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Comprehensive treatment for the peritoneal metastasis from gastric cancer

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World Journal of Surgical Procedures 2015年第2期5卷 187-197页

作者： Yutaka Yonemura Emel Canbay Yoshio Endou Haruaki Ishibashi Akiyosi Mizumoto Yan Li Yang Liu Kazuyoshi Takeshita Masumi Ichinose Nobuyuki Takao takuya Saitou Kousuke Noguchi Masamitu Hirano Oliver Glehen Bjorn Br?cher Paul H Sugarbaker NPO to Support Peritoneal Surface Malignancy Treatment Department of Regional Cancer Therapies Peritoneal Surface Malignancy Center Kishiwada Tokusyukai Houspital Kusatsu General Hospital Department of Experimental Therapeutics Cancer Research Institute Kanazawa University Department of Surgery Wuhan University Dēpartement de Chirurgie Gēnerale Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Surgical Oncology Department of Surgery T?bingen Comprehensive Cancer center University of T?bingen Center of Gastrointestinal Malignancies Program in Peritoneal Surface Malignancies Med Star Washington Hospital Center

Recently, a novel comprehensive treatment consisting of cytoreductive surgery(CRS) and perioperative chemotherapy(POC) was developed for the treatment of peritoneal metastasis(PM) with a curative intent. In the treatment, the macroscopic disease is completely removed by the peritonectomy techniques in combination with POC. This article reviews the results of the comprehensive treatment for PM from gastric cancer, and verifies the effects of CRS and POC, including neoadjuvant chemotherapy(NAC) and hyperthermic intraoperative intraperitoneal chemotherapy(HIPEC). Completeness of cytoreduction, peritoneal carcinomatosis index(PCI) less than the threshold levels after NAC,absence of ascites, cytologic status, pathologic response after NAC are the independent prognostic factors. Among these prognostic factors, PCI threshold level is the most valuable independent prognostic factor. After staging laparoscopy, patients with PM from gastric cancer are recommended to treat with NAC before CRS. After NAC, indication for CRS is determined by laparoscopy. The indications of the comprehensive treatment are patients with PCI less than the threshold levels, negative cytology, and responders after NAC. Patients satisfy these factors are the candidates for the CRS and HIPEC.

关键词： Gastric cancer Hyperthermic intraoperative intraperitoneal chemotherapy Peritoneal metastasis Peritonectomy

Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

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World Journal of Hematology 2014年第3期3卷 105-114页

作者： Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi Makoto Ide Kimihiro Kawakami Masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka takuya Matsunaga Department of Internal Medicine Division of En-docrinology and MetabolismHematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa University Department of Internal Medicine Division of HematologyTakamatsu Red Cross Hospital Department of Internal Medicine Division of HematologyKagawa Prefectural Central Hospital Department of Internal Medicine Division of HematologyKagawa Rosai Hospital Department of Internal Medicine Division of HematologyTakamatsu Municipal Hospital Department of Internal Medicine Division of HematologySakaide City Hospital

AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic ***: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age wou

关键词： Acute myeloid leukemia Elderly Adverse prognostic factor Overall survival Population-based study

电子鼻结合GC-MS检测沙拉酱对挪威三文鱼风味的影响

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食品工业科技 2019年第17期40卷 257-262,275页

作者：张彩霞奚印慈柳泽琢也牛琛周纷张艳霞王锡昌上海海洋大学食品学院上海201306 日本丘比株式会社东京1820002

为探究沙拉酱对三文鱼风味的影响,利用电子鼻技术结合顶空固相微萃取技术(HS-SPME)与气相色谱-质谱技术(GC-MS),对添加沙拉酱前后的三文鱼样品挥发性风味物质进行鉴定与比较。结果表明:通过感官实验分析,香甜味沙拉酱、原味沙拉酱与三... 详细信息

