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An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture

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World Journal of Gastroenterology 2008年第7期14卷 1091-1096页

作者： Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Kenosuke Ishido takuya Miura Norihito Kubo Mutsuo Sasaki Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic ***: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa ***: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely ***: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas.

关键词： Pancreaticojejunostomy Duct-to-mucosa contact method Fast-absorbable suture Irradiated polyglactin 910 Pancreatic fistula

SnO-SnO_(2) modified two-dimensional MXene Ti3C2Tx for acetone gas sensor working at room temperature

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Journal of Materials Science & Technology 2021年第14期73卷 128-138页

作者： Zijing Wang Fen Wang Angga Hermawan Yusuke Asakura takuya Hasegawa Hiromu Kumagai Hideki Kato Masato Kakihana Jianfeng Zhu Shu Yin School of Material Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science and TechnologyXi'an710021China Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan The Institute of Scientific and Industrial Research(ISIR) Osaka University Mihogaoka 8-1IbarakiOsaka567-0047Japan

Acetone,as widely used reagents in industry and laboratories,are extremely harmful to the *** the detection of acetone gas concentrations and leaks in special environments at room temperature is ***,the nanocomposite combining SnO-SnO_(2)(p-n junction)and Ti_(3)C_(2)T_(x) MXene was successfully synthesized by a one-step hydrothermal *** of the existence of a small amount of oxygen during the hydrothermal conditions,part of the p-type SnO was oxidized to n-type SnO_(2),forming in-situ p-n junctions on the surface of Sn *** hamburger-like SnO-SnO_(2)/Ti_(3)C_(2)T_(x) sensor exhibited improved acetone gas sensing response of 12.1(R_(g)/R_(a))at room temperature,which were nearly 11 and 4 times higher than those of pristine Ti_(3)C_(2)T_(x) and pristine SnO-SnO_(2),***,it expressed a short recovery time(9 s)and outstanding *** of the different work functions,the Schottky barrier was formed between the SnO and the Ti_(3)C_(2)T_(x) nanosheets,acting as a hole accumulation layer(HALs)between Ti_(3)C_(2)T_(x) and tin ***,the sensing mechanism based on the formation of hetero-junctions and high conductivity of the metallic phase of Ti_(3)C_(2)T_(x) MXene in SnO-SnO_(2)/Ti_(3)C_(2)T_(x) sensors was discussed in detail.

关键词： p-n junction Ti_(3)C_(2)T_(x)MXene Nanocomposites Acetone gas sensor Room temperature sensing

The Aesthetics of Nature in Deleuze＇s Philosophy

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Journal of Philosophy Study 2013年第9期3卷 880-887页

作者： takuya Kobayashi Ph.D. candidate Researcher Lecturer Faculty of Cultural Studies Kyoto Sangyo University Japan

In Critique of Pure Reason （1996）, Immanuel Kant says that the term ＂aesthetic＂ means ＂the science of the laws of sensibility＂ and suggests giving up usage of it to indicate ＂the critique of taste＂ which executes the criticism of the beautiful. It is well known that Gilles Deleuze was inspired by all genres of the arts, namely movies, paintings, music, and so on. However, this paper argues that what is more essential for Deleuzian philosophy is aesthetics as a science of sensibility. What motivated Deleuze, especially from the 1950s to the 1960s, seems to have consisted in discovering the weaknesses of the Kantian aesthetic in order to take it apart. In fact, one of the main themes in Difference and Repetition （1994） was to free ＂sensibility＂ itself from Kant＇s philosophical system. This theme subsisted in his writing even after the 1970s, and led him to develop a ＂natural philosophy＂ of sorts. This is because the supposition that ＂the sensibility itself＂ is independent from any human faculties gave him an opportunity to carefully consider the multiplicity and productivity of Nature itself. Finally, Deleuze created his own ＂ethology＂ that would capture the increasingly interrelated movements within Nature produced by heterogeneous elements. This paper describes the process of Deleuzian thought as outlined above, surveying his view of Kantian philosophy and the development of his natural philosophy as ＂the aesthetics of Nature.＂

关键词： Deleuze aesthetics natural philosophy Kant ethology

Modeling and Simulation of Particle-Packing Structures and Their Stability Using the Distinct Element Method

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Open Journal of Modelling and Simulation 2018年第4期6卷 59-70页

作者： takuya Uehara Department of Mechanical Systems Engineering Yamagata University Yonezawa Japan

