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A novel mouse model of adult T-cell leukemia cell invasion into the spinal cord

Animal Models and Experimental Medicine 2019年第1期2卷 64-67页

作者： Takeo Ohsugi Shuhei Tanaka Keigo Iwasaki Yusuke Nagano Tomohiro Kozako Kazuya Matsuda takuya hirose Kazushige Takehana Department of Laboratory Animal Sciences School of Veterinary MedicineRakuno Gakuen University Faculty of Pharmaceutical Sciences Department of BiochemistryFukuoka University Department of Veterinary Pathology School of Veterinary MedicineRakuno Gakuen University Department of Veterinary Microanatomy School of Veterinary MedicineRakuno Gakuen University

Adult T-cell leukemia( ATL) is a mature T-cell malignancy caused by human T-cell leukemia virus type I infection, and 10%-25% of patients show central nervous system( CNS) involvement. CNS involvement significantly reduces survival and there are no effective treatments for CNS involvement. Therefore, an appropriate animal model is required to evaluate the inhibitory effects of novel drugs on the progression of ATL with CNS involvement. Here, we established a mouse model of ATL with CNS involvement using ***-Prkdc~ (scid) Il2 rg ^(tm1Wjl)/SzJ mice inoculated with ATL cells intramuscularly in the postauricular region, and these mice showed paraparesis. Of the 10 mice inoculated with ATL cells intramuscularly(I.M.) at 5 weeks of age, 8(80%) showed paraparesis, whereas none of the 10 mice inoculated with ATL cells subcutaneously(S.C.) showed paraparesis. In the I.M. group, PCR detected HTLV-1-specific genes in the thoracic and lumbar vertebrae; however, in the S.C. group, the vertebrae were negative for HTLV-1 genes. Histological analysis revealed a particularly high incidence of tumors, characterized by accumulation of the injected cells, in the thoracic vertebrae of mice in the I.M. group. Tumor cell infiltration was relatively high in the bone marrow. Spinal cord compression caused by invasion of the tumor mass outside the pia mater was observed in the thoracic vertebrae of the spinal cord. In conclusion, we have reported a mouse model of tumor growth with paraparesis that may be used to assess novel therapeutic agents for ATL with CNS involvement.

关键词： adult T-cell leukemia(ATL) central nervous system(CNS) human T-cell leukemia virus type I(HTLV-1) mice NOD.Cg-Prkdc scid Il2rg tm1Wjl/SzJ mice

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Synchronous rectal and esophageal cancer treated with chemotherapy followed by two-stage resection

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World Journal of Clinical Cases 2013年第2期1卷 87-91页

作者： Setsuo Utsunomiya Keisuke Uehara takuya Kurimoto Ken hirose Masahide Fukaya Yu Takahashi Yoshiro Taguchi Keita Itatsu Masato Nagino Department of Gastrointestinal Oncology Nagoya Kyoritsu Hospital Division of Surgical Oncology Department of Surgery Nagoya University Graduate School of Medicine Department of Gastroenterology Nagoya Kyoritsu Hospital

We report a case of 61-year-old male who had synchronous advanced rectal cancer involving the urinary bladder massively associated with multiple liver metastases, and esophageal cancer successfully treated by neoadjuvant chemotherapy followed by two-stage resection. Although complete resection of each of the lesions was considered possible by performing anterior pelvic exenteration, liver resection, and esophagectomy, it might be impossible for the patient to endure the stress of all of these operative procedures at once. Therefore, we planned to perform staged treatment with prioritizing consideration. First, we instituted chemotherapy with the FOLFOX(oxaliplatin + fluorouracil + leucovorin) plus cetuximab regimen, which could adequately control both rectal and esophageal cancer. After 6 cycles of chemotherapy, high anterior resection combined with cystoprostatectomy and lateral segmentectomy plus partial hepatectomy was performed followed by staged esophagectomy with three-field lymph node dissection. It was possible to use oxaliplatin and cetuximab safely as neoadjuvant therapy not only for advanced rectal cancer but for esophageal cancer, and it was effective.

关键词： Rectal cancer Esophageal cancer Neoadjuvant chemotherapy Cetuximab Oxaliplatin

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