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Short RNAs in Tomato

journal of Integrative Plant Biology 2010年第4期52卷 388-392页

作者： tamas Dalmay School of Biological Sciences University of East Anglia

Short RNAs are 20-24 nucleotide long non-coding RNA molecules generated by one of the Dicer-like enzymes. They recognize specific RNA or DNA sequences and guide the RNA silencing complex to their targets leading to post-transcriptional or transcriptional gene silencing of the target. Most of our knowledge about short RNAs comes from studying the model species Arabidopsis. Recently, however, several reports emerged about short RNAs in tomato, which is a model plant for fleshy fruit development and ripening. Tomato short RNAs have been sequenced and a database was established. Novel non-conserved microRNAs were found that showed differential expression between fruit and other tissues, even during fruit development, suggesting that they may play a role in fruit formation. Several target genes were predicted and validated for both conserved and non-conserved miRNAs and some of these targets are key players in fruit ripening, such as Colourless non-ripening. The present study reviews the current state of tomato short RNAs research and suggests future directions.

关键词： Short RNAs in Tomato DCL RNA siRNAs

Overview and comparison of guidelines for management of pancreatic cystic neoplasms

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World journal of Gastroenterology 2019年第31期25卷 4405-4413页

作者： Aws Hasan Kavel Visrodia james j Farrell tamas A Gonda Division of Digestive and Liver Diseases Department of MedicineColumbia UniversityNew YorkNY 10032United States Division of Digestive Diseases Department of MedicineYale UniversityNew HavenCT 06520United States

Pancreatic cysts are identified at an increasing *** mucinous cystic neoplasms represent a pre-malignant condition,the majority of these lesions do not progress to *** the last 10 years several societies have established guidelines for the diagnosis,initial evaluation and surveillance of these *** we provide an overview of five commonly used guidelines:2015 American Gastroenterological Association,2017 International Association of Pancreatology,American College of Gastroenterology 2018,European Study Group and American College of *** describe the similarities and differences between the methods used to formulate these guidelines,the population they target and their approaches towards initial evaluation and surveillance of cystic lesions.

关键词： Pancreatic cyst surveillance Cyst malignancy Guidelines

Global optimum of microstructure parameters in the CMWP line-profile-analysis method by combining Marquardt-Levenberg and Monte-Carlo procedures

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journal of Materials Science & Technology 2019年第7期35卷 1508-1514页

作者： Gabor Ribarik Bertalan joni tamas Ungar Department of Materials Physics Edtvos University BudapestPO Box 32H-15J8Hungary School of Materials The University of ManchesterM139PLUK

Line profile analysis of X-ray and neutron diffraction patterns is a powerful tool for determining the microstructure of crystalline materials. The Convolutional-Multiple-Whole-Profile (CMWP) procedure is based on physical profile functions for dislocations, domain size, stacking faults and twin boundaries. Order dependence, strain anisotropy, hkl dependent broadening of planar defects and peak shape are used to separate the effect of different lattice defect types. The Marquardt-Levenberg (ML) numerical optimiza-tion procedure has been used successfully to determine crystal defect types and densities. However, in more complex cases like hexagonal materials or multiple phases the ML procedure alone reveals uncer-tainties. In a new approach the ML and a Monte-Carlo statistical method are combined in an alternative manner. The new CMWP procedure eliminates uncertainties and provides globally optimized parameters.

关键词： X-ray line profile analysis Neutron line profile analysis CMWP Global optimum Dislocation densities Grain size Planar defects Monte-Carlo method

Coupling the 4M crop model with national geo-databases for assessing the effects of climate change on agro-ecological characteristics of Hungary

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International journal of Digital Earth 2014年第5期7卷 391-410页

作者： Nandor Fodor Laszlo Pasztor tamas Nemeth Institute for Soil Science and Agricultural Chemistry Centre for Agricultural ResearchHungarian Academy of SciencesBudapestHungary Hungarian Academy of Sciences BudapestHungary

The 4M crop model was used to investigate the prospective effects of climate change on the agro-ecological characteristics of *** model was coupled with a detailed meteorological database and spatial soil information systems covering the whole territory of ***-specific model parameters were determined by inverse *** meteorological data were produced from the present meteorological data by combining a climate change scenario and a stochastic weather *** the available and the generated data,the present and the prospective agro-ecological characteristics of Hungary were *** to the simulation results,average yields will decrease considerably(-30%)due to climate *** rate of nitrate leaching will prospectively decrease as *** fluctuations of both the yields and the annual nitrate leaching rates will most likely increase approaching the end of the twenty-first *** the basis of the simulation results,the role of autumn crops is likely to become more significant in *** achieved results can be generalized for more extended regions based on the concept of spatial(geographical)analogy.