A numerical method for simulating the stability of particle-packing structures is presented. The packing structures were modeled on the basis of face-centered cubic (fcc) and body-centered cubic (bcc) structures, and the stability of these structures was investigated using the distinct element method. The interaction between the particles was simplified by considering repulsive, adhesive, and damping forces, and the stability against the gravitational force was simulated. The results under a certain set of parameters showed characteristic deformation when the particles were arranged in an fcc array. Focusing on the local structure, the resulting model was divided into several domains: The bottom base, four top corners, and intermediate domains. The bottom base notably became a body-centered tetragonal (bct) structure, which corresponds to a uniaxially compressed bcc structure. Conversely, the models based on the bcc arrangement were structurally stable, as no specific deformation was observed, and a monotonously compressed bct structure was obtained. Consequently, the bcc arrangement is concluded to be more stable against uniaxial compression, such as the gravitational force, in a particle-packing system.

关键词： Distinct Element Method Particle Packing Structural Stability Geometrical Symmetry Computer Simulation

Modeling of Adhesive Particles Using a Combination of the Two-Body Interaction and Phase-Field Methods

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Open Journal of Modelling and Simulation 2020年第2期8卷 35-47页

作者： takuya Uehara Department of Mechanical Systems Engineering Yamagata University Yonezawa Japan

Discrete materials such as powders and granular materials have been widely used due to their specific characteristics. The precise evaluation is accordingly becoming important, and various numerical schemes have been developed. However, the interactions among the constituent particles are still difficult to model precisely. Especially, contact conditions, which vary with material properties and circumstances, are difficult to formulate. In this study, a computational model for simulating adhesive particles on contact in a many-particle system is proposed. The interaction between the particles was represented by a two-body repulsive force that depends on the distance between particles and an additional adhesive force at the contact point. A phase-field variable was introduced to express the surface of each particle, and the adhesive force was formulated using the phase-field distribution. As a result, the adhesion of particles was properly expressed. For a mono-particle system, neighboring particles adhered and uniformly aggregated, while for a dual-particle system, several characteristic patterns were obtained depending on the initial arrangement of the particles. Repulsive contact was also considered as a specific case, and the corresponding results were obtained.

关键词： Phase Field Model Two-Body Interaction Multibody System Adhesive Force Particle Aggregation Computer Simulation

Molecular Dynamics Simulation of Grain Refinement in a Polycrystalline Material under Severe Compressive Deformation

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Materials Sciences and Applications 2017年第12期8卷 918-932页

作者： takuya Uehara Department of Mechanical Systems Engineering Yamagata University Yonezawa Japan

Grain refinement in a polycrystalline material resulting from severe compressive deformation was simulated using molecular dynamics. A simplified model with four square grains surrounded by periodic boundaries was prepared, and compressive deformation was imposed by shortening the length in the y direction. The model first deformed elastically, and the compressive stress increased monotonically. Inelastic deformation was then initiated, and the stress decreased drastically. At that moment, dislocation or slip was initiated at the grain boundaries or triple junction and then spread within the grains. New grain boundaries were then generated in some of the grains, and sub-grains appeared. Finally, a microstructure with refined grains was obtained. This process was simulated using two types of grain arrangements and three different combinations of crystal orientations. Grain refinement generally proceeded in a similar fashion in each scenario, whereas the detailed inelastic deformation and grain refinement behavior depended on the initial microstructure.

关键词： Molecular Dynamics Polycrystalline Material Microstructure Grain Boundary Grain Refinement Severe Plastic Deformation Computer Simulation

Phase-Field Modeling for the Three-Dimensional Space-Filling Structure of Metal Foam Materials

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Open Journal of Modelling and Simulation 2015年第3期3卷 120-125页

作者： takuya Uehara Department of Mechanical Systems Engineering Yamagata University Yonezawa Japan

Phase-field modeling for three-dimensional foam structures is presented. The foam structure, which is generally applicable for porous material design, is geometrically approximated with a space-filling structure, and hence, the analysis of the space-filling structure was performed using the phase field model. An additional term was introduced to the conventional multi-phase field model to satisfy the volume constraint condition. Then, the equations were numerically solved using the finite difference method, and simulations were carried out for several nuclei settings. First, the nuclei were set on complete lattice points for a bcc or fcc arrangement, with a truncated hexagonal structure, which is known as a Kelvin cell, or a rhombic dodecahedron being obtained, respectively. Then, an irregularity was introduced in the initial nuclei arrangement. The results revealed that the truncated hexagonal structure was stable against a slight irregularity, whereas the rhombic polyhedral was destroyed by the instability. Finally, the nuclei were placed randomly, and the relaxation process of a certain cell was traced with the result that every cell leads to a convex polyhedron shape.

