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Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta‑analysis,and meta‑regression

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World Journal of Pediatrics 2024年第4期20卷 340-352页

作者： tamara M.Hundscheid Silvia Gulden Mohamad F.Almutairi František Bartoš Giacomo Cavallaro Eduardo Villamor Division of Neonatology Department of PediatricsMosaKids Children’s HospitalMaastricht University Medical Center(MUMC+)School for Oncology and Reproduction(GROW)Maastricht UniversityP.Debyelaan 25.P.O.Box 58006202 AZ MaastrichtThe Netherlands Neonatal Intensive Care Unit Sant’Anna HospitalComoItaly Department of Psychology University of Amsterdam1001 NK AmsterdamThe Netherlands Neonatal Intensive Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly

Background Retinopathy of prematurity(ROP)is generally considered to be more frequent in males than in ***,it is not known whether sex differences in ROP affect all degrees of the condition,are global and have changed as neonatology has *** aimed to conduct a systematic review and meta-analysis of studies addressing sex differences in the risk of developing *** PubMed/MEDLINE and Embase databases were *** frequentist,random-effects risk ratio(RR)and 95%confidence interval(CI)were *** model averaged(BMA)meta-analysis was used to calculate the Bayes factors(BFs).The BF10 is the ratio of the probability of the data under the alternative hypothesis(H1)over the probability of the data under the null hypothesis(H0).Results We included 205 studies(867,252 infants).Frequentist meta-analysis showed a positive association between male sex and severe ROP(113 studies,RR=1.14,95%CI=1.07–1.22)but no association with any ROP(144 studies,RR=1.00,95%CI=0.96–1.03).BMA showed extreme evidence in favor of H1 for severe ROP(BF10=71,174)and strong evidence in favor of H0 for any ROP(BF10=0.05).The association between male sex and severe ROP remained stable over time and was present only in cohorts from countries with a high or high-middle sociodemographic *** Our study confirms the presence of a male disadvantage in severe ROP but not in less severe forms of the *** are variations in the sex differences in ROP,depending on geographical location and sociodemographic level of the countries.

关键词： Oxidative stress Retinopathy of prematurity Sex characteristics

Improving the Ambient Intelligence Living Using Deep Learning Classifier

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Computers, Materials & Continua 2022年第10期73卷 1037-1053页

作者： Yazeed Yasin Ghadi Mouazma Batool Munkhjargal Gochoo Suliman AAlsuhibany tamara al Shloul Ahmad Jalal Jeongmin Park Department of Computer Science and Software Engineering Al Ain UniversityAl Ain15551UAE Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science and Software Engieering United Arab Emirates UniversityAl Ain15551UAE Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Humanities and Social Science Al Ain UniversityAl Ain15551UAE Department of Computer Engineering Tech University of KoreaGyeonggi-do15073Korea

Over the last decade,there is a surge of attention in establishing ambient assisted living(AAL)solutions to assist individuals live *** a social and economic perspective,the demographic shift toward an elderly population has brought new challenges to today’s *** can offer a variety of solutions for increasing people’s quality of life,allowing them to live healthier and more independently for *** this paper,we have proposed a novel AAL solution using a hybrid bidirectional long-term and short-term memory networks(BiLSTM)and convolutional neural network(CNN)*** first pre-processed the signal data,then used timefrequency features such as signal energy,signal variance,signal frequency,empirical mode,and empirical mode *** convolutional neural network-bidirectional long-term and short-term memory(CNN-biLSTM)classifier with dimensional reduction isomap algorithm was then used to select ideal *** assessed the performance of our proposed system on the publicly accessible human gait database(HuGaDB)benchmark dataset and achieved an accuracy rates of 93.95 percent,*** reveal that hybrid method gives more accuracy than single classifier in AAL *** suggested system can assists persons with impairments,assisting carers and medical personnel.