关键词： agro-ecological features crop modeling climate change effects spatial soil information systems

Omics Approaches to Identify PotentialBiomarkers of Inflammatory Diseases in the FocalAdhesion Complex

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Genomics, Proteomics & Bioinformatics 2017年第2期15卷 101-109页

作者： johanne Brooks Alastair Watson tamas Korcsmaros Gut Health and Food Safety Institute Strategic Programme Institute of Food Research Norwich Research Park Norwich NR4 7UA United Kingdom Norwich Medical School University of East Anglia Norwich Research Park Norwich NR4 7T J United Kingdom Gastroenterology Department Norfolk and Norwich University Hospital Norwich NR4 7UY United Kingdom Earlham Institute Norwich Research Park Norwich NR4 7UZ United Kingdom

Inflammatory diseases such as inflammatory bowel disease(IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and assess disease activity, and to determine optimal therapeutic strategies. Simple ‘bedside’ biomarkers could be used in all phases of patient management to avoid unnecessary investigation and guide further management. The focal adhesion complex(FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, and multiple sclerosis. Utilizing omics technologies has proven to be an efficient approach to identify biomarkers from within the FAC in the field of cancer medicine. Predictive biomarkers are paving the way for the success of precision medicine for cancer patients, but inflammatory diseases have lagged behind in this respect. This review explores the current status of biomarker prediction for inflammatory diseases from within the FAC using omics technologies and highlights the benefits of future potential biomarker identification approaches.

关键词： Focal adhesion complex Biomarkers Inflammation Omics Systems biology

Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

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World journal of Gastroenterology 2006年第2期12卷 251-258页

作者： Annamaria Szabolcs Russel j Reiter tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin jarmay jozsef Kaszaki Reka Sari Zoltan Rakonczay jr janos Lonovics tamas Takacs st Department of Medicine University of SzegedHungary Department of Cellular and Structural Biology University of TexasHealth Science CentreSan AntonioTexasUnited States Institute of Chemistry University of SzegedHungary Biological Research Centre Hungarian Academy of SciencesSzegedHungary Biological Isotope Laboratory University of SzegedHungary Institute of Experimental Surgery University of SzegedHungary

AIM： To determine the effect of melatonin pre- and post-treatment on the severity of L-arginine （L-Arg） -induced experimental pancreatitis in rats. METHODS： Male Wistar rats （25） were divided into five groups. Those in group A received two injections of 3.2 g/kg body weight L-Arg i.p. at an interval of 1 h. In group MA, the rats were treated with 50 mg/kg body weight melatonin i.p. 30 min prior to L-Arg administration. In group AM, the rats received the same dose of melatonin 1 h after L-Arg was given. In group M, a single dose of melatonin was administered as described previously. In group C the control animals received physiological saline injections i.p. All rats were exsanguinated 24 h after the second L-Arg injection. RESULTS： L-Arg administration caused severe necrotizing pancreatitis confirmed by the significant elevations in the serum amylase level, the pancreatic weight/body weight ratio （pw/bw）, the pancreatic IL-6 content and the myeloperoxidase activity, relative to the control values. Elevation of the serum amylase level was significantly reduced in rats given melatonin following L-Arg compared to rats injected with L-Arg only. The activities of the pancreatic antioxidant enzymes （Cu/Zn-superoxide dismutase （CulZn-SOD） and catalase （CAT）） were significantly increased 24 h after pancreatitis induction. Melatonin given in advance of L-Arg significantly reduced the pancreatic CAT activity relative to that in the rats treated with L-Arg alone. In the liver, L-Arg significantly increased the lipid peroxidation level, and the glutathione peroxidase and Cu/Zn-SOD activities, whereas the Mn-SOD activity was reduced as compared to the control rats. Melatonin pre-treatment prevented these changes. CONCLUSION： Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis.

