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Large‑scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1466-1481页

作者： Di Zhao Ranran Liu Xiaodong tan Huimin Kang Jie Wang zheng Ma Haiquan Zhao Hai Xiang zhengfen Zhang Hua Li Guiping Zhao Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanChina State Key Laboratory of Animal Biotech Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijingChina Guangdong Tinoo’s Foods Group Co. Ltd.QingyuanChina

Background Carcass traits are crucial indicators of meat production ***,the molecular regulatory mechanisms associated with these traits remain *** In this study,we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory *** on association analyses with the elastic net(EN)model,we identified 12 candidate genes(AMY1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle ***6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co-expression network analysis and differential expression ***-level experiments confirmed that SERPINB6 promotes the proliferation of chicken DF1 cells and primary *** expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 ***,a dual-luciferase reporter assay proved that gga-miR-1615 targets the 3′UTR of *** Collectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by promoting fibroblast and myoblast ***,the downstream variant rs317934171 regulates SERPINB6 *** results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.

关键词： Carcass traits Chicken Genome SERPINB6 Transcriptome

Absorption characteristics,model,and molecular mechanism of hydrogen sulfide in morpholine acetate aqueous solution

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Chinese Journal of Chemical Engineering 2024年第2期66卷 125-135页

作者： Hongwei Jin Yun Teng Kangkang Li Zhou Feng Zhonghao Li Shiqi Qu Hongzhi Xia Huanong Cheng Yugang Li Xinshun tan Shiqing zheng College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

The solubility of H_(2)S was measured in solutions of N-butyl-N-methylmorpholine acetate([Bmmorp][Ac])containing 20%-40%(mass)water at experimental temperatures ranged from 298.15 to 328.15 K and pressures up to 320 k *** total solubility of H_(2)S increased with higher temperatures,lower pressures,and reduced water *** reaction equilibrium thermodynamic model was used to correlate the solubility *** results indicate that the chemical reaction equilibrium constant decrease with increasing water content and temperature,whereas Henry constant increase with increasing water content and *** with other ionic liquids,H_(2)S exhibits a higher physical absorption enthalpy and a lower chemical absorption enthalpy in[Bmmorp][Ac]aqueous *** suggests that[Bmmorp][Ac]has a strong physical affinity for H_(2)S and low energy requirement for *** chemical methods were used to investigate the molecular mechanism of H_(2)S absorption in ionic *** interaction energy analysis revealed that the binding of H_(2)S with the ionic liquid in a1:2 ratio is more *** analyses by the methods of the interaction region indicator and the atoms in molecules were conducted to the interactions between H_(2)S and the ionic liquid.

关键词： Ionic liquid Hydrogen sulfide Model Solubility Molecular mechanism

Global Marine Cold Seep Metagenomes Reveal Diversity of Taxonomy,Metabolic Function,and Natural Products

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 121-134页

作者： Tao Yu Yingfeng Luo Xinyu tan Dahe Zhao Xiaochun Bi Chenji Li Yanning zheng Hua Xiang Songnian Hu State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Cold seeps in the deep sea are closely linked to energy exploration as well as global climate *** alkane-dominated chemical energy-driven model makes cold seeps an oasis of deep-sea life,showcasing an unparalleled reservoir of microbial genetic ***,by analyzing 113 metagenomes collected from 14 global sites across 5 cold seep types,we present a comprehensive Cold Seep Microbiomic Database(CSMD)to archive the genomic and functional diversity of cold seep *** CSMD includes over 49 million non-redundant genes and 3175 metagenome-assembled genomes,which represent 1895 species spanning 105 *** addition,beta diversity analysis indicates that both the sampling site and cold seep type have a substantial impact on the prokaryotic microbiome community *** and anaerobic metabolisms are prevalent in microbial communities,accompanied by considerable mixotrophs and facultative anaerobes,highlighting the versatile metabolic potential in cold ***,secondary metabolic gene cluster analysis indicates that at least 98.81%of the sequences potentially encode novel natural products,with ribosomally synthesized and post-translationally modified peptides being the predominant type widely distributed in archaea and ***,the CSMD represents a valuable resource that would enhance the understanding and utilization of global cold seep microbiomes.

