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Journal of Earth Science 2014年第4期25卷 630-637页

作者： Yujiang Li Lianwang Chen pei tan Hong Li Key Laboratory of Crustal Dynamics Institute of Crustal Dynamics China Earthquake Administration School of the Earth Sciences and Resources China University of Geosciences Earthquake Administration of Beijing Municipality

The channel flow model was gradually being accepted with the more important multidisci- plinary evidences from geology and geophysics, but how the lower crustal flow influenced the surface deformation quantitatively was unknown. Here, we develop a three-dimensional viscoelastic model to explore the mechanical relations between the lower crustal flow and the surface deformation in western Sichuan. Based on numerous tests, our results show that the modeled results fit well with the observed GPS data when the lower crust flows faster than the upper crust about 11 mm/a in the rhombic block, which can be useful to understand the possible mechanism of the surface deformation in western Siehuan. Moreover, taking the Xianshuihe fault as an example, we preliminarily analyze the relation between the active fault and stress field, according to the boundary constraints that deduced from the best model. The results show that the maximum shear stress on the Xianshuihe fault zone is mainly located in the fault terminal, intersections and the bend of the fault geometry, the stress level on the northwestern segment that has the high slip rate is relatively high. Additionally, with the reduction of the Young＇s modulus in the fault zone, it＇s conducive to generate the greater strain distribution, hence forming the high stress level.

关键词： western Siehuan region lower crustal flow surface deformation stress distribution numerical simulation.

Design of a multi-channel free space optical interconnection component

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Optoelectronics Letters 2008年第6期4卷 407-409页

作者： JIA Da-gong ZHANG pei-song JING Wen-cai tan Jun ZHANG Hong-xia ZHANG Yi-mo College of Precision Instrument ＆ Optoelectronics Engineering Key Laboratory on Optoelectronics Information and Technical Science Ministry of Education Tianjin University Tianjin 300072 China The ProdUct Center Science ＆ Technology of National Defence Industry Nanchang 330002 China

A multi-channel free space optical interconnection component, fiber optic rotary joint, was designed using a Dove prism. When the Dove prism is rotated an angle of at around the longitudinal axis, the image rotates an angle of 2 at. The optical interconnection component consists of the signal transmission system, Dove prim and driving mechanism. The planetary gears are used to achieve the speed ratio of 2：l between the total optical interconnection component and the Dove prism. The Clenses are employed to couple different optical signals in the signal transmission system. The coupling loss between the receiving fiber of stationary part and the transmitting fiber of rotary part is measured.

关键词：多渠道自由空间光学互接信号传输系统光学

Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion

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Cancer Biology & Medicine 2021年第3期18卷 860-874页

作者： Xin Wang Zifei pei Aasma Hossain Yuting Bai gong Chen Department of Biology Huck Institutes of Life SciencesPennsylvania State UniversityUniversity ParkPA 16802USA GHM Institute of CNS Regeneration Jinan UniversityGuangzhou 510632China

Objective:Glioblastoma(GBM)is the most prevalent and aggressive adult primary cancer in the central nervous *** approaches for GBM treatment are under intense investigation,including the use of emerging ***,we propose an alternative approach to treat GBM through reprogramming proliferative GBM cells into non-proliferative ***:Retroviruses were used to target highly proliferative human GBM cells through overexpression of neural transcription ***,electrophysiological recording,and bulk RNA-seq were performed to investigate the mechanisms underlying the neuronal conversion of human GBM *** in vivo intracranial xenograft mouse model was used to examine the neuronal conversion of human GBM ***:We report efficient neuronal conversion from human GBM cells by overexpressing single neural transcription factor Neurogenic differentiation 1(Neuro D1),Neurogenin-2(Neurog2),or Achaete-scute homolog 1(Ascl1).Subtype characterization showed that the majority of Neurog2-and Neuro D1-converted neurons were glutamatergic,while Ascl1 favored GABAergic neuron *** GBM cell-converted neurons not only showed pan-neuronal markers but also exhibited neuron-specific electrophysiological *** analyses revealed that neuronal genes were activated in glioma cells after overexpression of neural transcription factors,and different signaling pathways were activated by different neural transcription ***,the neuronal conversion of GBM cells was accompanied by significant inhibition of GBM cell proliferation in both in vitro and in vivo ***:These results suggest that GBM cells can be reprogrammed into different subtypes of neurons,leading to a potential alternative approach to treat brain tumors using in vivo cell conversion technology.

