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Asian Journal of Andrology 2005年第2期7卷 217-220,页

作者： takuya Akashi Hideki Fuse Yasuo Kojima Mikiko Hayashi Sachiko Honda Department of Urology Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan Department of Obsterics and Gynecology Toyama Prefectural Central HospitalToyamaJapan Toyama Institute of Health ToyamaJapan

Aim:To report a birth after intracytoplasmic sperm injection (ICSI) of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome detected by fluorescence in situ hybridization (FISH) ***:A 35-year- old man with a normal appearance consulted our hospital because of sterility over a 5-year *** analysis showed low-incidence mosaic Klinefelter's *** FISH,96 % hyperploidy of the lymphocytes was *** examined the sex chromosome of the ejaculated *** FISH,we examined 200 ejacu- lated spermatozoa and no hyperploidy was ***:The 33-year-old female partner of the male patient underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined recombinant-follicle stimulating hormone (rec-FSH) + human menopausal gonadotrophin (hMG) protocol,following late luteal phase pituitary down *** culminated in the retrieval of seven oocytes,six of which were fertilized with ICSI. One ICSI attempt led to clinical pregnancy with a healthy baby ***:We report a male patient with low- incidence mosaic Klinefelter's syndrome whose ejaculated spermatozoa were identified as being haploid by FISH before ICSI,leading to the successful pregnancy of his wife and the birth of a healthy baby girl.

关键词： Klinefelter's syndrome intracytoplasmic sperm injection fluorescence in situ hybridization

Efficacy of adhesive strapping on umbilical hernia in children:a systematic review and meta-analysis of cohort studies

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World Journal of Pediatric Surgery 2023年第4期6卷 206-216页

作者： takuya Sugimoto Kazunori Tahara Koshi Uchida Kazuhiko Yoshimoto Department of Pediatric Surgery Japanese Red Cross Kumamoto HospitalKumamotoJapan

Background Although adhesive strapping(AS)for pediatric umbilical hernia(UH),which was once obsolete,has been reconsidered as a common practice in Japan,its efficacy is still *** study aimed to evaluate its efficacy by reviewing related *** A comprehensive literature search of PubMed,Cochrane,Google Scholar,and Igaku Chuo Zasshi via Ichushi-Web was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** studies reporting on the UH closure rate after AS compared with observation-only management were *** A total of 10 cohort studies were included,and the overall UH closure rate was not statistically significant(p=0.31,risk ratio(RR)=0.76,95%confidence interval(CI)0.45 to 1.28).However,there were significant differences in the UH closure rate at the age of 6 months(p<0.01,RR=0.55,95%CI 0.41 to 0.75)and the efficacy of preventing protruding umbilici with redundant skin(p=0.049,RR=0.16,95%CI 0.03 to 0.99).Conclusions Although the efficacy of AS on UH compared with observation-only management did not differ in terms of the UH closure rate,the application of AS may be effective for faster UH closure and the prevention of protruding ***,due to the high heterogeneity of the study,further large-scale studies,particularly randomized controlled trials,are warranted to reach a conclusion.

关键词： hernia prevention closure

Synthesis of crystal-phase and color tunable mixed anion co-doped titanium oxides and their controllable photocatalytic activity

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矿物冶金与材料学报:英文版 2023年第10期30卷 2036-2043页

作者： Jingdi Cao takuya Hhasegawa Yusuke Asakura Akira Yamakata Peng Sun Wenbin Cao Shu Yin Institute of Multidisciplinary Research for Advanced Materials Senda 980-8577Japan Kagami Memorial Research Institute for Materials Science and Technology Waseda UniversityShinju-ku 169-0051Japan Graduate School of Natural Science and Technology Okayama UniversityOkayama 700-8530Japan University of Science and Technology Beijing Beijing 100083China Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

B and N mixed anions co-doped titania with various crystal phases such as anatase,brookite,and rutile were successfully synthesized by a hydrothermal synthesis followed by heat treatment in an ammonia gas atmosphere at 550-650℃(denoted as BN-Ana_x,BN-Bro_x,and BN-Rut_x,x is the treatment temperature).The colors of as-prepared BN-Ana,BN-Bro,and BN-Rut are red,yellow-green,and cyangreen,*** color changing mechanism of titania was related to their various band gap structure and the existence of B-N *** nitridation temperature exhibits effective color changing compared to that of nitridation *** different phases of the mixed anion codoped titania possess different photocatalytic deNO_(x) *** BN-Ana and BN-Rut show poor photocatalytic deNO_(x) activity,while the BN-Bro shows excellent photocatalytic deNO_(x) activity,better than that of standard titania photocatalyst Degussa *** colorful titania with low-photocatalytic activity is heavy metal elements free,indicating their possible applications as nontoxic color pigments or novel cosmetic raw materials.

