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Gliquidone versus metformin： differential effects on aorta in streptozotocin induced diabetic rats

Chinese Medical Journal 2014年第7期127卷 1298-1303页

作者： tan zhongju xu zherong gui qifeng wu weizhen yang yunmei Department of Geriatrics First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

Background Diabetic cardiovascular complication is a major cause of mortality in type 2 diabetic *** markedly increases the risk of cardiovascular *** dysfunction is common in type 2 diabetes mellitus （DM） and is an early indicator of diabetic vascular ***,it is necessary to identify the effect of different hypoglycemic agents on vascular *** aim of the study was to examine and compare the effects of metformin and gliquidone on atherosclerotic lesions in streptozotocin-induced diabetic *** Forty male Sprague-Dawley rats （age,8 weeks; weight,180-200 g） were included in this study and fed with a normal chow diet for 1 *** （n=10） served as the normal control group （NC group） were fed with a normal chow for another 2 weeks and received an injection of *** rest 30 rats fed with a high-fat diet for 2 weeks and injected streptozotocin were randomly assigned to three groups （n=10 rats per group） as follow：type 2 DM group （DM group）,DM ＋ gliquidone group （GLI group） and DM ＋ metformin group （MET group）.Five weeks later,all rats were fasted overnight and taken tail blood samples for biochemical *** rats in the NC and DM groups were administrated with normal saline,while rats in the MET and GLI groups were administrated with metformin （100 mg/kg） or gliquidone （10 mg/kg）,*** medicines were given via intragastric administration for 8 *** 16 weeks,plasma triglyceride （TG）,total cholesterol （TC）,low density lipoprotein cholesterol （LDL-C）,high density lipoprotein cholesterol （HDL-C） were *** aortic arch was isolated from diabetic rats and was assessed by pathological sectioning using H＆E *** Metformin treatment prevented weight gain （（315.80±52.16） g vs.（318.70±68.48） g,P=0.773）,improved plasma TG,HDL-C and LDL-C levels （P=0.006,0.003,0.001,respectively,all P ＜0.05）.However,gliquidone showed no significant effects on plasma TG and TC levels

关键词： diabetes mellitus, type 2 atherosclerosis endothelial function metformin gliquidone

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