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Recent advances in magnetic electrospun nanofibers for cancer theranostics application

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Progress in Natural Science:Materials International 2021年第6期31卷 835-844页

作者： Paula I.P.Soares jo?o Paulo Borges CENIMAT/i3N Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa

Cancer theranostics is a recent concept that aims to combine in the same device diagnostic and therapeutic features. Magnetic nanoparticles(m NPs) are commonly used as a critical part of these systems due to their ability to respond to an external magnetic field. Consequently, m NPs can generate heat when an alternating magnetic field is applied and enhance image contrast in magnetic resonance. However, direct administration of m NPs intravenously or directly in the tumor can lead to undesired side effects because of m NP elimination by macrophages or leakage to healthy tissues. Therefore, m NPs can be retained in a polymeric nanofibrous mesh, thus preventing misplacing or loss of m NPs. Furthermore, these magnetic nanofibers can be directly implanted in the tumor site, thus ensuring high m NPs loading and higher magnetic response. In addition, polymeric nanofibers produced by electrospinning are frequently used to maintain a sustained drug release in the tumor site. Therefore,a magnetic polymeric nanofiber produced by electrospinning is an ideal nanosystem for cancer theranostics application. This review summarizes the most recent developments of magnetic nanofibers produced by electrospinning for cancer theranostics applications.

关键词： Electrospinning Nanofibers Iron oxide nanoparticles Magnetic fluid hyperthermia Cancer theranostics

A Novel Goodness of Fit Test Spectrum Sensing Using Extreme Eigenvalues

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Chinese journal of Electronics 2020年第6期29卷 1201-1206页

作者： LI He ZHAO Wenjing LIU Chang JIN Minglu YOO Sang-jo School of Information and Communication Engineering Dalian University of Technology Department of Information and Communication Engineering Inha University

The existing Goodness of fit(GoF) test based spectrum sensing algorithms mostly use samples or energies as observations to make decisions,which can hardly achieve satisfactory performance especially when the Primary user(PU) signals are highly ***,the eigenvalue of covariance matrix can reflect signal correlations *** by this,we study the distribution of eigenvalue and propose an eigenvalue based GoF spectrum sensing *** the proposed scheme,we use the ratios of maximum to minimum eigenvalue as observations and thus it can bring performance improvements through capturing correlation of PU *** also provide the related theoretical analysis for the proposed *** results show that the proposed method overcomes the problem of noise uncertainty and achieves performance improvement over the classical samples-based GoF test.

关键词： eigenvalue based GoF spectrum sensing algorithm GoF test based spectrum sensing algorithm primary user signal covariance matrix eigenvalue Radio links and equipment eigenvalues and eigenfunctions signal detection Algebra goodness of fit test spectrum sensing algorithm Linear algebra (numerical analysis) signal sampling signal denoising radio spectrum management correlation methods covariance matrices Signal detection signal correlation

The Development of Aerobic and Anaerobic Fitness with Reference to Youth Athletes

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journal of Science in Sport and Exercise 2020年第4期2卷 275-286页

作者： Neil Armstrong jo Welsman Children’s Health and Exercise Research Centre University of ExeterSt Lukes CampusHeavitree RoadExeter EX12LUUK

Purpose To challenge current conventions in paediatric sport science and use data from recent longitudinal studies to elu-cidate the development of aerobic and anaerobic fitness,with reference to youth ***(1)To critically review the traditional practice of ratio scaling physiological variables with body mass and,(2)to use multiplicative allometric models of longitudinal data,founded on 1053(550 from boys)determinations of 10-17-year-olds’peak oxygen uptake(VO2)and 763(405 from boys)determinations of 11-17-year-olds’peak power output(PP)and mean power output(MP),to investigate the development of aerobic and anaerobic fitness in *** The statistical assumptions underpinning ratio scaling of physiological variables in youth are seldom *** allometric modelling of longitudinal data has demonstrated that fat free mass(FFM)acting as a surrogate for active muscle mass,is the most powerful morphological influence on PP,MP,and peak *** FFM appropriately controlled for,age effects remain significant but additional,independent effects of maturity status on anaerobic and aerobic fitness are *** Ratio scaling of physiological variables with body mass is fallacious,confounds interpretation of the develop-ment of anaerobic and aerobic fitness,and misleads fitness comparisons within and across youth *** evalua-tion of the development of anaerobic and aerobic fitness in youth requires longitudinal analyses of sex-specific,concurrent changes in age-and maturation-driven morphological *** and maturation-driven changes in FFM are essential considerations when evaluating the physiological development of youth athletes.

