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World Journal of Gastroenterology 2014年第11期20卷 2995-3001页

作者： Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc nagy Zoltán Szepes noémi Vass Lajos S Kiss Tibor Wittmann tamás Molnár First Department of Medicine University of SzegedH6720 SzegedHungary First Department of Medicine Semmelweis UniversityH1088 BudapestHungary Department of Medical Physics and Informatics University of SzegedH6720 SzegedHungary Faculty of Medicine Pediatrics DepartmentUniversity of SzegedH6720 SzegedHungary

AIM: To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn... 详细信息

关键词： Crohn’ s disease, Ulcerative colitis, Biological therapy, Endoscopy, Mucosal healing

Should we resect colorectal cancer in patients over the age of 85?

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World Journal of Gastrointestinal Oncology 2021年第3期13卷 185-196页

作者： David E Flynn Derek Mao Stephanie Yerkovich Robert Franz Harish Iswariah Andrew Hughes Ian Shaw Diana tam Manju Chandrasegaram Department of General Surgery The Prince Charles HospitalChermside 4032QueenslandAustralia Department of General Surgery The Prince Charles HospitalBrisbane 4032QueenslandAustralia The Common Good Foundation The Prince Charles HospitalBrisbane 4032QueenslandAustralia

BACKGROUnD The prevalence of colorectal cancer in the elderly is rising,with increasing numbers of older patients undergoing ***,there is a paucity of information on the surgical outcomes and operative techniques used in this *** To evaluate the post-operative outcomes for patients≥85 years old following colorectal cancer resection as well as evaluating the outcomes of laparoscopic resection of colorectal cancer in patients over *** Patients who underwent colorectal cancer resection at our institution between January 2010 and December 2018 were *** study was divided into two *** part one,patients were divided into two groups based on age:Those age≥85 years old(n=48)and those aged 75-84 years old(n=136).Short term surgical outcomes and clinicopathological features were compared using appropriate parametric and non-parametric *** part two,patient’s over 85 years old were divided into two groups based upon operative technique:Laparoscopic(n=37)vs open(n=11)colorectal ***-term postoperative outcomes of each approach were *** The median length of stay between patients over 85 and those aged 75-85 was eight days,with no statistically significant difference between the groups(P=0.29).no significant difference was identified between the older and younger groups with regards to severity of complications(P=0.93),American Society of Anaesthesiologists grading(P=0.43)or 30-d mortality(2%vs 2%,P=0.96).Patients over 85 who underwent laparoscopic colorectal resection were compared to those who underwent an open *** median length of stay between the groups was similar(8 vs 9 d respectively)with no significant difference in length of stay(P=0.18).There was no significant difference in 30-d mortality rates(0%vs 9%,P=0.063)or severity of complication grades(P=0.46)between the laparoscopic and open surgical *** no significant short term surgical differences were identified in patients≥

关键词： Aged Colorectal neoplasms General surgery Open abdomen techniques Laparoscopy Colorectal surgery

Hybrid Procedure Utilizing Stent Grafts to Stabilize Distal Flaps after Common and Superficial Femoral Endarterectomy

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Surgical Science 2015年第3期6卷 109-115页

作者： David V. pham Bogdan Protyniak Samuel Hui Ryan n. Cappa George Constantinopoulos Department of Surgery Monmouth Medical Center Long Branch USA School of Medicine St. George’s University St. George’s Grenada

Background: Endarterectomy has long been the standard for common femoral artery (CFA) occlusive disease. Hybrid procedures utilizing endovascular and open techniques have recently been used for revascularization. The purpose of this study was to evaluate the effectiveness of the use of a stent graft to stabilize the distal flap and prevent further dissection after extensive endarterectomy. Methods: All patients from Monmouth Medical Center in Long Branch, nJ from September 2008 to March 2013 who underwent an extensive common and superficial femoral (SFA) endarterectomy combined with the use of a Viabahn (Gore Medical) stent graft to stabilize the distal flap were included in the study. These stents were deployed in the proximal SFA after extensive endarterectomy, under direct visualization, without the aid of fluoroscopy. Due to the location in the SFA, these flaps were not amenable to suture tacking. Results: Fifteen patients met these criteria and were included in our study. Twelve patients underwent femoral endarterectomy for severe claudication and three patients for limb salvage. Technical success was achieved in all 15 patients. Five patients also had stents placed proximally to increase inflow and one patient had an additional stent placed distally to improve outflow. There were no intraoperative or postoperative complications. Conclusion: Stent graft placement allows a more extensive endarterectomy to be performed by stabilizing the distal flap allowing a safe transition into the true lumen that is not possible with suture tacking.

