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Techniques and strategies for regional anesthesia in acute burn care—a narrative review

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Burns & Trauma 2021年第1期9卷 383-392页

作者： Clifford C.Sheckter Barclay T.Stewart Christopher Barnes Andrew Walters Paul I.Bhalla tam n.pham Department of Surgery UWMedicine Regional Burn Center at Harborview Medical CenterUniversity ofWashington3259th Ave.SeattleWA 98104USA Harborview Injury Prevention and Research Center University ofWashington401 Broadway.SeattleWA 98122USA Department of Anesthesia and Pain Medicine Harborview Medical Center.University ofWashington3259th Ave.SeattleWA 98104USA

Burn injuries and their treatments result in severe *** traumatic injuries that are characterized by a discrete episode of pain followed by recovery,burn-injured patients endure pain for a prolonged period that lasts through wound closure(*** pain,procedural pain,breakthrough pain,neuropathic pain and itch).Regional anesthesia,including peripheral nerve blocks and neuraxial/epidural anesthesia,offers significant benefits to a multimodal approach in pain treatment.A‘regional-first’approach to pain management can be incorporated into the workflow of burn centers through engaging regional anesthesiologists and pain medicine practitioners in the care of burn patients.A detailed understanding of peripheral nerve anatomy frames the burn clinician’s perspective when considering a peripheral nerve block/*** infra/supraclavicular nerve block provides excellent coverage for the upper extremity,while the trunk can be covered with a variety of blocks including erector spinae plane and quadratus lumborum plane *** lower extremity is targeted with fascia iliaca plane and sciatic nerve blocks for both donor and recipient *** centers that adopt regional anesthesia should be aware of potential complications and contraindications to prevent adverse events,including management of local anesthetic toxicity and epidural *** of anticoagulation around regional anesthesia placement is crucial to prevent hematoma and nerve ***,regional anesthesia can facilitate a better patient experience and allow for early therapy and mobility goals that are hallmarks of burn care and rehabilitation.

关键词： Burn Regional anesthesia nerve block Epidural nerve catheter Pain

A concise review on surface and structural modification of porous zeolite scaffold for enhanced hydrogen storage

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Chinese Journal of Chemical Engineering 2024年第6期70卷 33-53页

作者： B.A.Abdulkadir R.S.R.Mohd Zaki A.T.Abd Wahab S.n.Miskan Anh-tam nguyen Dai-Viet n.Vo H.D.Setiabudi Centre for Research in Advanced Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process Engineering Technology Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Center of Excellence for Green Energy and Environmental nanomaterials(CE@GrEEn) Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

Investigating zeolites as hydrogen storage scaffolds is imperative due to their porous nature and favorable physicochemical ***,the storage capacity of the unmodified zeolites has been rather unsatisfactory(0.224%-1.082%(mass))compared to its modified ***,the contemporary focus on enhancing hydrogen storage capacities has led to significant attention towards the utilization of modified zeolites,with studies exploring surface modifications through physical and chemical treatments,as well as the integration of various active *** enhanced hydrogen storage properties of zeolites are attributed to the presence of aluminosilicates from alkaline and alkaline-earth metals,resulting in increased storage capacity through interactions with the charge density of these ***,there is a great demand to critically review their role such as well-defined topology,pore structure,good thermal stability,and tunable hydrophilicity in enhanced hydrogen *** article aimed to critically review the recent research findings based on modified zeolite performance for enhanced hydrogen *** of the factors affecting the hydrogen storage capacities of zeolites that can affect the rate of reaction and the stability of the adsorbent,like pressure,structure,and morphology were studied,and ***,future perspectives,recommendations,and directions for modified zeolites were discussed.

关键词： Zeolites Hydrogen storage Surface modification Adsorption Active metal

Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 193-205页

作者： Anna Fábián Renáta Bor Béla Vasas Mónika Szűcs Tibor Tóth Zsófia Bősze Kata Judit Szántó Péter Bacsur Anita Bálint Bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka tamás Resál tamás Molnár Zoltán Szepes Department of Internal Medicine University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Pathology University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Medical Physics and Medical Informatics University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6720Hungary USZ Translational Colorectal Research Group Hungarian Centre of Excellence for Molecular MedicineSzeged 6725Hungary

BACKGROUnD Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is *** To evaluate long-term outcomes after endoscopic removal of malignant colorectal *** A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and *** disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were *** rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were *** risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were *** proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,*** differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,*** tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical *** analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance *** outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance *** Reporting of histological featur

关键词： Malignant colorectal polyps T1 tumor Endoscopic removal Outcomes Long-term Surveillance

ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECn1 interaction

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen ningning Li Shan Sun nana Wang Yang Chen Chunsheng Dong Kin Yip tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying Jiangsu Key Laboratory of neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China Dept.of Physiology&Medical Physics and FUTURE-nEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of Biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RnA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between BCL2 and BECn1/Beclin 1 by inhibiting BCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between BECn1 and BCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy BCL2 BECn1/Beclin 1 Dipeptide repeat neurodegeneration

