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Shape design of cerium oxide nanoparticles for enhancement of enzyme mimetic activity in therapeutic applications

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Nano Research 2017年第1期10卷 199-217页

作者： tamaki Naganuma Research Center for Functional Materials National Institute for Materials Science 1- I Namiki Tsukuba Ibaraki Japan

Cerium oxide nanoparticles （CONPs）, widely used in catalytic applications owing to their robust redox reaction, are now being considered in therapeutic applications based on their enzyme mimetic properties such as catalase and super oxide dismutase （SOD） mimetic activities. In therapeutic applications, the emerging demand for CONPs with low cytotoxicity, high cost efficiency, and high enzyme mimetic capability necessitates the exploration of alternative synthesis and effective material design. This study presents a room temperature aqueous synthesis for low-cost production of shape-selective CONPs without potentially harmful organic substances, and additionally, investigates cell viability and catalase and SOD mimetic activities. This synthesis, at room temperature, produced CONPs with particular planes： {111}/{100} nanopolyhedra, {100} nano/submicron cubes, and {111}/{100} nanorods that grew in [110] longitudinal direction. Enzymatic activity assays indicated that nanopolyhedra with a high concentration of Ce4＋ ions promoted catalase mimetic activity, while nanocubes and nanorods with high Ce3＋ ion concentrations enhanced SOD mimetic activity. This is the first study indicating that shape and facet configuration design of CONPs, coupled with the retention of dominant, specific Ce valence states, potentiates enzyme mimetic activities. These findings may be utilized for CONP design aimed at enhancing enzyme mimetic activities in therapeutic applications.

关键词： super oxide dismutase(SOD) and catalasemimetic activity shape and facetconfiguration Ce valence states room temperature aqueoussynthesis

Bridging long gap peripheral nerve injury using skeletal muscle-derived multipotent stem cells

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Neural Regeneration Research 2014年第14期9卷 1333-1336页

作者： Tetsuro tamaki Muscle Physiology & Cell Biology Unit Department of Regenerative MedicineDivision of Basic Clinical ScienceTokai University School of Medicine Isehara Japan

Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells （Sk-MSCs） can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerve gap injury resulted favorable axonal regeneration, which showing superior effects than gold standard therapy--healthy nerve autograft. This means that it does not need to sacrifice of healthy nerves or loss of related functions for repairing peripheral nerve injury.

关键词： peripheral nerve support cells Schwann cells perineurium endoneurium cytokine,paracrine effect blood vessel formation

Degradation behaviors of nonylphenol ethoxylates by isolated bacteria using improved isolation method

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Journal of Environmental Sciences 2008年第9期20卷 1025-1027页

作者： Hideyuki tamaki Yoichi Kamagata Institute for Biological Resources and Functions National Institute of Advanced Industrial Science and Technology

Nonylphenol ethoxylate (NPEO)-degrading bacteria were isolated from activated sludge using an improved isolation method, and the corresponding degradation behaviours were investigated. Eight NPEO-degrading strains distributed in genera Pseudomonas, Sphingomonas, Sphingobium, Cupriavidus, Ralstonia, Achromobacter, and Staphylococcus were acquired. The latter five genera have never been reported for the degradation of NPEOs. Four degradation patterns were observed for the eight pure strains. In pattern A, NPE...

关键词： nonylphenol ethoxylate (NPEO) biodegradation ssolation method

Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury

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Neural Regeneration Research 2017年第11期12卷 1811-1813页

作者： Tetsuro tamaki Muscle Physiology&Cell Biology Unit Department of Human Structure and FunctionTokai University School of Medicine143 ShimokasuyaIseharaKanagawaJapan

An overview of a long-gap peripheral nerve therapy： A long- gap peripheral nerve transection injury is an irreparable injury to the living body, and mostly leads to permanent loss of re- lated motor and sensory functions. In such long gap injuries, nerve end-to-end suture is physically impossible. Therefore, bridging a long nerve-gap is critical to re-establish adequate mechanical support for separated nerve ends, and prevent the diffusion of neurotrophic and neurotropic factors secreted by transected stumps （Deumens et al., 2010）.