为探究沙拉酱对三文鱼风味的影响,利用电子鼻技术结合顶空固相微萃取技术(HS-SPME)与气相色谱-质谱技术(GC-MS),对添加沙拉酱前后的三文鱼样品挥发性风味物质进行鉴定与比较。结果表明:通过感官实验分析,香甜味沙拉酱、原味沙拉酱与三文鱼食用比例分别确定为1∶6、1∶7时食品口感最佳,符合大多数人的感官需求。通过对电子鼻传感器响应值的分析比较及主成分分析得出,添加两种不同沙拉酱后三文鱼样品的醇醛类、碳氧化合物、有机化合物等物质均显著增加(P<0.05),添加沙拉酱前后的三文鱼样品具有较好的区分度,并且经GC-MS鉴定添加了沙拉酱以后三文鱼样品的醛酮类、醇类、酯类、酸类、烃类物质等含量显著增加(P<0.05),尤其是酯类和酸类物质的含量较多,检测结果与电子鼻分析结果较为一致。同时添加沙拉酱后检测三文鱼中的庚醛、己醛等腥味物质都有所降低,1-辛烯-3-醇未检测出,说明沙拉酱可以掩盖三文鱼某些腥味物质。综合来看,添加沙拉酱后不仅可以促进三文鱼食品整体风味物质的形成,还可以掩盖三文鱼中的腥味物质,从而进一步提高三文鱼食品的感官评分及营养价值。

关键词：沙拉酱三文鱼电子鼻气相色谱-质谱技术风味

局部缺血时的脂肪组织重构：脂肪细胞的死亡与干／祖细胞的激活

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中国美容整形外科杂志 2011年第7期22卷 I0023-I0023页

作者： Hirotaka Suga Hitomi Eto Noriyuki Aoi Harunosuke Kato Jun Araki Kentaro Doi takuya Higashino Kotaro Yoshimura 魏峰(译) 高景恒(译) 张晨(译) 日本东京东京大学医学院整形外科《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景许多整形外科手术后（如脂肪移植），脂肪组织开始缺血，导致组织缺氧和营养缺失。然而，很少有研究检测脂肪组织中的缺血和／或缺氧变化的报道。方法切断小鼠体内为腹股沟脂肪垫供血的血管，建立外科手术诱导的缺血模型。利用氧气... 详细信息

背景许多整形外科手术后（如脂肪移植），脂肪组织开始缺血，导致组织缺氧和营养缺失。然而，很少有研究检测脂肪组织中的缺血和／或缺氧变化的报道。方法切断小鼠体内为腹股沟脂肪垫供血的血管，建立外科手术诱导的缺血模型。利用氧气监视器测量脂肪组织的氧分压，利用全标本染色、免疫组化、流式细胞术和蛋白质印迹法分析缺血改变。作者还检测了体外低氧环境下的细胞寿命。结果3种程度缺血模型（轻度、中度、重度）的氧分压水平分别为正常脂肪组织（50．5±1．3）mmHg的75％、55％、20％。在第28天观察到脂肪组织萎缩伴随实质纤维变性，这取决于缺血的严重程度。在第1天观察到中度和重度缺血诱导低氧诱导因子1仪和纤维生长因子2表达的提高，中度和重度缺血还可导致脂肪组织中的退行性改变（如细胞凋亡、坏死、巨噬细胞侵噬）。死亡细胞包括脂肪细胞，血管内皮细胞，血源性细胞，但不包括脂肪源性干／祖细胞。退行性改变后可观察到再生性改变，包括血管形成、脂肪形成和细胞的增殖（包括脂肪源性干／祖细胞、血管内皮细胞和血细胞）。笔者还发现，严重缺氧时在体外用实验方法分化的脂肪细胞发生凋亡和／或坏死，而脂肪源性干／祖细胞仍然存活。结论脂肪组织严重缺血／缺氧导致退行性改变，继而发生相应的组织重构。在缺血环境下，脂肪细胞很容易死亡，而脂肪源性干／祖细胞却非常活跃，并有助于组织修复。

