检索结果-南通市图书馆

Clinical applications of stem cell-derived exosomes

Signal Transduction and Targeted Therapy 2024年第2期9卷 621-651页

作者： Fei tan Xuran Li zhao Wang Jiaojiao Li Khawar Shahzad Jialin Zheng Department of ORL-HNS Shanghai Fourth People’s Hospitaland School of MedicineTongji UniversityShanghaiChina Plasma Medicine and Surgical Implants Center Tongji UniversityShanghaiChina The Royal College of Surgeons in Ireland DublinIreland The Royal College of Surgeons of England LondonUK Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Nanocatalytic Medicine Tongji UniversityShanghaiChina

Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery,it nevertheless comes with inescapable drawbacks that might limit its clinical translation.Compared to stem cells,stem cell-derived exosomes possess numerous advantages,such as non-immunogenicity,non-infusion toxicity,easy access,effortless preservation,and freedom from tumorigenic potential and ethical issues.Exosomes can inherit similar therapeutic effects from their parental cells such as embryonic stem cells and adult stem cells through vertical delivery of their pluripotency or multipotency.After a thorough search and meticulous dissection of relevant literature from the last five years,we present this comprehensive,up-to-date,specialty-specific and disease-oriented review to highlight the surgical application and potential of stem cell-derived exosomes.Exosomes derived from stem cells(e.g.,embryonic,induced pluripotent,hematopoietic,mesenchymal,neural,and endothelial stem cells)are capable of treating numerous diseases encountered in orthopedic surgery,neurosurgery,plastic surgery,general surgery,cardiothoracic surgery,urology,head and neck surgery,ophthalmology,and obstetrics and gynecology.The diverse therapeutic effects of stem cells-derived exosomes are a hierarchical translation through tissue-specific responses,and cell-specific molecular signaling pathways.In this review,we highlight stem cell-derived exosomes as a viable and potent alternative to stem cell-based therapy in managing various surgical conditions.We recommend that future research combines wisdoms from surgeons,nanomedicine practitioners,and stem cell researchers in this relevant and intriguing research area.

关键词： viable stem capable

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blockchain-Based Key Management Scheme Using Rational Secret Sharing

引用

Computers, Materials & Continua 2024年第4期79卷 307-328页

作者： Xingfan zhao Changgen Peng Weijie tan Kun Niu State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China Guizhou Big Data Academy Guizhou UniversityGuiyang550025China

Traditional blockchain key management schemes store private keys in the same location,which can easily lead to security issues such as a single point of failure.Therefore,decentralized threshold key management schemes have become a research focus for blockchain private key protection.The security of private keys for blockchain user wallet is highly related to user identity authentication and digital asset security.The threshold blockchain private key management schemes based on verifiable secret sharing have made some progress,but these schemes do not consider participants’self-interested behavior,and require trusted nodes to keep private key fragments,resulting in a narrow application scope and low deployment efficiency,which cannot meet the needs of personal wallet private key escrow and recovery in public blockchains.We design a private key management scheme based on rational secret sharing that considers the self-interest of participants in secret sharing protocols,and constrains the behavior of rational participants through reasonable mechanism design,making it more suitable in distributed scenarios such as the public blockchain.The proposed scheme achieves the escrow and recovery of personal wallet private keys without the participation of trusted nodes,and simulate its implementation on smart contracts.Compared to other existing threshold wallet solutions and keymanagement schemes based on password-protected secret sharing(PPSS),the proposed scheme has a wide range of applications,verifiable private key recovery,low communication overhead,higher computational efficiency when users perform one-time multi-key escrow,no need for trusted nodes,and personal rational constraints and anti-collusion attack capabilities.

关键词： Blockchain smart contract rational secret sharing key management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laser-upgraded coal tar for smart pavements in road and bridge monitoring applications

引用

Microsystems & Nanoengineering 2024年第2期10卷 231-239页

作者： Jincai Huang Man Zhang Haoyun He Qingang Li Yixin zhao Qiulin tan Xining Zang Department of Mechanical Engineering Tsinghua UniversityBeijing100084China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing100084China Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan030051China School of Energy and Mining Engineering China University of Mining and Technology(Beijing)Beijing100083China

The implementation of an intelligent road network system requires many sensors for acquiring data from roads,bridges,and vehicles,thereby enabling comprehensive monitoring and regulation of road networks.Given this large number of required sensors,the sensors must be cost-effective,dependable,and environmentally friendly.Here,we show a laser upgrading strategy for coal tar,a low-value byproduct of coal distillation,to manufacture flexible strain-gauge sensors with maximum gauge factors of 15.20 and 254.17 for tension and compression respectively.Furthermore,we completely designed the supporting processes of sensor placement,data acquisition,processing,wireless communication,and information decoding to demonstrate the application of our sensors in traffic and bridge vibration monitoring.Our novel strategy of using lasers to upgrade coal tar for use as a sensor not only achieves the goal of turning waste into a resource but also provides an approach to satisfy large-scale application requirements for enabling intelligent road networks.