关键词： colorful titania toxic elements free mixed anion compounds pigment photocatalytic activity cosmetic application

Ge quantum dots light-emitting devices

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Frontiers of Optoelectronics 2012年第1期5卷 13-20页

作者： Jinsong XIA takuya MARUIZUMI Yasuhiro SHIRAKI Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Advance Research Laboratories Tokyo City UniversityTokyo 158-0082Japan

Si photonics becomes one of the research focuses in the field of photonics. Si-based light-emitting devices are one of the most important devices in this field. In this paper, we review the Si-based light-emitting devices fabricated by embedding Ge self-assembled quantum dots into optical microcavities. Ge self-assembled quantum dots emit light in the telecommunication wavelength range from 1.3 to 1.6 pro, for which Si is transparent. Ge self- assembled quantum dots were grown on silicon-on- insulator （SOI） by molecular beam epitaxy （MBE） in Stranski-Krastanov （S-K） mode. Then, electron beam lithography （EBL） was used to define the pattern of optical microcavities on the wafer. Finally, the pattern was transferred onto the Si/Ge slab by inductive coupled plasma （ICP） dry etching. Room-temperature photolumi- nescence （PL） was used to characterize the light-emitting properties of fabricated devices. The results showed that strong resonant light emission was observed in different optical microcavities. Significant enhancement of the intensity was obtained by the optical resonance. Based on the results of PL, we designed and fabricated current- injected light-emitting devices based on Ge self-assembled quantum dots in optical microcavities. Room-temperature resonant light emission was observed from Ge dots in a 3.8 μm microdisk resonator.

关键词： Si-based light-emitting devices Ge self-assembled quantum dots microcavities photonic crystal(PhC) microdisk

Hydriding properties of uranium alloys for purposes of searching for new hydrogen storage materials

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Nuclear Science and Techniques 2015年第1期26卷 121-126页

作者： Michio Yamawaki takuya Yamamoto Yuji Arita Fumihiro Nakamori Kazuhito Ohsawa Kenji Konashi Research Institute of Nuclear Engineering University of Fukui1-2-4 Kanawa-cho Tsuruga Fukui 914-0055 Japan Research Institute for Applied Mechanics Kyushu University6-1 Kasuga-koen Kasuga Fukuoka 816-8580 Japan Institute for Materials Research Tohoku University 2145-2 Narita-choOarai Higashi-Ibaragi-gun Ibaragi 311-1313 Japan

Hydriding properties of uranium alloys have been studied to search for new hydrogen storage materials to be applied to hydrogen energy systems. Application of uranium-base hydrogen storage materials can be expected to alleviate the risk, as well as to reduce the cost incurred by globally-stored large amounts of depleted uranium left after uranium enrichment. Various uranium alloys have been examined in terms of hydrogen absorptiondesorption properties, among which UNi Al intermetallic compound showed promising characteristics, such as lower absorption-desorption temperatures and better anti-powdering strength. First principle calculation has been carried out on UNi Al hydride to predict the change of crystal structure and the lattice constant with increasing hydrogen content, which showed this calculation to be promising in predicting candidates for good hydrogen absorbers.

关键词：氢化性能储氢材料铀合金第一原理计算金属间化合物能源系统解吸温度晶格常数

Synthesis and Properties of a Through-Space Interacting Diradicaloid

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Precision Chemistry 2023年第3期1卷 183-191页

作者： takuya Kodama Yasukazu Hirao Takashi Kubo Department of Chemistry Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(ICSOTRI)Osaka UniversitySuitaOsaka 565-0871Japan

Knowledge about electronic structures is important to gain an understanding of the unique functional properties of *** this study,we synthesized and characterized a diradicaloid in which two phenalenyl radical sites are coupled antiferromagnetically via a through-space *** results of quantum chemical,physicochemical(^(1)H NMR,electronic absorption,cyclic voltammetry,SQUID,ESR),and chemical reactivity studies show that this diradicaloid has singlet diradical *** assessment of the nature of the bonding interaction between two radical sites in this species using DFT calculations demonstrates that a small spatial overlap between the two SOMOs in this diradicaloid provides an efficient electron exchange path for the singlet state to be substantially lower in energy than the triplet state.

关键词： through-space interaction phenalenyl radical singlet diradical diradicaloid antiferromagnetic interaction

Kawasaki disease without changes in inflammatory biomarkers:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13038-13043页

作者： Kosei Yamashita Takeru Kanazawa Yoshifusa Abe takuya Naruto Masaaki Mori Children’s Medical Center Showa University Koto Toyosu HospitalTokyo 135-8577Japan Lifetime Clinical Immunology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8510Japan Department of Rheumatology Clinical Immunology and AllergologySt.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND Kawasaki disease(KD)is diagnosed based on clinical *** tests and other tests are auxiliary diagnostic *** KD is a disease caused by arterial inflammation,many patients with KD have elevated levels of inflammatory biomarkers,such as C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and serum amyloid A protein(SAA)in blood *** report our experience of a patient with KD who did not have elevated levels of inflammatory *** SUMMARY A 1-year-old boy presented with a 3-day history of *** of the six symptoms of KD were observed,except for changes in the lips and oral *** tests revealed no elevation in CRP,ESR,or SAA *** the blood test results were atypical,the patient was diagnosed with KD based on clinical symptoms and was admitted to the hospital for *** patient was administered intravenous immunoglobulin(IVIG)and *** commencing treatment,the fever persisted;therefore,additional IVIG was administered,the dosage of aspirin was increased,and ulinastatin was *** doses of IVIG were administered and the fever resolved on day 11 of KD symptoms *** tests performed during hospitalization showed normal levels of inflammatory *** examined leucine-rich alpha-2-glycoprotein 1-a protein that is elevated during the acute phase of *** protein levels did not increase during *** This case suggests the need to identify criteria and biomarkers for detecting KD conditions that do not require KD treatment.

