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Herbicide-Resistant Mutations in Acetolactate Synthase Can Reduce Feedback Inhibition and Lead to Accumulation of Branched-Chain Amino Acids

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Food and Nutrition Sciences 2013年第5期4卷 522-528页

作者： Masaki Endo Tsutomu Shimizu tamaki Fujimori Shuichi Yanagisawa Seiichi Toki Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan Life Science Research Institute Kumiai Chemical Industry Co. Ltd. Shizuoka Japan Plant Genome Engineering Research Unit Agrogenomics Research Center National Institute of Agrobiological Sciences Tsukuba Japan

The branched-chain amino acids (BCAAs) valine, leucine and isoleucine are essential amino acids that are critical for animal growth and development. Animals need to obtain BCAAs from their diet because they cannot synthesize them. Plants are the ultimate source of these amino acids. Acetolactate synthase (ALS) is the first common enzyme in the biosynthesis of BCAAs. The metabolic control of BCAA biosynthesis involves allosteric regulation of ALS by the end-products of the pathway, i.e., valine, leucine and isoleucine. ALS holoenzyme seems to consist of two large catalytic subunits and two small regulatory subunits. In a previous study, using homologous recombination dependent gene targeting we created rice plants in which W548Land S627I mutations were induced into the endogenous gene encoding the ALS catalytic subunit. These two amino acid substitutions conferred hypertolerance to the ALS-inhibiting herbicide bispyripac-sodium. In this study, we revealed that feedback regulation by valine and leucine was reduced by these two amino acid substitutions. Furthermore, in leaves and seeds of ALS mutants with W548Land/or S627I substitution, a 2- to 3-fold increase in BCAAs was detected. Our results suggest that the ALS catalytic subunit is also involved in feedback regulation of ALS, and that judicious modification of the regulatory and catalytic subunits of ALS-coding genes by gene targeting can lead to the efficient accumulation of BCAA in plants.

关键词： Rice Acetolactate Synthase Herbicide-Resistance Branched-Chain Amino Acids

Development of Flexible Spherical Actuator with 3D Coordinate Measuring Device

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Journal of Flow Control, Measurement & Visualization 2018年第2期6卷 95-106页

作者： Yasuko Matsui Tetsuya Akagi Shujiro Dohta Wataru Kobayashi Hiroaki tamaki Graduate School of Engineering Okayama University of Science Okayama Japan

Rehabilitation devices help to recover the physical abilities of patients. This study aims to develop a portable rehabilitation device that is safe to use when?patients are holding it by hands. In a previous study, to realize a home rehabilitation device, a flexible spherical actuator that can provide motion to patients was developed. In this study, to measure the relative position between both handling stages, a 3D coordinate measuring device using three wire-type linear potentiometers and an embedded controller was proposed and tested. In this paper, the spherical actuator with built-in 3D coordinate measuring device is described. The measuring method and experimental results obtained are also presented. The tracking position control of the actuator using the measuring device was carried out. As a result, the position of the handling stages can be successfully controlled using the feedback signal from the tested?measuring device.

关键词： Flexible Spherical Actuator Flexible Pneumatic Cylinder 3D Coordinate Measuring Device Wire-Type Linear Potentiometer

Efficacy and Safety Assessment of Antifungal Sequential Therapy from Micafungin to Liposomal Amphotericin B for Antibiotics-Refractory Febrile Neutropenia in Patients with Hematologic Malignancies

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Advances in Microbiology 2023年第6期13卷 315-322页

作者： Kazunori Nakase Koji Oka Keiki Kawakami Tetsuya Tsukada Shigehisa tamaki Atsushi Fujieda Department of Personalized Cancer Immunotherapy Mie University Graduate School of Medicine Tsu Japan Department of Hematology and Oncology Mie University Hospital Tsu Japan Department of Internal Medicine Suzuka Kaisei Hospital Kameyama Japan Department of Internal Medicine Suzuka Chuo Hospital Suzuka Japan Department of Internal Medicine Takeuchi Hospital Tsu Japan Department of Internal Medicine Ise Red Cross Hospital Ise Japan

Invasive fungal infections are a major challenging problem in the management of febrile neutropenia (FN) in patients with hematologic malignancies. Liposomal amphotericin B (L-AmB) or micafungin (MCFG) has been widely used as a first-line empirical antifungal therapy for suspected fungal infection in such patients. However, there are several issues in patients receiving these agents: drug related toxicities for L-AmB and breakthrough fungal infections for MCFG. In order to make the best use of these 2 agents, we conducted a prospective study of sequential therapy from MCFG to L-AmB, and evaluated the efficacy and safety of this strategy in FN patients with hematologic malignancies. A total of 18 patients were enrolled, and 11 patients who fulfilled the protocol defined criteria were evaluated. Underlying diseases consisted of acute leukemia (n = 9), non-Hodgkin lymphoma (n = 1), and myelodysplastic syndrome (n = 1). Treatment success was achieved in 8 patients (72.7%). Drug-related adverse events occurred in 8 patients (72.7%). All of those adverse events except one case were below grade 2. Three patients required discontinuation of L-AmB. Although our empirical antifungal sequential therapy seems to be encouraging for antibiotics-refractory FN in patients with hematologic malignancies, further investigation in large-scale studies is warranted.

