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Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer’s Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice

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Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： Yang Zhu hao Huang Zhi Chen Yong Tao Ling-Yi Liao shi-hao Gao Yan-Jiang Wang Chang-Yue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains *** studies suggested that mitochondrial functions are modulated by magnetic ***,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 *** vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ***,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 *** present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in *** provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

Regulation of the quantum barrier and carrier transport toward high-efficiency quasi-2D Dion-Jacobson tin perovskite solar cells

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Journal of Energy Chemistry 2024年第8期95卷 200-207,I0005页

作者： Huanhuan Yao Chang shi Tai Wu Shurong Wang Mingyu Yin Liming Ding Yong Hua Feng hao School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Yunnan Key Laboratory for Micro/Nano Materials&Technology School of Materials and EnergyYunnan UniversityKunming 650091YunnanChina Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Quasi-2D Dion-Jacobson(DJ)tin halide perovskite has attracted much attention due to its elimination of Van der Waals gap and enhanced environmental ***,the bulky organic spacers usually form a natural quantum well structure,which brings a large quantum barrier and poor film quality,further limiting the carrier transport and device ***,we designed three organic spacers with different chain lengths(ethylenediamine(EDA),1,3-propanediamine(PDA),and 1,4-butanediamine(BDA))to investigate the quantum barrier *** and experimental characterizations indicate that EDA with short chain can reduce the lattice distortion and dielectric confinement effect,which is beneficial to the effective dissociation of excitons and the inhibition of trap-free non-radiative *** addition,EDA cation shows strong interaction with the inorganic octahedron,realizing large aggregates in precursor solution and high-quality films with improved structural ***,femtosecond transient absorption proves that EDA cations can also weaken the formation of small n-phases with large quantum barrier to achieve effective carrier transport between different ***,the quasi-2D DJ(EDA)FA_(9)Sn_(10)I_(31)solar cells achieves a 7.07%power conversion efficiency with good environment ***,this work sheds light on the regulation of the quantum barrier and carrier transport through the chain length of organic spacer for qua si-2D DJ lead-free perovskites.

关键词： Chain lengths Organic spacers Quantum well Carrier transport Lattice distortion

Experimental observation of spontaneous symmetry breaking in a quantum phase transition

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 34-39页

作者： Wen Ning Ri-Hua Zheng Jia-hao Lu Fan Wu Zhen-Biao Yang shi-Biao Zheng Fujian Key Laboratory of Quantum Information and Quantum Optics College of Physics and Information EngineeringFuzhou UniversityFuzhou 350108China Hefei National Laboratory Hefei 230088China

Spontaneous symmetry breaking(SSB)plays a central role in understanding a large variety of phenomena associated with phase transitions,such as superfluid and *** far,the transition from a symmetric vacuum to a macroscopically ordered phase has been substantially *** process bridging these two distinct phases is critical to understanding how a classical world emerges from a quantum phase transition,but so far remains unexplored in *** here report an experimental demonstration of such a process with a quantum Rabi model engineered with a superconducting *** move the system from the normal phase to the superradiant phase featuring two symmetry-breaking field components,one of which is observed to emerge as the classical *** results demonstrate that the environment-induced decoherence plays a critical role in the SSB.

关键词： quantum phase transition Rabi model spontaneous symmetry breaking superconducting circuit Schrodinger cat states

Research on TensorMulti-Clustering Distributed Incremental Updating Method for Big Data

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Computers, Materials and Continua 2024年第1期81卷 1409-1432页

作者： Zhang, Hongjun Zhang, Zeyu Ruan, Yilong Ye, hao Li, Peng shi, Desheng School of Computer Science Nanjing University of Posts and Telecommunications Nanjing 210023 China Ministry of Science and Technology Innovation China Communications Services Corporation Limited Beijing 100071 China School of Artificial Intelligence The University of Manchester Manchester M13 9PL United Kingdom Ministry of Technology Innovation China Telecom Artificial Intelligence Technology (Beijing) Corporation Limited Beijing 100032 China Ministry of Science and Technology Innovation Zhongbo Information Technology Research Institute Corporation Limited Nanjing 210012 China Jiangsu Postal Big Data Technology and Application Engineering Research Center Nanjing University of Posts and Telecommunications Nanjing 210003 China

The scale and complexity of big data are growing continuously, posing severe challenges to traditional data processing methods, especially in the field of clustering analysis. To address this issue, this paper introduces a new method named Big Data Tensor Multi-Cluster Distributed Incremental Update (BDTMCDIncreUpdate), which combines distributed computing, storage technology, and incremental update techniques to provide an efficient and effective means for clustering analysis. Firstly, the original dataset is divided into multiple subblocks, and distributed computing resources are utilized to process the sub-blocks in parallel, enhancing efficiency. Then, initial clustering is performed on each sub-block using tensor-based multi-clustering techniques to obtain preliminary *** new data arrives, incremental update technology is employed to update the core tensor and factor matrix, ensuring that the clustering model can adapt to changes in data. Finally, by combining the updated core tensor and factor matrix with historical computational results, refined clustering results are obtained, achieving real-time adaptation to dynamic data. Through experimental simulation on the Aminer dataset, the BDTMCDIncreUpdate method has demonstrated outstanding performance in terms of accuracy (ACC) and normalized mutual information (NMI) metrics, achieving an accuracy rate of 90% and an NMI score of 0.85, which outperforms existing methods such as TClusInitUpdate and TKLClusUpdate in most scenarios. Therefore, the BDTMCDIncreUpdate method offers an innovative solution to the field of big data analysis, integrating distributed computing, incremental updates, and tensor-based multi-clustering techniques. It not only improves the efficiency and scalability in processing large-scale high-dimensional datasets but also has been validated for its effectiveness and accuracy through experiments. This method shows great potential in real-world applications where dynamic data growth is