关键词： Global marine cold seep Metagenome Prokaryotic microbiome Metabolic function Natural product

血栓负荷评估在急性肺血栓栓塞症诊治中的作用

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中华医学杂志 2017年第36期97卷 2818-2821页

作者：谭政许小毛北京医院国家老年医学中心呼吸与危重症医学科 100730

肺血栓栓塞症（PTE）是一种常见的疾病，具有潜在致死性，占心血管系统死亡原因第3位。其发病常隐匿，而加重过程又往往非常迅速，未经治疗的PTE患者致死率高达30％，如果临床医生能及时诊断和采取治疗措施，其病死率可降至2％-10％。C... 详细信息

肺血栓栓塞症（PTE）是一种常见的疾病，具有潜在致死性，占心血管系统死亡原因第3位。其发病常隐匿，而加重过程又往往非常迅速，未经治疗的PTE患者致死率高达30％，如果临床医生能及时诊断和采取治疗措施，其病死率可降至2％-10％。CT肺动脉造影（CTPA）具有高空间分辨率和扫描速度快的特点，随着其广泛运用，CTPA逐渐取代核素通气灌注显像和肺动脉造影，成为可疑PTE患者的首选影像学检查方法，通过CTPA可以观察肺动脉内血栓位置、形态，还可以通过显示栓子在肺动脉内的位置及阻塞程度，评估PTE的严重程度。

关键词：急性肺血栓栓塞症评估 CT肺动脉造影影像学检查方法诊治负荷 CTPA 心血管系统

IL-33 promotes the development of psoriasis in an IL-17 independent manner

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IL-33 promotes the development of psoriasis in an IL-17 inde...

IL-33 deficiency exacerbated EAE via modulating T cells and glia cells

第十三届全国免疫学学术大会

作者： Fanfan Zeng Jie Mao Yong Xu Ping Xiong zheng tan Feili Gong Fang zheng Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and Technology

Background: IL-33 is constitutively highly expressed in skin tissue. Psoriasis is a common autoimmune disease of the skin. The role of IL-33 in the development of psoriasis has rarely been ***: To study the roles of IL-33 in the development of psoriasis Methods: 1. The appropriate data set in GEO database was analyzed. 2. Western blot and IHC were performed using clinical samples. 3. 5% of imiquimod was applied to induce a psoriasis-like skin inflammation. The disease severity was assessed according to the PASI scoring standard. The lesion and non-lesion skin were subject to western blot, HE staining, immune cells analyzation by flow cytometry. mIL-33 was intradermally administered to WT and IL-17-/-mice to observe the inflammation progression. Immunofluorescence was carried out to confirm the main source of IL-33 and prominent ST2+ cells in skin. 4. Primary keratinocytes were stimulated by homogenate of skin lesions to detect the release of IL-33. IL-33 stimulation was performed to detect the expression of cytokines and chemokines related to ***: IL-33 mRNA and protein in lesion skin was higher than non-lesion skin in psoriasis patient and mice. IL-33 or ST2 gene knockout decreased the clinical scoring accompanied with remising in stratum corneum thickening, parakeratosis, inflammatory infiltration, vasodilation and Munro microabscess. The number of Th17, IL-17+ γδT cells, neutrophils and mast cells decreased in the lesion skin of IL-33 knockout mouse. Subcutaneous administration of IL-33 aggravated the severity of psoriasis-like inflammation and increased local neutrophil infiltration, and this process was independent on IL-17. IL-33 and ST2 were mainly expressed by keratinocyte. Psoriatic lesion homogenate promoted the expression and release of IL-33 by primary keratinocyte. IL-33 alone stimulation promoted gene expression of cytokines and chemokines associated with ***: IL-33 promotes the development of psoriasis in k

关键词： IL-33 keratinocyte neutrophils psoriasis

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IL-33 deficiency exacerbated EAE via modulating T cells and ...

