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再生障碍性贫血患者亲缘单倍体异基因造血干细胞移植后EB病毒感染危险因素及生存分析

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中国感染控制杂志 2024年第10期23卷 1228-1235页

作者：张新荷冯佳谭正伟赵越超胡慧瑾陈均法武利强俞庆宏吴迪炯叶宝东刘文宾浙江中医药大学第一临床医学院浙江杭州310006 浙江中医药大学附属第一医院血液科浙江杭州310006

目的分析再生障碍性贫血(AA)患者进行单倍体异基因造血干细胞移植(Haplo-HSCT)后EB病毒(EBV)感染危险因素及患者生存情况。方法回顾性分析2019年1月1日-2022年10月31日某院血液科78例进行Haplo-HSCT的AA患者临床资料,观察EBV血症、临床... 详细信息

目的分析再生障碍性贫血(AA)患者进行单倍体异基因造血干细胞移植(Haplo-HSCT)后EB病毒(EBV)感染危险因素及患者生存情况。方法回顾性分析2019年1月1日-2022年10月31日某院血液科78例进行Haplo-HSCT的AA患者临床资料,观察EBV血症、临床诊断的EBV相关性疾病(EBV病)及淋巴细胞增殖性疾病(PTLD)发生情况及出现时间,并分析其危险因素及生存情况。结果78例患者中男性38例,女性40例,中位年龄33(9~56)岁,其中53例患者发生EBV再激活,总发生率67.9%,发生EBV再激活的中位时间为移植后33(13,416)d。EBV再激活患者中,单纯EBV血症49例(62.8%),可能的EBV疾病2例(2.6%),已经证实的EBV疾病(PTLD)2例(2.6%)。单因素提示,移植时患者年龄<40岁、脐血辅助回输、移植后发生急性移植物抗宿主病(aGVHD)、合并巨细胞病毒(CMV)感染是AA患者进行Haplo-HSCT后发生EBV再激活的独立危险因素,多因素分析提示合并CMV感染是AA患者进行Haplo-HSCT后发生EBV再激活的独立危险因素(P=0.048)。干细胞回输前使用利妥昔单抗干预是EBV再激活时间长短的影响因素(P<0.05)。单纯EBV血症病死率为8.2%,EBV病病死率为50.0%,PTLD病死率为100%。EBV再激活患者2年总生存率为85.3%,EBV未激活患者2年生存率为90.7%,差异无统计学意义(P=0.897),但应用利妥昔单抗治疗的患者其2年生存率低于未使用的患者,差异有统计学意义(P=0.046)。结论EBV再激活是AA患者进行Haplo-HSCT后常见的严重并发症之一,影响患者的预后和生存。

关键词：再生障碍性贫血单倍体造血干细胞移植 EB病毒淋巴增殖性疾病

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基于意象认知模型的图像检索技术

浙江大学学报（工学版） 2008年第5期42卷 763-767,842页

作者：谭征宇孙守迁浙江大学计算机科学与技术学院浙江杭州310027

鉴于在产品造型设计过程中设计师对于图像检索技术的需求,提出了塑料产品的意象认知模型,并构建了基于该模型的意象看板系统(E-image board system).该系统运用语意差异法分别建立了塑料椅子的形态和材质意象认知模型,利用距离分布直方... 详细信息

鉴于在产品造型设计过程中设计师对于图像检索技术的需求,提出了塑料产品的意象认知模型,并构建了基于该模型的意象看板系统(E-image board system).该系统运用语意差异法分别建立了塑料椅子的形态和材质意象认知模型,利用距离分布直方图(DDH)结合Hu不变矩的形状提取与表示算法,提取和表示产品图像中的形态特征,采用纹理谱表示方法提取和表示产品图像中的纹理特征,并运用相似性度量和图像意象的相关度标注技术进行系统数据库的扩充和标注.该技术克服了传统检索方式不能体现用户意象的问题,满足了设计师利用意象词汇检索符合用户意象认知模型的产品图像的需求.

