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Toward Establishing a Low-cost UAV Coordinated Carbon Observation Network(LUCCN):First Integrated Campaign in China

Advances in Atmospheric Sciences 2024年第1期41卷 1-7页

作者： dongxu YANG Tonghui ZHAO Lu yao dong GUO Meng FAN Xiaoyu REN Mingge LI Kai WU Jing WANG Zhaonan CAI Sisi WANG Jiaxu GUO Liangfu CHEN Yi LIU Carbon Neutrality Research Center(CNRC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Middle Atmospheric Physics and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China National Remote Sensing Center of China Beijing 100036China The Administrative Center for China’s Agenda 21 Beijing 100862China

In this study,we introduce our newly developed measurement-fed-perception self-adaption Low-cost UAV Coordinated Carbon Observation Network(LUCCN)*** LUCCN primarily consists of two categories of instruments,including ground-based and UAV-based in-situ *** use the GMP343,a low-cost non-dispersive infrared sensor,in both ground-based and UAV-based *** first integrated measurement campaign took place in Shenzhen,China,4 May *** the campaign,we found that LUCCN’s UAV component presented significant data-collecting advantages over its ground-based counterpart owing to the relatively high altitudes of the point emission sources,which was especially obvious at a gas power plant in *** emission flux was calculated by a crosssectional flux(CSF)method,the results of which differed from the Open-Data Inventory for Anthropogenic Carbon dioxide(ODIAC).The CSF result was slightly larger than others because of the low sampling rate of the whole emission cross *** LUCCN system will be applied in future carbon monitoring campaigns to increase the spatiotemporal coverage of carbon emission information,especially in scenarios involving the detection of smaller-scale,rapidly varying sources and sinks.

关键词： CO_(2) measurement networks power station carbon emission cross-sectional flux method

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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

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Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SONG dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue yao Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1

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NoC节点编码及路由算法的研究

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计算机科学 2009年第3期36卷 86-89页

作者：杨晓强谭耀东朱宁洪韩俊刚西安电子科技大学微电子学院西安710071 西安邮电学院计算机系西安710061 西安科技大学计算机系西安710061

NoC的设计和实现受到芯片的面积、功耗、深亚微米效应的限制。将拓扑结构和节点编码相结合,提出一种基于约翰逊码的二维平面编码。该编码隐含了Torus网络拓扑结构以及网络节点之间的连接关系并且有很好的扩展性,能够简化Torus拓扑结构... 详细信息

NoC的设计和实现受到芯片的面积、功耗、深亚微米效应的限制。将拓扑结构和节点编码相结合,提出一种基于约翰逊码的二维平面编码。该编码隐含了Torus网络拓扑结构以及网络节点之间的连接关系并且有很好的扩展性,能够简化Torus拓扑结构上路由算法的实现和降低硬件成本。基于此编码和利用X-Y路由的路由确定性特点,提出改进X-Y路由,在中间节点只需要3或5个逻辑运算,降低路由的计算复杂性和硬件成本。最后,进行了节点结构设计。提出的编码不仅用于NoC的路由方面而且在NoC任务映射方面有重要应用。

关键词：片上网络拓扑结构节点编码片上路由

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Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis

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World Journal of Gastroenterology 2024年第35期30卷 3996-4010页

作者： Zhen-Hua Fu Zi-Yue Zhao yao-Bing Liang dong-Yu Cheng Jian-Ming Luo Hai-Xing Jiang Shan-Yu Qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of *** complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other ***-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its ***,the impact of metabolic syndrome components on HTGAP clinical outcomes remains *** To investigate the impact of metabolic syndrome component burden on clinical outcomes in *** In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical ***,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP *** This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical *** risk of complications increased with the number of metabolic syndrome *** for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic *** The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关键词： Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol Obesity Hyperglycemia Hypertension Clinical outcomes

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Screening for metastasis-related genes in mouse melanoma cells through sequential tail vein injection

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Biophysics Reports 2024年第1期10卷 15-21页

作者： Qinggang Hao Rui dong Weiyu Bai dong Chang Xinyi yao Yingru Zhang Huangying Xu Huiyan Li Xiang Kui Feng Wang Yan Wang Chengqin Wang Yujie Lei Yan Chen Junling Shen Lei Sang Yan Bai Jianwei Sun Center for Life Sciences Yunnan Key Laboratory of Cell Metabolism and Diseases State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life Sciences Yunnan University Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province Yan'an Hospital Affiliated to Kunming Medical University Shandong Provincial Key Laboratory of Animal Resistance Biology Collaborative Innovation Center of Cell Biology in Universities of Shandong Center for Cell Structure and Function Institute of Biomedical Science College of Life Sciences Shandong Normal University Department of Pathology The Second Affiliated Hospital of Kunming Medical University State Key Laboratory of Bioactive Molecules and Druggability Assessment Institute of Genomic Medicine College of Pharmacy Jinan University Department of Pathology School of Basic Medicine Qingdao University Department of Thoracic Surgery Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center

Tumor metastasis, responsible for approximately 90% of cancer-associated mortality, remains poorly understood. Here in this study, we employed a melanoma lung metastasis model to screen for metastasis-related genes. By sequential tail vein injection of mouse melanoma B16F10 cells and the subsequently derived cells from lung metastasis into BALB/c mice, we successfully obtained highly metastatic B16F15 cells after five rounds of in vivo screening. RNA-sequencing analysis of B16F15 and B16F10 cells revealed a number of differentially expressed genes, some of these genes have previously been associated with tumor metastasis while others are novel discoveries. The identification of these metastasis-related genes not only improves our understanding of the metastasis mechanisms, but also provides potential diagnostic biomarkers and therapeutic targets for metastatic melanoma.