关键词：干/祖细胞脂肪细胞局部缺血组织重构死亡血管内皮细胞退行性改变低氧诱导因子1

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中国液态锂铅包层材料研究进展

原子能科学技术 2007年第Z1期41卷 397-406页

作者：黄群英李春京李艳芬刘少军宋勇彭蕾章毛连朱志强高胜郭智慧王永亮吴宜灿周新贵万发荣单以银郁金南朱升云张品源杨建锋李合琴巨新室贺健夫长坂琢也大贯惣明 FDS团队中国科学院等离子体物理研究所安徽合肥230031 国防科技大学湖南长沙410073 北京科技大学北京100083 中国科学院金属研究所辽宁沈阳110016 中国原子能科学研究院北京102413 西安交通大学陕西西安710049 合肥工业大学安徽合肥230009 日本国立聚变研究所歧阜土歧509-5292日本北海道大学工学部札幌060-8628日本

液态锂铅包层是国际上普遍关注和最有发展潜力的聚变堆包层概念设计之一,而包层材料是液态锂铅包层的核心问题之一.目前,液态锂铅包层普遍选用低活化铁素体/马氏体钢(RAFM钢)作为结构材料,液态锂铅作为中子倍增剂及氚增殖剂.另外,部分... 详细信息

液态锂铅包层是国际上普遍关注和最有发展潜力的聚变堆包层概念设计之一,而包层材料是液态锂铅包层的核心问题之一.目前,液态锂铅包层普遍选用低活化铁素体/马氏体钢(RAFM钢)作为结构材料,液态锂铅作为中子倍增剂及氚增殖剂.另外,部分设计采用了耐高温、电绝缘流道插件作为功能材料,以降低磁流体动力学效应及提高冷却剂出口温度(高于700℃).为适应液态包层的发展需求,中国科学院等离子体物理研究所FDS团队联合国内外相关研究单位,进行了具有中国自主知识产权的中国低活化马氏体钢(CLAM钢)及液态锂铅包层功能材料研发,并开展了锂铅热对流及强迫对流回路的设计、研制及腐蚀实验研究,以研究液态金属锂铅的流动特性及其与结构和功能材料的相容性.同时建立了聚变堆材料数据库平台,为促进中国聚变堆液态包层及材料技术的研究和发展提供数据支持.

关键词：液态包层中国低活化马氏体钢锂铅回路

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深圳能源大厦

建筑实践 2019年第6期 26-33页

作者： Bjarke Ingels Andreas Klok Pedersen Martin Voelkle He Song Andre Schmidt Alessio Zenaro Alina Tamosiunaite Alysen Hiller Ana Merino Andreas Geisler Johansen Annette Jensen Armor Rivas Balaj IIulian Brian Yang Baptiste Blot Buster Christiansen Cecilia Ho Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Dave Brown Dennis Rasmussen Doug Stechschulte Eskild Nordbud Felicia Guldberg Fred Zhou Gaetan Brunet Gül Ertekin Henrik Kania Iris Van der Heide James Schrader Jan Magasanik Jan Borgstr?m Jeppe Ecklon Jelena Vucic Jo?o Albuquerque Jonas M?nster Karsten Hansen Malte Kloe Mikkel Marcker Stubgaard Michael Andersen Michal Kristof Min Ter Lim Oana Simionescu Nicklas A. Rasch Philip Sima Rasmus Pedersen Rune Hansen Rui Huang Sofia Gaspar Stanley Lung Sun Ming Lee takuya Hosokai Todd Bennett Xi Chen Xing Xiong Xiao Lu Xu Li Yijie Dan Zoltan Kalaszi BIG

深圳能源公司办公楼项目总建筑面积为96000m2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼... 详细信息

深圳能源公司办公楼项目总建筑面积为96000m2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼高120m,两座塔楼与邻近建筑的塔楼一起在深圳的中心形成一个连续的弧形天际线。在建筑底部,两座塔楼通过一个34m长,包括大厅、会议中心、自助餐厅和展览空间功

关键词： Michael 建筑面积建筑实践

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid