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Acute effect of moderate intensity physical exercise on postprandial hyperlipaemia of individuals with central obesity

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Health 2012年第12期4卷 1546-1550页

作者： Djeyne Silveira Wagmacker Karla Kurzendorff Souza Julia Vieira da Graca Geodania da Costa Barreto Paula Caroline Souza Macêdo tamara felix ferreira Ana M. Ladeia Bahian School of Medicine and Public Health Science Development Foundation of Bahia Bahia Brazil College of Adventist Bahia Bahia Brazil

Introduction: High postprandial triglyceride levels and obesity are associated with coronaropathy, and influence the pathogenesis and progression of atherosclerosis. Objective: To evaluate the effect of immediate acute physical exercise on postprandial hyperlipaemia in individuals with central obesity. Methods: Study included sedentary, normolipidemic individuals aged 18 - 30 years, with waist circumference >80 in for women and >94 for men. The physical exercise was performed for 45 minutes with 55% - 60% of the heart rate reserve. Triglyceride level tests were performed after fasting, and at time intervals of 1h and 3 h after lipid overload, a week before and immediately after a session of physical exercise. Results: Thirty-six individuals were evaluated (mean age 23.74 ± 4.05 years, 88.2% women, BMI = 28.4 ± 3.4). Fasting and post-prandial triglyceride levels were similar before and after the exercise (p = 0.87). A smaller rise in triglyceride levels was observed in the 1st hour in obese individuals (5%) compared with over-weight individuals (21%) p = 0.001. Conclusion: In individuals with central obesity, moderate intensity physical exercise performed immediately before lipid overload does not reduce the hyperlipidemic peak.

关键词： Postprandial Hyperlipaemia Exercise Central Obesity

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m6A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes

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Genes & Diseases 2023年第5期10卷 1751-1754页

作者： tamara Kleinbielen felix Olasagasti Elena Beristain Amparo Viguri-Díaz Isabel Guerra-Merino Africa García-Orad Marian Mde Pancorbo BIOMICs Research Group Lascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-GasteizAraba 01006Spain Bioaraba Health Research Institute Vitoria-GasteizAraba 01009Spain Department of Biochemistry and Molecular Biology University of the Basque CountryUPV/EHUVitoria-GasteizAraba 01006Spain Molecular Genetics Laboratory Araba University HospitalOsakidetza Basque Health ServiceVitoria-GasteizAraba 01009Spain Pathology Department Araba University HospitalVitoria-GasteizAraba 01009Spain Department of Genetics Physical Anthropology and Animal PhysiologyUniversity of the Basque Country(UPV/EHU)LeioaBizkaia 48940Spain BioCruces Bizkaia Health Research Institute BarakaldoBizkaia 48903Spain Department of Zoology and Animal Biology.University of the Basque Country(UPV/EHU) LeioaBizkaia 48940Spain

N6-methyladenosine(m6A)is the most abundant modification in eukaryotic messenger RNA.1 This modification is dynamic,reversible,and mediated by proteins characterized as methyltransferases and *** investigations have found that aberrant expression of methyltransferases and demethylases results in m6A dysregulation and,in consequence,affects the biological functions in which this modification is ***,m6A dysregulation affects the development and maintenance of various diseases,including cancer.2 For this reason,we explored the potential role that m6A modification has in invasive breast cancer of no special type(IBC-NST)and its molecular subtypes luminal A,luminal B HER2-,luminal B HER2+,HER2+,and triple-negative breast cancer(TNBC)whose degree of global m6A methylation has not yet been studied.

关键词： breast cancer HER2

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Nonalcoholic fatty liver disease-A multisystem disease?

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World Journal of Gastroenterology 2016年第43期22卷 9488-9505页

作者： Ivana Mikolasevic Sandra Milic tamara Turk Wensveen Ivana Grgic Ivan Jakopcic Davor Stimac felix Wensveen Lidija Orlic Department of Gastroenterology UHC Rijeka51000 Rijeka Croatia Department of Endocrinology Diabetes and Metabolic Diseases UHC Rijeka51000 Rijeka Croatia Department of Cardiology UHC Rijeka51000 Rijeka Croatia School of Medicine 51000 Rijeka Croatia Department of Histology and Embryology School of Medicine51000 Rijeka Croatia Department of Nephrology Dialysis and Kidney Transplantation UHC Rijeka51000 Rijeka Croatia

Non-alcoholic fatty liver disease(NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome(Met S). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of Met S. However, accumulating evidence indicates that the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease(CVD), diabetes mellitus type 2(T2DM) and chronic kidney disease(CKD). It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with Met S, such as insulin resistance, chronic systemic inflammation and dyslipidemia. As a result, they have been shown to be independent reciprocal risk factors. In addition, recent data have shown that NAFLD actively contributes to aggravation of the pathophysiology of CVD, T2 DM, and CKD, as well as several other pathologies. Thus, NAFLD is a direct cause of many chronic diseases associated with MetS, and better detection and treatment of fatty liver disease is therefore urgently needed. As non-invasive screening methods for liver disease become increasingly available, detection and treatment of NAFLD in patients with MetS should therefore be considered by both(sub-) specialists and primary care physicians.

关键词：不含酒精的脂肪肝疾病新陈代谢的症候群糖尿病 mellitus 类型 2 心血管的疾病长期的肾疾病 Multisystem 疾病

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