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Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第9期14卷 1370-1377页

作者： Kenichi Hakamada Norihisa Kimura takuya Miura Hajime Morohashi Keinosuke Ishido Masaki Nara Yoshikazu Toyoki Shunji Narumi Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of MedicineJapan

AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body.

关键词： Small hepatocellular carcinoma Hepatic resection Des-gamma-carboxy prothrombin Vascular invasion Prognostic factor

Sensor Selection and Routing Design for State Estimation over Wireless Sensor Networks

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Sensor Selection and Routing Design for State Estimation ove...

Hybrid Rubisco with Complete Replacement of Rice Rubisco Small Subunits by Sorghum Counterparts Confers C4 Plant-like High Catalytic Activity

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作者： Yuchi Wu takuya Iwaki Junfeng Wu Karl Henrik Johansson Ling Shi Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology KTH Royal Institute of Technology

ISBN: (纸本)9781538629185

In this paper,we consider a wireless sensor network that consists of a group of sensor nodes estimating multiple independent LTI *** point-to-point link between the sensor nodes is a slow frequency-flat fading channel and the states of the channel are described by a finite-state Markov channel（FSMC） *** propose a transmission schedule of the sensors such that the overall estimation error at the remote estimator is ***,we present an event-based routing scheme with respect to channel state,i.e.,online routing among the selected sensors to ensure the zero outage-probability at a constant transmission rate with the least transmission *** channel inversion,we separate the sensor scheduling and routing as two independent *** results for a simple wireless sensor network is presented to compare the energy cost with and without event-based routing.

关键词： sensor network routing slow fading channel inversion networked control state estimation

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Molecular Plant 2020年第11期13卷 1570-1581页

作者： Hiroyoshi Matsumura Keita Shiomi Akito Yamamoto Yuri Taketani Noriyuki Kobayashi takuya Yoshizawa Shun-ichi Tanaka Hiroki Yoshikawa Masaki Endo Hiroshi Fukayama Department of Biotechnology College of Life SciencesRitsumeikan University1-1-1 Noji-HigashiKusatsu 525-8577Japan Graduate School of Agricultural Science Kobe University1-1 Rokkodai-tyouNada-kuKobe 657-8501Japan Faculty of Agriculture Kobe University1-1 Rokkodai-tyouNada-kuKobe 657-8501Japan Division of Applied Genetics Institute of Agrobiological SciencesNational Agriculture and Food Research Organization1-2 OwashiTsukuba 305-8634Japan Department of Biomolecular Chemistry Kyoto Prefectural UniversityHangi-choShimogamoSakyo-kuKyoto 606-8522Japan

Photosynthetic rate at the present atmospheric condition is limited by the CO2-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)because of its extremely low catalytic rate(kcat)and poor affinity for C02(Kc)and specificity for CO2(Sc/O).Rubisco in C4 plants generally shows higher k cat than that in C3 *** consists of eight large subunits and eight small subunits(RbcS).Previously,the chimeric incorporation of sorghum C4-type RbcS significantly increased the k cat of Rubisco in a C3 plant,*** this study,we knocked out rice RbcS multigene family using the CRISPR-Cas9 technology and completely replaced rice RbcS with sorghum RbcS in rice *** hybrid Rubisco showed almost C4 plant-like catalytic properties,i.e.,higher kcai,higher Kc,and lower Sc/*** lines expressing the hybrid Rubisco accumulated reduced levels of Rubisco,whereas they showed slightly but significantly higher photosynthetic capacity and similar biomass production under high C 02 condition compared with wild-type ***-resolution crystal structural analysis of the wild-type Rubisco and hybrid Rubisco revealed the structural differences around the central pore of Rubisco and the pC-pD hairpin in *** propose that such differences,particularly in the pC-pD hairpin,may impact the flexibility of Rubisco catalytic site and change its catalytic properties.

关键词： CRISPR-Cas9 C4 plant photosynthesis rice Rubisco

Numerical Evaluation of the Surface Energy of Polyhedral Nanoparticles

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Materials Sciences and Applications 2020年第12期11卷 837-850页

作者： takuya Uehara Junya Fujiwara Department of Mechanical Systems Engineering Yamagata University Yonezawa Japan Graduate School of Science and Engineering Yamagata University Yonezawa Japan

Nanoparticles have been used widely in various fields, and their size and shape greatly affect the functional properties. Therefore, controlling the morphology of the particles is important, and evaluation of the surface energy is indispensable for that purpose. In this study, the surface energy of nanoparticles was evaluated by numerical simulation and formulated in a polynomial equation. First, molecular dynamics simulations were carried out for variously shaped polyhedral nanoparticles. A cube and an octahedron were introduced as reference shapes, and truncated hexahedrons and truncated octahedrons were created by cutting out their vertices. The surface energy was plotted for various polyhedrons. The lowest energy was observed in an octahedron because of the stability of the (111) plane, and the highest energy was observed in a cube because of the relatively higher energy of the (100) plane. Then, the surface energy was formulated in a polynomial equation, in which the parameters obtained by the molecular-dynamics simulations were introduced. As a result, stability of the octahedron and relative instability of the cube were fairly captured by the proposed polynomial equation, while a slight underestimation was inevitable. Finally, the parameters were revised to continuous numbers to extend the application range. Consequently, an application for various materials, such as a cube having equivalent stability to an octahedron, was demonstrated by imposing rather exaggerated parameters.

关键词： Surface Energy Nanoparticle Fcc Crystal Interatomic Potential Molecular Dynamics Computer Simulation

A Study on Detection Method of Falling Symptoms

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Journal of Computer and Communications 2020年第12期8卷 73-82页

作者： Jin Zhang takuya Tajima Fukuoka Institute of Technology Graduate School Fukuoka Institute of Technology Fukuoka Japan

The purpose of this study is to prevent the occurrence of falls by defining the symptoms of falls and detecting them in advance. The focus of the study is on the specific definition of “Falling Symptoms”. In this regard, we conducted a questionnaire survey on people of different ages to obtain the state of themselves and their surroundings when they fell down. In addition, we used the elderly simulated experience kit to achieve the purpose of using young people to replace the elderly. Young people were asked to walk on different roads in different shoes with and without elderly simulated experience kit and photographed them with a high-speed camera to observe the changes of their muscles and joints. We also simulated the movement of center of gravity of the people with and without elderly simulated experience kit by a pressure distribution sensor mat.

关键词： Falling Symptoms Questionnaire High-Speed Camera Center of Gravity Elderly Simulated Experience Kit

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

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Neuroscience Bulletin 2016年第3期32卷 273-285页

作者： Kai Zhang Yunqi Zhu Yuankai Zhu Shuang Wu Hao Liu Wei Zhang Caiyun Xu Hong Zhang takuya Hayashi Mei Tian Department of Nuclear Medicine The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009 China Zhejiang University Medical PET Center Hangzhou 310009China Institute of Nuclear Medicine and Molecular Imaging Zhejiang University Hangzhou 310009 China Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009 China Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009 China Functional Architecture Imaging Unit RIKEN Center for Life Science Technologies Kobe 650-0047 Japan

Major depressive disorder（MDD） is a significant cause of morbidity and mortality worldwide,correlating with genetic susceptibility and environmental risk ***,functional,and structural imaging approaches have been increasingly used to detect neurobiological changes,analyze neurochemical correlates,and parse pathophysiological mechanisms underlying *** reviewed recent neuroimaging publications on MDD in terms of molecular,functional,and structural alterations as detected mainly by magnetic resonance imaging（MRI） and positron emission *** structure and function of brain regions involved in the cognitive control of affective state have been *** abnormal default mode network,as revealed by resting-state functional MRI,is likely associated with aberrant metabolicand serotonergic function revealed by radionuclide *** multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD.

关键词： Major depressive disorder Molecularimaging ositron emission tomography Magneticresonance imaging Functional connectivity Serotonin

Intraoperative ultrasound as an educational guide for laparoscopic biliary surgery

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World Journal of Gastroenterology 2008年第15期14卷 2370-2376页

作者： Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Motonari Oohashi takuya Miura Hiroyuki Jin Syuichi Yoshihara Michihiro Sugai Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To analyze the efficacy of routine intraoperative ultrasound (IOUS) as a guide for understanding biliary tract anatomy, to avoid bile duct injury (BDI) after laparoscopic cholecystectomy (LC), as well as any burden during the learning period. METHODS: A retrospective analysis was performed using 644 consecutive patients who underwent LC from 1991 to 2006. An educational program with the use of IOUS as an operative guide has been used in 276 cases since 1998. RESULTS: IOUS was highly feasible even in patients with high-grade cholecystitis. No BDI was observed after the introduction of the educational program, despite 72% of operations being performed by inexperienced surgeons. Incidences of other morbidity, mortality, and late complications were comparable before and after the introduction of routine IOUS. However, the operation time was significantly extended after the educational program began (P < 0.001), and the grade of laparoscopic cholecystitis (P = 0.002), use of IOUS (P = 0.01), and the experience of the surgeons (P = 0.05) were significant factors for extending the length of operation. CONCLUSION: IOUS during LC was found to be a highly feasible modality, which provided accurate, real- time information about the biliary structures. Theeducational program using IOUS is expected to minimize the incidence of BDI following LC, especially when performed by less-skilled surgeons.

关键词： Intraoperative ultrasound Cholecystolithiasis Laparoscopic cholecystectomy Bile duct injury Education program

Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

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World Journal of Gastroenterology 2007年第11期13卷 1666-1671页

作者： Ichiro Hirata Shingo Yasumoto Ken Toshina takuya Inoue Takashi Nishikawa Naoko Murano Mitsuyuki Murano Fang-Yu Wang Ken-ichi Katsu Department of Gastroenterology Fujita Health University Jaoan Second Department of Internal Medicine Osaka Medical College Japan Department of Gastroenterology Jinling Hospital Nanjing University School of Medicine Nanjing 210002 Jiangsu Province China

AIM: To evaluate the effect of pyrrolidine dithio- carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupⅠ(low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured. RESULTS: The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC- treated groupⅡ. CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis.

关键词： Ulcerative colitis DSS-induced colitis Pyrrolidine dithiocarbamate NF-κB Mice

Environmental Restoration by New Technology for Prevention of Soil Erosion and Revegetation on Bare Slopes

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Journal of Environmental Science and Engineering(A) 2017年第2期6卷 60-67页

作者： takuya Marumoto Nobuyuki Kohno Takino Filter Inc. Kudamatsu 744-0061 Japan

In order to prevent soil erosion and promote reforestation on devastated bare slopes, the ecological new technology using MS （Mulching Sheet： nonwoven fabric sheet with two to four layer structures） and GB （Green Bag： made of MS containing plant seeds, fertilizers, vegetation base materials, and mycorrhizal fungi） has been applied to bare slopes not only in Japan but also in Korea, Taiwan, China, Indonesia, Vietnam etc. since 1990. From the results of them, the following conclusions were obtained：（1） This technology was significantly effective in preventing soil erosion and promoting the early revegetation on bare slopes; （2） It was suggested that the initial reforestation period could be accelerated for about 50 years by this technology in the Temperate Zone by many field data obtained.

关键词： Ecological reforestation MS (Mulching Sheet) GB (Green Bag) mycorrhizal fungi.