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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi tan.ir ahmed siddiqui Md.Muzahid ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(pirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan siddiqui Misbah Shaikh Afia Salman Muhammad ahmed Ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I²=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I²=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I²=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I2=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I2=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatment.

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

Achieving Energy Efficiency in Wireless Sensor Networks Using Dynamic Channel Polling and Packet Concatenation

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China Communications 2021年第8期18卷 249-270页

作者： Shama siddiqui Anwar ahmed Khan Sayeed Ghani Department of Computer Science DHA Suffa UniversityKarachiPakistan Department of Computer Science Institute of Business AdministrationKarachiPakistan Department of Computer Science Sindh Institute of Management&TechnologyKarachiPakistan

There has been a significant interest of researchers to combine different schemes focused on optimizing energy performance while developing aMAC protocol for Wireless Sensor Networks(WSNs).In this paper,we propose to integrate two cross-layer schemes:dynamic channel polling and packet concatenation using a recent asynchronous MAC protocol“Adaptive&Dynamic Polling MAC”(ADPMAC).ADP-MAC dynamically selects the polling interval distribution based on characterization of incoming traffic patterns using Coefficient of variation(CV).Packet Concatenation(PC)refers to combining the individually generated data packets into a single super packet and sending it at the polling ***,the Block Acknowledgement(BA)scheme has been developed for ADP-MAC to work in conjunction with the packet *** proposed schemes have been implemented in Tiny-OS for Mica2 platform and Avrora emulator has been used for conducting *** results have revealed that the performance both in terms of energy&packet loss improves when ADP-MAC is used in conjunction with the additional features of PC&***,the proposed scheme has been compared with a stateof-art packet concatenation primitive PiP(Packet-in-Packet).It has been observed that ADP-MAC supersedes the performance of PiP in terms of PDR(Packet Delivery Ratio)due to better management of synchronization between source and sink.

关键词： energy efficiency concatenation dynamic polling

Flow Injection Chemiluminescence Method for Nalbuphine Hydrochloride in Pharmaceutical Formulations Using Tris(2,2′-bipyridyl)ruthenium(II)Chloride-diperiodatocuprate(III)Reaction

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Chemical Research in Chinese Universities 2021年第3期37卷 629-638页

作者： ahmed Khan MUHAMMAD Asghar MOHAMMED Yaqoob MASOOD ahmed siddiqui SAMAR Ali Department of Chemistry University of BalochistanSariab RoadQuetta87300Pakistan

A sensitive and selective method employing chemiluminescence(CL)coupled with flow injection(FI)is reported for nalbuphine hydrochloride(NAL)assay in pharmaceutical *** enhancement effect of NAL on the CL reaction between tris(2,2′-bipyridyl)ruthenium(II)chloride-diperiodatocuprate(III){Ru[(bpy)_(3)]^(2+)-Cu(III)complex}in acidic medium is used as analytical *** optimal conditions of the CL reaction were sulfuric acid 1.0×10^(−3) mol/L,Ru[(bpy)s]2+7.5×10^(−5) mol/L,Cu(III)/Ag(III)complexes 4.0×10^(−4)/5.0×10^(−4) mol/L,sample loop volume of 120µL and flow rate of 2.5 mL/*** sensitivities of the method in terms of detection(S/N=3)and quantification(S/N=10)limits are 5×10^(−4) and 0.001 ppm(1 ppm=1 mg/L),*** linear response of the instrument in the form of CL intensity with respect to NAL concentration is over the range 0.001-15.0 ppm(R^(2)=0.9999)with relative standard deviation from 0.8%to 3.2%and injection throughput of 120 injection/*** applications of the method include the quantitative analysis of NAL in pharmaceutical injection *** and the average results of the proposed method are not significantly different from the results of a reported method by applying F-and paired student *** most likely CL reaction mechanism is written in accordance with spectrophotometric and CL studies.