关键词： Therapeutic capacities of human muscle-derived stem cells

Tremor Associated with Muscle Fatigue Is Temporary and Beneficial: A Case Report

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Journal of Biomedical Science and Engineering 2022年第3期15卷 103-107页

作者： Hiroyuki tamaki Futoshi Ogita Department of Sports and Life Science National Institute of Fitness and Sports Kanoya Japan

Enhanced physiological tremor (EPT) associated with fatiguing static muscle contractions is generally thought to limit continuous muscle work. However, the EPT dies away, allowing the continuous muscle contraction to be maintained at low-level workload. Here, we report a case study of a 22-year-old male volunteer who performed static plantar flexion at 30% maximal voluntary contraction (MVC) for 66 min with repeated EPT events. Comparative analysis of 1 min pre- and post-EPT phases revealed lower electromyographic (EMG) activity, heart rate, and blood pressure levels during the post-EPT phases, while the popliteal artery blood-flow volume and vascular conductance were raised. EPT may therefore be a mechanism for removing factors that inhibit continuous muscle contraction. This unique case report provides new insight into the functional significance of EPT during prolonged static muscle contractions.

关键词： Enhanced Physiological Tremor Electromyography Blood Flow

Influence of volute distortion on the performance of turbocharger centrifugal compressor with vane diffuser

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Science China(Technological Sciences) 2013年第11期56卷 2778-2786页

作者： ZHENG XinQian JIN Lei tamaki Hideaki State Key Laboratory of Automotive Safety and Energy Tsinghua University Turbo Machinery and Engine Technology Department IHI Corporation

As the geometry of the volute of turbocharger compressor is non-axisymmetric,it causes a distortion at the outlet of the diffuser and influences the upstream components.A distortion model in which a pressure distortion was applied as outlet boundary condition was established to simulate the distortion induced by the *** turned out to be sufficient to impose a circumferentially asymmetric pressure distribution at the outlet of the diffuser to replace the *** on the distortion model which was verified,the influence of the amplitude of the distortion on the performance of centrifugal compressor was studied in *** results show that the distortion severely harms aerodynamic stability of the investigated *** larger the amplitude of the distortion,the worse the performance of the *** distortion induced by asymmetric volute propagates to upstream components and causes local flow separation at part of diffuser and impeller,and then causes the compressor *** the amplitude of the volute distortion is 10%,the stable flow range of the centrifugal compressor decreases to near *** authors’knowledge,the relationship between the compressor performance and distortion amplitude is first obtained quantitatively,which provides evidence to improve the performance of turbocharger compressor by decreasing the distortion induced by asymmetric volute.

关键词：离心压缩机涡轮增压器叶片扩压器蜗壳性能出口边界条件失真模型气动稳定性

Environmental pressure rather than ongoing hybridization is responsible for an altitudinal cline in the morphologies of two oaks

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Journal of Plant Ecology 2020年第4期13卷 413-422页

作者： Ichiro tamaki Yae Yamada Gifu Academy of Forest Science and Culture 88 SodaiMinoGifu 501-3714Japan

在相关类群之间的接触区,表型变异可能源于遗传和/或环境梯度。本研究旨在阐明两种栎属植物[Quercus crispula(QCC)和***(QCM)],在其接触区沿海拔梯度形成叶片形态表型变异的原因。对于源自接触区48个个体和QCC和QCM的每个参照种群24个... 详细信息

在相关类群之间的接触区,表型变异可能源于遗传和/或环境梯度。本研究旨在阐明两种栎属植物[Quercus crispula(QCC)和***(QCM)],在其接触区沿海拔梯度形成叶片形态表型变异的原因。对于源自接触区48个个体和QCC和QCM的每个参照种群24个个体样本,我们测定其6种叶片形态特征,同时记录13个核微卫星位点的基因型。我们通过构建模型解释表型变异(叶片形态)与环境(海拔)和遗传(参照种群世系)梯度的关系。研究结果表明,形态和遗传标记均能较好地区分参照种群中的两个品种。我们能够确认形态和遗传标记的作用。接触区种群内的个体具有略偏向QCM分支的中间世系,其形态分布与参照种群中两个变种的形态分布重叠。海拔会显著影响叶片形态性状,而遗传对叶片形态性状无显著影响。接触区种群的世系和种间杂合性分布与F2或后代杂交种中的分布相似。这些结果表明,在两种栎属植物QCC和QCM之间的接触区,并没有发生杂交,但环境压力通过表型可塑性和/或功能基因的变异,导致了其在形态性状上的海拔梯度效应。