关键词： Melanoma Lung metastasis model Gene screening Tail vein injection

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Surface-derived phosphate layer on NiFe-layered double hydroxide realizes stable seawater oxidation at the current density of 1 A·cm^(−2)

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Nano Research 2024年第7期17卷 5786-5794页

作者： Chaoxin Yang Zhengwei Cai Jie Liang Kai dong Zixiao Li Hang Sun Shengjun Sun dongdong Zheng Hui Zhang Yongsong Luo Yongchao yao Yan Wang Yuchun Ren Qian Liu Luming Li Wei Chu Xuping Sun Bo tang College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Department of Science and Environmental Studies Faculty of Liberal Arts and Social Sciencethe Education University of Hong KongHong Kong 999077China Institute for Advanced Study Chengdu UniversityChengdu 610106China Laoshan Laboratory Qingdao 266237China

Seawater electrolysis,especially in coastlines,is widely considered as a sustainable way of making clean and high-purity H2 from renewable energy;however,the practical viability is challenged severely by the limited anode durability resulting from side reactions of chlorine ***,we report an effective Cl^(−) blocking barrier of NiFe-layer double hydroxide(NiFe-LDH)to harmful chlorine chemistry during alkaline seawater oxidation(ASO),a pre-formed surface-derived NiFe-phosphate(Pi)***,the PO_(4)^(3−)-enriched outer-layer is capable of physically and electrostatically inhibiting Cl−adsorption,which protects active Ni^(3+)sites during *** NiFe-LDH with the NiFe-Pi outer-layer(NiFe-LDH@NiFe-Pi)exhibits higher current densities(j)and lower overpotentials to afford 1 A·cm^(−2)(η1000 of 370 mV versusη1000 of 420 mV)than the NiFe-LDH in 1 M KOH+***,the NiFe-LDH@NiFe-Pi also demonstrates longer-term electrochemical durability than NiFe-LDH,attaining 100-h duration at the j of 1 A·cm^(−2).Additionally,the importance of surface-derived PO_(4)^(3−)-enriched outer-layer in protecting the active centers,γ-NiOOH,is explained by ex situ characterizations and in situ electrochemical spectroscopic studies.

关键词： seawater oxidation phosphate outer-layer layered double hydroxide electrostatic repulsion in situ Raman

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低温破碎及装药结构对内弹道性能影响的数值分析

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火炸药学报 2024年第4期47卷 381-392页

作者：林杨淦刘东尧南京理工大学能源与动力工程学院江苏南京210094

以大口径火炮密实装药发射安全性为背景,对火药颗粒低温破碎及装药结构对内弹道特性的影响进行了数学建模和仿真分析。针对中心点传火管结构的大口径火炮密实装药,建立传火管及装药床的双一维两相流数学模型,结合膛内火药颗粒应力及破... 详细信息

以大口径火炮密实装药发射安全性为背景,对火药颗粒低温破碎及装药结构对内弹道特性的影响进行了数学建模和仿真分析。针对中心点传火管结构的大口径火炮密实装药,建立传火管及装药床的双一维两相流数学模型,结合膛内火药颗粒应力及破碎度函数,采用数值差分方法对内弹道过程进行数值仿真,研究火药温度及混合装药方案对火药颗粒破碎度及火炮内弹道性能的影响。结果表明,在低温条件下,单一装药结构火药颗粒将发生破碎,且破碎度随温度降低而增大,在-20℃和-40℃条件下,最大破碎度分别达到1.896和2.487,膛内压力分别为690.32MPa和803.64MPa,增幅达到16.4%;在总装药质量6.25kg不变的条件下,小颗粒药装药质量从0增至0.4kg,最大破碎度从2.487减至1.803,膛内压力从803.64MPa减至740.81MPa,由此可见混合装药结构可以有效避免火药颗粒的破碎。

关键词：物理化学火药破碎低温破碎内弹道发射安全性大口径火炮

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结合空间—光谱信息的快速自训练高光谱遥感影像分类

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遥感学报 2024年第1期28卷 219-230页

作者：金垚董燕妮杜博中国地质大学(武汉)地球物理与空间信息学院武汉430074 湖北珞珈实验室武汉430079 武汉大学测绘遥感信息工程国家重点实验室武汉430079 武汉大学资源与环境科学学院武汉430079 武汉大学计算机学院武汉430072