关键词： Acute pancreatitis Melatonin Scavengers

Changing human-environment interactions in medium mountains:the Apuseni Mts(Romania)as a case study

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journal of Mountain Science 2016年第9期13卷 1675-1687页

作者： TELBISZ tamas IMECS Zoltan MARl Laszlo BOTTLIK Zsolt Department of Physical Geography Eotvos University1117BudapestPazrnany Peter setany 1/CBudapestHungary Department of Geography in Hungarian Babes-Bolyai University400006Cluj-NapocaStr.Clinicilor 5-7Romania Department of Regional Science Eotoos University1117BudapestPazmany Peter setany 1/CBudapestHungary

The study of human-environment relationships in mountain areas is important for both theoretical and practical reasons, as many mountain areas suffer similar problems, such as depopulation, unemployment and natural hazards. Medium mountains constitute a special case within mountains, because they are more populated but less attractive as tourist destinations than high mountains. In this context, the Apuseni Mts （Romania） are considered as a ease study. In this paper, we apply GIS-based, quantitative methods to characterize the strength and dynamics of human-environment interactions, taking into consideration some environmental factors （elevation, relative height, slope, river distance, lithology, land cover, natural attractions） as well as historical population and recent tourism data. We found that population density has strong （r2〉0.8） relationships with all relief factors （elevation, relative height, slope, river distance）, and that best-fit functions are nonlinear. We outlined the varying demographic scenarios by elevation zones and interpreted the historically switching sign of population change versus elevation relationship. We demonstrated that lithology also has an impact on the spatial distribution of population, although it is not independent from the relief effect. The land cover of the mainly cultural landscape is very strongly correlated with relief parameters （especially slope）, which suggests good adaptation. We pointed out the dominance of karst objects in the natural tourism potential of the Apuseni Mts and also explored further components of real tourism （spas, heritage, towns）. Finally, we concluded that the environmental settings investigated do in fact constrain the spatial framework of society, but soeio-economic changes in history can be explained from the side of society, which conforms to the theory of cultural possibilism.

关键词： Human-environment relations ApuseniMountains Geographical information system (GIS) Possibilism Tourism Karst

On Modifications of Continuous and Discrete Maximum Principles for Reaction-Diffusion Problems

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Advances in Applied Mathematics and Mechanics 2011年第1期3卷 109-120页

作者： Istvan Farago Sergey Korotov tamas Szabo Department of Applied Analysis and Computational Mathematics Eotvos Lorand UniversityH–1117BudapestPazmany P.s.1/c.Hungary BCAM-Basque Center for Applied Mathematics Bizkaia Technology ParkBuilding 500E–48160 DerioBasque CountrySpain

In this work,we present and discuss some modifications,in the form of two-sided estimation(and also for arbitrary source functions instead of usual sign-conditions),of continuous and discrete maximum principles for th... 详细信息

关键词： Reaction-diffusion problem maximum principle discrete maximum principle monotone matrix two-sided a priori estimation code validification

Gemcitabine-induced haemolytic uremic syndrome,although infrequent,can it be prevented:A case report and review of literature

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World journal of Clinical Cases 2018年第12期6卷 531-537页

作者： Esther U Cidon Pilar A Martinez tamas Hickish Department of Medical Oncology Royal Bournemouth and Christchurch Hospital NHS Foundation Trust Department of Oncology Clinical University HospitalValladolid Department of Medical Oncology Royal Bournemouth and Christchurch Hospital NHS Foundation Trust and Bournemouth University

Gemcitabine is an antineoplastic used to treat several malignancies including pancreatic cancer. Its toxicity profile is well known with myelotoxicity, increased vascular permeability and peripheral oedema as most frequent adverse events. However, several cases of acute renal failure have been reported and haemolytic uremic syndrome(HUS) seems to be the underlying process. The cause of HUS remains unknown but its consequences can be lethal. Therefore, a high grade of suspicion is crucial to diagnose it and promptly treat it. This hopefully will reduce its morbidity. HUS is characterized by progressive renal failure associated with microangiopathic haemolytic anaemia and thrombocytopenia. The primary event is damage to endothelial cells and thrombotic microangiopathy(TMA) is the histopathological lesion. TMA affects mainly renal microvasculature. However, some cases evolve with central nervous or cardiovascular systems involvement. We present here a case of gemcitabine-induced HUS, with renal and cardiovascular system affected at the time of diagnosis which to our knowledge this is the first time of such case to be reported.

关键词： Thrombocytopenia Haemolytic uremic syndrome Thrombotic microangiopathy Gemcitabine Microangiopathic haemolytic anaemia