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Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis

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World Journal of Gastroenterology 2004年第15期10卷 2275-2277页

作者： Péter Hegyi Zoltán RakonczayJr Réka Sári László Czakó norbert Farkas Csaba Góg József németh János Lonovics tamás Takács First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary Jr.School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary

AIM:In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8),the process of regeneration following L-arginine (Arg)-induced pancreatitis is *** rats that were also diabetic(induced by streptozotocin,STZ),pancreatic regeneration was not *** aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats. METHODS:Male Wistar rats were used for the experiments. Diabetes mellitus was induced by administering 60mg/kg body mass of STZ intraperitoneally(i.p.),then,on d 8, pancreatitis was induced by 200mg/100 g body mass Arg *** at an interval of 1 *** animals were injected subcutaneously twice daily(at 7 *** 7 p.m.)with 1 μg/kg of CCK-8 and/or 2 IU mixed insulin(300g/L short- action and 700g/L intermediate-action insulin) for 14 d after pancreatitis *** this the animals were killed and the serum amylase,glucose and insulin levels as well as the plasma glucagon levels,the pancreatic mass/body mass ratio(pm/bm),the pancreatic contents of DnA,protein,amylase,lipase and trypsinogen were *** tissue samples were examined by light microscopy on paraffin-embedded sections. RESULTS:In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein,amylase and lipase vs the rats receiving only CCK-8 ***-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities,whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats. COnCLUSIOn:Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats, the simultaneous administration of exogenous insulin restored this *** results clearly demonstrate that insulin is necessary for the hypertrophic ef

关键词： Animals Diabetes Mellitus, Experimental Hypoglycemic Agents Insulin Male Pancreatitis, Acute necrotizing Rats Rats, Wistar Regeneration Research Support, non-U.S. Gov't Sincalide

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Strategies to Promote Sustainable Development of Industrial Parks in Vietnam＇s northern Key Economic Zone

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Journal of Modern Accounting and Auditing 2012年第2期8卷 289-295页

作者： Huong T. Vu Long pham Lan n. pham national Economics University Vietnam Minot State University USA University of Labor and Social Affairs Vietnam

Industrial Parks （IPs） in the northern Key Economic Zone of Vietnam （nKEZ） have been making significant contributions to the development of the zone since the first two industrial parks--noi Bai in Hanoi and nomura in Hal Phong--were established 15 years ago. So far, there have been 51 IPs in the zone, covering a total area of 13,000 ha. Such IPs play a crucial role in mobilizing capital from domestic and international investors for investments in infrastructure enhancement, trade and production aimed at promoting the economic structure transition. However, besides the above benefits, there are a number of unstable factors preventing further development of the IPs. Thus, the objectives of this study are two-fold. The first is to analyze the unstable factors, and the second is to map out strategies to enhance sustainable development of industrial parks in Vietnam＇s northern key economic zone.

关键词： industrial park Vietnam economic zone investment density ratio development scale technology level sustainable development strategy planning

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Versatile sensing devices for self-driven designated therapy based on robust breathable composite films

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nano Research 2022年第2期15卷 1027-1038页

作者： Zhaofeng Ouyang Songbo Cui Houyong Yu Dewen Xu Chuang Wang Dongping Tang Kam Chiu tam Key Laboratory of Advanced Textile Materials and Manufacturing Technology Ministry of EducationSchool of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada

Flexible wearable electronics were developed for applications such as electronic skins,human-machine interactions,healthcare monitoring,and anti-infection *** conventional materials showed impermeability,single sensing ability,and no designated therapy,which hindered their *** it was still a great challenge to develop electronic devices with multifunctional sensing properties and self-driven anti-infection ***,flexible and breathable on-skin electronic devices for multifunctional fabric based sensing and self-driven designated anti-infection therapy were prepared successfully with cellulose nanocrystals/iron(Ⅲ)ion/polyvinyl alcohol(CnC/Fe^(3+)/PVA)*** resultant composite films possessed robust mechanical performances,outstanding conductivity,and distinguished breathability(3.03 kg/(m^(2)·d)),which benefited from the multiple interactions of weak hydrogen bonds and Fe^(3+) chelation and synergistic effects among CnC,polyaniline(PAnI),and ***,the film could be assembled as a multifunctional sensor to actively monitor real-time physical and infection related signals such as temperature,moisture,pH,nH3,and human movements even at sweat *** importantly,this multifunctional device could act as a self-driven therapist to eliminate bacterial by the release of Fe^(3+),which was driven by the damage of metal coordination Fe-O bonds due to the high temperature caused by infection at wound ***,the composite films had potential versatile applications in electronic skins,smart wound dressings,human-machine interactions,and self-driven anti-infection therapy.