第十二届全国免疫学学术大会

作者： xiao yifan Chen Huoying Lai Lin Xu Yong tan zheng Gong Feili zheng Fang Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and Technology

Background:Interleukin(IL)-33 induces innate and adaptive immune responses and plays a protective role in many diseases including autoimmune ***-33 is expressed highly in CNS suggesting a potential role of IL-33 in *** has been found that IL-33 and receptor ST2 were expressed in spinal cord and the blockage of the CNS-derived IL-33 exac-

关键词： EAE interleukin-33 Th1/Th17 astrocytes BV2

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一种基于大脑情感学习的快速分类改进算法

电子学报 2017年第11期45卷 2663-2670页

作者：梅英谭冠政刘振焘中南大学信息科学与工程学院湖南长沙410083 湖南文理学院电气与信息工程学院湖南常德415000 中国地质大学自动化学院湖北武汉430074

为了提高数据分类的快速性与准确性,本文在大脑情感学习(Brain Emotional Learning,BEL)模型的基础上,结合遗传算法(Genetic Algorithm,GA),提出了一种基于GA-BEL的快速分类改进算法.BEL模型根据大脑中杏仁体和眶额皮质之间相互学习的... 详细信息

为了提高数据分类的快速性与准确性,本文在大脑情感学习(Brain Emotional Learning,BEL)模型的基础上,结合遗传算法(Genetic Algorithm,GA),提出了一种基于GA-BEL的快速分类改进算法.BEL模型根据大脑中杏仁体和眶额皮质之间相互学习的神经生物学原理建立,模拟了情感刺激在大脑短反射通路中被快速处理的过程.因此,基于BEL模型的网络运算速度快.进一步采用遗传算法优化BEL网络权值,提高其分类正确率.在UCI数据集上的对比实验结果表明,无论对于小样本还是大样本数据集,较其他分类算法,GA-BEL算法均有较高的分类正确率和计算效率.

关键词：快速分类大脑情感学习遗传算法数据集

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世界电影强国评价体系与中国电影的提升

当代电影 2020年第12期 129-135页

作者：谭政张燕中国文联电影艺术中心北京师范大学艺术与传媒学院

将中国发展成电影强国的目标已提出多年,但如何评价何为电影强国一直未有清晰的衡量标尺。考察现有的世界电影产业格局以及科技强国等相关的评价体系,电影强国的评价体系应该包括国内影响力和国际影响力两个一级指标,产业基础、产业规... 详细信息

将中国发展成电影强国的目标已提出多年,但如何评价何为电影强国一直未有清晰的衡量标尺。考察现有的世界电影产业格局以及科技强国等相关的评价体系,电影强国的评价体系应该包括国内影响力和国际影响力两个一级指标,产业基础、产业规模等六个二级指标,影院与银幕数、电影产量等二十个三级指标。在此评价体系的衡量下,当下只有美国是电影强国,中国和印度具备未来发展成电影强国的潜力。中国应该在加强青年电影扶持力度和质量、加大海外推广、成为非发达国家电影的主要目标市场等方面努力提升,以坚实地助力其由电影大国向电影强国迈进。

关键词：中国电影电影大国电影强国评价体系软实力

构件抗力与多层钢框架结构抗倒塌能力的关联性分析

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中南大学学报（自然科学版） 2023年第5期54卷 1990-2005页

作者：钟炜辉郑玉辉谭政孟宝西安建筑科技大学土木工程学院陕西西安710055 西安建筑科技大学结构工程与抗震教育部重点实验室陕西西安710055

讨论构件抗力与结构抗力的关联性,分别给出不同结构参数下(层数与跨数)层间抗弯能力、层间水平约束以及大变形阶段层间极限轴力的计算模型。借助构件性能指标并结合各层构件的实际受力状态(包括拉弯、受弯和压弯),得到多层框架起始屈服... 详细信息

讨论构件抗力与结构抗力的关联性,分别给出不同结构参数下(层数与跨数)层间抗弯能力、层间水平约束以及大变形阶段层间极限轴力的计算模型。借助构件性能指标并结合各层构件的实际受力状态(包括拉弯、受弯和压弯),得到多层框架起始屈服抗力、最终屈服抗力与极限抗力的计算式。通过可靠的数值模型对多层钢框架模型抗力评估过程的3个步骤进行验证与分析。研究结果表明,多层框架层间内力主要体现为小变形阶段层间抗弯能力与大变形阶段层间轴力的差异;计算结果与数值结果较为接近,该理论方法可体现层间内力的相互作用并建立构件与结构抗力之间的关系,为多层钢框架抗倒塌能力的评估与计算提供参考。

关键词：连续倒塌多层钢框架层间约束倒塌抗力理论计算

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