关键词： Blood test C-reactive protein Erythrocyte sedimentation rate Intravenous immunoglobulin Kawasaki disease Case report

Determination of the Dzyaloshinskii-Moriya interaction using pattern recognition and machine learning

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npj Computational Materials 2021年第1期7卷 198-204页

作者： Masashi Kawaguchi Kenji Tanabe Keisuke Yamada takuya Sawa Shun Hasegawa Masamitsu Hayashi Yoshinobu Nakatani Department of Physics The University of TokyoTokyo 113-0033Japan Toyota Technological Institute Nagoya 468-8511Japan Department of Chemistry and Biomolecular Science Faculty of EngineeringGifu UniversityGifu 501-1193Japan University of Electro-Communications Tokyo 182-8585Japan

Machine learning is applied to a large number of modern devices that are essential in building an energy-efficient smart *** and face recognition are among the most well-known technologies that make use of such artificial *** materials research,machine learning is adapted to predict materials with certain functionalities,an approach often referred to as materials ***,we show that machine learning can be used to extract material parameters from a single image obtained in *** Dzyaloshinskii–Moriya(DM)interaction and the magnetic anisotropy distribution of thin-film heterostructures,parameters that are critical in developing next-generation storage class magnetic memory technologies,are estimated from a magnetic domain *** simulation is used to generate thousands of random images for training and model validation.A convolutional neural network system is employed as the learning *** DM exchange constant of typical Co-based thin-film heterostructures is studied using the trained system:the estimated values are in good agreement with ***,we show that the system can independently determine the magnetic anisotropy distribution,demonstrating the potential of pattern *** approach can considerably simplify experimental processes and broaden the scope of materials research.

关键词： pattern interaction system

An openable artificial intestinal tract system for the in vitro evaluation of medicines

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Microsystems & Nanoengineering 2015年第1期1卷 106-111页

作者： Satoshi Konishi takuya Fujita Koji Hattori Yusuke Kono Yoshifumi Matsushita Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan Department of Pharmaceutical Sciences Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan Ritsumeikan-Global Innovation Research Organization Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan Graduate School of Science and Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan

In vitro drug screening systems for pharmacological targets have been studied as substitutes for whole-animal *** cells or tissues provide promising substitution models when coupled with technological innovations in micro total analysis *** this study,we focus on an intestinal drug absorption assay,as the oral route is most frequently used for drug *** studies have reported the development of artificial vessels that include tubular ***,it is difficult to observe the insides of these tubes in *** address this problem,we developed a micro-device that uses a pneumatic balloon actuator(PBA)to open and close an artificial intestinal tract.A human colon carcinoma cell line(Caco-2)was cultivated on the flat surface of the micro-device for 7 days to form the inner cellular layer of an artificial intestinal tract with which to evaluate drug *** artificial intestinal tract was completely actuated from a flat plate to a circular tube via a PBA with a pressure of 65 kPa,and drugs were perfused at a flow rate of 0.05 mL min^(−1) into the tubular artificial intestinal tract for 1 *** the openable artificial intestinal tract,the in vitro absorption of calcein and Texas Red were successfully estimated as models of hydrophilic and hydrophobic drugs,*** artificial intestinal tract enables the effective evaluation of the in vitro intestinal absorption of drug candidates and contributes to the reduction of costs incurred during the initial stage of drug development.

关键词： Caco-2 cells drug absorption intestinal tract microfluidic device pneumatic balloon actuator

Phenomenological aspects of possible vacua of a neutrino flavor model

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Chinese Physics C 2018年第2期42卷 27-37页

作者： takuya Morozumi Hideaki Okane Hiroki Sakamoto Yusuke Shimizu Kenta Takagi Hiroyuki Umeeda Graduate School of Science Hiroshima University Core of Research for the Energetic Universe Hiroshima University Graduate School of Science and Engineering Shimane University

We discuss a supersymmetric model with discrete flavor symmetry A4×Z3. The additional scalar fields which contribute masses of leptons in the Yukawa terms are introduced in this model. We analyze their scalar potential and find that they have various vacuum structures. We show the relations among 24 different vacua and classify them into two types. We derive expressions of the lepton mixing angles, Dirac CP violating phase and Majorana phases for the two types. The model parameters which are allowed by the experimental data of the lepton mixing angles are different for each type. We also study the constraints on the model parameters which are related to Majorana phases. The different allowed regions of the model parameters for the two types are shown numerically for a given region of two combinations of the CP violating phases.

关键词： flavor symmetry non-Abelian discrete group neutrino flavor model