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Structure optimization of the organ-pipe cavitating nozzle and its erosion ability test on hydrate-bearing sediments

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Petroleum Science 2023年第2期20卷 1104-1118页

作者： Xiao-Ya Wu Yi-Qun Zhang Zhen-Qiang Xu Shuai Zhao Gen-Sheng Li Shou-Ceng Tian Ya-wen tan Ke-wen Peng College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China College of Safety and Ocean Engineering China University of Petroleum-BeijingBeijing102249China State Key Laboratory of Natural Gas Hydrate China University of Petroleum-BeijingBeijing102249China National Engineering Research Center of Gas Hydrate Exploration and Development Guangzhou Marine Geological SurveyGuangzhou510075GuangdongChina Guangdong Provincial Key Laboratory of Distributed Energy Systems Dongguan University of TechnologyDongguan523808GuangdongChina

Cavitating jet is a promising drilling rate improvement technology in both the marine natural gas hydrate (NGH) fluidization exploitation method and the integrated radial jet drilling and completion method. In present study, we aim to improve the efficiency of jet erosion and extracting NGH. With a computational fluid dynamics (CFD) method, the pressure, velocity and cavitation field characteristics of organ-pipe cavitating jet (OPCJ) are analysed. The divergent angle, throat length, and divergent length of OPCJ nozzle are preferred to obtain stronger jet cavitation erosion effect. Laboratory experiments of gas hydrate-bearing sediments (GHBS) erosion by OPCJ and conical jet (CJ) are conducted to compare and validate the jet erosion performance. The impinging models of OPCJ and CJ are constructed to study the impact characteristics. Results show that the preferred values of divergent angle, throat length, and divergent length are 15°, 1d, and 3d, respectively, in present simulation conditions. For GHBS, the OPCJ possesses the advantages of high efficiency and low energy consumption. Moreover, the OPCJ has higher penetration efficiency, while showing equivalent penetration ability compared to CJ. During the impinging process, the OPCJ can induce stronger impact pressure and turbulence effect, and also shows stronger chambering effect and bottom cleaning ability compared to CJ. This study presents the erosion performance of OPCJ and CJ on GHBS, and provides preliminary insights on the potential field applications in NGH exploitation.

关键词： Natural gas hydrate Cavitating jet Structure optimization Computational fluid dynamics Experimental study

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Elemental Composition and Geochemical Characteristics of Iron-Manganese Nodules in Main Soils of China

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Pedosphere 2006年第1期16卷 72-81页

作者： tan wen-Feng LIU Fan LI Yong-Hua HU Hong-Qing HUANG Qiao-Yun College of Resources and Environment Huazhong Agricultural University Wuhan 430070 （China）. Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101（China）

Elemental composition and geochemical characteristics of iron-manganese nodules from nine main soils in China were studied by chemical and multivariate statistical analyses to better understand the reactions and functions of iron-manganese nodules in soils and sediment. Compared to the corresponding soils, Mn, Ba, Cd, Co and Pb had strong accumulation, Ni had moderate accumulation, while Ca, Cu, Fe, Na, P, Sr and Zn accumulated to a minor degree in the iron-manganese nodules. In contrast, Si, Al, K, Mg and Ti were reduced in the iron-manganese nodules. The contents of Ba, Cd, Co, Cu, Ni, Pb and Zn were positively and significantly correlated with that of MnO2 in the iron-manganese nodules, while the contents of Cr, Cu, Ni, Pb and Zn were positively and significantly correlated with that of Fe2O3 in soils. Based on a principle component analysis, the elements of iron-manganese nodules were divided into four groups: 1) Mn, Ba, Cd, Co, Cu, Li, Ni, Pb and Zn that were associated with Mn oxides, 2) Fe, Cr and P that were associated with Fe oxides, 3) Si, K, and Mg that were included in the elemental composition of phyllosilicate, and 4) Ca, Na, Al and Ti that existed in todorokite, birnessite, lithiophorite and phyllosilicate. It was suggested that accumulation, mineralization and specific adsorption were involved in the formation processes of soil iron-manganese nodules.