关键词： gauge bridge smart

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seismic safety assessment with non-Gaussian random processes for train-bridge coupled systems

引用

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 241-260页

作者： zhao Han Gao Lei Wei Biao tan Jincheng Guo Peidong Jiang Lizhong Xiang Ping Key Laboratory of Geomechanics and Embankment Engineering of Ministry of Education Hohai UniversityNanjing 210024China School of Civil Engineering Central South UniversityChangsha 410075China

Extensive high-speed railway(HSR)network resembled the intricate vascular system of the human body,crisscrossing mainlands.Seismic events,known for their unpredictability,pose a significant threat to both trains and bridges,given the HSR’s extended operational duration.Therefore,ensuring the running safety of train-bridge coupled(TBC)system,primarily composed of simply supported beam bridges,is paramount.Traditional methods like the Monte Carlo method fall short in analyzing this intricate system efficiently.Instead,efficient algorithm like the new point estimate method combined with moment expansion approximation(NPEM-MEA)is applied to study random responses of numerical simulation TBC systems.Validation of the NPEM-MEA’s feasibility is conducted using the Monte Carlo method.Comparative analysis confirms the accuracy and efficiency of the method,with a recommended truncation order of four to six for the NPEM-MEA.Additionally,the influences of seismic magnitude and epicentral distance are discussed based on the random dynamic responses in the TBC system.This methodology not only facilitates seismic safety assessments for TBC systems but also contributes to standard-setting for these systems under earthquake conditions.

关键词： train-bridge coupled(TBC)system random vibration new point estimate method(NPEM) seismic safety assessment moment expansion approximation(MEA) non-Gaussian distributions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

引用

Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma Xing-Yao Yin zhao-Yun Zong Yuan-Yuan tan Ya-Ming Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is indispensable.However,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the earth.Hence,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical experiments.Based on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic background.Further,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked rock.The analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity anisotropy.Moreover,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip angle.The increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip angle.By comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness coefficients.Moreover,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the orthorhombic rock.

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

引用

Chemical Research in Chinese Universities 2024年第2期40卷 173-189页

作者： zhao Long HU Haolan MA Xiaoqian LYU Yifan YUAN Quan tan Weihong Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha410082P.R.China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou310022P.R.China Institute of Molecular Medicine(IMM) Renji HospitalSchool of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240P.R.China Furong Laboratory Changsha410082P.R.China

Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular activities.Analysis of membrane proteins is of paramount importance for studying molecular events inside cells and organisms and holds promising prospects for early disease diagnosis and treatment assessment.Benefiting from obvious merits including high affinity,high specificity and ease of modification,aptamers have been regarded as ideal molecular recognition elements in membrane protein analysis and molecular diagnostics strategies.This review summarised recent advances in membrane protein-specific aptamer screening,aptamer-based static and dynamic membrane protein analysis,and aptamer-based molecular diagnostic techniques.Prospects and challenges were also discussed.

关键词： Membrane protein Aptamer DNA nanotechnology Bioanalysis Molecular diagnostics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events:a prospective observational study

引用

Neural Regeneration Research 2024年第5期19卷 1156-1160页

作者： Ying zhao Dawei Dong Ding Yan Bing Yang Weirong Gui Man Ke Anding Xu Zefeng tan Department of Neurology and Stroke Center the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Clinical Neuroscience Institute the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurology the First People’s Hospital of FoshanFoshanGuangdong ProvinceChina

Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy populations.However,the ability of retinal vasculature changes,specifically focusing on retinal vessel diameter,to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined comprehensively.While previous studies have shown a link between retinal vessel diameter and recurrent cerebrovascular events,they have not incorporated this information into a predictive model.Therefore,this study aimed to investigate the relationship between retinal vessel diameter and subsequent cerebrovascular events in patients with acute ischemic stroke.Additionally,we sought to establish a predictive model by combining retinal veessel diameter with traditional risk factors.We performed a prospective observational study of 141 patients with acute ischemic stroke who were admitted to the First Affiliated Hospital of Jinan University.All of these patients underwent digital retinal imaging within 72 hours of admission and were followed up for 3 years.We found that,after adjusting for related risk factors,patients with acute ischemic stroke with mean arteriolar diameter within 0.5-1.0 disc diameters of the disc margin(MAD_(0.5-1.0DD))of≥74.14μm and mean venular diameter within 0.5-1.0 disc diameters of the disc margin(MVD_(0.5-1.0DD))of≥83.91μm tended to experience recurrent cerebrovascular events.We established three multivariate Cox proportional hazard regression models:model 1 included traditional risk factors,model 2 added MAD_(0.5-1.0DD)to model 1,and model 3 added MVD0.5-1.0DD to model 1.Model 3 had the greatest potential to predict subsequent cerebrovascular events,followed by model 2,and finally model 1.These findings indicate that combining retinal venular or arteriolar diameter with traditional risk factors could improve the prediction of recurrent cerebrovascular events in patients with acute ischemic stroke,and that retinal imaging could be a useful and non-invasive method for ide