A High-order Coupled Compact Integrated RBF Approximation Based Domain Decomposition Algorithm for Second-order Differential Problems

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Computer Modeling in Engineering & Sciences 2015年第4期104卷 251-304页

作者： C.M.T.Tien n.pham-Sy n.Mai-Duy C.-D.Tran T.Tran-Cong Computational Engineering and Science Research Centre Faculty of HealthEngineering and SciencesThe University of Southern QueenslandToowoombaQueensland 4350Australia

This paper presents a high-order coupled compact integrated RBF(CC IRBF)approximation based domain decomposition(DD)algorithm for the discretisation of second-order differential *** Schwarz DD algorithms,including one-level additive/multiplicative and two-level additive/multiplicative/hybrid,are *** CCIRBF based DD algorithms are analysed with different mesh sizes,numbers of subdomains and overlap sizes for Poisson *** convergence analysis shows that the CCIRBF two-level multiplicative version is the most effective algorithm among various schemes employed ***,the present CCIRBF two-level method converges quite rapidly even when the domain is divided into many subdomains,which shows great promise for either serial or parallel *** practical tests,we then incorporate the CCIRBF into serial and parallel two-level multiplicative *** numerical examples,including those governed by Poisson and navier-Stokes equations are analysed to demonstrate the accuracy and efficiency of the serial and parallel algorithms implemented with the *** results show:(i)the CCIRBF-Serial and-Parallel algorithms have the capability to reach almost the same solution accuracy level of the CCIRBF-Single domain,which is ideal in terms of computational calculations;(ii)the CCIRBF-Serial and-Parallel algorithms are highly accurate in comparison with standard finite difference,compact finite difference and some other schemes;(iii)the proposed CCIRBF-Serial and-Parallel algorithms may be used as alternatives to solve large-size problems which the CCIRBF-Single domain may not be able to deal *** ability of producing stable and highly accurate results of the proposed serial and parallel schemes is believed to be the contribution of the coarse mesh of the two-level domain decomposition and the CCIRBF *** is noted that the focus of this paper is on the derivation of highly accurate serial and parallel algorithms

关键词： Coupled compact integrated RBF (CCIRBF) Schwarz domain decomposition one-level two-level coarse meshes additive multiplicative hybrid serial parallel colouring technique Poisson equation naiver-Stokes equation liddriven cavity

Isolation and Identification of Two Flavonoid Compounds from Acclimatized Angelica acutiloba Kitagawa Growing in Vietnam

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 413-416页

作者： Thi Minh tam pham Thi Thu Cuc Le Viet Hung Tran Van Thanh nguyen Department of Microbiology Institute of Drug Quality ControlDepartment of Analytical Chemistry and Quality ControlUniversity of Medicine and PharmacyHo Chi Minh CityVietnam Department of Analytical Chemistry and Quality Control Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam Department of Microbiology Institute of Drug Quality ControlHo Chi Minh CityVietnam

Traditional Vietnamese Medicine has its own development based on the local endemic herbs,but it also inherits from Traditional Chinese Medicine using Chinese herbal *** the history of cultural exchange between two countries,the adoption of Chinese Danggui,Angelica sinensis(Oliv.)Diels.,has been made by Vietnamese traditional medicine practitioners for a long ***,the acclimatization has never been *** Danggui,or Angelica acutiloba Kitagawa,is recently being acclimatized and cultivated in several Vietnamese *** the huge climate change between the two countries,the herb adapted exquisitely well to the humid tropical ***,so far,there are no studies that have evaluated the effect of acclimatization on the overall quality of this medicinal *** aim of our study is screening secondary metabolites of this acclimatized herb for new natural compound(s),if *** analysis of flavonoid fraction from this herb led to the identification of two known compounds which previously have not been isolated from this species *** detection showed that the herb has reacted to the new environment.

关键词： Abiotic stress Angelica acutiloba danggui isoquercitrin rutin

Endangered lowland oak forest steppe remnants keep unique bird species richness in Central Hungary

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Journal of Forestry Research 2022年第1期33卷 343-355页

作者： GáborÓnodi Zoltán Botta‑Dukát Dániel Winkler tamás Rédei Institute of Ecology and Botany Centre for Ecological ResearchVácrátótHungary Department of Botany and Biodiversity Research University of ViennaViennaAustria Institute of Wildlife Management and Wildlife Biology University of SopronSopronHungary

The biodiversity of natural or semi-natural native,old oak woodlands have high conservation importance,especially in landscapes of monocultural forest plantations and arable *** a wider variety of microhabitats and foraging sources,such old oak forests can provide essential habitat for native forest bird *** conducted a study using bird point counts to compare the forest bird communities of old pedunculate oak(Quercus robur)remnants with native and non-native plantations in central Hungary in a landscape of mostly arable fields,settlements,and monocultural *** surveys were carried out in old oak forest remnants,middle-aged oak,white poplar(Populus alba),hybrid poplar(Populus×euramericana),black locust(Robinia pseudoacacia),and pine(Pinus spp.)*** has been carried out in nine study sites,where all six habitat types were represented(with a few exceptions),to determine total abundance,species richness,Shannon–Wiener diversity,species evenness,dominant and indicator species,and guild *** found that old oak forest remnants were the most diverse habitats among the studied forest types,while hybrid poplar and pine plantations exhibited the lowest avian *** avian guilds most sensitive to the loss of old oak forest remnants were ground foragers,bark foragers,cavity-nesters,residents,and Mediterranean migratory *** habitats were more diverse than non-native *** results suggest that it is important to conserve all remaining high biodiversity old oak stands and to avoid clear-cutting of monocultural plantations in favour of practices such as mixed-species plantations,longer rotation lengths,or retention forestry.