关键词： Data accuracy

Prediction model for the initial seed clearing angles of a precision seed meter based on vector fields

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 140-148页

作者： Wan Jiao Junjie Zhang Xuhui Chen hao Shen Yuxiang Huang Jiangtao shi College of Mechanical and Electric Engineering Northwest A&F UniversityYangling 712100ShaanxiChina Xi’an YaAo Agricultural Machinery Ltd Xi’an 710300China

Seed clearing is a critical stage during precision seed metering process to ensure high seed ***,there is a lack of understanding of the dynamics in the seed clearing *** this study,a model was developed to predict initial seed clearing angle,in the seed clearing process using vector *** model was applied to an existing high-speed metering device and soybean seeds,and the model was evaluated with bench testing *** showed that dynamic changes in forces and constraints of seeds during the seed clearing process could be abstracted as vectors,and the changes of vector directions could be described by their phase *** phase angles were functions of the rotational angle of the seed *** phase angle of the constraint boundary linearly increases with the increase of the rotational *** phase angle of the force fluctuates,as the rotational angle *** seed clearing angle obtained from the phase angles varies from 8°to 59°,depending on the seeder travel *** comparing the values of the initial seed clearing angles predicted by the model with those from the bench tests,the root mean square error(RMSE)were from 2.73 to 3.14,and the correlation(r)between predict and observer were all higher than 0.98,indicating that the model had reasonably good accuracy.

关键词： mechanical precision seeder initial seed clearing angle prediction model vector fields high-speed photography technology

Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan tan Ying-shi Zou Ying-Lin Yu Le-Yi Hu Ting Zhang Hui Chen Ling Jin Duo-Ru Lin Yi-Zhi Liu hao-Tian Lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study

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Congenital Heart Disease 2024年第3期19卷 279-291页

作者： Yang Hua Jinyu Sun Yuxuan Lou hao Zhang Jing shi Wei Sun Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China

Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and ***,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged *** retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk ***:226 patients with migraine and PFO were consecutively initially *** factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model *** discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration ***:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of *** magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML *** regression screened out potential variables and subsequent multivariate analysisfinally identified age,mean platelet volume,andfibri-nogen(FIB)as independent predictive factors of *** area under the ROC curve(AUC)was ***-mer-Lemeshow test and calibration curve verified a consistency between the predicted and actual ***:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies.

关键词： White matter lesion migraine patent foreman ovale nomogram predictive model

Effects of high-pressure activated slightly acidic electrolyzed water on cleaning and sterilization of pig transfer vehicles

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 53-59页

作者： Xuedong Zhao Shengnan Tao Fei Qi hao Li Zhengxiang shi Department of Agricultural Structure and Bioenvironmental Engineering College of Water Resources&Civil EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural Engineering in Structure and Environment Ministry of Agriculture and Rural AffairsBeijing 100083China Beijing Engineering Research Center on Animal Healthy Environment Beijing 100083China

The establishment of biosafety system is of enormous importance to the livestock and poultry production in terms of mitigating the transmission of diseases and implementing regional prevention and control ***,the current sterilization technology presents several drawbacks,including time-consuming procedures,chemical residues,and challenges in treating the sewage after *** this study,a novel cleaning and sterilization method that combines slightly acidic electrolyzed water and high pressure water-jet was *** orthogonal test was conducted to examine the correlation between high-pressure conditions and the various non-structural parameters on the efficacy of sterilization *** a field test,the effectiveness of the technology in cleaning pig transfer vehicles was evaluated by the total plate count and variations of community *** findings revealed that the combination of process parameters,including an available chlorine concentration of 200 mg/L,rinsing pressure of 170 bar,rinsing duration of 10 s,and residence time of 15 min,resulted in a removal rate of colony concentration on the surface of pig transfer vehicles of(96.50±0.91)%.Moreover,it was demonstrated to effectively inhibit a variety of pathogenic *** innovative cleaning system has the potential to replace traditional methods and reduces pollution while saving time and *** introduces a novel approach for sterilization of transportation in livestock and poultry farms as well as the biosafety construction of the animal husbandry.

关键词： slightly acidic electrolyzed water high pressure water-jet sterilization biosafety concentrated animal production

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基于车联网的汽车导航多屏交互体验

包装工程 2017年第20期38卷 17-22页

作者：谭浩许诗卉湖南大学汽车车身先进设计制造国家重点实验室长沙410082 湖南大学设计艺术学院长沙410082

目的汽车导航信息在多屏交互模式下,对用户的体验进行测量研究。方法被试通过宋模拟驾驶实验完成体验后,对体验进行主观评分。结论得出不同显示区域,不同信息类型,对用户舒适性及安全感体验的影响。不同的信息类别显示在不同的显示区域... 详细信息

目的汽车导航信息在多屏交互模式下,对用户的体验进行测量研究。方法被试通过宋模拟驾驶实验完成体验后,对体验进行主观评分。结论得出不同显示区域,不同信息类型,对用户舒适性及安全感体验的影响。不同的信息类别显示在不同的显示区域,造成的用户体验有很大的差异,多屏化交互的趋势下,视觉信息的布局的设计应简洁化,并通过分区来提升对有效信息的提取。

关键词：车联网多屏交互车载导航用户体验主观量表