关键词： Common Femoral Endarterectomy Superficial Femoral Endarterectomy Stent Graft Distal Flap Vollmar Ring Dissector Viabahn Stent

Stress Analysis of Bolted Joints Part II. Contact and Slip Analysis of a Four Bolt Joint

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Modern Mechanical Engineering 2014年第1期4卷 46-55页

作者： László Molnár Károly Váradi János Holubán Andor tamási Department of Machine and Product Design Budapest University of Technology and Economics Budapest Hungary

For up-to-date bolted joints, first of all in vehicles, high strength bolts of 10.9 or even 12.9 are used, which are preloaded up to 90% or even 100% of the yield strength. The primary aim of this high degree utilization is the weight reduction. For the analytic dimensioning of bolted joints, the VDI 2230 Richtlinien German standard [1] provides support. However, the analytic model can mostly consider the true structural characteristics only in a limited way. The analytic modeling is especially uncertain in case of multiple bolted joints when the load distribution among the bolts depends reasonably upon the elastic deformation of the participating elements in the joints over the geometry of the bolted joint. The first part of this paper deals with the problems of numerical modeling and stress analysis, respectively specifying the analytic dimensioning procedure by applying elastic or rather elastic-plastic material law. The error magnitude in bolted joint calculation was examined in case of omitting the existing threaded connection—between the bolt and the nut—in order to simplify the model. The second part of the paper deals with the dimensioning of stands and cantilevers’ multi-bolt fixing problems, first of all, with the load distribution among the bolts keeping in view the analysis of the local slipping relations. For demonstrating the above technique, an elaborated numeric procedure is presented for a four-bolted cantilever, having bolted joints pre-tightened to the yield strength.

关键词： Bolted Joints numerical Modeling Stress Analysis

机器人轨迹跟踪的间接自适应模糊控制(英文)

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控制理论与应用 2004年第5期21卷 748-756,764页

作者：吴玉香王灏毛宗源 Peter K.S.tam 华南理工大学自动化科学与工程学院广东广州510640 香港理工大学

为把已有的模糊控制算法应用于多自由度机器人的实时控制中,将间接自适应模糊控制算法从单输入单输出(SISO)系统推广至多输入多输出(MIMO)系统,并给出了系统收敛的严格数学证明.另外对于n关节的机器人轨迹跟踪问题,设计了一种新型控制... 详细信息

为把已有的模糊控制算法应用于多自由度机器人的实时控制中,将间接自适应模糊控制算法从单输入单输出(SISO)系统推广至多输入多输出(MIMO)系统,并给出了系统收敛的严格数学证明.另外对于n关节的机器人轨迹跟踪问题,设计了一种新型控制器能够保证系统的最终一致有界性(u.u.b.).通过对具有远程独立电机驱动的双连杆机械臂的仿真试验证明了该方案的可行性.

关键词：轨迹跟踪机器人自适应模糊控制机械臂远程系统实时控制一致有界性收敛数学证明

Effect of fly ash and slag on concrete:Properties and emission analyses

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Frontiers of Engineering Management 2019年第3期6卷 395-405页

作者： Vivian W.Y.tam Khoa n.LE Ana Catarina Jorge EVAnGELISTA Anthony BUTERA Cuong n.n.TRAn Ashraf TEARA College of Civil Engineering Shenzhen UniversityShenzhen 518061China Western Sydney University School of ComputingEngineering and MathematicsLocked Bag 1797PenrithNSW 2751Australia

Recycled concrete is a material with the potential to create a sustainable construction ***,recycled concrete presents heterogeneous properties,thereby reducing its applications for some structural purposes and enhancing its application in *** paper provides an insight into a solution in the deformation control for recycled concrete by adding supplementary cementitious materials fly ash and blast furnace *** of this study indicated that the 50%fly ash replacement of Portland cement increased the rupture modulus of the recycled ***,a mixture with over 50%cement replacement by either fly ash or slag or a combination of both exhibited detrimental effect on the compressive strength,rupture modulus,and drying *** combined analysis of environmental impacts and mechanical properties of recycled concrete demonstrated the possibility of optimizing the selection of recycled concrete because the best scenario in this study was obtained with the concrete mixture M8(50%of fly ash+100%recycled coarse aggregate).

