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Potential role of micro ribonucleic acids in screening for anal cancer in human papilloma virus and human immunodeficiency virus related malignancies

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World Journal of Gastrointestinal Pathophysiology 2021年第4期12卷 59-83页

作者： Samar Al Bitar tala ballouz Samer Doughan Hala Gali-Muhtasib Nesrine Rizk Department of Biology American University of BeirutBeirut 11072020Lebanon Department of Internal Medicine American University of Beirut Medical CenterBeirut 11072020Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 11072020Lebanon Department of Biology and Center for Drug Discovery American University of BeirutBeirut 11072020Lebanon

Despite advances in antiretroviral treatment(ART),human immunodeficiency virus(HIV)continues to be a major global public health issue owing to the increased mortality rates related to the prevalent oncogenic viruses among people living with HIV(PLWH).Human papillomavirus(HPV)is the most common sexually transmitted viral disease in both men and women ***-risk or oncogenic HPV types are associated with the development of HPV-related malignancies,including cervical,penile,and anal cancer,in addition to oral *** incidence of anal squamous cell cancers is increasing among PLWH,necessitating the need for reliable screening methods in this population at *** fact,the currently used screening methods,including the Pap smear,are invasive and are neither sensitive nor *** are interested in circulatory and tissue micro ribonucleic acids(miRNAs),as these small non-coding RNAs are ideal biomarkers for early detection and prognosis of *** miRNAs are deregulated during HIV and HPV infection and their deregulation contributes to the pathogenesis of ***,we will review the molecular basis of HIV and HPV co-infections and focus on the pathogenesis and epidemiology of anal cancer in *** limitations of screening for anal cancer and the need for a reliable screening program that involves specific miRNAs with diagnostic and therapeutic values is also discussed.

关键词： Human papillomavirus Human immunodeficiency virus Anal cancer Micro ribonucleic acids Biomarkers Cancer screening

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