosis West China Second University HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND During meiosis,the recombination of homologous chromosomes produces some new heritable mutations,which are the basis of biological evolution and ***,when there is pericentric inversion of chromosomes,unbalanced gametes will be formed in the process of germ cell *** SUMMARY A 23-year-old pregnant woman at 25 wk of gestation wanted to terminate her pregnancy due to fetal chromosomal *** had no exposure to toxic or hazardous substances before and during pregnancy,no history of medication usage during pregnancy,and she underwent cystectomy of ovarian cysts in *** the second day of the 16th week of gestation,non-invasive prenatal testing showed chromosome 8 copy number *** genetic counseling,her pregnancy was *** Recombinant offspring chromosome is rarely seen when the inversion segment is shorter than one-third of the chromosome *** terms of the mechanism of chromosome 8 duplication/deletion occurrence,attention should be paid to the production of unbalanced gametes by the pairing of homologous chromosome during meiosis,and the possibility of mitotic recombination exchange as well.

关键词： Chromosome 8 Spontaneous mutation Mitosis Non-invasive prenatal testing Case report

Phenotypic analysis of a dwarf and deformed flower3 (ddf3) mutant in rice (Oryza sativa L.) and characterization of candidate genes

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Journal of Integrative Agriculture 2018年第5期17卷 1057-1065页

作者： WANG Yu-peng tang shuang-qin WU Zhi-feng SHI Qing-hua WU Zi-ming Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of Education/Collaborative Innovation Center for the Modernization Production of Double Cropping Rice/College of AgronomyJiangxi Agricultural University

Dwarf mutants are the crucial resources for molecular biology research and rice breeding. Here, a rice mutant, dwarf and deformed flower3（ddf3）, was identified in tissue culture of Oryza sativa cv. Dongjin. Compared with wild type, the ddf3 mutant exhibited severe dwarfism, a greater number of tillers and significantly decreased fertility. In addition, leaf length, panicle length, and grain length, were significantly shorter. All internodes of ddf3 were shorter than those of wild type, and histological analysis revealed that internode cell elongation was significantly inhibited in ddf3. In the ddf3 mutant, pollen activity was significantly decreased, and the development of most stigmas was abnormal. Genetic analysis indicated that the ddf3 mutant phenotypes are controlled by a single or tightly linked nuclear genes. Using an F2 mapping population generated from a cross between ddf3 and Yangdao 6（9311）, the DDF3 gene was mapped to a 45.21-kb region between insertion-deletion（In Del） markers M15 and M16 on the long arm of chromosome 7. Sequencing revealed a 13.98-kbdeletion in this region in the ddf3 mutant genome that resulted in the complete or partial deletion of ZF（DHHC type zinc finger protein）, EP（expressed protein）, and FH2（actin-binding FH2 domain-containing protein） genes. Quantitative RT-PCR analyses revealed that in wild type, the transcript levels of FH2 were almost the same in all organs, while ZF was mainly expressed in the panicle, and no expression of EP was detected in any organ. Based on these results, ZF and FH2 could be potential DDF3 candidate genes involved in the regulation of rice morphology and flower organ development. Our work has laid the foundation for future functional analysis of these candidate genes and has provided a profitable gene resource for rice breeding for increased fertility in the future.

关键词： rice dwarf and deformed flower 3 mapping DHHC-type actin-binding FH2 domain

Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment

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Bioactive Materials 2023年第4期22卷 567-587页

作者： Dongdong Zheng Jin Zhou Lang Qian XueJiao Liu Cai Chang shuang tang Hongbo Zhang Shichong Zhou Department of Ultrasound Fudan University Shanghai Cancer CenterShanghai200032PR China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityFI-00520TurkuFinland Cancer Institute Fudan University Shanghai Cancer CenterShanghai200032PR China Institutes of Biomedical Sciences and Department of Chemistry Fudan UniversityShanghai200032PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Turku Bioscience Center University of Turku andÅbo Akademi UniversityFI-00520TurkuFinland The First Affiliated Hospital of Wenzhou Medical University Wenzhou325000PR China

In clinical practice,we noticed that triple negative breast cancer(TNBC)patients had higher shear-wave elasticity(SWE)stiffness than non-TNBC patients and a higherα-SMA expression was found in TNBC tissues than the non-TNBC ***,SWE stiffness also shows a clear correlation to neoadjuvant response *** elaborate this phenomenon,TNBC cell membrane-modified polylactide acid-glycolic acid(PLGA)nanoparticle was fabricated to specifically deliver artesunate to regulate SWE stiffness through inhibiting CAFs functional *** tested in MDA-MB-231 and E0771 orthotopic tumor models,CAFs functional status inhibited by 231M-ARS@PLGA nanoparticles(231M-AP NPs)had reduced the SWE stiffness as well as attenuated hypoxia of tumor as tumor soil loosening agent which amplified the antitumor effects of paclitaxel and PD1 ***-cell sequencing indicated that the two main CAFs(extracellular matrix and wound healing CAFs)that produces extracellular matrix could influence the tumor SWE stiffness as well as the antitumor effect of ***,biomimetic nanoparticles inhibited CAFs function could attenuate tumor hypoxia by increasing proportion of inflammatory blood vessels and oxygen transport ***,our finding is fundamental for understanding the role of CAFs on affecting SWE stiffness and drugs antitumor effects,which can be further implied in the potential clinical theranostic predicting in neoadjuvant therapy efficacy through non-invasive analyzing of SWE imaging.