自训练方法被广泛应用于高光谱影像分类任务中以解决标记样本获取困难的问题。传统的自训练方法不仅忽略了高光谱影像所能提供的空间信息,导致最终分类精度受到影响;同时在每次迭代过程中都需要完成一次对未标记数据的分类任务,导致需... 详细信息

自训练方法被广泛应用于高光谱影像分类任务中以解决标记样本获取困难的问题。传统的自训练方法不仅忽略了高光谱影像所能提供的空间信息,导致最终分类精度受到影响;同时在每次迭代过程中都需要完成一次对未标记数据的分类任务,导致需要大量的时间成本。因此,针对上述问题,本文提出了一种基于空间—光谱信息的快速自训练方法用于高光谱影像分类。与传统的自训练方法不同,该方法在迭代过程中使用空间—光谱信息对未标记数据进行筛选完成标记样本的扩充,而不是使用分类器对未标记样本进行分类。首先针对初始标记样本使用空间邻域块选择空间近邻点,然后使用自适应阈值对空间近邻点进行二次筛选得到空谱近邻点赋予标记,最后根据扩充后的标记样本对分类器进行训练完成分类任务。结果表明,在Washington DC Mall Subimage高光谱数据集中每类分别选择2个和10个训练样本时,整体分类精度分别达到了93.17%和95.43%;而在Indian Pines数据集中整体分类精度分别达到了59.75%和86.13%。我们提出的结合空间—光谱信息的快速自训练方法和对比方法相比,我们的方法有明显的提升。

关键词：高光谱遥感半监督分类小样本问题空间—光谱信息自训练方法

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A comprehensive review of heart rate variability as an indicator in the regulation of the autonomic nervous system by acupuncture:a bibliometric analysis

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Integrative Medicine Discovery 2024年第14期8卷 1-14页

作者： Yi-Feng Shen Kun Zhu Jun-Long Zhu Xiao-Peng Huang De-Gui Chang yao-dong You dong-dong Yang TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610075China Clinical Medicine School Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Neurology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610075China.

This study sought to conduct a bibliometric analysis of acupuncture studies focusing on heart rate variability(HRV)and to investigate the correlation between various acupoints and their effects on HRV by utilizing association rule mining and network analysis.A total of 536 publications on the topic of acupuncture studies based on *** disease keyword analysis revealed that HRV-related acupuncture studies were mainly related to pain,inflammation,emotional disorders,gastrointestinal function,and hypertension.A separate analysis was conducted on acupuncture prescriptions,and Neiguan(PC6)and Zusanli(ST36)were the most frequently used *** core acupoints for HRV regulation were identified as PC6,ST36,Shenmen(HT7),Hegu(LI4),Sanyinjiao(SP6),Jianshi(PC5),Taichong(LR3),Quchi(LI11),Guanyuan(CV4),Baihui(GV20),and Taixi(KI3).Additionally,the research encompassed 46 reports on acupuncture animal experiments conducted on HRV,with ST36 being the most frequently utilized *** research presented in this study offers valuable insights into the global research trend and hotspots in acupuncture-based HRV studies,as well as identifying frequently used combinations of *** findings may be helpful for further research in this field and provide valuable information about the potential use of acupuncture for improving HRV in both humans and animals.

关键词： heart rate variability acupuncture autonomous nerves system bibliometric analysis data mining

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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

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Chinese Journal of Natural Medicines 2024年第06期 486-500页

作者： YANG Yanqiu CHE Yue FANG Mingxia yao Xiaohu ZHOU Di WANG Feng CHEN Gang LIANG dong LI Ning HOU Yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health Sciences Northeastern University National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City Shenyang Pharmaceutical University State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University

Neuroinflammation, mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3（NLRP3） inflammasome, is a significant contributor to the pathogenesis of neurodegenerative diseases（NDDs）. Reynosin, a natural sesquiterpene lactone（SL）, exhibits a broad spectrum of pharmacological effects, suggesting its potential therapeutic value. However, the effects and mechanism of reynosin on neuroinflammation remain elusive. The current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide（LPS）. Our findings reveal that reynosin effectively reduces microglial inflammation in vitro, as demonstrated by decreased CD11b expression and lowered interleukin-1 beta（IL-1β） and interleukin-18（IL-18） mRNA and protein levels. Correspondingly, in vivo, results showed a reduction in the number of Iba-1 positive cells and alleviation of morphological alterations, alongside decreased expressions of IL-1β and IL-18. Further analysis indicates that reynosin inhibits NLRP3 inflammasome activation, evidenced by reduced transcription of NLRP3 and caspase-1, diminished NLRP3 protein expression, inhibited apoptosis-associated speck-like protein containing a CARD（ASC） oligomerization, and decreased caspase-1 self-cleavage. Additionally, reynosin curtailed the activation of nicotinamide adenine dinucleotide phosphate（NADPH） oxidase, demonstrated by reduced NADP+and NADPH levels, downregulation of gp91phoxmRNA, protein expression, suppression of p47phoxexpression and translocation to the membrane. Moreover, reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in vitro. These collective findings underscore reynosin's capacity to mitigate microglial inflammation by inhibiting the NLRP3 inflammasome, thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

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