关键词： elemental composition geochemical characteristics iron-manganese nodule soil

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High Time-Resolved Imaging of Targets in Turbid Media Using Ultrafast Optical Kerr Gate

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Chinese Physics Letters 2012年第2期29卷 102-104页

作者： TONG Jun-Yi tan wen-Jiang SI Jin-Hai CHEN Feng YI wen-Hui HOU Xun Key Laboratory for Physical Electronics and Devices of the Ministry of Education Shaanxi Key Lab of Information Photonic TechniqueSchool of Electronics and Information EngineeringXi’an Jiaotong UniversityXi’an 710049

We demonstrate the ultrafast imaging of a submillimeter bar chart that is either hidden behind glass diffusers or inside a solution of polystyrene spheres,using an ultrafast optical Kerr gate (OKG).The results show that the time-resolved imaging of the target in the turbid media with an optical depth of 11.4 is achieved using the OKG with a 1.6 ps opening *** image contrast is improved by about 70% compared with the shadowgraph imaging.

关键词： spheres polystyrene resolved

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An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation

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Acta Pharmaceutica Sinica B 2014年第1期4卷 79-85页

作者： Xuemei Zhang Qing Liu Junhua Hu Ling Xu wen tan School of Bioscience and Bioengineering South China University of TechnologyGuangzhou 510006China Key-Pharma Biomedical Inc. Dongguan 523000China

An aerosol formulation containing 7.5 mg of R-salbutamol sulfate was *** aerosol was nebulized with an air-jet nebulizer,and further assessed according to the new European Medicines Agency(EMA)guidelines.A breath simulator was used for studies of delivery rate and total amount of the active ingredient at volume of 3 mL.A next generation impactor(NGI)with a cooler was used for analysis of the particle size and in vitro lung deposition rate of the active ingredient at *** anti-asthmatic efficacy of the aerosol formulation was assessed in guinea pigs with asthma evoked by intravenous injection of histamine compared with racemic *** results show that this aerosol formulation of R-salbutamol sulfate met all the requirements of the new EMA guidelines for *** efficacy of a half-dose of R-salbutamol equaled that of a normal dose of racemic salbutamol.

关键词： R-salbutamol Nebulizer NGI Particle size Dose uniformity Guinea pigs Asthma

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Functional XPF polymorphisms associated with lung cancersusceptibility in a Chinese population

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Frontiers of Medicine 2010年第1期4卷 82-89页

作者： Dian-Ke YU Chen WU wen tan Dong-Xin LIN State Key Laboratory of Molecular Oncology and Department of Etiology&Carcinogenesis Cancer Institute&HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100210China

Variation of individuals’DNA repair capacity has been linked to cancer *** xeroderma pigmentsum group F(XPF)plays a pivotal role in nucleotide-excision repair(NER)*** study was to examine the functional signiﬁcance of XPF promoter polymorphisms and their association with lung cancer *** function of XPF promoter polymorphisms was tested by a set of biochemical assays,and their effects on lung cancer risk were determined by a case-control analysis of 988 patients with lung cancer and 986 *** XPF–673T allele showed a signiﬁcantly higher transcriptional activity as compared with the–673C ***–673TT genotype was associated with a decreased risk of lung cancer compared with the CC genotype(adjusted OR=0.62,95%CI=0.42–0.91;P=0.015)and this effect was more signiﬁcant among males(adjusted OR=0.55,95%CI=0.35–0.86;P=0.009),elder subjects(adjusted OR=0.51,95%CI=0.30–0.86;P=0.012),and light smokers(adjusted OR=0.35,95%CI=0.14–0.88;P=0.026).Theseﬁndings suggest that functional polymorphisms inﬂuencing DNA repair capa-city may confer susceptibility to lung cancer.

关键词： XPF polymorphism lung cancer

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Hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients

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World Journal of Gastroenterology 2015年第28期21卷 8653-8659页

作者： Guo-Hong Ge Yun Ye Xin-Bei Zhou Li Chen Cong He Dan-Feng wen You-wen tan Department of Hepatosis The Third Hospital of Zhenjiang Affiliated Jiangsu University