关键词：意象认知塑料产品图像检索

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury

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Genes & Diseases 2024年第1期11卷 449-463页

作者： Yixin Ma Lili Huang zheng Zhang Pengfei Yang Qingsong Chen Xujia Zeng Fangyan tan Chunxia Wang Xiongzhong Ruan Xiaohui Liao Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China Department of Cell Biology and Genetics Chongqing Medical UniversityChongqing 400016China Centre for Nephrology Royal Free and University College Medical SchoolUniversity College LondonRoyal Free CampusRowland Hill StreetLondon NW32PFUnited Kingdom Centre for Lipid Research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of EducationChongqing Medical UniversityChongqing 400016China Kuanren Laboratory of Translational Lipidology Centre for Lipid ResearchSecond Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Reactive oxidative species(ROos)production-driven ferroptosis plays a role in acute kidney injury(Akl).However,its exact molecular mechanism is poorly *** receptor CD36 has important roles in oxidizing lipids,lipid accumulation,metabolic syndrome,and insulin resistance in chronic kidney disease,but its roles remain unexplored in *** present study investigated the role and mechanism of CD36 in regulating proximal tubular cell ferroptosis and *** expression of CD36 was found to be significantly up-regulated in AKI renal tissues and correlated with renal function,which might serve as an independent biomarker for AKl ***,in adult mice subjected to AKl,deletion of CD36(CD36-/-)induced tubular cell Ros accumulation,ferroptosis activation,and renal ***,combining LC-MS/MS,co-IP,and ubiquitination analyses revealed that CD36 could specifically bind to ferroptosis suppressor protein 1(FSP1)and regulate its ubiquitination at sites K16 and K24,leading to FSP1 degradation and progression of ferroptosis in *** present results emphasize a novel mechanism of CD36 in cisplatin-induced *** discovery of the special CD36 roles in promoting ferroptosis and AKI development by regulating the ubiquitination of FSP1 in proximal tubular cells may be potential therapeutic targets for ***,CD36 may play a key role in the progression of ***,targeting CD36 may provide a promising treatment option for AKI.

关键词： Acute kidney injury CD36 Ferroptosis FSP1 Ubiquitin-dependent degradation

Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming Xiao Heng zheng Ping Yuan Jun-Hui Luo Lin-Lin Shen Jie-Feng tan Xian-You Luo De Li Yong Chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan UniversityFoshan 528000China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan UniversityHaikou 570228China

Hard carbon(HC)has emerged as one of the superior anode materials for sodium-ion batteries(SIBs),with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl(decreasing from 5.71 at%to 2.12 at%)and hydroxyl groups(decreasing from 7.73 at%to 6.26 at%).Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na^(+).Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na^(+)*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g^(-1)to an impressive 251.97 m Ah·g^(-1)at a current density of 50 mA·g^(-1).Even at 400 mA·g^(-1),the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·g^(-1).Hence,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Hard carbon Spark plasma sintering Sodiumion batteries Closed pores Oxygen functional groups

Solid-state non-volatile memories based on vdW heterostructure-based vertical-transport ferroelectric field-effect transistors

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Science China(Information Sciences) 2024年第6期67卷 198-206页

作者： Qiyu YANG zheng-Dong LUO Fei XIAO Junpeng ZHANG Dawei ZHANG Dongxin tan Xuetao GAN Yan LIU Zhufei CHU Yinshui XIA Genquan HAN Hangzhou Institute of Technology Xidian University State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University School of Artificial Intelligence Xidian University School of Materials Science and Engineering University of New South Wales (UNSW) Sydney ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET) University of New South Wales (UNSW) Sydney Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical University Faculty of Electrical Engineering and Computer Science Ningbo University

Driven by the explosive development of data-centric computation applications, it is becoming urgent to develop in-memory computing devices that are beyond the von Neumann architecture with an arrangement of separated logic and memory components. The transistor-type solid-state non-volatile memories,such as ferroelectric field-effect transistors(Fe FETs), have long been regarded as a competitive candidate for future in-memory computing architectures. However, the density scaling towards high-density arrays would require advanced Fe FETs with reduced footprints, which remains a great challenge so far. Here, a vertical-transport(VT) Fe FET that flips the charge transport channel perpendicular to the substrate plane is proposed, in which a ferroelectric gate and a van der Waals(vd W) heterojunction channel are vertically integrated, effectively reducing the device footprints. The proposed VT-Fe FET shows not only the robust binary non-volatile memory states but also several key synaptic functionalities at the device level. An artificial neural network with supervised learning was simulated based on the device conductance switching properties,showing excellent classification accuracy for the MNIST handwritten digits. These findings suggest that the proposed VT-Fe FET could offer a new solution for future non-volatile memories as well as more advanced neuromorphic systems.