关键词： Empirical Antifungal Therapy Micafungin Liposomal Amphotericin B Febrile Neutropenia Hematologic Malignancy

The Outcome of Treatment for Patients with Borrmann Type 4 Advanced Gastric Cancer

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Journal of Cancer Therapy 2016年第12期7卷 953-962页

作者： Rie tamaki Fumio Amano Tohru Hashida Hironaga Satake Hisateru Yasui Akihito Tsuji Clinical Trial Management Center Kobe City Medical Center General Hospital Kobe Japan Laboratory of Biodefense & Regulation Osaka University of Pharmaceutical Sciences Takatsuki Japan Department of Medical Oncology Kobe City Medical Center General Hospital Kobe Japan Department of Clinical Oncology Faculty of Medicine Kagawa University Takamatsu Japan

Introduction: The survival rate of patients with Borrmann type 4 advanced gastric cancer is extremely poor in comparison to patients with gastric cancers of other histological types. An optimal chemotherapeutic regimen has yet to be determined. Patients and Methods: We retrospectively examined the outcome of patients who were treated for Borrmann type 4 advanced gastric cancer from July 2011 and June 2015. Results: The data from 42 cases were collected for this study. Of the 42 cases, 13 cases (31.0%) were locally advanced and 29 cases (69.0%) were metastatic advanced. Median Overall Survival (OS) for locally advanced cancer was 29.6 months and for metastatic advanced cancer was 11.5 months. The presence or absence of peritoneal metastases did not affect survival (8.9 and 11.5 months, respectively;p = 0.831). In the 23 patients who received chemotherapy, S-1 plus cisplatin was prescribed as first-line treatment in 16 cases (69.5%). Other treatment regimens included capecitabine plus cisplatin and S-1 plus oxaliplatinin one each (4.3%), S-1 monotherapy in two (8.6%), and capecitabine monotherapy, paclitaxel, and docetaxel in one each (4.3%). We found no median OS difference between S-1 plus cisplatin and other treatments (20.7 and 19.3 months;p = 0.094). Conclusion: We found that S-1 plus cisplatin treatment does not improve OS in patients with Borrmann type 4 advanced gastric cancer compared with other chemotherapeutic regimens.

关键词： Gastric Cancer Adenocarcinoma Scirrhous Cisplatin Chemotherapy Metastasis

Circularly Polarized Light-Assisted Synthesis of Optically Active Polymers

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Circularly Polarized Light-Assisted Synthesis of Optically A...

A Large Calcifying Cystic Odontogenic Tumor Occupying the Maxillary Sinus: A Case Report and Review of Literature

The 5th Symposium on Molecular Chirality of Chinese Chemical Society & International Chiral Meeting

作者： tamaki NAKANO Yue WANG Nan XIAO Shun MURAKI Catalysis Research Center and Graduate School of Chemical Sciences and Engineering Hokkaido UniversityN 21W 10Kita-kuSapporo 001-8628Japan

＜正＞Polymers with helical chirality,in particular,areknown to feature excellent functions, including chiral recognition *** active helical polymers have been synthesized by asymmetric polymerization using complexes of chiral ligands and metallic species or by supramolecular interactions between polymer chains and external chiral molecules.* Herein,we report a novel method of preparation of an optically active artificial polymer with molecular chirality from an achiral source material using single-handed circularly polarized light（CPL）. The potential for use of CPL for the production of optically active materials was

关键词： helix circularly polarized light excited states fluorene

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Open Journal of Stomatology 2017年第5期7卷 291-298页

作者： Hiroshi Nakamura Shigehiro tamaki Nobuhiro Ueda Nobuhiro Yamakawa Yuichiro Imai Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University Nara Japan Department of Oral Surgery Takai Hospital Tenri Japan Department of Oral Surgery Rakuwakai Otowa Hospital Kyoto Japan

Calcifying cystic odontogenic tumor (CCOT) is an uncommon benign cystic neoplasm of the jaw that develops from the odontogenic epithelium. It is clinically characterized as a painless—slow-growing tumor that affects the maxilla as well as the mandible, and generally occurs in young adults in the third or fourth decade of life. Herein, we present the case of a 16-year-old Japanese boy who showed a CCOT in the maxillary sinus. Panoramic radiography showed a unilocular lesion in the left maxillary sinus. Computed tomography showed an approximately 5-cm well-defined unilocular expansile lesion with multiple radiopaque calcific specks, arising from the left maxillary alveolar ridge. The lesion was surgically removed, under general anesthesia, and the patient was followed up for 3 years after the surgery, and there have not been any signs of recurrence.

