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Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 93-99页

作者： Tsutomu Nishida Shusaku Tsutsui Motohiko Kato takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka takuya yamada Shinichiro Shinzaki Hideki Iijima Masahiko Tsujii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan

Treatment strategies,whether as follow-up or"total incisional biopsy"for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic *** on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive ***,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade *** studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness.

关键词： Gastric intraepithelial neoplasia Adenoma Dysplasia Endoscopic submucosal dissection Endoscopic mucosal resection Endoscopic resection Adenocarcinoma

Determination of the Dzyaloshinskii-Moriya interaction using pattern recognition and machine learning

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npj Computational Materials 2021年第1期7卷 198-204页

作者： Masashi Kawaguchi Kenji Tanabe Keisuke yamada takuya Sawa Shun Hasegawa Masamitsu Hayashi Yoshinobu Nakatani Department of Physics The University of TokyoTokyo 113-0033Japan Toyota Technological Institute Nagoya 468-8511Japan Department of Chemistry and Biomolecular Science Faculty of EngineeringGifu UniversityGifu 501-1193Japan University of Electro-Communications Tokyo 182-8585Japan

Machine learning is applied to a large number of modern devices that are essential in building an energy-efficient smart *** and face recognition are among the most well-known technologies that make use of such artificial *** materials research,machine learning is adapted to predict materials with certain functionalities,an approach often referred to as materials ***,we show that machine learning can be used to extract material parameters from a single image obtained in *** Dzyaloshinskii–Moriya(DM)interaction and the magnetic anisotropy distribution of thin-film heterostructures,parameters that are critical in developing next-generation storage class magnetic memory technologies,are estimated from a magnetic domain *** simulation is used to generate thousands of random images for training and model validation.A convolutional neural network system is employed as the learning *** DM exchange constant of typical Co-based thin-film heterostructures is studied using the trained system:the estimated values are in good agreement with ***,we show that the system can independently determine the magnetic anisotropy distribution,demonstrating the potential of pattern *** approach can considerably simplify experimental processes and broaden the scope of materials research.

关键词： pattern interaction system

Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer

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World Journal of Gastroenterology 2006年第24期12卷 3878-3882页

作者： Kenoki Ohuchida Kazuhiro Mizumoto Nami Ishikawa Yasuhiro Ogura Daisuke yamada takuya Egami Hayato Fujita Seiji Ohashi Eishi Nagai Masao Tanaka Department of Surgery and Oncology Graduate School of Medical Sciences Kyushu UniversityFukuokaJapan

AIM： To investigate c-met expression during early pancreatic carcinogenesis. METHODS： We used 46 bulk tissues and 36 microdissected samples, including normal pancreas, chronic pancreatitis, and pancreatic cancer, for quantitative realtime reverse transcription-polymerase chain reaction. RESULTS： In bulk tissue analyses, pancreatic cancer tissues expressed significantly higher levels of c-met than did chronic pancreatitis and normal pancreas tissues. c-met levels did not differ between chronic pancreatitis and normal pancreas tissues. In microdissection-based analyses, c-met was expressed at higher levels in microclissected pancreatic cancer cells and pancreatitisaffected epithelial cells than in normal ductal epithelial cells （both, P 〈 0.01）. Interestingly, pancreatitis-affected epithelial cells expressed levels of c-met similar to those of pancreatic cancer cells. CONCLUSION： Overexpression of c-met occurs during the early stage of pancreatic carcinogenesis, and a single alteration of c-met expression is not sufficient for progression of chronic pancreatitis-affected epithelial cells to pancreatic cancer cells.

关键词： c-met', Pancreatic cancer Chronic pancreatitis Pancreatic carcinogenesis

Anomeric Proton and Carbon (H1-C1) NMR Chemical Shifts of Antigenic Mannans Obtained from Pathogenic Yeast Candida tropicalis

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Advances in Microbiology 2021年第5期11卷 296-301页

作者： takuya Kuraoka Takayoshi yamada Yuki Takatsutsumi Yukiko Ogawa Hidemitsu Kobayashi Divisions of Microbiology Department of Pharmaceutical Science Nagasaki International University Nagasaki Japan Divisions of Infection Control and Prevention Department of Pharmaceutical Science Nagasaki International University Nagasaki Japan