关键词： Cancer-associated fibroblasts Biomimetic nanoparticles Shear-wave elasticity imaging Theranostic prediction

Genetic Analysis and Molecular Mapping of a Stripe Rust Resistance Gene YrH9014 in Wheat Line H9014-14-4-6-1

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Journal of Integrative Agriculture 2013年第4期12卷 638-645页

作者： MA Dong-fang HOU Lu tang Ming-shuang WANG Hai-ge LI Qiang JING Jin-xue State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant Protection Northwest A&F University

Stripe rust, caused by Puccinia striiformis f. sp. tritici （Pst）, is one of the most widespread and destructive wheat diseases in many wheat-growing regions of the world. The winter wheat translocation line H9014-14-4-6-1 has all stage resistance. To identify stripe rust resistance genes, the segregating populations were developed from the cross between H9014-14-4-6-1 and Mingxian 169 （a wheat cultivar susceptible to all Pst races identified in China）. The seedlings of the parents and F1 plants, Fz, F3 and BC1 generations were tested with Pst races under controlled greenhouse conditions. Two genes for resistance to stripe rust were identified, one dominant gene conferred resistance to SUN11-4, temporarily designated YrH9014 and the other recessive gene conferred resistance to CYR33. The bulked segregant analysis and simple sequence repeat （SSR） markers were used to identify polymorphic markers associated with YrH9014. Seven polymorphic SSR markers were used to genotype the F2 population inoculated with SUN11-4. A linkage map was constructed according to the genotypes of seven SSR markers and resistance gene. The molecular map spanned 24.3 cM, and the genetic distance of the two closest markers Xbarc13 and Xbarc55 to gene locus was 1.4 and 3.6 cM, respectively. Based on the position of SSR marker, the resistance gene YrH9014 was located on chromosome arm 2BS. Amplification of a set of nulli-tetrasomic Chinese Spring lines with SSR marker Xbarc13 indicated that YrH9014 was located on chromosome 2B. Based on chromosomal location, the reaction patterns and pedigree analysis, YrH9014 should be a novel resistance gene to stripe rust. This new gene and flanking markers got from this study should be useful for marker-assisted selection （MAS） in breeding programs for stripe rust.

关键词： wheat cultivar Puccinia striiformis f. sp. tritici resistance genes molecular mapping Psathyrostachyshuashanica Keng

Formation Flight Control and Cooperative Obstacle Avoidance of Multiple UAVs

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Guidance, Navigation and Control 2023年第4期3卷 111-134页

作者： Xiaotong Jiang Wangcheng Zhang Mingyang Sun shuang tang Ziyang Zhen College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 P.R.China CASIC Research Institute of Intelligent Decision Engineering Wuhan 430040 P.R.China

This paper primarily focuses on the obstacle avoidance issue of followers in unmanned aerial vehicle(UAV)formation flight while considering formation *** on consensus theory and the artificial potential field(APF)principle,a new fusion UAV formation control algorithm is *** method employs a formation control strategy that combines the leader-following method and the virtual structure method,enabling the generation,maintenance and transformation of the formation through the utilization of a consensus *** response to the specific problem of the follower within the formation entering the no-fly zone and the self-collision among UAVs,APF-based formation path replanning and self-collision prevention algorithms are *** simulation results demonstrate the effectiveness of the proposed algorithm.

关键词： Formation flight collaborative control consensus theory artificial potential field

Synthesis and Properties of High Performance Functional Polyimides Containing Rigid Nonplanar Conjugated Fluorene Moieties

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Chinese Journal of Polymer Science 2019年第4期37卷 416-427,I0008页

作者： Yi-Wu Liu Li-shuang tang Lun-Jun Qu Si-Wei Liu Zhen-Guo Chi Yi Zhang Jia-Rui Xu PCFM Lab GD HPPC LabGuangdong Engineering Technology Research Centre for High-performance Organic and Polymer Photoelectric Functional FilmsState Key Laboratory of Optoelectronic Materials and TechnologiesSchool of ChemistrySun Yat-sen University Key Laboratory of Advanced Packaging Materials and Technology of Hunan Province School of Packaging and Materials EngineeringHunan University of Technology

A diamine(WuFDA) containing vertical rigid non-planar conjugated fluorene moiety and low polarizability group(C―F)was designed and synthesized through three steps of reactions(halogenated reaction, Suzuki coupling reaction, and reduction reaction).Four kinds of high performance functional polyimides(WuFPI-6 F, WuFPI-BP, WuFPI-BT, and WuFPI-PM) were thus prepared by the condensation polymerization of WuFDA with four commercial dianhydride 6 FDA, BPDA, BTDA, and PMDA, respectively. The polyimides exhibited low dielectric constant, excellent thermal stability, outstanding solubility, good film-forming property, and mechanical properties. The dielectric constants of the polyimides were in the range of 2.28-2.88(f = 10~4 Hz). The 5% weight-loss temperatures(Td 5%)in nitrogen were in the range of 555-584 °C, and the glass transition temperatures(T_g) were in the range of 408-448 °C. The weight loss of WuFPI-BP maintaining at 450 and 500 °C for half an hour was only 0.33% and 1.26%, respectively. All the WuFPIs could be dissolved in almost all organic solvents, even chloroform. The tensile strength and tensile modulus of these films were in the ranges of 78.6-85.7 MPa and 3.1-3.2 GPa, respectively. In addition, the polyimides displayed light color with special fluorescent and resistive switching(ON-OFF) characteristics; the maximum fluorescence emission was observed at 422-424 nm in NMP solution and at 470-548 nm in film state. The memory devices with the configuration of indium tin oxide/WuFPIs/aluminum(ITO/WuFPIs/Al) exhibited distinct volatile memory characteristics of static random access memory(SRAM), with an ON/OFF current ratio of 10~5-10~6. These functional polyimides showed attractive potential applications in the field of high performance flexible polymer photoelectronic devices or polymer memory devices.

关键词： Functional polyimide Fluorene derivative moieties Fluorescence polymer Low dielectric constant Thermal stability