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液质联用-网络药理-分子对接技术对加味过敏煎干预特应性皮炎的机制研究

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成都医学院学报 2024年第2期19卷 193-200页

作者：韦唯谭冰燕朱禹万李吴贤波贵州中医药大学贵阳550001 成都体育学院成都610041

目的基于超高效液相色谱-质谱、网络药理学及分子对接技术,探索加味过敏煎治疗特应性皮炎(AD)的作用机制。方法使用超高效液相色谱-质谱方法对加味过敏煎冻干粉及含药血清进行分析,获取加味过敏煎入血成分。SwissTargetPrediction数... 详细信息

目的基于超高效液相色谱-质谱、网络药理学及分子对接技术,探索加味过敏煎治疗特应性皮炎(AD)的作用机制。方法使用超高效液相色谱-质谱方法对加味过敏煎冻干粉及含药血清进行分析,获取加味过敏煎入血成分。SwissTargetPrediction数据库获取加味过敏煎入血成分的靶点,通过检索GeneCards、DisGeNET及OMIM数据库得到AD疾病靶点。Cytoscape 3.9.1软件构建“成分-靶点”及蛋白质互作网络。DAVID数据库对交集靶点进行基因本体(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析。AutoDock软件对排名前5的活性成分与核心靶点进行分子对接验证。结果共获得57个加味过敏煎入血成分,检索到807个入血成分靶点,2 067个AD靶点,287个交集靶点,筛选出31个核心靶点。KEGG分析主要富集在TNF、JAK-STAT、FcεRI等信号通路。分子对接显示,加味过敏煎活性成分可与核心靶点自发结合。结论加味过敏煎治疗AD的主要活性成分可能为3-甲基丁酸苯甲酯、肠内酯、荜茇酰胺、镰叶芹二醇、诺米林等,这些活性成分通过作用于STAT3、SRC、PIK3R1、AKT1、MAPK1等靶点和TNF、JAK-STAT、FcεRI信号通路发挥对AD的干预作用。

关键词：加味过敏煎超高效液相色谱-质谱联用网络药理学分子对接特应性皮炎

DEVELOPING TREND ANALYSIS AND FORECAST OF DEBRIS FLOW ACTIVITIES IN THE THREE-GORGE RESERVOIR AREA

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Natural Disaster Reduction in China 2003年第3期 10-16页

作者： tan bingyan (The Southwest Research Branch, Chinese Academy of Railway Sciences, Chengdu 610031, China)

The water level of the Three-Gorge Reservoir will reach the height of 135m, and the government pays great attention to security of cities/towns and emigration villages that may be affected by debris flow activities. How will the debris flow activities develop when the water level of the Reservoir reaches 175 m in height in 2009? This paper analyzes the change of environment for debris flow before and after storing water comprehensively, and special attention is given to the effects of the Reservoir bank rebuilding-process on debris flow activities, and the probability of appearance of new manmade debris flow due to irrational human activities during the construction of the Reservoir. 11 items of predicted results on the developing trend of debris flow activities in the Reservoir area and a suggestion are presented for relevant branches as references in the discussion and implementation of prevention and control of geological disasters in the Reservoir area.

关键词： debris flow forecast Three-Gorge Reservoir

Research on heat dissipation characteristics of magnetic fluid bearings under multiple field coupling effects

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High Technology Letters 2024年第3期30卷 263-270页

作者： CHEN Liwen WU Weiying GAO Dianrong ZHAO Jianhua CUI bingyan College of Mechanical Engineering North China University of Science and TechnologyTangshan 063210P.R.China College of Mechanical Engineering Yanshan UniversityQinhuangdao 066000P.R.China

This paper analyzes the sources of heat losses in magnetic fluid bearings,proposes various cou-pling relationships of physical fields,divides the coupled heat transfer surfaces while ensuring the continuity of heat flux density,and analyzes the overall heat dissipation pathways of the *** changing parameters such as input current,rotor speed,and inlet oil flow rate,the study applies a multi-physics field coupling method to investigate the influence of different parameters on the temper-ature field and heat dissipation patterns of the bearings,which is then validated through *** research provides a theoretical basis for the optimal design of magnetic fluid bearing sys-tems.