关键词： cellulose nanocrystals polyvinyl alcohol composite films mechanical performances

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EXISTEnCE AnD STABILITY OF PERIODIC AnD ALMOST PERIODIC SOLUTIOnS TO THE BOUSSInESQ SYSTEM In UnBOUnDED DOMAInS

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Acta Mathematica Scientia 2022年第5期42卷 1875-1901页

作者： Thieu Huy nGUYEn Truong Xuan.pham Thi ngoc Ha VU The Sac LE School of Applied Mathematics and Informatics Hanoi University of Science and Technology Vien Toan ung dung va Tin hocDai hoc Bach khoa Hanoi 1DaiCoVietHanoiVietnam Department of Mathematics Faculty of Information TechnologyThuyloi university Khoa Cong nghe Thong tinBo mon ToanDai hoc Thuy loi175 Tay SonDong DaHa NoiViet Nam Thuyloi University Dai hoc Thuy Loi175 Tay SonDong DaHanoiViet Nam

In this paper we investigate the existence and stability of periodic solutions(on a half-line R_(+))and almost periodic solutions on the whole line time-axis R to the Boussinesq system on several classes of unbounded domains of R^(n) in the framework of interpolation *** the linear Boussinesq system we combine the L^(p)—L^(q)-smoothing estimates and interpolation functors to prove the existence of bounded mild ***,we prove the existence of periodic solutions by invoking Massera’s *** also prove the existence of almost periodic *** we use the results of the linear Boussinesq system to establish the existence,uniqueness and stability of the small periodic and almost periodic solutions to the Boussinesq system using fixed point arguments and interpolation *** results cover and extend the previous ones obtained in[13,34,38].

关键词： Boussinesq systems periodic solutions almost periodic solutions unbounded domains smoothing estimates dual estimates interpolation spaces stability

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Carbon deficiency introduced plasticity of rock-salt-structured transition metal carbides

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Journal of Materials Science & Technology 2023年第33期164卷 205-214页

作者： Buhao Zhang Youwei Wang Jie Yin Yichen Wang Hangfeng Zhang tamás Csanádi Ján Dusza Michael J.Reece nan Lin Xiao Yang Xuejian Liu Zhengren Huang Dongliang Jiang State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Faculty of Engineering University of NottinghamNottinghamNG7 2RDUnited Kingdom School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon E1 4NSUK Institute of Materials Research Slovak Academy of SciencesWatsonova 4704353KošiceSlovak Republic College of Materials Science and Engineering Hunan UniversityChangsha410082China

High-hardness rock-salt structured transitional metal carbides(TMC)are attracting substantial interest as potential next-generation thermal protection ***,the intrinsic brittleness of TMC ceramics impedes their performance in aerodynamically harsh *** this work,a promising strategy is proposed to introduce plasticity in TaC–HfC solid solutions by manipulating carbon *** approach combines density-functional theory(DFT)with experiments and takes Pugh's ratio(k)as the *** of carbon atoms in TaC–HfC solid solutions results in the de-localizing of valence electrons,deviation of spatial modulus along different crystal plane directions,and leading to significant elastic *** carbon deficient Ta_(0.8)Hf_(0.2)C_(0.8) is predicted to be a‘softer phase’with reduced modulus and Pugh's ratio(k=0.58).A series of Ta1–xHfxCy(x=0.2 and 0.8,y=0.8,0.9,and 1.0)bulk ceramics are experimentally fabricated by an excessive metal alloying *** and hexagonal close-packed structured carbides are derived when the carbon deficiency y decreased to *** indentation modulus drops from 641.8±14.8 GPa for Ta_(0.8)Hf_(0.2)C_(1.0) to 555.8±9.9 GPa for *** specific stoichiometric composition of Ta_(0.8)Hf_(0.2)C_(0.8) is experimentally verified to possess both plasticity(k=0.41)and ultra-high nanohardness(41.3±1.3 GPa).