AIM:To investigate the virological relapse rate in hepatitis B e antigen(HBeAg)-negative patients after antiviral therapy discontinuation and analyze the factors associated with virological ***:Among patients diagnosed with chronic hepatitis B infection between May 2005 and July2010,204 were eligible for *** Kaplan-Meier method and log-rank test were used to calculate the cumulative rate of relapse and compare cumulative relapse rates between *** Cox proportional hazards regression model was used to evaluate the predictive factor of virological ***:The 2 and 1 year cumulative risks of virological relapse after antiviral therapy discontinuation were 79.41%(162/204) and 43.82%(71/162),*** analysis revealed that only post treatment hepatitis B surface antigen(HBsAg)level was associated with virological relapse {P= 0.011).The cumulative risk of virological relapse was higher in the patients with HBsAg levels ≥1500 IU/L than in those with HBsAg levels < 1500 IU/L(P= 0.0013).The area under the curve was 0.603(P= 0.033).The cutoff HBsAg value for predicting virological relapse was 1443IU/L CONCLUSION:We found that the virological relapse rate remained high after antiviral therapy discontinuation in the HBeAg-negative patients and that the post treatment HBsAg levels predicted virological relapse.

关键词： Chronic hepatitis B Virological relapse Hepatitis B surface antigen

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Diagnostic value of FIB-4, aspartate aminotransferaseto-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase

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World Journal of Gastroenterology 2017年第31期23卷 5746-5754页

作者： You-wen tan Xing-Bei Zhou Yun Ye Cong He Guo-Hong Ge Department of Hepatology the Third Hospital of Zhenjiang Affiliated Jiangsu University

AIM To assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index(APRI), and liver stiffness measurement(LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase(PNALT).METHODS We enrolled 245 patients with chronic hepatitis B: 95 in PNALT group, 86 in intermittently elevated alanine transaminase(PIALT1) group [alanine transaminase(ALT) within 1-2 × upper limit of normal value(ULN)], and 64 in PIALT2 group(ALT > 2 × ULN). All the patients received a percutaneous liver biopsy guided by ultrasonography. LSM, biochemical tests, and complete blood cell counts were *** The pathological examination revealed moderate inflammatory necrosis ratios of 16.81%(16/95), 32.56%(28/86), and 45.31%(28/64), and moderate liverfibrosis of 24.2%(23/95), 33.72%(29/86), and 43.75%(28/64) in the PNALT, PIALT1, and PIALT2 groups, respectively. The degrees of inflammation and liver fibrosis were significantly higher in the PIALT groups than in the PNALT group(P 0.05) was found in AUCs for all comparisons(P > 0.05 for all). In the overall patients, a significant difference in the AUCs was found only between LSM and APRI(P < 0.05).CONCLUSION APRI and FIB-4 are not the ideal noninvasive hepatic fibrosis markers for PNALT patients. LSM is superior to APRI and FIB-4 in PNALT patients because of the influence of liver inflammation and necrosis.

关键词： Liver stiffness measurement Hepatitis B virus FIB-4 Aspartate aminotransferase-to-platelet ratio index Normal Alanine aminotransferase

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Association between genetic variations in tumor necrosis factor receptor genes and survival of patients with T-cell lymphoma

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Chinese Journal of Cancer 2012年第7期31卷 335-341页

作者： Kan Zhai Jiang Chang Chen Wu Ning Lu Li-Ming Huang Tong-wen Zhang Dian-Ke Yu wen tan Dong-Xin Lin Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100021P.R.China

The prognosis of T-cell lymphoma (TCL) has been shown to be associated with the clinical characteristics of patients. However, there is little knowledge of whether genetic variations also affect the prognosis of TCL. This study investigated the associations between single nucleotide polymorphisms(SNPs) in tumor necrosis factor receptor superfamily(TNFRSF) genes and the survival of patients with TCL. A total of 38 tag SNPs in 18 TNFRSF genes were genotyped using Sequenom platform in 150 patients with TCL. Kaplan-Meier survival estimates were plotted and significance was assessed using log-rank tests. Cox proportional hazard models were used to analyze each of these 38 SNPs with adjustment for covariates that might influence patient survival, including sex and international prognostic Index score. Hazard ratios (HRs) and their 95% confidence intervals(CIs) were calculated. Among the 38 SNPs tested, 3 were significantly associated with the survival of patients with TCL. These SNPs were located at LTβR (rs3759333C>T) and TNFRSF17(rs2017662C>T and rs2071336C>T). The 5-year survival rates were significantly different among patients carrying different genotypes and the HRs for death between the different genotypes ranged from 0.45 to 2.46. These findings suggest that the SNPs in TNFRSF genes might be important determinants for the survival of TCL patients.