关键词： Ru[(bpy)_(3)]^(2+) Cu(III)/Ag(III)complex Chemiluminescence Flow injection analysis Nalbuphine hydrochloride Pharmaceutical

Vegetation-environment relationships in the forests of Chitral district Hindukush range of Pakistan

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Journal of Forestry Research 2013年第2期24卷 205-216页

作者： Nasrullah Khan Syed Shahid Shaukat Moinuddin ahmed Muhammad Faheem siddiqui Department of Botany University of Malakand Dept. of Botany University of Karachi Laboratory of Dendrochronology and Plant Ecology Department of Botany Federal Urdu University of Arts Science and Technology

We investigated the composition of plant communities to quantify their relationships with environmental parameters in the Chitral Hindukush range of Pakistan. We sampled tree vegetation using the Point Centered Quarter （PCQ） method while understory vegetation was sampled in 1.5-m circular quadrats. Cedrus deodara is the national symbol of Pakistan and was dominant in the sampled communities. Because environmental variables determine vegetation types, we analyzed and evaluated edaphic and topographic factors. DCA-Ordination showed the major gradient as an amalgam of elevation （p〈0.05） and slope （p〈0.01） as the topographic factors correlated with species distribution. Soil variables were the factors of environmental significance along DCA axes. However, among these factors, Mg2＋ , K ＋ and N2＋ contributed not more than 0.054% 0.20% and 0.073%, respectively, to variation along the first ordination axis. We conclude that the principal reason for weak or no correlation with many edaphic variables was the anthropogenic disturbance of vegetation. The understory vegetation was composed of perennial herbs in most communities and was most dense under the tree canopy. The understory vegetation strongly regulates tree seedling growth and regeneration patterns. We recommend further study of the understory vegetation using permanent plots to aid development of forest regeneration strategies.

关键词： environmental relationship multivariate analysis cluster analysis ordination anthropogenic factors forest, Hindukush range

Population structure,age and growth rates of conifer species and their relation to environmental variables at Malam Jabba,Swat District,Pakistan

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Journal of Forestry Research 2020年第2期31卷 429-441页

作者： Arsalan Muhammad Faheem siddiqui Moinuddin ahmed Syed Shahid Shaukat Alamdar Hussain Department of Botany University of KarachiKarachi 75270Pakistan Dr.Moinuddin ahmed Laboratory of Plant Ecology and Dendrochronology Department of BotanyFederal Urdu UniversityKarachiPakistan Institute of Environmental Studies University of KarachiKarachiPakistan Department of Botany Karakoram International UniversityGilgitGilgit-BaltistanPakistan

This study focuses on age,growth rate and diameter distribution of pine forests in the Malam Jabba area,Swat District,*** core samples were taken from twenty *** smithiana was the oldest at 234 years with a 112-cm *** pindrow was 125 years with an 80-cm diameter while the oldest Pinus wallichiana was 122 years with 75-cm *** fastest overall growth rate of 1.5±0.1 year/cm was for *** on a west-facing aspect,while the slowest 5.8±2.6 year/cm growth was *** on an eastfacing *** and *** exhibited marked differences in growth rates over a 5-year *** highest growth was by *** from 1966 to *** showed less growth over the same years,such pattern simultaneously reverse from 1911 to *** relationship between diameter and age,diameter and growth rate and age and growth rate were *** and *** ages were correlated with diameter and growth *** age was positive correlated with ***,topographic and edaphic factors did not show significant correlations with growth rates,although some appreciable correlations were *** growth of *** was correlated with elevation while *** was correlated with maximum water retaining *** and age produced uneven size classes and many size gaps,which could be the result of anthropogenic disturbances.

关键词： Dendrochronology Environmental variables Conifer species Forest structure Age classes

Effect of interest rate on economic performance: evidence from Islamic and non-Islamic economies

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Financial Innovation 2016年第1期2卷 108-121页

作者： Saba Mushtaq Danish ahmed siddiqui Karachi University Business School University of KarachiKarachiPakistan

Background:Saving and investment are two of the most important tools for economic *** interest rate has always been considered an important determinant of saving and ***,according to Islamic teachings,riba or earning interest on saving or investment is forbidden,and thus,many Muslims try to avoid earning income from the interest ***,the aim of this study is to assess the effects of this religious guideline on the financial decisions of an Islamic country’s population and its impact on saving and ***:We applied the random effect and system generalized method of moments(GMM)model separately to data of 17 non-Islamic and 17 Islamic countries from 2005 to ***:The results suggest that people in Islamic countries are not concerned about the interest rate on saving,but in non-Islamic countries,the interest rate,per capita income,and inflation have significant positive impacts,and national expenditure has a significant negative impact on ***,in Islamic countries,remittances received and national expenditure have negative significant impacts,and per capita income has a positive significant impact on *** the case of investment,interest rate and inflation show a negative effect on investment while trade affects investment positively in both Islamic and non-Islamic ***,domestic credit provided by banks has a negative significant effect on investment in non-Islamic countries,while in Islamic countries,remittances show a positive significant impact on ***:The governments and policy makers of Islamic countries should not imitate the economic policies of non-Islamic countries because religious factors play an important role in the interest rate-saving ***,they should increase per capita income by improving employment conditions and by reducing remittances received and national *** on saving should not allow earning ***,in