关键词： acute ischemic stroke arteriolar cerebrovascular events diameter digital retinal imaging microvasculature prediction recurrent retina venular

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantum nonlocality evolution for two entangled mesoscopic fields under decoherence

引用

Communications in Theoretical Physics 2024年第1期76卷 24-28页

作者： zhao-Song tan Shou-Bang Yang Zhen-Biao Yang Shi-Biao Zheng Fujian Key Laboratory of Quantum Information and Quantum Optics Fuzhou UniversityFuzhouFujian 350116China

Investigation of the nonlocality evolution of entangled mesoscopic fields under decoherence not only is important for understanding the quantum–classical transition,but also has relevance to quantum communication and quantum computation protocols based on continuous variables.According to previous formulations of Bell inequalities,the system loses nonlocal features far before the disappearance of entanglement.We here construct a new version of Bell signal based on rotated and displaced on–off correlations,with which the Bell inequality is violated as long as there remains entanglement and the field state components keep quasiorthogonal.Consequently,the nonlocal character revealed by our formulation decays much slower compared with those based on previous ones.More importantly,there exists a wide regime where the Bell inequality is restored with previous formulations but remains to be violated based on our correlation operators.

关键词： entangled mesoscopic fields rotated and displaced on-off correlations Bell inequality nonlocality evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

FPSblo:A Blockchain Network Transmission Model Utilizing Farthest Point Sampling

引用

Computers, Materials & Continua 2024年第2期78卷 2491-2509页

作者： Longle Cheng Xiru Li Shiyu Fang Wansu Pan He zhao Haibo tan Xiaofeng Li Hefei Institutes of Physical Science Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

Peer-to-peer(P2P)overlay networks provide message transmission capabilities for blockchain systems.Improving data transmission efficiency in P2P networks can greatly enhance the performance of blockchain systems.However,traditional blockchain P2P networks face a common challenge where there is often a mismatch between the upper-layer traffic requirements and the underlying physical network topology.This mismatch results in redundant data transmission and inefficient routing,severely constraining the scalability of blockchain systems.To address these pressing issues,we propose FPSblo,an efficient transmission method for blockchain networks.Our inspiration for FPSblo stems from the Farthest Point Sampling(FPS)algorithm,a well-established technique widely utilized in point cloud image processing.In this work,we analogize blockchain nodes to points in a point cloud image and select a representative set of nodes to prioritize message forwarding so that messages reach the network edge quickly and are evenly distributed.Moreover,we compare our model with the Kadcast transmission model,which is a classic improvement model for blockchain P2P transmission networks,the experimental findings show that the FPSblo model reduces 34.8%of transmission redundancy and reduces the overload rate by 37.6%.By conducting experimental analysis,the FPS-BT model enhances the transmission capabilities of the P2P network in blockchain.

关键词： Blockchain P2P networks scalability farthest point sampling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discrepant responses of soil organic carbon dynamics to nitrogen addition in different layers: a case study in an agroecosystem

引用

Frontiers of Agricultural Science and Engineering 2024年第2期11卷 314-325页

作者： Hualing HU Liang zhao Wenbing tan Guoan WANG Beidou XI Technical Centre for Soil Agriculture and Rural Ecology and Environment Ministry of Ecology and Environment State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences College of Resources and Environmental Sciences China Agricultural University

Empirical research indicates that heightened soil nitrogen availability can potentially diminish microbial decomposition of soil organic carbon（SOC）.Nevertheless, the relationship between SOC turnover response to N addition and soil depth remains unclear. In this study, soils under varying N fertilizer application rates were sampled up to 100 cm deep to examine the contribution of both new and old carbon to SOC across different soil depths,using a coupled carbon and nitrogen isotopic approach. The SOC turnover time for the plot receiving low N addition(250 kg·ha-1·yr-1N) was about 20-40 years. Conversely, the plot receiving high N(450 kg·ha-1·yr-1N) had a longer SOC turnover time than the low N plot, reaching about 100 years in the upper 10-20 cm layer. The rise in SOC over the entire profile with low N addition primarily resulted from an increase in the upper soil（0-40 cm）whereas with high N addition, the increase was mainly from greater SOC in the deeper soil（40-100 cm）. Throughout the entire soil layer, the proportion of new organic carbon derived from maize C4plant sources was higher in plots treated with a low N rate than those treated with a high N rate. This implies that, in contrast to low N addition agricultural practices, high N addition predominantly enhances the soil potential for fixing SOC by transporting organic matter from surface soils to deeper layers characterized by more stable properties. This research offers a unique insight into the dynamics of deep carbon under increased N deposition, thereby aiding in the formulation of policies for soil carbon management.

关键词： case study agroecosystem Discrepant responses soil

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：