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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.taha SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD JAMIL The Second Affiliated Hospital of Harbin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

Real and Altered Fingerprint Classification Based on Various Features and Classifiers

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Computers, Materials & Continua 2023年第1期74卷 327-340页

作者： Saif Saad Hameed ismail taha Ahmed Omar Munthir Al Okashi College of Computer Sciences and Information Technology University of AnbarAnbarIraq

Biometric recognition refers to the identification of individuals through their unique behavioral features(e.g.,fingerprint,face,and iris).We need distinguishing characteristics to identify people,such as fingerprints,which are world-renowned as the most reliablemethod to identify *** recognition of fingerprints has become a standard procedure in forensics,and different techniques are available for this *** current techniques lack interest in image enhancement and rely on high-dimensional features to generate classification ***,we proposed an effective fingerprint classification method for classifying the fingerprint image as authentic or altered since criminals and hackers routinely change their fingerprints to generate fake *** order to improve fingerprint classification accuracy,our proposed method used the most effective texture features and *** Analysis(DCA)and Gaussian Discriminant Analysis(GDA)are employed as classifiers,along with Histogram of Oriented Gradient(HOG)and Segmentation-based Feature Texture Analysis(SFTA)feature vectors as *** performance of the classifiers is determined by assessing a range of feature sets,and the most accurate results are *** proposed method is tested using a Sokoto Coventry Fingerprint Dataset(SOCOFing).The SOCOFing project includes 6,000 fingerprint images collected from 600 African people whose fingerprints were taken ten *** distinct degrees of obliteration,central rotation,and z-cut have been performed to obtain synthetically altered replicas of the genuine *** proposal achieved massive success with a classification accuracy reaching 99%.The experimental results indicate that the proposed method for fingerprint classification is feasible and *** experiments also showed that the proposed SFTA-based GDA method outperformed state-of-art approaches in feature dimension and classification accuracy.

关键词： Fingerprint classification HOG SFTA discriminant analysis(DCA)classifier gaussian discriminant analysis(GDA)classifier SOCOFing

Synthesis of 1,3-Oxazepine Derivatives Derived from 2-(1H-Benzo[d][1,2,3]Triazol-1-yl) Acetohydrazide by Using Microwave Irradiation

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International Journal of Organic Chemistry 2017年第3期7卷 219-228页

作者： Nihad ismail taha Department of Chemistry College of Science Kirkuk University Kirkuk Iraq

A series of Schiff base and their derivative (oxazepine) have been synthesized. 8-hydrazone(schiff-bases) derivatives type (E)-2-(1H-benzo[d][1,2,3]triazole-1-yl)-N-(substituted benzylidene)aceto-hydrazide were prepared by condensation 1H-benzo[d][1,2,3]triazol-1-yl)hydrazine with various aromatic aldehyde in ethanol in the presence of dimethyl formamid or acetic acid as catalyst by using MWI to yield the Schiff bases. These Schiff’s base on treatment with Maleic anhydride in dry conditions by using MWI to give 7-membered heterocyclic ring system (oxezapine) of (2-(1H)benzo[d][1,2,3]triazol-1-yl)-N-(2-(substituted penyl)-4, 7-dioxo-4,7-dihydro-1,3-oxazepin-3-(2H)-yl)acetamide. The purity of the compounds was confirmed by TLC. The final products were identified by their melting point, IR, 1HNMR, and UV-visible spectra.

关键词： Hydrazone Microwave Oxezapine Benzotriazole Hydrazine

Morpholine hydrazone scaffold： Synthesis, anticancer activity and docking studies

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Chinese Chemical Letters 2017年第3期28卷 607-611页

作者： Muhammad taha Syed Adnan Ali Shah Muhammad Afifi Manar Zulkeflee Sadia Sultan Abdul Wadood Fazal Rahim Nor Hadiani ismail Atta-ur-Rahman Institute for Natural Product Discovery (AuRlns) Universiti Teknologi MARA Puncak Alam Campus 42300 Bandar Puncak Alam SelangorD. E. Malaysia Faculty of Applied Science UiTM Shah Alam 40450 Shah Alam Selangor D.E. Malaysia Faculty of Pharrnacy Universiti Teknologi MARA Puncat~ Alam Campus 42300 Baadar Puncak Alam Selangor D.E. Malaysia Department of Biochemistry Abdul Wali Khan University Mardan 23200 Pakistan Department of Chemistry Hazara University Mansehra 21300 Pakistan