关键词： magnetic fluid bearing multi-physics field coupling multiple parameter varia-tion heat dissipation pattern

Molybdenum and cadmium co-induce necroptosis through Th1/Th2 imbalance-mediated endoplasmic reticulum stress in duck ovaries

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Journal of Environmental Sciences 2024年第8期142卷 92-102页

作者： Ting Cui Xueyan Dai Huiling Guo Dianyun Wang bingyan Huang Wenjing Pu Xuesheng Chu Caiying Zhang Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045China

Cadmium(Cd)and excess molybdenum(Mo)pose serious threats to animal *** previous study has determined that Cd and/or Mo exposure can cause ovarian damage of ducks,while the specific mechanism is still *** further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary,forty 8-day-old female ducks were randomly allocated into four groups for 16 weeks,and the doses of Cd and Mo in basic diet per kg were as follows:control group,Mo group(100 mg Mo),Cd group(4 mg Cd),and Mo+Cd group(100 mg Mo+4 mg Cd).Cadmium sulfate 8/3-hydrate(CdSO_(4)·8/3H_(2)O)and hexaammonium molybdate((NH_(4))_(6)Mo_(7)O_(24)·4H_(2)O)were the origins of Cd and Mo,*** the 16th week of the experiment,all ovary tissues were collected for the detection of related *** data indicated that Mo and/or Cd induced trace element disorders and Th1/Th2 balance to divert toward Th1 in the ovary,which activated endoplasmic reticulum(ER)stress and then provoked necroptosis through triggering RIPK1/RIPK3/MLKL signaling pathway,and eventually caused ovarian pathological injuries and necroptosis *** alterations of above indicators were most apparent in the joint *** all,this research illustrates that Mo and/or Cd exposure can initiate necroptosis through Th1/Th2 imbalance-modulated ER stress in duck ovaries,and Mo and Cd combined exposure aggravates ovarian *** research explores the molecular mechanism of necroptosis caused by Mo and/or Cd,which reveals that ER stress attenuation may be a therapeutic target to alleviate necroptosis.

关键词： Molybdenum Cadmium Th1/Th2 imbalance Endoplasmic reticulum stress Necroptosis Ovary

Orchestrating seed storage protein and starch accumulation toward overcoming yield–quality trade-off in cereal crops

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Journal of Integrative Plant Biology 2024年第3期66卷 468-483页

作者： Shuanghe Cao bingyan Liu Daowen Wang Awais Rasheed Lina Xie Xianchun Xia Zhonghu He State Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center Institute of Crop SciencesBeijing 100081China College of Agronomy Henan Agricultural UniversityZhengzhou 450002China International Maize and Wheat Improvement Center(CIMMYT)China Office Chinese Academy of Agricultural SciencesBeijing 100081China

Achieving high yield and good quality in crops is essential for human food security and ***,there is usually disharmony between yield and *** storage protein(SSP)and starch,the predominant components in cereal grains,determine yield and quality,and their coupled synthesis causes a yield–quality ***,dissection of the underlying regulatory mechanism facilitates simultaneous improvement of yield and ***,we summarize current findings about the synergistic molecular machinery underpinning SSP and starch synthesis in the leading staple cereal crops,including maize,rice and *** further evaluate the functional conservation and differentiation of key regulators and specify feasible research approaches to identify additional regulators and expand *** also present major strategies to leverage resultant information for simultaneous improvement of yield and quality by molecular ***,future perspectives on major challenges are proposed.

关键词： cereal crops grain yield and quality seed storage protein starch synergistic regulation

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泥石流沟严重程度的数量化综合评判

铁道学报 1986年第2期 74-82页

作者：谭炳炎铁道部科学研究院西南研究所

泥石流沟的判别条件和严重程度的评判准则不仅是理论问题,也是山区国土开发和管理工作中都要优先解决的重大课题。本文根据国内近一千条泥石流沟的实地调查和统计,提出泥石流沟严重程度的数量化评判方法。本方法从决定泥石流沟严重程度... 详细信息

泥石流沟的判别条件和严重程度的评判准则不仅是理论问题,也是山区国土开发和管理工作中都要优先解决的重大课题。本文根据国内近一千条泥石流沟的实地调查和统计,提出泥石流沟严重程度的数量化评判方法。本方法从决定泥石流沟严重程度的诸因素中选择十五项基本因素,按数量化理论的要求进行评分。用本法对国内86条泥石流沟的资料进行了验证,其结果和现场调查时专家们的现场评议结果是一致的。本方法可供调查、勘测和设计试用。

关键词：泥石流沟严重程度数量化理论判别条件数学理论定性变量山地灾害泥石流灾害综合评判

A general and facile calcination method to synthesize single-site catalysts for highly efficient electrochemical CO_(2) reduction

