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Continuous Gum Chewing Exercise Improves Perioral Muscle Strength

Health 2024年第8期16卷 750-762页

作者： Mutsumi Takahashi Yogetsu Bando takuya fukui Department of Physiology The Nippon Dental University School of Life Dentistry at Niigata Niigata Japan Bando Dental Clinic Ishikawa Japan Department of Sport Science Kanazawa Gakuin University of Sport Science Ishikawa Japan Japan Gymnastics Association Trampoline Committee Tokyo Japan

Objective: The purpose of this study was to examine the effects of continuous gum chewing exercise on perioral muscle strength. Methods: Thirty healthy adults (24.1 ± 2.0 years) with normal occlusion performed gum chewing exercise 3 times daily for 3 months. Each exercise session lasted 5 min and involved alternating of chewing 10 times using the left molars and then 10 times using the right molars, with the mouth closed. The effect of the exercise on oral function was evaluated by measuring tongue pressure (TP), cheek pressure (CP), and labial closure strength (LCS) immediately before starting exercise, at 2 weeks and 1, 2, and 3 months after starting exercise, and at 3 months after cessation of exercise. Changes in TP, CP, and LCS according to sex and duration of exercise were analyzed by repeated two-way ANOVA. Results: Measurements for all muscles were significantly greater in men than in women at all time points. After starting exercise, TP was markedly increased at 2 months in men and women, and both CP and LCS were markedly increased at 2 weeks in men and at 1 month in women. These effects persisted for 3 months. Three months after cessation of exercise, TP, CP, and LCS tended to decrease, but were not significantly attenuated as compared with 3 months after beginning of exercise in either sex. Conclusion: The results of this study revealed that gum chewing exercise contributed to an improvement in perioral muscle strength, and that this effect was maintained for at least 3 months after discontinuation of exercise.

关键词： Oral Function Gum Chewing Exercise Tongue Pressure Cheek Pressure Labial Closure Strength

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重睑成形术治疗潜在的眼睑下垂和上睑凹陷

重睑成形术治疗潜在的眼睑下垂和上睑凹陷

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第4届东方国际美容外科大会

作者： takuya fukui M.D.Ph.D.Sakura Clinic Japan

＜正＞重睑成形术是亚洲最常见的整形手术之一,但是,我们经常遇到一些复杂的病历,如潜在的眼睑下垂和上睑凹陷的患者。对于这些患者我们采用腱膜切开术和肉毒素注射,以增强睁眼的力量和松弛前额肌。我们将介绍一些术前和术后的病例,供...

＜正＞重睑成形术是亚洲最常见的整形手术之一,但是,我们经常遇到一些复杂的病历,如潜在的眼睑下垂和上睑凹陷的患者。对于这些患者我们采用腱膜切开术和肉毒素注射,以增强睁眼的力量和松弛前额肌。我们将介绍一些术前和术后的病例,供同行们探讨。

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PMSSC:Parallelizable multi-subset based self-expressive model for subspace clustering

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Computational Visual Media 2023年第3期9卷 479-494页

作者： Katsuya Hotta takuya Akashi Shogo Tokai Chao Zhang Department of Engineering University of FukuiFukui-shi 910-8507Japan Faculty of Science and Engineering Iwate UniversityMorioka-shi 020-8551Japan

Subspace clustering methods which embrace a self-expressive model that represents each data point as a linear combination of other data points in the dataset provide powerful unsupervised learning ***,when dealing with large datasets,representation of each data point by referring to all data points via a dictionary suffers from high computational *** alleviate this issue,we introduce a parallelizable multi-subset based self-expressive model(PMS)which represents each data point by combining multiple subsets,with each consisting of only a small proportion of the *** adoption of PMS in subspace clustering(PMSSC)leads to computational advantages because the optimization problems decomposed over each subset are small,and can be solved efficiently in ***,PMSSC is able to combine multiple self-expressive coefficient vectors obtained from subsets,which contributes to an improvement in *** experiments on synthetic and real-world datasets show the efficiency and effectiveness of our approach in comparison to other methods.