关键词： Brittle Plasticity Transitional metal carbides Pugh's ratio Carbon deficiency

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Physical Examination Indicated Rescue Cerclage to Improve Live Birth Rate at Hung Vuong Hospital in Vietnam

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Open Journal of Obstetrics and Gynecology 2020年第3期10卷 400-408页

作者： Huynh nguyen Khanh Trang Tran Thi ngoc tam pham Huynh Phuc Hung Hoang Thi Diem Tuyet pham ngoc Thach University of Medicine HCMC Vietnam Hung Vuong Hospital HCMC Vietnam

Emergency cerclage with advanced cervical dilatation and bulging of fetal membranes is still challenging to obstetricians.?Objective:?To identify the live birth rate after physical examination indicated rescue cerclage. Methods:?A retrospective cohort study of 36 pregnant women, who underwent rescue cerclage at Hung Vuong hospital from January 2015 to January 2019. Selection criteria: cervical dilation 10 to 40 mm, at 20 to 30 gestational weeks. Exclusion criteria: multiple pregnancy, birth defects, pregnancy termination due to maternal or fetal indications. Results: Delivery of live infant rate was 72.22%;mean pregnancy prolongation was 42.8 ±?34.15 days. Early live birth rate was 77.78%. The percentage of delivery after 34 and 37 weeks was 44.45% and 27.78%, respectively. Live birth weight was 400 to 3600?g, with mean being 1878.06 ±?1049.04?g. no procedure-related complication was observed. Conclusions:?Rescue cerclage may be an effective and safe method in prolonging pregnancy and improving neonatal outcome in women with cervical dilation 10 to 40 mm. It should be considered as a viable option for women with a dilated cervix in 20 to 30 gestational weeks. Future controlled studies are needed.

关键词： Emergency Cerclage Delivery of Live Infant Rate

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novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody

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World Journal of Gastroenterology 2017年第1期23卷 48-59页

作者： Yuichi Matsuo Yasutoshi Kido Junko Akada Seiji Shiota Tran Thanh Binh Tran Thi Huyen Trang Ho DQ Dung pham Huu Tung Tran Dinh Tri ngo P Minh Thuan Le Quang tam Bui Chi nam Vu Van Khien Yoshio Yamaoka Department of Environmental and Preventive Medicine Oita University Faculty of Medicine Department of General Medicine Oita University Faculty of Medicine Department of Endoscopy Cho Ray Hospital Department of Molecular Biology 108 Military Central Hospital Department of Endoscopy Daklak Hospital Department of Endoscopy Lao Cai Hospital Department of Hepatogastroentrology 108 Military Center Hospital Department of Medicine-Gastroenterology Baylor College of Medicine and Michael E.De Bakey Veterans Affairs Medical Center

AIMTo develop a novel Helicobacter pylori (H. pylori) CagA antibody enzyme-linked immunosorbent assay (ELISA) suitable for detecting serum anti-CagA antibodies with high *** East Asian-type CagA protein was purified and immobilized for ELISA. Serum samples from 217 Vietnamese individuals (110 H. pylori-infected and 107 uninfected individuals) were applied. Conventional ELISA from Western-type CagA and our East Asian-type CagA ELISA were evaluated by comparing 38 subjects with the Western-type genotype and 72 subjects with the East Asian-type cagA genotype. Histological scores of the gastric mucosa were determined using the updated Sydney System to examine the relationship with anti-CagA antibody *** 70-100 kDa fragments were immobilized on the ELISA plate. In ROC analysis, the area under the curve of our East Asian-type CagA ELISA was comparable to that of conventional CagA ELISA. The sensitivity of the two ELISAs differed depending on the cagA genotype. The sensitivity of East Asian-type CagA ELISA was higher for subjects infected with East Asian-type cagA H. pylori (P nd the sensitivity of the conventional CagA ELISA tended to be higher for subjects infected with Western cagA H. pylori (P = 0.056). The titer of anti-CagA antibody tended to correlate with monocyte infiltration scores (r = 0.25, P = 0.058) and was inversely correlated with H. pylori density (r = -0.26, P = 0.043).COnCLUSIOnThe novel ELISA is useful to detect anti-CagA antibodies in East Asian countries, and the titer may be a marker for predicting chronic gastritis.