关键词： Forest bird community Bird conservation Old oak forest-steppe remnant Plantation forestry Forest conservation non-native plantation

Two-dimensional perovskite SrnbO_(2) n with Zr doping for accelerating photoelectrochemical water splitting

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Journal of Materials Science & Technology 2023年第11期142卷 176-184页

作者： Thanh tam Thi Tran Van-Huy Trinh Jeongsuk Seo Department of Chemistry College of Natural SciencesChonnam National University77 Yongbong-roBuk-guGwangju 61186South Korea

The superior ability of perovskite-type SrnbO_(2) n to absorb intensive visible light makes it a potential semiconductor to produce hydrogen and oxygen by photoelectrochemical(PEC)water splitting under *** surface morphologies,such as shape and structure,of the oxynitride strongly affect its photoactivity,although the mechanism has been hardly ***,we report a two-dimensional(2D)porous SrnbO_(2) n plate with Zr doping,nitrided from layered perovskite Sr_(5)nb_(4)O_(15) and also its largely enhanced PEC water splitting ***^(4+)was doped in Sr_(5)nb_(4)O_(15) during flux-assisted calcination using KCl,producing 2D-type truncated-octahedral Sr_(5)nb_(4)O_(15):Zr plates approximately 50 nm in *** nitridation completely transformed Sr_(5)nb_(4)O_(15):Zr to 2D single-crystalline SrnbO_(2) n:Zr with a large surface area,which was subsequently used to fabricate a thin and uniform photoanode by the spin coating *** a result,the Co(OH)_(x)/SrnbO_(2) n:Zr/FTO photoanode capable of absorbing visible light of up to 680 nm exhibited an activity of 2.0 mA cm^(-2) at 1.23 V vs the reversible hydrogen electrode for water splitting under AM 1.5G simulated *** improvement in photoactivity mainly originated from the 2D surface morphology of SrnbO_(2) n:Zr,which is clearly distinguishable from 3D-type *** to electrochemical analyses,the 2D structure of SrnbO_(2) n:Zr boosted the separation and accelerated the transfer of charges photogenerated during the water splitting,thus driving the reaction ***,the result empirically demonstrates that controlling the surface morphology of SrnbO_(2) n is an effective strategy to suppress the recombination of charges and minimize their diffusion pathway,eventually enhancing the PEC activity.

关键词： Solar water splitting Water oxidation BanbO_(2)n Doping engineering Flux-assisted calcination Spin coating

Effects of used lubricating oil on two mangroves Aegiceras corniculatum and Avicennia marina

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Journal of Environmental Sciences 2007年第11期19卷 1355-1360页

作者： YE Yong tam n FY State Key Laboratory of Marine Environmental Science Xiamen University Xiamen 361005 China Department of Biology and Chemistry City University of Hong Kong Hong Kong China

An outdoor experiment was set up to investigate the effects of used lubricating oil （5 L/m^2） on Aegiceras corniculatum Blanco. and Avicennia marina （Forsk） Vierh., two salt-excreting mangroves. A. marina was more sensitive to used lubricating oil than A. corniculatum and canopy-oiling resulted in more direct physical damage and stronger lethal effects than base-oiling. When treated with canopy-oiling, half of A. corniculatum plants survived for the whole treatment time （90 d）; but, for A. marina, high mortality （83%） resulted from canopy-oiling within 3 weeks and no plants survived for 80 d. Base-oiling had no lethal effects on A. corniculatum plants even at the termination of this experiment, but 83% of A. marina plants died 80 d after treatment. Forty days after canopyoiling, 93% ofA. corniculatum leaves fell and no live leaves remained on A. marina plants. By the end of the experiment, base-oiling treatment resulted in about 45% ofA. corniculatum leaves falling, while all A. mar/na leaves and buds were burned to die. Lubricating oil resulted in physiological damage to A. corniculatum leaves, including decreases in chlorophyll and carotenoid contents, nitrate reductase, peroxidase and superoxide dismutase activities, and increases in malonaldehyde contents. For both species, oil pollution significantly reduced leaf, root, and total biomass, but did not significantly affect stem biomass. Oil pollution resulted in damage to the xylem vessels of fine roots but not to those of mediate roots.

关键词： used lubricating oil mangrove Aegiceras corniculatum Avicennia marina