关键词： subspace clustering self-expressive model big data subsetting

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Hydriding properties of uranium alloys for purposes of searching for new hydrogen storage materials

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Nuclear Science and Techniques 2015年第1期26卷 121-126页

作者： Michio Yamawaki takuya Yamamoto Yuji Arita Fumihiro Nakamori Kazuhito Ohsawa Kenji Konashi Research Institute of Nuclear Engineering University of Fukui1-2-4 Kanawa-cho Tsuruga Fukui 914-0055 Japan Research Institute for Applied Mechanics Kyushu University6-1 Kasuga-koen Kasuga Fukuoka 816-8580 Japan Institute for Materials Research Tohoku University 2145-2 Narita-choOarai Higashi-Ibaragi-gun Ibaragi 311-1313 Japan

Hydriding properties of uranium alloys have been studied to search for new hydrogen storage materials to be applied to hydrogen energy systems. Application of uranium-base hydrogen storage materials can be expected to alleviate the risk, as well as to reduce the cost incurred by globally-stored large amounts of depleted uranium left after uranium enrichment. Various uranium alloys have been examined in terms of hydrogen absorptiondesorption properties, among which UNi Al intermetallic compound showed promising characteristics, such as lower absorption-desorption temperatures and better anti-powdering strength. First principle calculation has been carried out on UNi Al hydride to predict the change of crystal structure and the lattice constant with increasing hydrogen content, which showed this calculation to be promising in predicting candidates for good hydrogen absorbers.

关键词：氢化性能储氢材料铀合金第一原理计算金属间化合物能源系统解吸温度晶格常数

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Effectiveness and safety of chemotherapy for patients with malignant gastrointestinal obstruction:A Japanese populationbased cohort study

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World Journal of Clinical Cases 2022年第16期10卷 5253-5265页

作者： Gota Fujisawa Ryota Niikura takuya Kawahara Tetsuro Honda Kenkei Hasatani Naohiro Yoshida Tsutomu Nishida Tetsuya Sumiyoshi Shu Kiyotoki Takashi Ikeya Masahiro Arai Yoku Hayakawa Takashi Kawai Mitsuhiro Fujishiro Department of Gastroenterology Graduate school of MedicineThe University of TokyoTokyo 1138655Japan Gastroenterological Endoscopy Tokyo Medical UniversityTokyo 1600023Japan Clinical Research Support Center The University of Tokyo HospitalTokyo 1138655Japan Department of Gastroenterology Nagasaki Harbor Medical CenterNagasaki 8508555Japan Department of Gastroenterology Fukui Prefectural HospitalFukui 9108526Japan Department of Gastroenterology Ishikawa Prefectural Central HospitalIshikawa 9208530Japan Department of Gastroenterology Toyonaka Municipal HospitalOsaka 5608565Japan Department of Gastroenterology Tonan HospitalHokkaido 0600004Japan Department of Gastroenterology Shuto General HospitalYamaguchi 7420032Japan Department of Gastroenterology St.Luke's International HospitalTokyo 1048560Japan Department of Gastroenterology Nerima Hikarigaoka HospitalTokyo 1790072Japan

BACKGROUND The impacts of chemotherapy on patients with malignant gastrointestinal obstructions remain unclear,and multicenter evidence is *** To evaluate the effectiveness and safety of chemotherapy in patients with unresectable malignant gastrointestinal *** We conducted a multicenter retrospective cohort study that compared the chemotherapy group who received any chemotherapeutics after interventions,including palliative surgery or selfexpandable metal stent placement,for unresectable malignant gastrointestinal obstruction vs the best supportive care(BSC)group between 2014 and 2019 in nine *** primary outcome was overall survival,and the secondary outcomes were patency duration and adverse events,including gastrointestinal perforation and gastrointestinal *** In total,470 patients in the chemotherapy group and 652 patients in the BSC group were *** the follow-up period of 54.1 mo,the median overall survival durations were 19.3 mo in the chemotherapy group and 5.4 mo in the BSC group(log-rank test,P<0.01).The median patency durations were 9.7 mo[95% confidence interval(CI):7.7-11.5 mo]in the chemotherapy group and 2.5 mo(95%CI:2.0-2.9 mo)in the BSC group(log-rank test,P<0.01).The perforation rate was 1.3%(6/470)in the chemotherapy group and 0.9%(6/652)in the BSC group(P=0.567).The gastrointestinal bleeding rate was 1.5%(7/470)in the chemotherapy group and 0.5%(3/652)in the BSC group(P=0.105).CONCLUSION Chemotherapy after interventions for unresectable malignant gastrointestinal obstruction was associated with increased overall survival and patency duration.

