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Biomass responses to intraspecific competition differ between wild species and CO_(2)

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Journal of Plant Ecology 2008年第1期1卷 25-32页

作者： Xianzhong Wang Angela R.Ngigi Daniel L.Smith tamara M.McPeek Department of Biology Indiana University–Purdue University Indianapolis723 WestMichigan StreetIndianapolisIN 46202USA Department of Biological Sciences Butler University4600 Sunset AvenueIndianapolisIN 46208USA

Aims How growth of wild and crop species responds to global environmental perturbations has both ecological and agricultural significance in a changing *** primary aim of this synthesis was to quantitatively assess the interactive effects of intraspecific competition and elevated CO_(2) on biomass production in herbaceous *** Using meta-analytical techniques,we synthesized data from publications before 2006 that reported biomass responses to elevated CO_(2) in 321 herbaceous species grown in isolation or in competition with con-specific *** findings Intraspecific competition differentially modified biomass responses to elevated CO_(2) in wild and crop *** example,competition reduced CO_(2) stimulation of total biomass(WT)from 27 to 23%in wild species,but by a much greater magnitude,i.e.,from 43 to 32%in *** had no effect on responses of either above-(WAG)or below-ground(WBG)biomass to elevated CO_(2) in wild species,but significantly diminished CO_(2) enhancement of WAG,although not of WBG,in *** variations were found among functional groups in the modification of growth responses to elevated CO_(2) by intraspecific competition,which exerted greater depression on CO_(2) enhancement in C3 than in C4 species and in non-legumes than in *** CO_(2) affected leaf and stem growth of individually grown C3 graminoids and forbs similarly,but increased leaf growth only in C4 graminoids and stem growth only in C4 *** from this synthesis demonstrated that intraspecific competition differentially affected growth responses to elevated CO_(2) in wild and crop *** wildcrop species differences will have important implications for understanding primary production by herbaceous species in both natural and agricultural ecosystems in the future when atmospheric CO_(2) is significantly higher than the current level.

关键词： biomass production CO_(2)enrichment functional groups meta-analysis

Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

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Neural Regeneration Research 2023年第7期18卷 1450-1456页

作者： tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires Department of Physiological Sciences Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Laboratory of Molecular and Behavioral Neurobiology Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Department of Biochemistry and Immunology Institute o Biological SciencesUniversidade Federal de Minas GeraisAvenida Antônio CarlosBelo HorizonteBrazil

Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 ***’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic *** addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-*** it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s *** addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative *** such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s *** enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating *** this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic *** describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease.

关键词： acetylcholine brain-derived neurotrophic factor dopamine environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor glutamate molecular mechanisms Parkinson’s disease

Minimum invasive associating liver partition and portal vein ligation for staged hepatectomy

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第1期3卷 1-5页

作者： Michal Kawka tamara M.H.Gall Long R.Jiao Hepato-pancreato-biliary Surgical Unit Department of Surgery&CancerImperial CollegeHammersmith Hospital CampusLondonW120HSUnited Kingdom

Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has gained interest,as the potential alternative to portal vein embolisation for inducing future liver remnant hypertrophy in patients at risk of post-hepatectomy liver failure but is associated with high morbidity and *** a result,several variant ALPPS have been reported to reduce ALPPS related morbidity and *** is able to induce more extensive hypertrophy in a shorter time-period than portal vein ***-invasive surgery,which has known benefits with regards to morbidity and mortality,has also been applied to ALPPS,with promising results regarding safety and feasibility and patient *** suggests that both laparoscopic and robot-assisted ALPPS present technically feasible and safe options for ***-invasive ALPPS offers a clear benefit to patients,including reduction of fibrous adhesions,shorter length of hospital stay,and lower ***,the technical difficulty of the procedure still limits its wide application,even to experienced hepato-pancreato-biliary centres.

关键词： ALPPS Robotic hepatectomy Laparoscopic hepatectomy Staged liver resection

Ultra-processed food targets bone quality via endochondral ossification

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Bone Research 2021年第2期9卷 200-212页

作者： Janna Zaretsky Shelley Griess-Fishheimer Adi Carmi tamara Travinsky Shmul Lior Ofer Tali Sinai Svetlana Penn Ron Shahar Efrat Monsonego-Ornan School of Nutrition Science Institute of BiochemistryFood Science and NutritionThe Hebrew UniversityRehovot 76100Israel Koret School of Veterinary Medicine The Robert H.Smith Faculty of AgricultureFoodand EnvironmentThe Hebrew UniversityRehovot 76100Israel