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Nano Research 2024年第5期17卷 3895-3901页

作者： Rui Sui bingyan Wang Yongsheng Wang Jiajing Pei Wei Zhu Wenxing Chen Chunhui Li Ailing Sun Zhongbin Zhuang Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China College of Chemistry and Green Catalysis Center Zhengzhou UniversityZhengzhou 450001China State Key Lab of Organic-Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

The electrochemical CO_(2) reduction reaction(CO_(2)RR)has received widespread attention as a promising method for producing sustainable chemicals and mitigating the global ***,we demonstrate a general and facile synthetic route for the metal-nitrogen-carbon(M-N-C)type catalyst by simply calcinating metal acetate and urea with commercial carbon black,which have potential application in CO_(2)*** synthesized Ni-NC-600 catalyst has the structure of single Ni atom coordinated with one N atom and three C atoms(Ni-N_(1)C_(3)),which is suggested by X-ray absorption *** Ni-NC-600 catalyst exhibits high CO_(2)RR catalytic performance and a high CO Faraday efficiency above 98%in a wide potential range from-0.7 to-1.3 V(*** hydrogen electrode(RHE)),superior to most of the reported Ni-N-C *** work has developed a facile strategy to synthesize high performance CO_(2)RR catalyst.

关键词： nickel single atom catalyst CO_(2)reduction reaction CO production electrocatalyst

Interplay between topology and localization on superconducting circuits

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Chinese Physics B 2024年第6期33卷 240-246页

作者：关欣霍炳燕陈刚 Department of Materials and Chemical Engineering Taiyuan UniversityTaiyuan 030032China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Physics Zhengzhou UniversityZhengzhou 450001China

Topological insulators occupy a prominent position in the realm of condensed matter physics. Nevertheless, the presence of strong disorder has the potential to disrupt the integrity of topological states, leading to the localization of all *** study delves into the intricate interplay between topology and localization within the one-dimensional Su–Schrieffer–Heeger(SSH) model, which incorporates controllable off-diagonal quasi-periodic modulations on superconducting *** the application of external alternating current(ac) magnetic fluxes, each transmon undergoes controlled driving,enabling independent tuning of all coupling strengths. Within a framework of this model, we construct comprehensive phase diagrams delineating regions characterized by extended topologically nontrivial states, critical localization, and coexisting topological and critical localization phases. The paper also addresses the dynamics of qubit excitations, elucidating distinct quantum state transfers resulting from the intricate interplay between topology and localization. Additionally, we propose a method for detecting diverse quantum phases utilizing existing experimental setups.

关键词： topology localization superconducting circuits

Antimony oxides-protected ultrathin Ir-Sb nanowires as bifunctional hydrogen electrocatalysts

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Nano Research 2024年第3期17卷 1042-1049页

作者： bingyan Xu Xuan Huang Shangheng Liu Zhiwei Hu Cheng-Wei Kao Ting-Shan Chan Hongbo Geng Ying Zhang Xiaoqing Huang Country State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Max Planck Institute for Chemical Physics of Solids Dresden 01187Germany “National Synchrotron Radiation Research Center” Hsinchu 30076TaiwanChina School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Developing electrocatalysts with fast kinetics and long-term stability for alkaline hydrogen oxidation reaction(HOR)and hydrogen evolution reaction(HER)is of considerable importance for the industrial production of green and sustainable ***,an ultrathin Ir-Sb nanowires(Ir-Sb NWs)protected by antimony oxides(SbO_(x))was synthesized as an efficient bifunctional catalyst for both HOR and HER under alkaline *** from the much higher mass activities of Ir-Sb nanowires than those of Ir nanowires(Ir NWs)and commercial Pt/C,the SbO_(x) protective layer also contributes to the maintenance of morphology and anti-CO poisoning ability,leading to the long-term cycling performance in the presence of ***,the Ir-Sb NW/SbO_(x) exhibits the highest catalytic activities,which are about 3.5 and 4.8 times to those of Ir NW/C and commercial Pt/C toward HOR,*** work provides that the ultrathin morphology and H_(2)O-occupied Sb sites can exert the intrinsic high activity of Ir and effectively optimize the absorption of OH*both in alkaline HER/HOR electrolysis.

关键词： Ir nanowire amorphous antimony oxides bifunctional mechanism hydrogen evolution reaction hydrogen oxidation reaction