关键词： recycled aggregate recycled concrete fly ash and slag

糖尿病肾病大鼠原代肾小管上皮细胞的提取及体外培养

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广西医学 2024年第4期46卷 535-542页

作者：王慧玲黄国东陈宇刘少芳王龙龙范氏泰和广西中医药大学附属国际壮医医院肾病科广西南宁市530201 广西中医药大学研究生院广西南宁市530200

目的探讨糖尿病肾病(Dn)大鼠原代肾小管上皮细胞(RTECs)的提取及体外培养方法。方法取SD雄性大鼠25只,随机分为正常组(n=5)和模型组(n=20)。对模型组大鼠构建Dn大鼠模型,不给予正常组任何处理。获取两组大鼠双肾组织,一部分组织用于HE... 详细信息

目的探讨糖尿病肾病(Dn)大鼠原代肾小管上皮细胞(RTECs)的提取及体外培养方法。方法取SD雄性大鼠25只,随机分为正常组(n=5)和模型组(n=20)。对模型组大鼠构建Dn大鼠模型,不给予正常组任何处理。获取两组大鼠双肾组织,一部分组织用于HE染色及Masson染色以观察肾组织结构,另一部分用于RTECs的提取及培养。RTECs的提取、培养方法:将肾皮质组织在80目筛网上研磨,经100目筛网过滤、Ⅰ型胶原酶消化25 min后,使用含10%胎牛血清、1%胰岛素⁃转铁蛋白⁃硒⁃乙醇胺添加剂和1%青链霉素双抗溶液的DMEM/F-12完全培养基培养细胞。用免疫荧光染色法检测细胞角蛋白18的表达情况以鉴定所获得的细胞。结果(1)建模后模型组大鼠出现多饮、多食、多尿、体重下降、血糖升高等特征,尿蛋白定性呈阳性,肾组织病理检测提示肾小球结构不完整且出现明显缺损,RTECs明显肿胀、变性,肾小管管腔萎缩,肾小管间质纤维化严重。(2)培养72 h后,两组RTECs均已经贴壁并呈岛屿状聚集生长,培养5~8 d后细胞呈多边鹅卵石样。模型组RTECs高表达细胞角蛋白18,阳性率>95%。结论采用在80目筛网上研磨、100目筛网过滤、Ⅰ型胶原酶消化25 min的方法可以得到数量较多、活性良好、纯度较高的Dn大鼠模型RTECs,且在形态与贴壁情况方面与正常大鼠RTECs无明显差异。

关键词：糖尿病肾病肾小管上皮细胞原代细胞细胞提取细胞鉴定大鼠

Real-Time Optimization of Irrigation Scheduling in Agriculture 25th

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Real-Time Optimization of Irrigation Scheduling in Agricultu...

Synthesis and characterization of naYF4:Yb3+,Er3+@silica-n=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

第25届中国控制与决策会议

作者： M.H.pham S.K.Saleem n.Okello national ICT Australia （nICTA） Department of Electrical and Electronic Engineering University of Melbourne

ISBN: (纸本)9781467355339

A simulation optimization approach is developed for managing irrigation operations in agriculture. The approach combines a highly complex crop growth and yield simulation model with an optimization algorithm to calculate an irrigation sequence that maximizes crop yield. The approach overcomes the limitations of many existing irrigation scheduling optimization methods that rely on simpler but more inaccurate crop growth and yield models to ensure computational tractability. The performance of the approach is demonstrated through simulation.

关键词： Optimization simulations of biological systems irrigation scheduling dynamical model FAO Crop Model (AquaCrop).

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： Ha Thi Phuong Tran Thu Huong Le Thi Vinh Hoang Thi Khuyen Do Thi Thao nguyen Thanh Huong pham Thi Lien Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized naYF4:Yb^3+,Er^3+for biomedical *** synthesis,these naYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized naYF4:Yb^3+,Er^3+@silica-n=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of naYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized naYF4:Yb^3+,Er^3+@silica-n=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide naYF4:Er^3+,Yb^3+@silica-n=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence naYF4:Yb^3+,Er^3+ nanophosphors Bioimaging Cancer cell Rare earths

Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease

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World Journal of Gastrointestinal Surgery 2017年第7期9卷 167-173页

作者： Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc nagy Klaudia Farkas tamás Molnár First Department of Internal Medicine University of Szeged Department of Pathology University of Szeged Department of Surgery University of Szeged Department of Medical Physics and Informatics University of Szeged

AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative *** Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.

关键词： Submucosal plexitis Postoperative recurrence Crohn’s disease Stricturing disease behavior Isolated ileal disease