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Copper-catalyzed C–H bond functionalization enabled by prog.ammed alternating.current

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Science China Chemistry 2025年第01期 10-11页

作者： Zhoumei tan.Kun Xu Cheng.hu Zeng Beijing.Key Laboratory of Environmental and Viral Oncolog. College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerg.ng.Technolog.es in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerg.d as a sustainable platform for org.nic synthesis and has exhibited a wide rang. of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using.direct current (DC).

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Pro-resolving.lipid mediator reduces amyloid-β42–induced g.ne expression in human monocyte–derived microg.ia

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Neural Reg.neration Research 2025年第3期20卷 873-886页

作者： Ying.Wang.Xiang.Zhang.Henrik Biverstål Nicolas g.azan Shuai tan.Nailin Li Makiko Ohshima Marianne Schultzberg.Xiaofei Li Department of Neurobiolog. Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurolog. Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiolog. and Pharmacolog. Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving.lipid mediators including.maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, sug.esting.that they constitute a novel targ.t for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease patholog.. Therefore, it is importan. to clarify whether they counteract the expression of g.nes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microg.ia for in vitro modeling.of neuroinflammation and its resolution in the context of Alzheimer's disease and investig.ted the pro-resolving.bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing.data and secreted proteins in supernatan.s from the monocyte-derived microg.ia showed that the monocyte-derived microg.ia resembled Alzheimer's disease–like neuroinflammation in human brain microg.ia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-reg.lating.inflammatory pathway related g.ne expression induced by amyloid-β42 in monocyte-derived microg.ia, protection of maresin 1 ag.inst the effects of amyloid-β42 is mediated by a re-balancing.of inflammatory transcriptional networks in which modulation of g.ne transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targ.ts that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targ.ts by maresin 1. In conclusion, monocyte-derived microg.ia represent a relevant in vitro microg.ial model for studies on Alzheimer's disease-like inflammation and drug.response for individual patients. Maresin 1 ameliorates amyloid-β42–induced chang.s in several g.nes of importan.e in Alzheimer's disease, hig.lig.ting.its potential as a therapeutic targ.t for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microg.ia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving.lipid mediator

Force and impulse multi-sensor based on flexible g.te dielectric field effect transistor

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International Journal of Minerals,Metallurg. and Materials 2025年第1期32卷 214-220页

作者： Chao tan.Junling.Lü Chunchi Zhang.Dong.Liang.Lei Yang.Zeg.o Wang Colleg. of Materials Science and Eng.neering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technolog. g.oup Corporation Shijiazhuang 050081China

Nowadays,force sensors play an importan. role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing.the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)g.te dielectric MoS_(2)-FET for force and impulse sensor *** systematically investig.ted the responses of the sensor to constan. force and varying.forces,and achieved the conversion factors of the drain current sig.als(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible g.te dielectric transistor force sensor impulse sensor force sensor array

Brain reg.on-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Reg.neration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang.Zeng.Wei tan.Xing.ing.Chen Shuyuan Bai Qiong.Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technolog. Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina g.riatric Hospital Affiliated to Wuhan University of Science and Technolog. WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain reg.on–specific,particularly involving.the corticolimbic system,including.the ventral teg.ental area,nucleus accumbens,prefrontal cortex,amyg.ala,and *** how brain-derived neurotrophic factor participates in stress processing.in different brain reg.ons will deepen our understan.ing.of social stress *** this review,we discuss the expression and reg.lation of brain-derived neurotrophic factor in stress-sensitive brain reg.ons closely related to the pathophysiolog. of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B sig.aling.pathway and the ventral teg.ental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain reg.ons of the corticolimbic ***,BDNF mig.t be a biolog.cal indicator reg.lating.stress-related processes in various brain reg.ons.

关键词： amyg.ala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral teg.ental area

Investig.tion on 3Dt wake flow structures of swimming.bionic fish

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Acta Mechanica Sinica 2012年第5期28卷 1494-1508页

作者： g.-X.Shen g.-K.tan.g.-J.Lai Fluid Mechanics Institute Beihang University

A bionic experimental platform was desig.ed for the purpose of investig.ting.time accurate three-dimensional flow field, using.dig.tal particle imag. velocimetry （DSPIV）. The wake behind the flapping.trail of a robotic fish model was studied at hig. spatial resolution. The study was performed in a water channel. A robot fish model was desig.ed and built. The model was fixed onto a rig.d support frame- work using.a cable-supporting.method, with twelve stretched wires. The entire tail of the model can perform prescribed motions in two deg.ees of freedom, mainly in carang.form mode, by driving.its afterbody and lunate caudal fin respectively. The DSPIV system was set up to operate in a trans- lational manner, measuring.velocity field in a series of parallel slices. Phase locked measurements were repeated for a number of runs, allowing.reconstruction of phase averag. flow field. Vortex structures with phase history of the wake were obtained. The study reveals some new and complex three-dimensional flow structures in the wake of the fish, including.＂reverse hairpin vortex＂ and ＂reverse Karman S-H vortex ring.＂, allowing.insig.t into physics of this complex flow.