关键词： Age Growth Maturation Multiplicative allometric modelling Peak oxygen uptake Peak power output

Pattern and antibiogram of urinary tract infection at the University of Port Harcourt Teaching Hospital

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Asian Pacific journal of Tropical Medicine 2010年第1期3卷 66-69页

作者： Wariso KT Siminialayi IM Odigie jo Department of Medical Microbiology and Parasitology College of Health SciencesUniversity of Port Harcourt Department of Pharmacology and Toxicology College of Health SciencesUniversity of Port Harcourt

Objective:To explore the prevalence,pathogenicity,and antibiotic susceptibility patterns of urinary tract infections at the University of Port Harcourt Teaching ***:Samples from 400 patients with a presumptive diagnosis of urinary tract infection including 250 non pregnant females and 150 males were used for this *** were distributed into two groups: children aged 2 to 17(Croup A) and adults aged 18 to 75(Croup B).The standard wire loop and agar diffusion technique were employed for culture and susceptibility testing,*** obtained were analysed using SPSS,version ***:30.0%of Group A and 41.0%of Group B had significant bacteriuria with 66.7%and 79.3%as females,*** commonest isolates cultured were Escherichia coli(32.8%),Staphylococcus aureus(17.2%),and Klebsiella spp.(16.4%).About 76.6%of isolates were sensitive to the fluorinated quinolones,31.2%to the aminoglycosides,and 22.7%to the urinary antiseptic,*** isolates were nonsensitive to tetracycline(93.8%),cotrimoxazole(92.2%),and nalidixic acid(86.7%).Most isolates showed non-uniform sensitivity patterns to the cephaloporins(cefuroxime and ceftazidime). Pseudomonas *** were generally resistant to the fluorinated ***: Though the fluorinated quinolones are still largely effective for empirical therapy in urinary tract infections,the importance of prior sensitivity testing in checking the emergence of bacterial antibiotic resistance can not be overemphasized.

关键词： Urinary tract infection Bacterial susceptibility Antibiotic resistance Port Harcourt

Effect of CaO addition on ignition behavior in molten AZ31 and AZ91D Magnesium alloys

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Rare Metals 2006年第Z2期25卷 155-159页

作者： LEE Jin-Kyu jo Hyung-Ho KIM Shae K. Department of Advanced Material Engineering Sungkyunkwan University 300 Chunchun-dong Jangan-gu Suwon Gyunggi-do 440-746 KoreaAdvanced Material Center Korea Institute of Industrial Technology 7-47 Songdo-dong Yeonsu-gu Incheon 406-840 Korea dvanced Material Center Korea Institute of Industrial Technology 7-47 Songdo-dong Yeonsu-gu Incheon 406-840 Korea

Mg alloys have been widely used in automobile and electronic industries because of high specific strength, good castability, etc. However, molten Mg alloys will burn rapidly in air if not protected. To solve this problem, the molten metal should be protected from oxidation by blanketing the surface with flux or protective gases. SF6 gas is widely used for Mg alloys as a cover gas and has proved to be a successful inhibitor. However, the use of SF6 gas is limited because of its high cost and its significant impact on non-global warming potential. Therefore, SF6 gas is being replaced by alternative protection gases. Recent studies show that there has been another attempt by adding CaO into Mg alloys. The aim of this study is to evaluate the effect of CaO on the minimum amount of protective gas, which is necessary not to make ignition in the molten AZ31 and AZ91 Mg alloys.

关键词： AZ91 AZ31 CaO clean production ignition resistance

Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases

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Cellular & Molecular Immunology 2018年第4期15卷 312-323页

作者： Maaike Cockx Mieke Gouwy jo Van Damme Sofie Struyf Laboratory of Molecular Immunology Department of Microbiology and ImmunologyRega Institute for Medical ResearchUniversity of LeuvenLeuven 3000Belgium

Patients with primary ciliary dyskinesia(PCD)and cystic fibrosis(CF),two inherited disorders,suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable *** present in high counts,neutrophils fail to clear infection in the *** levels of C-X-C motif chemokine ligand 8/interleukin-8(CXCL8/IL-8),the most potent chemokine to attract neutrophils to sites of infection,are detected in the sputum of both patient groups and might cause the high neutrophil influx in the ***,in CF,airway neutrophils are highly activated because of the genetic defect and the high levels of proinflammatory chemoattractants and cytokines(e.g.,CXCL8/IL-8,tumor necrosis factor-αand IL-17).The overactive state of neutrophils leads to lung damage and fuels the vicious circle of infection,excessive inflammation and tissue *** inflammatory process in CF airways is well characterized,whereas the lung pathology in PCD is far less *** knowledge of CF lung pathology could be useful to guide molecular investigations of the inflammatory processes in PCD *** available therapies can not completely remedy the chronic airway infections in these *** review gives an overview of the role that chemoattractants and cytokines play in these neutrophil-dominated lung ***,the most frequently applied treatments in CF and PCD and new experimental therapies to reduce neutrophil-dominated airway inflammation are described.

