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Does Obesity without Hyperglycemia Delay Wound Healing in an Obese Mouse Model Induced by a High-Fat Diet?

Health 2017年第12期9卷 1660-1679页

作者： tamae urai Yukari Nakajima Kanae Mukai Kimi Asano Mayumi Okuwa Junko Sugama Toshio Nakatani Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative Kanazawa University Ishikawa Japan Department of Clinical Nursing Graduate Course of Nursing Science Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Ishikawa Japan Faculty of Health Sciences Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Ishikawa Japan

It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a splint. Three-week-old male mice (C57BL/6N) were fed high-fat diets (60% of calories from fat) in the obesity group, and commercial diets in the control group for 15 weeks. Two circular (4 mm in diameter) full-thickness wounds were made on the dorsal skin. Body weights and serum leptin levels were significantly higher in the obesity group than in the control group until day 15 after wounding. Fasting blood glucose levels before wounding were lower in the obesity group than in a hyperglycemic rodent model. The macrophage infiltration into subcutaneous fat before wounding in the obesity group was negligible. The ratios of the wound area were not significantly different between the two groups. No significant differences were observed in the number of neutrophils or macrophages or new blood vessels and ratio of myofibroblasts or collagen fibers between the two groups. Our results demonstrated that cutaneous wound healing was not delayed in the obesity group without hyperglycemia and macrophage infiltration into the subcutaneous fat and with high serum leptin levels.

关键词： Obesity Mouse Cutaneous Wound Healing Splint Inflammation

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The Relationship between Cutaneous Wounds Made on Obese Mice or Those with Decreased Body Weight and Serum Leptin Level

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Health 2016年第11期8卷 1015-1028页

作者： tamae urai Haryanto Kanae Mukai Tatsuhiko Matsushita Kimi Asano Yukari Nakajima Mayumi Okuwa Junko Sugama Toshio Nakatani Department of Clinical Nursing Graduate Course of Nursing Science Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Faculty of Health Sciences Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kan-azawa Japan Division of Clinical Radiology Service Kyoto University Hospital Kyoto Japan Wellness Promotion Science Center Institute of Medical Pharmaceutical and Health Sciences Kanazawa Uni-versity Kanazawa Japan

Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Three-week-old male mice were fed high-fat diets (containing 60% fat) in the diet group, and commercial diets in the control group, ad libitum for 15 weeks. Circle-full-thickness cutaneous wounds were made on the dorsal skin of mice. From day 0 to day 15 after wounding, we analyzed wound healing process. We measured the blood concentration of leptin, and observed the distribution of leptin-positive cells in each wound. Results: Mean body weight, the areas of subcutaneous fat and visceral fat, and the weight of epididymal fat in the diet group were significantly greater than those in the control group at 15 weeks after feeding. The diet group did not feed on the diet after wounding;their body weight decreased remarkably to the level of the control group. The ratio of wound area, re-epithelialization, and collagen fibers did not differ between the diet and control groups on each day. The blood concentration of leptin in the diet group was significantly greater than that in the control group before wounding and until day 6 after wounding (day 0, 10 hour and day 1: p < 0.01, day 6: p < 0.05). Conclusion: The results show that the wound healing process is similar between obese and non-obese mice, and that the decrease in the leptin level in the obese mouse to that in the non-obese mouse may depend on the decrease of body weight of obese mouse.

关键词： Obesity High-Fat Diet Wound Healing Leptin Tension

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Progress in the R&D Experiments About a Novel Method of Electr Scattering off Short-lived Nuclei

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Plasma Science and Technology 2012年第5期14卷 419-423页

作者：王硕 T. SUDA M. WAKASUGI T. tamae K. KURITA A. NODA T. SHIRAI H. TONGU Y. YANO School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University RIKEN Nishina Center Laboratory of Nuclear Science Tohoku University Department of Physics Rikkyo University Institute of Chemical Research Kyoto University

A novel method has been established to realize the experiment of electron scattering off short-lived nuclei. The method was based on the well known ＂ion trapping＂ phenomenon in electron storage rings. In the R^D experiments at Kyoto University, stable nucleus, 133^Cs, was employed as the target nucleus. The luminosity of scattering experiment was nearly 1026 cm^-2s^-1 at electron beam current around 75 mA. The angular distribution of elastically scattered electrons from trapped Cs ions was measured and the result was well fitted by theoretical calculation. It was indicated that higher luminosity can be reached with larger electron beam current.

关键词： electron scattering ion trapping luminosity angular distribution

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Energy calibration of tagged photons by the d(γ,π^-pp) reaction

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Chinese Physics C 2010年第1期34卷 35-38页

作者：韩运成 Nobuyuki Chiga Yu Fujii Kenta Futatsukawa Osamu Hashimoto Kentaro Hirose Takatsugu Ishikawa Hiroki Kanda Masashi Kaneta Daisuke Kawama Kazushige Maeda Tomofumi Maruta Nayuta Maruyama Akihiko Matsumura Youhei Miyagi Koji Miwa Satoshi N. Nakamura Hajime Shimizu Koutarou Shirotori Koutaku Suzuki Tadaaki tamae Hirokazu Tamura Kyo Tsukada 王铁山 Hirohito Yamazaki School of Nuclear Science and Technology Lanzhou University Department of Physics Tohoku University Laboratory of Nuclear Science Tohoku University

The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d（γ,π-pp） reaction. Charged pions and protons in the final state were detected with the Neutral Kaon Spectrometer （NKS2）. Photon energies were obtained from the reaction of d（γ,π-pp）. The derived photon energy was consistent with the design of the tagger system and the previous measurement using electron-positron pair production. The consistency demonstrates the performance of NKS2 and the capability of the photon energy calibration using d（γ,π-pp）.

关键词： deuteron pion photoproduction tagged photon

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Study of Charged Pion Photoproduction on Deuteron with Tagged Photons

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原子核物理评论 2009年第S1期26卷 83-87页

作者： N. Chiga Y. Fujii K. Futatsukawa O. Hashimoto K. Hirose T. Ishikawa H. Kanda M. Kaneta D. Kawama O. Konno K. Maeda T. Maruta N. Maruyama A. Matsumura Y. Miyagi K. Miwa S. N. Nakamura A. Sasaki H. Shimizu K. Shirotori K. Suzuki T. tamae H. Tamura K. Tsukada H. Yamazaki Department of Physics Tohoku University Laboratory of Nuclear Science Tohoku University Ichinoseki National College of Technology Department of Electrical and Electric Engineering Akita University

The reactions γd→π-pp and γd→npπ+π-have been studied in an energy range from 0.8 to 1.1 GeV at the tagged photon facility of Laboratory of Nuclear Science,Tohoku University. Charged pions and protons in the final state were measured by using the Neutral Kaon Spectrometer (NKS2). The analysis of the γd→π-pp was mainly used to check the acceptance of the NKS2 and to calibrate the tagged photon energy. The photoproduction of the Δ++Δ-was identified in the γd→npπ+π-reaction. Since the data analyses are still in progress,we issue an interim report and preliminary results.

关键词： deuteron double delta pion photoproduction

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