关键词： Glioblastoma neuronal conversion transcription factors Neuro D1 neurogenin-2 Ascl1

Effect of Enhanced Plasma Density on the Properties of Aluminium Doped Zinc Oxide Thin Films Produced by DC Magnetron Sputtering

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Journal of Materials Science & Technology 2011年第5期27卷 393-397页

作者： Jun gong Xiaobo Zhang Zhiliang pei Chao Sun Lishi Wen Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Aluminum doped zinc oxide （AZO） thin films were prepared by DC magnetron sputtering at low substrate temperature. A coaxial solenoid coil was placed near the magnetron target to enhance the plasma density （Ji）. The enhanced plasma density improved significantly the bulk resistivity （p） and its homogeneity in spatial distribution of AZO films. X-ray diffraction （XRD） analysis revealed that the increased Ji had influenced the crystallinity, stress relaxation and other material properties. The AZO films deposited in low plasma density （LPD） mode showed marked variation in p （ranging from -6.5x10-2 to 1.9x10-3 Ω.cm）, whereas those deposited in high plasma density （HPD） mode showed a better homogeneity of films resistivity （ranging from ~1.3x10-3 to 3.3x10-3 ~.cm） at different substrate positions. The average visible transmittance in the wavelength range of 500-800 nm was over 80%, irrespective of the deposition conditions. The atomic force microscopy （AFM） surface morphology showed that AZO films deposited in HPD mode were smoother than that in LPD mode. The high plasma density produced by the coaxial solenoid coil improved the electrical property, surface morphology and the homogeneity in spatial distribution of AZO films deposited at low substrate temperature.

关键词： Sputtering Electronic conductivity Ion bombardmentPlasma density

Effects of Cr and Al Contents on the Preparation of SiC Fiber-Reinforced NiCrAl Alloy Matrix Composite

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Acta Metallurgica Sinica(English Letters) 2020年第10期33卷 1416-1422页

作者： Haoqiang Zhang Xixi Niu Zhiliang pei Nanlin Shi Jun gong Chao Sun Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

In this work,the effects of Cr and Al contents on the preparation of SiC fiber-reinforced NiCrAl alloy matrix composites(SiCf/Ni-20Cr-5Al,SiCf/Ni-15Cr-5Al,SiCf/Ni-10Cr-5Al and SiCf/Ni-10Cr-3Al)were thoroughly *** composites were prepared by vacuum hot pressing process using matrix-coated *** was found that Cr solute atoms played a significant role in retarding the recrystallization of NiCrAl alloy matrix,and the Al elements in the form of γ'-Ni3Al phase had a suppression effect on the plastic flow of the ***,the reduction in Cr and Al contents was conductive to the recrystallization and plastic flow of NiCrAl alloy matrix,thereby reduced the size and number of micro-voids in the *** addition,this work provides some guidance for designing and manufacturing reasonable SiC fiber-reinforced Ni alloy matrix composites.

关键词： SiC fiber NiCrAl alloy Composite Recrystallization Plastic flow

An effective strategy towards construction of CVD SiC fiber-reinforced superalloy matrix composite

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Journal of Materials Science & Technology 2020年第14期47卷 179-185页

作者： Haoqiang Zhang Lin Liu Zhiliang pei Nanlin Shi Jun gong Chao Sun Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

In this work,a modified approach for preparing CVD SiC fiber-reinforced superalloy matrix composites was rationally *** composites were fabricated by vacuum hot pressing(VHP)process using precursor wires coated with(Al+Al2O3)diffusion barrier layers and GH4169 superalloy ***-7 brazing filler metals were introduced on the surface of precursor wires in order to decrease the temperature of the VHP *** was found that the VHP temperature was reduced by about 100℃,and the melting,diffusion,nucleation and growth processes of BNi-7 fillers at 900?C motivated the recrystallization and plastic flow of the matrix under the increasing pressure,thereby a compact composite composed of intact SiC fibers and fine equiaxial grain structure superalloy matrix was ***,the elements were distributed homogeneously among the fibers in the composite and no interfacial reactions *** method provides a new insight for designing and manufacturing high-quality composites in practical engineering.