关键词： Gastrointestinal cancer Chemotherapy Malignant gastrointestinal obstruction Self-expandable metal stent Palliative surgery

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Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study

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World Journal of Gastrointestinal Endoscopy 2013年第6期5卷 281-287页

作者： Jiro Watari Toshihiko Tomita Fumihiko Toyoshima Jun Sakurai Takashi Kondo Haruki Asano Takahisa Yamasaki takuya Okugawa Hisatomo Ikehara Tadayuki Oshima Hirokazu fukui Hiroto Miwa Division of Upper Gastroenterology Department of Internal Medicine Hyogo College of Medicine

AIM: To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study. METHODS: We investigated the clinical outcomes and risk factors for the development of perforation in 98 consecutive gastric neoplasms undergoing ESD regarding. Demographic and clinical parameters including patient-, tumor-, and treatment-related factors, clinical parameters, and duration of hospital stay were analyzed for risk factors for perforation. In subgroup analysis, we also compared the clinical outcomes between perforation and "silent" free air without endoscopically visible perforation detected only by computed ***: Perforation was identified in 8.2% of patients. All patients were managed conservatively by the administration of antibiotics. The mean procedure time was significantly longer in patients with endoscopic perforation than in those without. According to the receiver-operating characteristic analysis, the resulting cutoff value of the procedure time for perforation was 115 min (87.5% sensitivity, 56.7% specificity). Prolonged procedure time (≥ 115 min) was associated with an increased risk of perforation (odds ratio 9.15; 95%CI: 1.08-77.54; P = 0.04). Following ESD, body temperature and C-reactive protein level were significantly higher in patients with perforation than in those without (P = 0.02), whereas there was no difference between these patient groups on the starting day of oral intake or of hospitalization. In subgroup analysis, the post-ESD clinical course was not different between endoscopic perforation and silent free air. CONCLUSION: Only prolonged procedure time (≥ 115 min) was significantly associated with perforation. The clinical outcomes of perforation are favorable and are comparable to those of patients with or without silent free air.

关键词： Gastric cancer Endoscopic submucosal dissection Perforation Risk factors Treatment outcome

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What types of early gastric cancer are indicated for endoscopic ultrasonography staging of invasion depth?

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World Journal of Gastrointestinal Endoscopy 2016年第16期8卷 558-567页

作者： Jiro Watari Shigemitsu Ueyama Toshihiko Tomita Hisatomo Ikehara Kazutoshi Hori Ken Hara Takahisa Yamasaki takuya Okugawa Takashi Kondo Tomoaki Kono Katsuyuki Tozawa Tadayuki Oshima Hirokazu fukui Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Inflammatory Bowel Disease Hyogo College of Medicine

AIM To clarify the diagnostic efficacy and limitations of endoscopic ultrasonography(EUS) and the characteristics of early gastric cancers(EGCs) that are indications for EUS-based assessment of cancer invasion *** We retrospectively investigated the cases of 153 EGC patients who underwent conventional endoscopy(CE) and EUS(20 MHz) before *** We found that 13.7% were "inconclusive" cases with low-quality EUS images, including all nine of the cases with protruded(0-I)-type EGCs. There was no significant difference in the diagnostic accuracybetween CE and EUS. Two significant independent risk factors for misdiagnosis by EUS were identified-ulcer scarring [UL(+); odds ratio(OR) = 4.49, P = 0.003] and non-indication criteria for endoscopic resection(ER)(OR = 3.02, P = 0.03). In the subgroup analysis, 23.1% of the differentiated-type cancers exhibiting SM massive invasion(SM2) invasion(submucosal invasion ≥ 500 μm) by CE were correctly diagnosed by EUS, and 23.1% of the undifferentiated-type EGCs meeting the expanded-indication criteria for ER were correctly diagnosed by *** There is no need to perform EUS for UL(+) EGCs or 0-I-type EGCs, but EUS may enhance the pretreatment staging of differentiated-type EGCs with SM2 invasion without UL or undifferentiated-type EGCs revealed by CE as meeting the expanded-indication criteria for ER.

关键词： Gastric cancer Endoscopic ultrasonography Invasion depth diagnosis Conventional endoscopy Endoscopic submucosal dissection

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