关键词：栎属植物蒙古栎叶片形态微卫星杂交带

Highly flexible,mechanically strengthened metallic glass-based composite electrode with enhanced capacitance and cyclic stability

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Rare Metals 2022年第11期41卷 3717-3728页

作者： Yi Xu Pak Man Yiu Yu-Kun Wang Xiao-Meng Qin tamaki Shibayama Seiichi Watanabe Masato Ohnuma Da-Zhu Chen Hua Cheng Chan-Hung Shek Zhou-Guang Lu Chen Liu Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen518060China Department of Materials Science and Engineering City University of Hong KongHong Kong999077China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen518060China Division of Quantum Science and Engineering Faculty of EngineeringCentre for Advanced Research of Energy and MaterialsHokkaido UniversitySapporo0608628Japan Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen518060China

The design of flexible composite electrodes has become the top priority in energy storage devices for the development of future wearable intelligent ***,searching for fully integrated,ultrathin flexible composite electrodes with satisfying electrochemical performance is still a major ***,we introduce a nanoporous gold metallic glass(MG) ribbon-based composite electrode with excellent electric conductivity,mechanical flexibility,and extra capacitance by integrating polypyrrole(PPy) into wrinkled nanoporous ribbon(NPG@MG).The freestanding,ultrathin,highly conductive and flexible" nature of the composite electrode prevents the conducting polymer from structural instability resulting from the volume swell and shrink during the charging/discharging circulation,and the packed PPy provides protection for the wrinkled topology on the surface of the MG *** capacitance of pure NPG@MG-PPy composite electrode reached 393 mF·cm^(-2).The ultra-thin all-solid-state flexible supercapacitor demonstrates an excellent capacitance of 172 mF·cM^(-2)(14.8 F·cm^(-3)),accompanied by a superior cycling capability after 8000 charge/discharge cycles attributed to mechanical *** areal energy density also reached 0.74 mWh·cm^(-3)(9μWh·cm^(-2)) at a power density of 1 μW·cm^(-2).This work provides valuable concepts on the design of PPy-based hybrid materials for flexible energy storage systems with greatly enhanced electrochemical performances.

关键词： Metal-matrix composites(MMCs) Thin films Porosity Nano-structures

The Most Complete Pistosauroid Skeleton from the Triassic of Yunnan,China

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Acta Geologica Sinica(English Edition) 2008年第2期82卷 283-286页

作者： ZHAO Lijun tamaki SATO LI Chun Department of Earth Sciences Zhejiang University Hangzhou Zhejiang 310027 China Zhejing Museum of Natural History Hangzhou Zhejiang 310012 China Department of Natural Science Tokyo Gakugei University Nukui Kita-Machi 4-1-1 Koganei City Tokyo 184-8501 Japan Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

A new specimen discovered from the Falang Formation in northeastern Yunnan represents the most complete skeleton of Triassic pistosauroids. The new specimen is referred to Yunguisaurus Cheng et al., 2006 on the basis of the skull features, such as the presence of a separated nasal entering the external naris, a large pineal foramen located at the frontal/parietal suture and an interpterygoid vacuity with a narrow anterior extension. The new specimen differs from the type species of Yunguisaurus liae Cheng et al., 2006 in some aspects. Most of these differences can be attributed to ontogenetic variations. The new specimen is provisionally considered as Yunguisaurus cf. liae although its relatively short snout of the skull and slenderer hyoid may not be explained ontogenetically. Whether or not the new specimen represents a different taxon has to wait for a detailed study of the whole skeleton.

关键词： Pistosauroid Yunguisaurus complete skeleton Falang Formation late Middle Triassic,Yunnan