关键词： Helicobacter pylori cagA genotype Anti-CagA antibody Enzyme-linked immunosorbent assay Inflammation Gastritis

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Defect engineering of water-dispersible g-C_(3)n_(4) photocatalysts by chemical oxidative etching of bulk g-C_(3)n_(4) prepared in different calcination atmospheres

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Journal of Materials Science & Technology 2022年第8期103卷 232-243页

作者： Thi Kim Anh nguyen Thanh-Truc pham Bolormaa Gendensuren Eun-Suok Oh Eun Woo Shin School of Chemical Engineering University of UlsanDaehakro 93Ulsan 44610South Korea Department of Material Technology Faculty of Applied ScienceHo Chi Minh City University of Technology and Education(HCMUTE)No.1 Vo Van Ngan StreetLinh Chieu WardThu Duc DistrictHo Chi Minh City 700000Viet Nam

In this study,water-dispersible graphitic carbon nitride(g-C_(3)n_(4))photocatalysts were successively prepared through the chemically oxidative etching of bulk g-C_(3)n_(4) that was polymerized thermally in different calcination atmospheres such as air,CO_(2),and n_(2).The different calcination atmospheres directly influenced the physicochemical and optical properties of both bulk and water-dispersible g-C_(3)n_(4),changing the photocatalytic degradation behavior of methylene blue(MB)and tetracycline hydrochloride(TCHCl)for water-dispersible g-C_(3)n_(4).The bubble-burst process in the thermal polymerization of thiourea produced defective edges containing C=O groups that preferred substituting the C-nHx groups over bulk g-C_(3)n_(4).In the oxygen-free n_(2) atmosphere among the different calcination atmospheres,more C=O functional groups were generated on the defective edges of bulk g-C_(3)n_(4),resulting in the highest n vacancy of the tri-s-triazine *** the successive chemical oxidation,S-or O-containing functional groups were introduced onto water-dispersible g-C_(3)n_(4).The water-dispersible g-C_(3)n_(4) photocatalyst from the oxygen-free n_(2) atmosphere(nTw)contained the most O-and S-functional groups on the g-C_(3)n_(4) ***,nTw exhibited the highest photocatalytic activity in the MB and TC-HCl photodegradation because of its slowest recombination process,which was ascribed to the unique surface properties of nTw such as abundant functional groups on the defective edges and n-deficient property.

关键词： g-C_(3)n_(4) Water-dispersible photocatalyst Calcination atmosphere Charge separation Chemically oxidative etching Defect edges

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Severity of gastroesophageal reflux disease influences daytime somnolence: A clinical study of 134 patients underwent upper panendoscopy

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World Journal of Gastroenterology 2004年第12期10卷 1798-1801页

作者： Pái Demeter Katalin Várdi Visy nóra Gyulai Róbert Sike tamás G Tóth János novák Pál Magyar Outpatient Clinic of Gastroenterology St.John's HospitalBudapestHungary Department of Pulmonology Semmelweis Medical UniversityBudapestHungary Dept.of

AIM: To asses the relationship between severity of gastroesophageal refluxe disease and Epworth sleepiness scale as an indicator of daytime somnolence. METHODS: One hundred and thirty-four patients underwent an upper panendoscopy as indicated by the typical reflux symptoms and were also investigated with regard to somnolence. Sleepiness was evaluated by Epworth Sleepiness Scale, which was compared to the severity of endoscopic findings (Savary-Miller/modified by Siewert). Patients with psychiatric disorders or being on sedato-hypnotics as well as shift workers were excluded from the study. The relationship between the severity of the reflux disease and daytime somnolence was analyzed with the help of multivariate regression analysis. RESULTS: A positive tendency was found between the severity of the reflux disease and the corresponding Epworth Sleepiness Scale. In the case of the more severe type-Savary-Miller Ⅲ- at least a mild hypersomnia was found. For this group daytime somnolence was significantly higher than in the case of the non-erosive type of Gastroesophageal Reflux Disease representing the mildest stage of reflux disease. COnCLUSIOn: The severity of Gastroesophageal Reflux Disease influences daytime somnolence.

关键词： Severity of Illness Index Adult Aged Disorders of Excessive Somnolence Endoscopy, Digestive System Female Gastroesophageal Reflux Humans Linear Models Male Middle Aged Predictive Value of Tests

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Relevance of α-defensins(HnP1-3) and defensin β-1 in diabetes

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World Journal of Gastroenterology 2014年第27期20卷 9128-9137页

作者： Balázs Csaba németh tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs nyiraty Péter Kempler Yvette Mándi Department of Medical Microbiology and Immunology University of Szeged Department of Molecular and Cell Biology Boston University Henry M. Goldman School of Dental Medicine First Department of Internal Medicine University of Szeged

AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.

关键词： α-defensins HnP1-3 β-defensin 1 Diabetes Copy number polymorphism Single nucleotide polymorphism

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