关键词： vdW heterostructure non-volatile memory vertical-transport transistor ferroelectric field-effect transistor memristive devices

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关于我国水库运行管理方式的探讨

人民长江 2011年第10期42卷 105-108页

作者：谭政华北水利水电学院河南郑州450000

我国水库大多建于20世纪50~70年代,受当时经济、技术、资料的限制,很多工程建设标准低,质量较差,加上经过多年运行及水库管理水平参差不齐,许多水库存在安全隐患问题。为了保证水库的安全运行并充分发挥其社会经济效益,需要加强水库的... 详细信息

我国水库大多建于20世纪50~70年代,受当时经济、技术、资料的限制,很多工程建设标准低,质量较差,加上经过多年运行及水库管理水平参差不齐,许多水库存在安全隐患问题。为了保证水库的安全运行并充分发挥其社会经济效益,需要加强水库的管理工作。在分析我国水库管理现状的基础上,针对我国水库管理存在的管理水平参差不齐,许多水库存在着管理体制不顺、管理经费无保障、缺乏运行管理监测设施、无运行管理资料记录、水库存在安全隐患、水库效益欠佳等问题,从水库管理体制改革,病险水库除险加固,明确水库管理范围与职责,建立健全水库管理体制等方面提出了完善我国水库管理的建议。

关键词：水库管理病险水库水库功能管理体制管理措施

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基于三维虚拟的农村景观设计系统设计

现代电子技术 2018年第22期41卷 38-41页

作者：谭征南阳理工学院河南南阳473000

基于三维虚拟的农村景观设计是当今研究方向的热点之一,农村景观的三维虚拟技术是实现未来数字化管理农村的基础,三维景观设计系统设计将实现二维分布图向三维立体景观的转换,将给人们带来"身临其境"的感觉,全方位地、动态地感觉现实景... 详细信息

基于三维虚拟的农村景观设计是当今研究方向的热点之一,农村景观的三维虚拟技术是实现未来数字化管理农村的基础,三维景观设计系统设计将实现二维分布图向三维立体景观的转换,将给人们带来"身临其境"的感觉,全方位地、动态地感觉现实景观。在此采用3ds MAX和ArcGIS软件进行三维虚拟农村景观设计,充分利用3ds MAX建模软件搭建三维平台,通过ArcGIS软件实现系统设计。通过数据获取、模型建立将所有模型的要素类均转换成点要素,将由点要素组成的三维模型图层数据导入ArcGIS三维系统,建立数字农村系统。将三维模型与GIS平台融合,实现农村景观的三维可视化,并完成系统数据的管理与展示功能,以及空间信息查询、空间分析功能。

关键词：三维虚拟农村景观系统设计 GIS技术 3dsMAX 数据采集

Characterizing the photodegradation-induced release of volatile organic compounds from bottled water containers

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Eco-Environment & Health 2024年第2期3卷 145-153页

作者： Ruijuan Liu Zhianqi Liao Jing zheng Xinni Wu Zongyi tan Huase Ou Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655China Key Laboratory of Philosophy and Social Science in Guangdong Province of Community of Life for Man and Nature Jinan UniversityGuangzhou 511443China

While plastic water bottles are known to potentially release various volatile organic compounds(VOCs)when exposed to light,existing knowledge in this field remains *** this study,we systematically examined the composition,yield,and toxicity of VOCs released from six plastic containers obtained from different continents under UV-A and solar *** light exposure,all containers released VOCs,including alkanes,alkenes,alcohols,aldehydes,carboxylic acids,aromatics,*** 1#,3#,4#,5#,and 6#containers exhibited 35,32,19,24 and 37 species of VOCs,***,the 2#container released 28 and 32 series of VOCs after 1-day(short-term)and 7-day(long-term)UV-A irradiation,respectively,compared to 30 and 32 species under solar *** half of the VOCs identified were oxidized compounds alongside various short-chain *** differences in VOC compositions among the containers were observed,potentially originating from light-induced aging and degradation of the polyethylene terephthalate structure in the *** predictions unveiled distinctive toxic characteristics of VOCs from each *** example,among the various VOCs produced by the 2#container,straight-chain alkanes like n-hexadecane(544-76-3)were identified as the most toxic *** long-term irradiation,the yield of these toxic VOCs from the 2#container ranged from 0.11 ng/g to 0.79 ng/*** the small mass of a single bottle,the volatilization of VOCs from an individual container would be *** after prolonged exposure to light,the potential health risks associated with inhaling VOCs when opening and drinking bottled water appear manageable.

关键词： Plastic contaminants Volatile organic compounds Drinking water safety Sunlight Ultraviolet

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试论新时期西部地区高校的成人艺术教育

新闻界 2010年第5期 188-189页

作者：谭正西南民族大学艺术学院成都610064

高校艺术工作者应转变观念,克服盲目向普通艺术教育看齐的思想,整合高校成人艺术教育的物资资源和教师资源,优化成人艺术教育的培养机制和体制,提高成人职业艺术人才培养与教育的水平,促进西部地区成人艺术教育的发展。

关键词：西部高校成人艺术教育