In this paper, synthesis and anticancer activities of morpholine hydrazones scaffold（1-17） thoroughly studied. Small series of morpholine hydrazones synthesized by treating 5-morpholinothiophene-2-carbaldehyde with different aryl hydrazides to form morpholine hydrazones scaffold（1-17）. The in vitro anticancer potential of all these compounds was checked against human cancer cell lines like Hep G2（human hepatocellular liver carcinoma） and MCF-7（human breast adenocarcinoma）. Analogs 13 had similar substantial cytotoxic effects towards Hep G2 with IC_（50） value 6.31±1.03μmmol/L when compared with the standard Doxorubicin（IC_（50）value 6.00±0.80μmmol/L）; while compounds 5,8 and 9 showed potent cytotoxicity against MCF-7 with IC_（50） value 7.08±0.42μmmol/L, 1.26±0.34μmmol/L and11.22±0.22μmmol/L respectively when compared with the standard Tamoxifen（IC_（50）= 11.00±0.40μmol/L）. Molecular docking studies also performed to understand the binding interaction.

关键词： Morpholine hydrazones Synthesis HepG2 MCF-7 Molecular docking

Seasonal changes in testicular ultrasonogram pixel-intensity and their association with semen characteristics in rams

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Asian pacific Journal of Reproduction 2020年第1期9卷 49-54页

作者： Mohamed Gamal Hedia Mohamed Shehata El-Belely Sayed taha ismail Amal Mahmoud Abo El-Maaty Department of Theriogenology Faculty of Veterinary MedicineCairo UniversityGizaEgypt Department of Animal Reproduction and AI Veterinary DivisionNational Research CenterDokkiGizaEgypt

Objective:To establish reference values for pixel intensity of testicular ultrasonogram of rams in breeding and non-breeding seasons,and to investigate if the seasonal changes in testicular echogenicity and heterogeneity are associated with semen ***:Five Awassi rams aged 3-5 years old and weighing 45-60 kg were subjected to ultrasonographic scanning of the testes twice monthly for one year(from January 2018 to December 2018),together with semen collection and evaluation of ejaculate volume,sperm motility,sperm concentration,sperm morphology and *** ejaculate volume was determined in a graduated collection tube(scale of 0.1 mL).Mass and individual sperm motility was expressed in percentage of motile spermatozoa under optical microscope equipped with a warm *** concentration was determined by using a Neubauer *** smears stained with eosin-nigrosin were used to determine the percentage of live spermatozoa and sperm cell morphology by using a light ***:The mean testicular pixel intensity was the lowest in winter and increased gradually from breeding season to non-breeding season,reaching its maximum value in summer(P<0.05).Pixel intensity was found to have a significant negative correlation with progressive motility(r=-0.605,P<0.05),and sperm concentration(r=-0.619,P<0.05).It is also positively correlated with the percentage of sperm morphological abnormalities(r=0.666,P<0.05).Conclusions:Pixel intensity values of testicular ultrasonogram in rams undergo marked seasonal changes that are associated with fluctuations in photoperiod and ambient *** resulting values of testicular echogenicity(pixel intensity)throughout the year provide useful reference values for predicting the testicular function in Awassi rams.

关键词： Testes Echotexture Pixel intensity Semen Season Rams

Isolation and characterization of marine-derived actinomycetes with cytotoxic activity from the Red Sea coast

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 651-657页

作者： Mohamed Saleh Abdelfattah Mohammed ismail Youssef Elmallah Usama Wahid Hawas Lamia taha Abou El-Kassema Mennat Allah Gamal Eid Marine Natural Products Research Unit Faculty of Science Helwan University Marine Chemistry Department Faculty of Marine Sciences King Abdulaziz University Pharmacognosy Department National Research Centre

Objective: To isolate and evaluate the cytotoxic activity of different actinomycetes species isolated from the Red Sea coast in Sharm el-Sheikh, ***: Forty actinomycetes strains were isolated from different sediments and seawater samples collected from the Red Sea coast in Egypt. Actinomycetes were recognized by morphological and microscopic examinations. Cell viability and cytotoxicity induced by the crude extracts on breast cancer cell lines MDA-MB-231 were assessed using methylene blue assay. The strains with promising cytotoxic activity were identified by sequencing and amplifying the 16 S r RNA genes. The antibacterial activities of the crude extracts were performed using Kirby–Bauer disc diffusion ***: The results indicated that five ethyl acetate extracts exhibited cytotoxicity towards breast cancer cell lines MDA-MB-231. The highest cytotoxic activity was found for the ethyl acetate extracts of EGY2 and EGY39. The isolate EGY3 was identified as a new Streptomyces species, while the actinomycete EGY22 was found to be a member of the genus Nocardiopsis sp. The crude extract of the isolate EGY8 showed slightly high antimicrobial activity against different test ***: The results of the present study reveal that marine sediments of the Red Sea are a potent source of novel species of actinomycetes. The isolates may be useful in discovery of novel bioactive compounds and an important step in the development of microbial natural product research.