关键词： SiC fiber Superalloy Diffusion barrier Brazing filler metal

Toward an Optimum Design of an Amorphous Silicon Photovoltaic/Thermal System:Simulation and Experiments

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Journal of Thermal Science 2023年第3期32卷 947-964页

作者： REN Xiao LI Jing LIU Weixin ZHU Chuanyong pei Gang gong Liang College of New Energy China University of Petroleum(East China)Qingdao 266580China Research Center for Sustainable Energy Technologies Energy and Environment InstituteUniversity of HullHU67RXUK Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei 230026China

Amorphous silicon photovoltaic/thermal(a-Si-PV/T)technology is promising due to the low power temperature coefficient,thin-film property,thermal annealing effect of the solar cells,and high conversion efficiency in *** design of a-Si-PV/T system is influenced by a number of thermodynamic,structural,and external *** analysis is useful for a good design of the system.A dynamic distributed parameter model is built and verified in this *** tests are carried *** impacts of operating temperature,mass flow rate,cover ratio of solar cells,heat transfer area,and frame shadow ratio on its performance are theoretically and experimentally *** results indicate that seven or eight copper tubes are suitable to achieve a high overall efficiency of the a-Si-PV/T *** frame and tilt angle shall avoid a shadow ratio of more than 8.3%during *** difference between power outputs at operating temperatures of 35℃and55℃in the first month is about 0.21%while it drops to less than 0.1%in the twelfth *** with conventional PVT systems,the a-Si-PV/T system benefits from a higher design temperature with a minor efficiency decrement.

关键词： amorphous silicon cell photovoltaic thermal system parametric analysis distributed parameter model frame shadow

Microstructure,Mechanical,and Tribological Properties of Amorphous WB2/Ti Multilayer Coatings

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Acta Metallurgica Sinica(English Letters) 2023年第8期36卷 1385-1396页

作者： Wenhe Li Wenshuang Gu Yuqiu Chen Jun gong Zhiliang pei Chao Sun Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

Amorphous WB2/Ti multilayer coatings with different modulation ratios(1,5,15,and 30)and different bilayer numbers(10,20,30,50,and 70)were deposited by direct-current magnetron *** effect of modulation ratio and bilayer number on the microstructure,mechanical,and tribological properties of WB2/Ti multilayer coatings was studied *** the investigation for the influence of modulation ratio,the hardness of the multilayer coatings increases with the increment of modulation *** indentation toughness shows a different changing tendency compared to that of the hardness with different modulation *** wear rates of the multilayer coatings with different modulation ratios are at the same level with the influence of both hardness and indentation *** the investigation for the influence of bilayer number,both hardness and indentation toughness increase first and then decrease with an increasing bilayer ***2/Ti multilayer coating with a modulation ratio of 5 and bilayer number of 50 exhibits the highest hardness of 20.4 GPa and lowest wear rate of 1.76×10−16 m3/*** addition,the hardness strengthening mechanism and wear mechanism of the multilayer coatings were discussed in detail.

关键词： Magnetron sputtering WB /Ti multilayer Mechanical properties Tribological properties

Recent Research Progress of n-Type Conjugated Polymer Acceptors and All-Polymer Solar Cells

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Chinese Journal of Polymer Science 2023年第5期41卷 640-651,I0006页

作者： Xiao-Jun Li Guang-pei Sun Yu-Fei gong Yong-Fang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

The active layer of all polymer solar cells(all-PSCs)is composed of a blend of a p-type conjugated polymer(p-CP)as donor and an n-type conjugated polymer(n-CP)as ***-PSCs possess the advantages of light weight,thin active layer,mechanical flexibility,low cost solution processing and high stability,but the power conversion efficiency(PCE)of the all-PSCs was limited by the poor photovoltaic performance of the n-CP acceptors before *** the report of the strategy of polymerized small molecule acceptors(PSMAs)in 2017,the photovoltaic performance of the PSMA-based n-CPs improved rapidly,benefitted from the development of the A-DA’D-A type small molecule acceptors(SMAs).PCE of the all-PSCs based on the PSMA acceptors reached 17%-18%*** this review article,we will introduce the development history of the n-CPs,especially the recent research progress of the ***,the structure-property relationship of the PSMAs is introduced and ***,current challenges and prospects of the n-CP acceptors are analyzed and discussed.

关键词： n-Type conjugated polymers All-polymer solar cells Polymer acceptors Polymerized small molecule acceptors

Nanocarrier based on the assembly of protein and antisense oligonucleotide to combat multidrug resistance in tumor cells

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Science China Chemistry 2017年第10期60卷 1318-1323页

作者： Xuan Yu Liang gong Jing Zhang Zilong Zhao Xiaobing Zhang Weihong tan Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences and Aptamer Engineering Center of Hunan Province Hunan University Changsha 410082 China

Chemotherapy-induced multi-drug resistance(MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein(P-gp), can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide(ASO) to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment.

关键词： multi-drug resistance P-glycoprotein antisense oligonucleotide nanocarrier