关键词： Ambient assisted living convolutional neural network dimensionality reduction frequency-time features wearable technology

Regulation of Pathogen-Triggered Tryptophan Metabolism in Arabidopsis thaliana by MYB Transcription Factors and Indole Glucosinolate Conversion Products

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Molecular Plant 2016年第5期9卷 682-695页

作者： Henning Frerigmann Mariola Pislewska-Bednarek Andrea Sanchez-Vallet Antonio Molina Erich Glawischnig tamara Gigolashvili Pawel Bednarek Botanical Institute and Cluster of Excellence on Plant Sciences(CEPLAS) University of Cologne BioCenter Zulpicher Straβe 47b 50674 Cologne Germany Institute of Bioorganic Chemistry Polish Academy of Sciences Noskowskiego12/14 61-704 Pozna(n) Poland Centro de Biotecnologiay Genomica de Plantas Unlversidad Politecnica de Madrid Campus Montegancedo Pozuelo de Alarcon 28223 Madrid Spain Lehrstuhl for Genetik Technische Universitat Munchen Emil-Ramann-Str. 8 85354 Freising Germany ETH Zurich Department of Environmental Systems Science GHN H41 Universitatsstrasse 16 8092 Zurich Switzerland

MYB34, MYB51, and MYB122 transcription factors are known as decisive regulators of indolic glucosinolate （IG） biosynthesis with a strong impact on expression of genes encoding CYP79B2 and CYP79B3 enzymes that redundantly convert tryptophan to indole-3-acetaldoxime （IAOx）. This intermediate represents a branching point for IG biosynthesis, and pathways leading to camalexin and indole-carboxylic acids （ICA）. Here we investigate how these MYBs affect the pathogen-triggered Trp metabolism. Our experiments indicated that these three MYBs affect not only IG production but also constitutive biosynthesis of other IAOx- derived metabolites. Strikingly, the PENETRATION 2 （PEN2）-dependent IG-metabolism products, which are absent in myb34/51/122 and pen2 mutants, were indispensable for full flg22-mediated induction of other IAOx-dedved compounds. However, germ induction and accumulation of ICAs and camalexin upon path- ogen infection was not compromised in myb34/51/122 plants, despite strongly reduced IG levels. Hence, in comparison with cyp79B2/B3, which lacks all IAOx-derived metabolites, we found myb34/51/122 an ideal tool to analyze IG contribution to resistance against the necrotrophic fungal pathogen Plectosphaerella cucumerina. The susceptibility of myb34/51/122 was similar to that of pen2, but much lower than susceptibility of cyp79B2/B3, indicating that MYB34/51/122 contribute to resistance toward P. cucumerina exclu- sively through IG biosynthesis, and that PEN2 is the main leaf myrosinase activating IGs in response to microbial pathogens.

关键词： indolic glucosinate P/ectosphaere//a cucumerina MAMP-triggered immunity Trp metabolism indole-3-carboxylic acids camalexin

Grace at Arm＇s Length： The Cultural Importance of Utilizing ＂Expositive Puzzle＂ in Independent Film

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Journalism and Mass Communication 2017年第2期7卷 102-107页

作者： tamara Johnson Youngstown State University Youngstown Ohio USA

Many independent films provide a realistic interpretation of everyday events. Passive viewing techniques used by independent scriptwriters and filmmakers require active engagement from the viewer in order to interpret characters and/or events. The following proposes that the ＂expositive puzzle＂ is an example of these techniques. It uses the fim Short Term 12 in order to demonstrate how the ＂expositive puzzle＂ works and to encourage use in real-world interactions in order to avoid interaction based on stereotypes.

关键词： Independent film Short Term 12 character analysis film viewing techniques childhood abuse emotional trauma expositive puzzle

Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability

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Cellular & Molecular Immunology 2019年第10期16卷 837-840页

作者： Xin Xie Martin Endara-Coll Raza Mahmood Robertas Jankauskas tamara Gjorgjieva Piergiorgio Percipalle Science Division Biology ProgramNew York University Abu Dhabi(NYUAD)P.O.Box 129188 Abu DhabiUnited Arab Emirates Department of Molecular Biosciences The Wenner-Gren InstituteStockholm UniversitySE-10691StockholmSweden New York University Center for Genomics and Systems Biology NYUNew YorkNYUSA

Antiviral innate immunity acts as a defensive barrier to viral infection in both immune and nonimmune *** viral nucleic acids present in the cytoplasm after viral replication can activate sensors such as the RIG-I-lik... 详细信息

关键词： immunity immune stability

Esophageal metastasis of stem cell-subtype hepatocholangio carcinoma:Rare presentation of a rare tumor

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World Journal of Gastroenterology 2018年第7期24卷 870-875页

作者： Maeva Salimon Nicolas Chapelle tamara Matysiak-Budnik Jean-Francois Mosnier Eric Frampas Yann Touchefeu Institut des Maladies de l’Appareil Digestif Nantes University HospitalNantes 44000France Department of Pathology Nantes University HospitalNantes 44000France Department of Radiology Nantes University HospitalNantes 44000France

Hepatocholangiocarcinoma(c HCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable c HCC-ICC with stemcell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis. Histological and immunohistochemical analyses of biopsies from the esophageal lesion and the hepatic tumor confirmed the diagnosis of c HCC-ICC with a stem cell-subtype, according to the World HealthOrganization classification. After a multidisciplinary meeting, the patient was treated with chemotherapy. He received two cycles of a gemcitabine plus cisplatin regimen before bone progression, and he died 3 mo after the initial diagnosis.