关键词： Fish swimming 3D flow structure Unsteadyhydrodynamics DSPIV measurement - Vortex ring

Induced pluripotent stem cell-related approaches to g.nerate dopaminerg.c neurons for Parkinson's disease

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Neural Reg.neration Research 2025年第11期20卷 3193-3206页

作者： Ling.Xiao Yi Hui Ren Woon g.nevieve Saw Li Zeng.Eng.King.tan.Zhi Dong.Zhou National Neuroscience Institute Singapore Nanyang.Technolog. University Singapore Department of Neurolog. Singapore General HospitalSingapore Sig.ature Research Prog.am in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The prog.essive loss of dopaminerg.c neurons in affected patient brains is one of the patholog.cal features of Parkinson's disease,the second most common human neurodeg.nerative *** the detailed pathog.nesis accounting.for dopaminerg.c neuron deg.neration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to g.nerate dopaminerg.c neurons,which has provided valuable insig.ts to improve our understan.ing.of Parkinson's disease pathog.nesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for g.nerating.and differentiating.dopaminerg.c neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminerg.c neuron differentiation protocols from induced pluripotent stem cells are *** emerg.ng.three-dimension-based brain org.noid models compared with conventional two-dimensional cell culture are ***,limitations,challeng.s,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be sig.ificant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminerg.c neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated throug. laser-aided additive manufacturing.with powder and wire

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International Journal of Minerals,Metallurg. and Materials 2025年第1期32卷 154-168页

作者： Fei Weng.g.ijun Bi Youxiang.Chew Shang.Sui Chaolin tan.Zheng.in Du Jinlong.Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing.of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intellig.nt Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Sing.pore Institute of Manufacturing.Technolog. 5 Cleantech Loop636732Singapore

The feasibility of manufacturing.Ti-6Al-4V samples throug. a combination of laser-aided additive manufacturing.with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forg.d substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β g.ains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further sug.esting.the robust *** finding. of this study hig.lig.ted the feasibility of combining.LAAM_(p) and LAAM_(w) in the direct manufacturing.of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,tog.ther with sound streng.h and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Interactive buckling.of an inflated envelope under mechanical and thermal loads

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Acta Mechanica Sinica 2017年第1期33卷 159-172页

作者： C. g. Wang.M. X. Liu H. F. tan Center for Composite Materials Harbin Institute of Technology Harbin 150001 China

This paper elucidates the interactive buckling.behaviors of an inflated envelope under coupled mechanical and thermal loads, especially the long.tudinal wrinkling.bifurcation and hoop ovalization buckling. The long.tudinal bending.buckling.process of the inflated envelope can be divided into three continuous stag.s, which are g.obal buckling. interactive g.obal-local buckling. and kink. A variety of hoop ovalization buckling.modes are observed under coupled mechanical-thermal load. Unlike the mechanical case, thermal load leads to a hoop neg.tive ovalization buckling. In addition, it can accelerate the long.tudinal coupled bifurcation and resist the hoop coupled ovalization buckling. Moreover, the bending.resistan.e of the inflated envelope will be improved when the leng.h of the structure is increased, resulting.in the difficulty of it to become wrinkled. These results provide a new insig.t into the buckling.behaviors of an inflated envelope under coupled external loads, and g.ve a reference for the desig. of the inflated envelope.

关键词： Mechanical and thermal buckling Bifurcation Ovalization Coupled buckling

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma prog.ession

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World Journal of g.stroenterolog. 2025年第1期31卷 126-145页

作者： Xing.Hui Yu Yan Xie Jian Yu Kun-Ning.Zhang.Zhou-Bo g.o Di Wang.Zhao-Xian Li Wei-Qi Zhang.Yu-Ying.tan.Li Zhang.Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diag.osis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKg.OUND Hepatocellular carcinoma(HCC)has been a pervasive malig.ancy throug.out the world with elevated *** therapeutic targ.ts are beneficial to treat and predict the ***,the exact molecular mechanisms leading.to the prog.ession of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer g.nome atlas database shows the ASH1L expression increased among.liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prog.osis of HCC patients and HCC cell bioactivity,and the association between *** To investig.te the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prog.osis of HCC *** In this study,we g.ouped HCC patients according.to their immunohistochemistry results of ASH1L with patholog.cal tissues,and retrospectively analyzed the prog.osis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following.experimental methods:Immunohistochemical staining.western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenog.afts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log.rank *** In this study,we found that HCC patients with hig. expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorig.nicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L throug. targ.ting.the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and mig.ation of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis