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Ileo-ileal intussusception caused by lymphangioma of the small bowel treated by single-incision laparoscopic-assisted ileal resection

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World Journal of Gastroenterology 2017年第1期23卷 167-172页

作者： Atsushi Kohga Akihiro Kawabe Yuto Hasegawa Kiyoshige Yajima takuya okumura Kimihiro Yamashita Jun Isogaki Kenji Suzuki Akira Komiyama Division of Surgery Fujinomiya City General Hospital Division of Pathology Fujinomiya City General Hospital

Intraabdominal lymphangiomas are uncommon;additionally,those affecting the gastrointestinal tract are rare and account for less than 1%of *** caused by a cystic lymphangioma of the small bowel is extremely *** patient was a20-year-old woman who visited our emergency room with a complaint of abdominal pain.A computed tomography image revealed ileo-ileal intussusception with a leading hypovascular mass measuring 1 cm in a ***-incision laparoscopic-assisted ileal resection was *** surgical specimen consisted of a soft polycystic ***,a pedunculated polyp with a convolutional pattern was ***,the inner surfaces of the cysts were covered with a single layer of endothelial *** immunohistochemical examination,the endothelial cells were partially positive for D2-40 and *** muscle cells were also found around the *** lesion was diagnosed as a cystic *** of cases of small bowel lymphangiomas have previously been *** these,cases with intussusception were very *** is the first case of small bowel intussusception due to lymphangioma treated by singleincision laparoscopic-assisted surgery.

关键词： Intussusception Single-incision laparoscopic-assisted surgery Lymphangioma

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Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 925-932页

作者： Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu okumura Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medical UniversityAsahikawa 078-8510Japan Pathological Department of Asahikawa Medical University Hospital Asahikawa Medical UniversityAsahikawa 078-8510Japan

BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric *** previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic *** SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before *** resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and *** final diagnosis was submucosa-invasive poorly differentiated gastric ***,additional gastrectomy was recommended to obtain a complete *** patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular *** patients remained in remission for more than half a *** positivity was determined by EBV-encoded RNA in situ *** also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by *** Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is *** prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection.

关键词： Herpesvirus 4 Human Stomach neoplasms Gastric carcinoma with lymphoid stroma Epstein-Barr virus-associated gastric carcinoma Case report

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Expression Analysis of Aquaporin-1 (Aqp-1) in Human Biliary Tract Carcinoma

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Journal of Cancer Therapy 2016年第1期7卷 17-23页

作者： Shinichi Sekine Tomoyuki okumura takuya Nagata Kazuto Shibuya Isaku Yoshioka Koshi Matsui Ryouta Hori Kazuhiro Tsukada Department of Surgery and Science University of Toyama Toyama Japan

Background: Aquaporins (AQPs) are important in controlling bile water secretion. AQP is related to the invasion and metastasis of cancer. However, the relationship of biliary tract cancer is not clear. The role of AQP-1 in cancer cell is also unknown. Methhods: We analyzed AQP-1 expression using tissue microarray (TMA) in 99 samples immunohistochemically (50 gallbladder carcinoma, 39 bile duct carcinoma and 10 Papilla Vater carcinoma patients who underwent surgery at our department from 1997 to 2011). Gene expressions were evaluated by the combination of the immunohistological intensity and distribution. The expression level is compared to the clinico-pathological data of the patients. Results: In the TMA, depth of tumor invasion and histological type are associated with AQP-1 expression. The group of patients with high AQP-1 expression is associated with higher rates of disease specific survival (log-rank p = 0.013). Cox’s proportional hazard model reveals that AQP-1 expression is an independent prognostic factor (RR, 0.324;p = 0.001) in multivariate analysis. There is a correlation between AQP-1 expression and tumor invasion. Conclusions: These observations of this study suggest that AQP-1 expression may be favorable biomarkers associated with prognosis and tumor invasion in biliary tract carcinoma.

关键词： Aquaporin Biliary Tract Carcinoma Tissue Microarray Immunohistochemistry

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