关键词： Calcifying Cystic Odontogenic Tumor Maxillary Sinus Ghost Cells

全球构造与边缘盆地的建造——太平洋西部的作用

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世界地震译丛 1994年第2期25卷 75-79页

作者： K.tamaki E.Honza 苏怡之国家地震局地壳应力研究所

1.引言自从 Karig(1971),Pacham 和 Falvey(1971),Sleep 和 Toks(?)z(1971)首次提出后弧盆地的概念以来,人们一直在对活动性大陆边缘的边缘盆地起源进行研究和讨论。然而,尽管板块构造理论问世以来,在短期内已解决了地质学和地球物理学... 详细信息

1.引言自从 Karig(1971),Pacham 和 Falvey(1971),Sleep 和 Toks(?)z(1971)首次提出后弧盆地的概念以来,人们一直在对活动性大陆边缘的边缘盆地起源进行研究和讨论。然而,尽管板块构造理论问世以来,在短期内已解决了地质学和地球物理学领域的大量问题。

关键词：太平洋边缘盆地全球构造

金刚石砂轮金属结合剂的气中单脉冲电火花放电去除机理

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机械工程学报 2007年第7期43卷 93-98页

作者：谢晋汤勇田牧纯一华南理工大学机械工程学院广州510640 北见工业大学微纳米加工学研究室

针对金属结合剂金刚石砂轮修锐困难的问题,提出采用气中电火花接触放电修锐的方法。为有效地实现微细金刚石砂轮的修锐,建立单脉冲电火花放电去除加工的试验系统,研究金属结合剂的气中和液中电火花放电去除机理。在试验研究中,主要分析... 详细信息

针对金属结合剂金刚石砂轮修锐困难的问题,提出采用气中电火花接触放电修锐的方法。为有效地实现微细金刚石砂轮的修锐,建立单脉冲电火花放电去除加工的试验系统,研究金属结合剂的气中和液中电火花放电去除机理。在试验研究中,主要分析无负荷电压和放电极性对脉冲放电电流、脉冲放电间隙、脉冲放电去除量、电极磨耗比等的影响。结果表明,正极性不易发生短路现象,而且气中的脉冲放电间隙小于液中的1/3-1/2,适应于微细金刚石砂轮的修锐。此外,在气中放电中存在由绝缘破坏引起的火花放电向附有电弧柱的电弧放电转变的临界无负荷电压,且电火花放电的去除量可以明显小于电弧放电的去除量,但是当无负荷电压小于某一定值时电极消耗比会快速增加。修锐的试验结果显示,利用气中单脉冲电火花放电去除加工条件可以实现金属结合剂微细金刚石砂轮的修锐,产生较好的砂轮出刃形貌,改善磨削表面质量。

关键词：金属结合剂金刚石砂轮单脉冲电火花放电加工火花放电电弧放电修锐

Structure-Function Relationship of a Gellan Family of Polysaccharide, S-198 Gum, Produced by Alcaligenes ATCC31853

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Advances in Biological Chemistry 2016年第3期6卷 55-69页

作者： Masakuni Tako Seiko kitajima Takuya Yogi Keiko Uechi Masayuki Onaga Yukihiro tamaki Shuntoku Uechi Department of Subtropical Bioscience and Biotechnology University of the Ryukyus Okinawa Japan Health and Longevity Research Laboratory Integrated Innovation Research Center University of the Ryukyus Okinawa Japan

The structure-function relationship of a gellan family of polysaccharides, S-198 gum produced by Alcaligenes ATCC31853 was investigated in terms of rheological aspects. The flow curves of S-198 gum showed plastic behavior above 0.3%. Gelation did not occur in S-198 gum solution at low temperature (0℃), even at 0.8%. Both the viscosity and the elastic modulus remained constant with increasing temperature up to 80?C. The elastic modulus decreased a little with the addition of CaCl2 (6.8 mM), but then once again remained constant up to 80℃. The highest elastic modulus was observed for deacylated gellan gum with the addition of CaCl2 and increased slightly with increasing temperature up to 80℃, which was considered to be a transition temperature, after which it decreased rapidly. The elastic modulus of S-198 gum in the presence of urea (4.0 M) was lower than that in aqueous solution at low temperature (0℃), but remained constant with increasing temperature up to 80℃. The intramolecular associations, (hydrogen bonding and van der Waals forces of attraction), of S-198 gum molecules in aqueous solutions were proposed. The gellan family of polysaccharides, S-198, S-88, S-657, rhamsan, welan and gellan gum, provided a good opportunity to investigate the structure-function relationship for polysaccharides.

关键词： S-198 Gum Alcaligenes ATCC31853 Thermal Stability Intramolecular Associations Gellan Family of Polysaccharide