关键词：肿瘤坏死因子受体遗传变异受体基因淋巴瘤患者细胞单核苷酸多态性 SNPs

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Peptide binding specificities of HLA-B*5701 and B*5801

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Science China(Life Sciences) 2012年第9期55卷 818-825页

作者： ZHANG YaLan MEI Hu WANG Qing XlEJiangAn LV Juan PAN XianChao tan wen Key Laboratory of Biorheological Science and Technology(Ministry of Education)Chongqing University Chongqing 400044China College of Bioengineering Chongqing UniversityChongqing 400044China

Recently, genome wide association studies showed that there is a strong association between abacavir-induced serious, idio- syncratic, adverse drag reactions （ADRs） and human leukocyte antigen-B＊5701 （HLA-B＊5701）. Studies also found that ab- acavir-induced ADRs were seldom observed in patients carrying the HLA-B＊5801 subtype. HLA-B＊5801 of the same sero- type （B17） as B＊5701 differs by only 4 amino acids from B＇5701. It is believed that because of these sequence differences, HLA-B＊5801 cannot bind the specific peptides which are required for HLA-B＊5701 to stimulate the T cell immune response. Thus, the difference in peptide binding profiles between HLA-B＊5701 and B＊5801 is an important clue for exploring the mechanisms of abacavir-induced ADRs. VHSE （principal component score vector of hydrophobic, steric, and electronic prop- erties）, a set of amino acid structural descriptors, was employed to establish QSAR models of peptide-binding affinities of HLA-B＊5701 and B＊5801. Optimal linear SVM （support vector machine） models with high predictive capabilities were ob- tained for both B＊5701 and B＇5801. The R2 （coefficient of determination）, Q2 （cross-validated R：）, and RpRE2 （R2 of test set） of two optimal models were 0,7530, 0.7037, 0.6153 （B＇5701） and 0.6074, 0.5966, 0.5762 （B＊5801）, respectively. For B＇5701 and B＇5801, the mutations in positions 45 （MET-THR） and 46 （ALA-GLU） have little influence on the selection specificity of the P2 position of the bound peptide. However, the mutation in position 97 （VAL-ARG） greatly influences the selection speci- ficity of the P7 position. HLA-B＊5701 prefers the bulky and positively charged amino acids at the P7 position. In contrast, HLA-B＊5801 prefers the non-polar hydrophobic amino acids at the P7 position while positively charged amino acids are un- favored.

关键词： human leukocyte antigen B*5701 B*5801 SVM P-I concept VHSE

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Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma

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Cancer Communications 2018年第1期38卷 158-169页

作者： Jun Li wenle tan Linna Peng Jialiang Zhang Xudong Huang Qionghua Cui Jian Zheng wen tan Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 210009P.R.China

Background:Pancreatic duct adenocarcinoma(PDAC)remains a major health problem because conventional can-cer treatments are relatively ineffective against *** studies have linked many genes to pancreatic cancer,but the available data have not been extensively mined for potential insights into *** study attempted to identify PDAC-associated genes and signaling pathways based on six microarray-based profiles of gene expression in pancre-atic cancer deposited in the gene expression omnibus ***:Pathway network methods were used to analyze core pathways in six publicly available pancreatic cancer gene(GSE71989,GSE15471,GSE16515,GSE32676,GSE41368 and GSE28735)expression *** potentially linked to PDAC were assessed for potential impact on survival time based on data in The Cancer Genome Atlas and International Cancer Genome Consortium databases,and the expression of one candidate gene(CKS2)and its association with survival was examined in 102 patients with PDAC from our *** of CKS2 knockdown were explored in the PDAC cell lines BxPC-3 and ***:The KEGG signaling pathway called“pathway in cancer”may play an important role in pancreatic cancer development and *** genes(BIRC5,CKS2,ITGA3,ITGA6 and RALA)in this pathway were significantly associated with survival time in patients with ***2 was overexpressed in PDAC samples from our hospital,and higher CKS2 expression in these patients was associated with shorter survival ***2 knockdown substantially inhibited PDAC cell proliferation in ***:Analysis integrating existing microarray datasets allowed identification of the“pathway in cancer”as an important signaling pathway in *** integrative approach may be powerful for identifying genes and pathways involved in cancer.

关键词： Pancreatic cancer GEO Pathway network CKS2

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