关键词： Interest rate Economic performance Islamic countries Riba Saving Investment

3-D seismic interpretation of stratigraphic and structural features in the Upper Jurassic to Lower Cretaceous sequence of the Gullfaks Field,Norwegian North Sea:A case study of reservoir development

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Energy Geoscience 2021年第4期2卷 287-297页

作者： Muhammad Usman Numair ahmed siddiqui Eduardo Garzanti Muhammad Jamil Qazi Sohail Imran Luqman ahmed Laboratory for Provenance Studies Department of Earth and Environmental SciencesUniversity of Milano-BicoccaPiazza Della Scienza 420126MilanoItaly Geoscience Department Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Shale Gas Research Group Institute of Hydrocarbon RecoveryUniversiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Institute of Geology University of the PunjabLahore56300Pakistan

The 3-D seismic dataset is a key tool to analyze and understand the mechanism of structural and stratigraphic hydrocarbon(HC)trapping in the *** used subsurface seismic characterization methods for fractures are based on the theory of effective anisotropy *** aim of this work is to improve the structural images with dense sampling of 3-D survey to evaluate structural and stratigraphic models for reservoir development to predict reservoir *** present study of the Gullfaks Field,located in the Norwegian North Sea Gullfaks sector,identifies the shallowest structural *** steepness of westward structural dip decreases eastward during the Upper Jurassic to Lower Cretaceous *** sands consist of the Middle Jurassic deltaic deposits and Lower Jurassic fluvial channel and delta plain *** supply steadily prevails on sea-level rise and the succession displays a regressive trend indicated by a good continuous stacking *** key factor for the development of reservoirs in the Gullfaks Field is fault transmissibility with spatially distributed *** majority of mapped faults with sand-to-sand contacts are non-sealing,which provide restriction for the HC flow between the fault *** traps for HC accumulation occur between the post-rift and syn-rift strata,*** set by extensional system,unconformity trap at the top of syndeposition,and structural trap due to normal *** reservoir quality in the studied area is generally excellent with average 35%porosity and permeability in the Darcy *** findings are useful to better understand the development of siliciclastic reservoirs in similar geological settings worldwide.

关键词： 3-D seismic model Mesozoic stratigraphic boundary Structural trap Reservoir quality Gullfaks Field

Antiacanthamoebic properties of natural and marketed honey in Pakistan

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 967-972页

作者： Farzana Abubakar Yousuf Malik Hassan Mehmood Abdul Malik Ruqaiyyah siddiqui Naveed ahmed Khan Department of Biological and Biomedical Sciences Aga Khan University Department of Biological Sciences Faculty of Science and Technology Sunway University

Objective: To determine antiacanthamoebic activity of natural and marketed honey ***: Natural honey samples were collected directly from the bee hive and marketed honey samples were purchased from the local market in Karachi, Pakistan. Both honey samples were tested for their flavonoid content(quercetin equivalent per gram of the extract) and phenolic content(gallic acid equivalent per gram). Furthermore, their antioxidant activity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl. Using amoebistatic and amoebicidal assays, the effects of honey samples were tested against growth and viability of Acanthamoeba ***: Natural honey exhibited potent amoebistatic and amoebicidal effects, in a concentration-dependent manner. Honey-treated Acanthamoeba castellanii showed loss of acanthopodia, following which amoebae detached, rounded up, reduced in size,decreased in cytoplasmic mass and they were observed floating in the culture ***, honey-treated amoebae did not revive when inoculated in fresh growth medium, however, glycerol-treated amoebae exhibited viable trophozoite and active growth. In contrast, marketed honey samples varied in their efficacy against Acanthamoeba castellanii. The proportion of flavonoid, as determined by quercetin measurements and the proportion of phenolic, as determined by gallic acid measurements was higher in natural honey compared with marketed honey. Similarly, the antioxidant activity, as determined by 2,2-diphenyl-1-picrylhydrazyl scavenging activity was higher in natural honey vs. marketed ***: This study shows that natural honey has antiacanthamoebic properties and possesses higher flavonoid, phenolic and antioxidant properties compared with the marketed honey. These findings are of concern to the public, health officials, and to the manufacturers regarding production of honey for medical applications.

关键词： Honey Acanthamoeba Amoebicidal Amoebistatic