Ultra-processed foods have known negative implications for health;however,their effect on skeletal development has never been ***,we show that young rats fed ultra-processed food rich in fat and sugar suffer from growth retardation due to lesions in their tibial growth *** bone mineral density decreases significantly,and the structural parameters of the bone deteriorate,presenting a sieve-like appearance in the cortices and poor trabecular parameters in long bones and *** results in inferior mechanical performance of the entire bone with a high fracture *** sequence analysis of the growth plates demonstrated an imbalance in extracellular matrix formation and degradation and impairment of proliferation,differentiation and mineralization *** findings highlight,for the first time,the severe impact of consuming ultra-processed foods on the growing *** pathology extends far beyond that explained by the known metabolic effects,highlighting bone as a new target for studies of modern diets.

关键词： consuming sugar skeleton

Automatic Anomaly Monitoring in Public Surveillance Areas

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Intelligent Automation & Soft Computing 2023年第3期35卷 2655-2671页

作者： Mohammed Alarfaj Mahwish Pervaiz Yazeed Yasin Ghadi tamara al Shloul Suliman A.Alsuhibany Ahmad Jalal Jeongmin Park Department of Electrical Engineering College of EngineeringKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Computer Science Bahria UniversityIslamabadPakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain15551UAE Department of Humanities and Social Science Al Ain UniversityAl Ain15551UAE Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Computer Science Air UniversityIslamabadPakistan Department of Computer Engineering Korea Polytechnic University237 Sangidaehak-ro Siheung-siGyeonggi-do15073Korea

With the dramatic increase in video surveillance applications and public safety measures,the need for an accurate and effective system for abnormal/sus-picious activity classiﬁcation also *** it has multiple applications,the problem is very *** this paper,a novel approach for detecting nor-mal/abnormal activity has been *** used the Gaussian Mixture Model(GMM)and Kalmanﬁlter to detect and track the objects,*** that,we performed shadow removal to segment an object and its *** object segmentation we performed occlusion detection method to detect occlusion between multiple human silhouettes and we implemented a novel method for region shrinking to isolate occluded *** c-mean is utilized to verify human silhouettes and motion based features including velocity and opticalﬂow are extracted for each identiﬁed *** Wolf Optimizer(GWO)is used to optimize feature set followed by abnormal event classiﬁcation that is performed using the XG-Boost classiﬁ*** system is applicable in any surveillance appli-cation used for event detection or anomaly *** of proposed system is evaluated using University of Minnesota(UMN)dataset and UBI(Uni-versity of Beira Interior)-Fight dataset,each having different type of *** mean accuracy for the UMN and UBI-Fight datasets is 90.14%and 76.9%*** results are more accurate as compared to other existing methods.

关键词： Abnormal event classiﬁcation gray wolf optimizer region shrinking xg-boost classiﬁer

Fungal Bioactive Compounds with Antiviral Effect

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Journal of Pharmacy and Pharmacology 2015年第8期3卷 357-371页

作者： tamara Teplyakova Tatiana Kosogova State Research Center of Virology and Biotechnology Vector Koltsovo Novosibirsk Region 630559 Russia

Basidial fungi have long been known as sources of antitumor compounds such as polysaccharides. Studies conducted by scientists from different countries demonstrate that polysaccharides and other fungal compounds （proteins, glycoproteins, terpenoids, melanins, nucleosides, etc.） exhibit antiviral activity against many viruses pathogenic for humans. The review presents data on the studied antiviral activities of higher basidial fungi against herpes, West Nile, influenza, human immunodeficiency and hepatitis viruses as well as orthopoxviruses including variola virus. Many species of basidial fungi and various classes of biologically active compounds obtained from them are capable of effectively inhibiting the development of viruses in cells and animals while possessing low toxicity. Biologically active compounds from the same fungal species can exhibit antiviral effects against different pathogens. Effective strains isolated from wild mushrooms in culture represent promising objects for the development of biotechnological drugs, including ones possessing antiviral activity. The data on antitumor and antiviral activities of compounds from the same fungal species indicate the correlation of these properties. In this connection, preparations of basidial fungi may have prophylactic value in preventing cancers of viral etiology.