关键词： Hepatocholangiocarcinoma Stem cellsubtype Esophageal metastasis Chemotherapy Gemcitabine plus platinum-based chemotherapy

Does playing a sports active video game improve object control skills of children with autism spectrum disorder?

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Journal of Sport and Health Science 2017年第1期6卷 17-24,127页

作者： Jacqueline Edwards Sarah Jeffrey tamara May Nicole J.Rinehart Lisa M.Barnett School of Health and Social Development Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Department of Paediatrics Faculty of MedicineDentistry and Health SciencesUniversity of MelbourneParkvilleVIC 3052Australia School of Psychology Faculty of HealthDeakin UniversityGeelongVIC 3125Australia Murdoch Childrens Research Institute ParkvilleVIC 3052Australia

Background: Active video games(AVGs) encourage whole body movements to interact or control the gaming system, allowing the opportunity for skill development. Children with autism spectrum disorder(ASD) show decreased fundamental movement skills in comparison with their typically developing(TD) peers and might benefit from this approach. This pilot study investigates whether playing sports AVGs can increase the actual and perceived object control(OC) skills of 11 children with ASD aged 6–10 years in comparison to 19 TD children of a similar *** was a secondary ***: Actual(Test of Gross Motor Development) and perceived OC skills(Pictorial Scale of Perceived Movement Skill Competence for Young Children) were assessed before and after the intervention(6 × 45 min).Results: Actual skill scores were not improved in either group. The ASD group improved in perceived skill. All children completed the required dose and parents reported the intervention was ***: The use of AVGs as a play-based intervention may not provide enough opportunity for children to perform the correct movement patterns to influence skill. However, play of such games may influence perceptions of skill ability in children with ASD, which could improve motivation to participate in physical activities.

关键词： Autism spectrum disorder Child Exergaming Fundamental movement skills Physical self-perception Xbox

Motifs and Impediments for the Harmonization of Accounting Regulations for Small and Medium-Sized Companies in the EU

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Chinese Business Review 2011年第11期10卷 1021-1027页

作者： tamara Cirkveni RRiF High School for Financial Management Zagreb Croatia

Small and medium-sized companies in most EU countries form a considerable share in the total number of companies and are also an important development impeller of the entire economy. Therefore, one of the most essential goals of accounting authorities in the EU is accomplishing the harmonization of accounting regulations for these companies. In this paper, the author have discussed and explained the main motifs and impediments for this harmonization. One of the main motifs is a big span and complexity of international standards of financial reports which is allowed and even prescribed in many countries. Some of the main impediments are a lack of uniformity as far as criteria for classification of small and medium-sized companies according to size are concerned as well as the determining of limitations up to which the requirements in accounting standards for small and medium-sized companies should be set.

关键词： IFRS for SMEs accounting regulation small and medium sized entities motifs impediments

Russian and English View on Lies in Conflict Dialogues—— Analysis of Conflict Communication Acts in Russian and English Fiction

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Journalism and Mass Communication 2012年第8期2卷 840-851页

作者： tamara Leontieva Vladivostok State University of Economics and Service Vladivostok Russia

What is a lie？ Why do people tell lies？ What compels them to make false utterances？ How do people treat lie, deception or fudge？ Is the attitude to them the same in different cultures？ If not, what differences are there？ An answer to these and some other questions is being sought in the paper. Producing a false utterance, the sender deprives the communication partner of the right to receive full information. The article presents views of Russians and representatives of Anglo-American culture on telling lies drawing the readers＇ attention to very serious situations, such as family conflicts between spouses, aggravated with lies. The material for analysis is taken from the texts by Russian playwright Anton Chekhov and the American novel writer Irwin Shaw. The analysis is based on the study of verbal and non-verbal markers of false utterances generated by quarreling spouses. A complex method of researching the literary material combining linguistic, extra-linguistic, and paralinguistic analysis of conflict speech acts with false utterances of different kinds is applied.

关键词： telling lies conflict situations false utterances speech act