关键词： chemoattractants cystic fibrosis cytokines primary ciliary dyskinesia

Efficient Computation Offloading in Mobile Cloud Computing for Video Streaming Over 5G

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Computers, Materials & Continua 2019年第8期61卷 439-463页

作者： Bokyun jo MdJalil Piran Daeho Lee Doug Young Suh DEE Kyung Hee UniversityYongin17104South Korea DCSE Sejong UniversitySeoul05006South Korea

In this paper,we investigate video quality enhancement using computation offloading to the mobile cloud computing(MCC)*** objective is to reduce the computational complexity required to covert a low-resolution video to high-resolution video while minimizing computation at the mobile client and additional communication *** do so,we propose an energy-efficient computation offloading framework for video streaming services in a MCC over the fifth generation(5G)cellular *** the proposed framework,the mobile client offloads the computational burden for the video enhancement to the cloud,which renders the side information needed to enhance video without requiring much computation by the *** cloud detects edges from the upsampled ultra-high-resolution video(UHD)and then compresses and transmits them as side information with the original low-resolution video(e.g.,full HD).Finally,the mobile client decodes the received content and integrates the SI and original content,which produces a high-quality *** our extensive simulation experiments,we observed that the amount of computation needed to construct a UHD video in the client is 50%-60% lower than that required to decode UHD video compressed by legacy video encoding ***,the bandwidth required to transmit a full HD video and its side information is around 70% lower than that required for a normal UHD *** subjective quality of the enhanced UHD is similar to that of the original UHD video even though the client pays lower communication costs with reduced computing power.

关键词： 5G video streaming cloud computation offloading energy efficiency upsampling MOS

A study on the interference effects for tidal current power rotors

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Science China(Technological Sciences) 2010年第11期53卷 3094-3101页

作者： Chul-Hee jo Kang-Hee LEE Jin-Young YIM Department of Naval Architecture & Ocean Engineering Inha University

Due to global warming, the need to secure an alternative resource has become more important nationally. With the high tidal range of up to 9.7 m on the west coast of Korea, numerous tidal current projects are being planned and constructed. To extract a significant quantity of power, a tidal current farm with a multi-arrangement is necessary in the ocean. The rotor, which initially converts the energy, is a very important component because it affects the efficiency of the entire system, and its performance is determined by various design variables. The power generation is strongly dependent on the size of the rotor and the incoming flow velocity. However, the interactions between devices also contribute significantly to the total power capacity. Therefore, rotor performance considering the interaction problems needs to be investigated for generating maximum power in a specific field. This paper documents a performance study of devices considering the interference between rotating rotors with axial, transverse and diagonal arrangements.

关键词： TCP (tidal current power) renewable energy interference effect rotor CWC (circulation water channel) CFD (computational fluid dynamics)

Fracture Characteristics of Frit Bonding through In-Situ Nano-Indentation Testing

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journal of Materials Science & Technology 2016年第11期32卷 1204-1210页

作者： Won Je jo Hee-Jun Ahn jong Hyoung Kim Dongil Kwon Department of Materials Science and Engineering Seoul National University

Because frit bonding material is brittle, sudden impacts such as dropping may damage the bonding significantly. Strain-rate-controlled in-situ nano-indentation testing, which can determine localized material properties, was carried out on the frit-bonded specimen, especially on the frit bonding matrix and the filler. The results were compared with the drop-impact fracture behavior to understand the fracture characteristics. Mechanical properties at static condition or low strain rate did not show proper relationship with the fracture tendency of the drop tested result of the frit bonding. From the relationship between fracture toughness and the ratio of modulus/hardness, fracture characteristics at the drop impact situation could be estimated by the values at the high strain rate nano-indentation. The ratio between modulus and hardness on frit matrix showed close relationship with drop impact fracture. Though crack propagation path deflected at filler interface, filler property gave less influence on fracture tendency of drop impact fracture due to its small volume fraction. The properties of frit matrix were crucial to the fracture characteristics of the frit bonding.

关键词： Nanoindentation Bonding Fracture behavior