关键词： Red Sea Breast cancer Actinomycetes 16S rRNA Cytotoxicity

Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 155-162页

作者： Haslet Eksi-Kocak Sibel Ilbasmis tamer Sebnem Yilmaz Merve Eryilmaz ismail Hakkl Boyaci Ugur tamer Department of Biomedical Engineering Faculty of Engineering Istanbul Aydin University Department of Pharmaceutical Technology Faculty of Pharmacy Gazi University Department of Analytical Chemistry Faculty of Pharmacy Gazi University Food Research Center Hacettepe University

In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution(MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower salicylic acid concentrations. In addition, the distribution of major excipient, lactose, was examined in the tablet form. A calibration curve was obtained by plotting the intensity of the Raman signal at 1635 cm^(-1) versus the concentration of salicylic acid and the correlation was found to be linear within the range of 0.5%–3.9% with a correlation coefficient of 0.99. The limit of detection for the technique was determined 0.35%. The ability of the technique to quantify salicylic acid in tablet test samples was also investigated.

关键词： Raman mapping Multivariate curve resolution FT-Raman spectroscopy Salicylic acid

Numerical and experimental analysis for simulating fuel reactor in chemical looping combustor system

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International Journal of Coal Science & Technology 2020年第3期7卷 551-559页

作者： tamer M.ismail Lu Ding Khaled Ramzy MAbd El-Salam Department of Mechanical Engineering Suez Canal UniversityIsmailiaEgypt Institute of Clean Coal Technology East China University of Science and TechnologyShanghai200237China Department of Basic Science Cairo UniversityGizaEgypt

The greenhouse problem has a significant effect on our communities such as,health and *** dioxide is one of the main gases that cause global ***,CO2 capture techniques have been the focus of attention these *** chemical looping combustion technique adopted the air reactor and fuel reactor to recycle heat *** study presents a numerical and experimental investigation on a fuel reactor in chemical looping combustor(CLC)*** present numerical model is introduced by the kinetic theory of granular flow and coupled with gas–solid flow with chemical reactions to simulate the combustion of solids in the *** k–εturbulent model was used to model the gas phase and the particle *** developed model simplify the prediction of flow patterns,particle velocities,gas velocities,and composition profiles of gas products and the distribution of heterogeneous reaction rates under the same operating *** predicted and experimental results were compared according to the basis of determination coefficient(R2).In addition the results showed that there is a good agreement between the predicted and experimental *** value of(R2)for CO,CO2 and CH4 was 0.959,0.925 and 0.969 *** shows that the present model is a promising simulation for solid particle combustion and gives the power direction for the design and optimization of the CLC systems.

关键词： Chemical looping combustion Mathematical modeling Fluidized bed Coal Kinetic model

Oxazolidinones Antibiotics, Chemistry, Applications and Role in COVID-19 Treatment

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Pharmacology & Pharmacy 2023年第1期14卷 19-32页

作者： Alaa Saleh Mahdi Baraa G. Alani ismail taha Ibrahim College of Pharmacy AL Bayan University Baghdad Iraq Department of Pharmacy Al-Huda University College Alanbar Iraq

Oxazolidinones are groups of synthetic antimicrobial agents, which have a novel chemical structure. Their mechanism of antimicrobial mainly bacteriostatic via inhibition of protein synthesis. Oxazolidinones are used in serious cases of bacterial infections. Their spectrum of action against a lot of microbes, which often infect humans vigorously, like penicillin and cephalosporin-resistant Streptococcus pneumonia, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Oxazolidinones chemical structure possesses a ring called oxazolidone, which is characterized by the S configuration of the substituent at C5, the acyl-amino-methyl group connected to C5 and the N-aryl substituent. Some oxazolidinones like linezolid were believed to have a role in COVID-19 treatment. It is also noticed that oxazolidinones have a role in improving clinical status of patients with COVID-19 and in decreasing the risk of mortality caused by co-infections. This review was conducted to discuss the chemistry, mechanism, applications and role of oxazolidinones in the treatment of COVID-19.

关键词： Oxazolidinones Antibiotics Linezolid Infection COVID-19