关键词： Foam Structure Phase Field Model Kelvin Cell Space-Filling Structure Computer Simulation

The ion balance of Shotokuseki extract promotes filaggrin fragmentation and increases amino acid production and pyrrolidone carboxylic acid content in three-dimensional cultured human epidermis

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Natural Products and Bioprospecting 2022年第1期12卷 586-594页

作者： Kei Tsukui takuya Kakiuchi Masamitsu Suzuki Hidetomo Sakurai Yoshihiro Tokudome Laboratory of Cosmetic Sciences Graduate School of Advanced Health SciencesSaga University1 HonjoSaga 840-8502Japan Laboratory of Dermatological Physiology Faculty of Pharmacy and Pharmaceutical SciencesJosai University1-1 KeyakidaiSakadoSaitama 350-0295Japan Zeria Pharmaceutical Co. Ltd.10-11 NihonbashiKobuna-choChuo-kuTokyo 103-8351Japan Laboratory of Cosmetic Sciences Regional Innovation CenterSaga University1 HonjoSaga 840-8502Japan

Natural moisturizing factor(NMF)in the stratum corneum contributes to the retention of moisture *** purpose of this study was to determine the penetration of ions in Shotokuseki extract(SE)into the three-dimensional cultured epidermis and the effect of NMF on the biosynthesis of amino acids and pyrrolidone carboxylic acid ***-ous ions,amino acids and pyrrolidone carboxylic acid were quantified by inductively coupled plasma mass spectrom-etry,fully automatic amino acid analyzer or high-performance liquid chromatography(HPLC)in three-dimensional cultured epidermis after application of *** expression levels of profilaggrin,calpain1,caspase14,and bleomycin hydrolase,which are involved in NMF production,were determined by reverse-transcription qPCR and bleomycin hydrolase activity was determined by aminopeptidase *** application of SE increased Na,K,Mg,Ca,Al,and Fe levels in three-dimensional cultured *** mRNA levels of the starting material of amino acid synthesis profilaggrin,and calpain1 and bleomycin hydrolase,which are involved in its fragmentation,*** activity of bleomycin hydrolase also ***,the levels of amino acids and pyrrolidone carboxylic acid increased in the three-dimensional cultured *** suggests that the ionic composition of SE may be involved in its moisturizing effect on the stratum corneum.

关键词： Shotokuseki extract Epidermis Amino acid Pyrrolidone carboxylic acid Ion Gene expression

A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients

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World Journal of Gastroenterology 2009年第22期15卷 2782-2786页

作者： Shuichi Sato Tatsuya Miyake Hiroshi Tobita Naoki Oshima Junichi Ishine takuya Hanaoka Yuji Amano Yoshikazu Kinoshita Department of Gastroenterology and Hepatology Shimane UniversitySchool of Medicine Division of Gastrointestinal Endoscopy Shimane University Hospital

AIM:To examine whether a dose-up to 900 mg of ursodeoxycholic acid(UDCA) decreases transaminases in hepatitis C ***:From January to December 2007,patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus(HCV)(43-80 years old) showing positive serum HCV-RNA who had already taken 600 mg/d of UDCA were recruited into this *** parameters were examined at 4,8 and 24 wk after increasing the dose of oral UDCA from 600 to 900 mg/***:Serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transpeptidase(GGT) levels were signifi cantly decreased following the administration of 900 mg/d as compared to 600 mg/*** decrease in ALT from immediately before the dose-up of UDCA to 8 wk after the dose-up was 14.3 IU/L,while that for AST was 10.5 IU/L and for GGT was 9.8 IU/*** count tended to increase after the dose-up of UDCA,although it did not show a statistically signifi cant level(P=0.05).Minor adverse events were observed in 3 cases,although no drop-outs from the study ***:Oral administration of 900 mg/d of UDCA was more effective than 600 mg/d for reducing ALT,AST,and GGT levels in patients with HCV-related chronic liver disease.

关键词： Chronic hepatitis Hepatitis C virus Liver fibrosis Transaminase Ursodeoxycholic acid