关键词： Biologically active compounds basidial fungi pathogenic viruses antiviral activity.

m6A levels and expression of its modification genes show significant differences in breast cancer molecular subtypes

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Genes & Diseases 2023年第5期10卷 1751-1754页

作者： tamara Kleinbielen Felix Olasagasti Elena Beristain Amparo Viguri-Díaz Isabel Guerra-Merino Africa García-Orad Marian Mde Pancorbo BIOMICs Research Group Lascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-GasteizAraba 01006Spain Bioaraba Health Research Institute Vitoria-GasteizAraba 01009Spain Department of Biochemistry and Molecular Biology University of the Basque CountryUPV/EHUVitoria-GasteizAraba 01006Spain Molecular Genetics Laboratory Araba University HospitalOsakidetza Basque Health ServiceVitoria-GasteizAraba 01009Spain Pathology Department Araba University HospitalVitoria-GasteizAraba 01009Spain Department of Genetics Physical Anthropology and Animal PhysiologyUniversity of the Basque Country(UPV/EHU)LeioaBizkaia 48940Spain BioCruces Bizkaia Health Research Institute BarakaldoBizkaia 48903Spain Department of Zoology and Animal Biology.University of the Basque Country(UPV/EHU) LeioaBizkaia 48940Spain

N6-methyladenosine(m6A)is the most abundant modification in eukaryotic messenger RNA.1 This modification is dynamic,reversible,and mediated by proteins characterized as methyltransferases and *** investigations have found that aberrant expression of methyltransferases and demethylases results in m6A dysregulation and,in consequence,affects the biological functions in which this modification is ***,m6A dysregulation affects the development and maintenance of various diseases,including cancer.2 For this reason,we explored the potential role that m6A modification has in invasive breast cancer of no special type(IBC-NST)and its molecular subtypes luminal A,luminal B HER2-,luminal B HER2+,HER2+,and triple-negative breast cancer(TNBC)whose degree of global m6A methylation has not yet been studied.

关键词： breast cancer HER2

Nonalcoholic fatty liver disease-A multisystem disease?

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World Journal of Gastroenterology 2016年第43期22卷 9488-9505页

作者： Ivana Mikolasevic Sandra Milic tamara Turk Wensveen Ivana Grgic Ivan Jakopcic Davor Stimac Felix Wensveen Lidija Orlic Department of Gastroenterology UHC Rijeka51000 Rijeka Croatia Department of Endocrinology Diabetes and Metabolic Diseases UHC Rijeka51000 Rijeka Croatia Department of Cardiology UHC Rijeka51000 Rijeka Croatia School of Medicine 51000 Rijeka Croatia Department of Histology and Embryology School of Medicine51000 Rijeka Croatia Department of Nephrology Dialysis and Kidney Transplantation UHC Rijeka51000 Rijeka Croatia

Non-alcoholic fatty liver disease(NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome(Met S). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of Met S. However, accumulating evidence indicates that the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease(CVD), diabetes mellitus type 2(T2DM) and chronic kidney disease(CKD). It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with Met S, such as insulin resistance, chronic systemic inflammation and dyslipidemia. As a result, they have been shown to be independent reciprocal risk factors. In addition, recent data have shown that NAFLD actively contributes to aggravation of the pathophysiology of CVD, T2 DM, and CKD, as well as several other pathologies. Thus, NAFLD is a direct cause of many chronic diseases associated with MetS, and better detection and treatment of fatty liver disease is therefore urgently needed. As non-invasive screening methods for liver disease become increasingly available, detection and treatment of NAFLD in patients with MetS should therefore be considered by both(sub-) specialists and primary care physicians.

关键词： Nonalcoholic fatty liver disease Metabolic syndrome Diabetes mellitus type 2 Cardiovascular disease Chronic kidney disease Multisystem disease

Hydrochemical Peculiarities of Bog Ecosystems in the North-Siberian Lowland

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Journal of Water Resource and Protection 2010年第7期2卷 665-674页

作者： tamara Efremova Stanislav Efremov 不详

Surface waters of eutrophic bogs (fens) in the North-Siberian (Taimyr) lowland are characterized by hydrocarbonate, sulfate as well as hydro carbonate-sulfate calcium-magnesium composition. They relate to the type of oxygen waters, mainly, to the class of neutral weakly alkaline and to the family of ultrafresh and fresh waters and to the kind of waters poor with dissolved organic matter. Natural hydrochemical background of bog ecosystems makes in heavy metals in the first approximation: Co–0.16, Pb–0.57, Ni–4.67 and Cu–5.94 mkg/L. In most cases the surface waters are not polluted by heavy metals. Bog waters located in immediate closeness from Norilsk mining and smelting industrial complex are polluted by nickel at mid-level.

关键词： Bogs Hydrochemical Characteristics Heavy Metals Pollution