On two dimensional maps of 1H-13C correlation spectroscopy (H-C COSY) analysis for the mannan of Candida tropicalis, nine cross peaks of anomeric proton and carbon were useful for the purpose of obtaining information on the chemical structure of this molecule. Namely, the mannans was comb-like structure constructed with the linear α-1,6-linked polymannnosyl backbone and several oligomannnosyl side chains composed of α-1,2-, α-1,3-, and β-1,2-linkages. Therefore, in the structural investigation of comb-like mannan, two-dimensional H-C COSY analysis is as useful as two-dimensional nuclear Hartmann-Hahn (HOHAHA) analysis.

关键词： Candida tropicalis Cell Wall Mannan Comb-Like Structure 1H-13C Correlation Spectroscopy Anomeric Carbon Chemical Shift α-1 3-Linked Mannose

Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2076-2087页

作者： takuya Sho Kenichi Morikawa Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren yamada Taku Shigesawa Mugumi Kimura Masato Nakai Goki Suda Mitsuteru Natsuizaka Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638HokkaidoJapan

The phase III clinical trial of the novel molecular targeted agent(MTA)lenvatinib for patients with advanced hepatocellular carcinoma(HCC)(REFLECT trial)found that lenvatinib was non-inferior to sorafenib in overall ***,the efficacy of multiple MTAs,including lenvatinib,in practice has been reported,and therapeutic strategies for Barcelona Clinic Liver Cancer(BCLC)intermediate stage HCC are undergoing major *** on these results,lenvatinib could be recommended for patients with transcatheter arterial chemoembolization(TACE)-refractory,ALBI grade 1,within the up-to-seven criteria in the BCLC intermediate *** provides a more favorable outcome than TACE,even in cases with large or multinodular HCC beyond the up-to-seven criteria with Child-Pugh grade *** patients meet the definitions of TACE-refractory or TACE-unsuitable,switching to systemic chemotherapy,including lenvatinib,is for favorable for preserving liver *** initial treatment,including MTA,has a significant therapeutic effect and downstaging of HCC is obtained,additional TACE or surgical resection should be *** also has a therapeutic effect for poorly differentiated type and non-simple nodular type HCC thanks to the survival-prolonging effect of this ***,a significant therapeutic effect is expected in tumors with more than 50%liver involvement or main portal vein invasion,which have traditionally been considered to have a poor prognosis in *** suggests that at the start of lenvatinib treatment,HCC patients with ALBI grade 1 may be able to maintain liver functional reserve.

关键词： Hepatocellular carcinoma Lenvatinib Molecular targeted agent TACE refractory TACE-unsuitable Barcelona Clinic Liver Cancer intermediate stage

Determination of α-1,3-Linked Mannose Residue in the Cell Wall Mannan of Candida tropicalisNBRC 1400 Strain

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Advances in Microbiology 2020年第1期10卷 14-26页

作者： takuya Kuraoka Takayoshi yamada Akito Ishiyama Hiroko Oyamada Yukiko Ogawa Hidemitsu Kobayashi Divisions of Microbiology Nagasaki International University Huis Ten Bosch Sasebo Nagasaki Japan Sanko Medical Tomato Pharmacy Co. Ltd. Shimogumigo Kawatanacho Nagasaki Japan Sasebo City General Hospital Hirasecho Sasebo Nagasaki Japan Divisions of Infection Control and Prevention Department of Pharmaceutical Science Nagasaki International University Huis Ten Bosch Sasebo Nagasaki Japan

To investigate the chemical structure of cell wall mannan obtained from pathogenic yeast, Candida tropicalis NBRC 1400 (former antigenic standard strain, IFO 1400). As a result of two-dimensional NMR analysis, it was shown that the mannan of this strain is composed of α-1,6-, α-1,3-, α-1,2- and β-1,2-linked mannose residues. In this research, the mannan was subjected to three degradation procedures, acid-treatment, α-mannosidase, and acetolysis under two conditions in order to determine the chemical structure of the antigenic oligomannosyl side chains in this molecule. The 1H-nuclear magnetic resonance spectra of resultant oligosaccharides, pentaose and hexaose, demonstrated the existence of the oligomannosyl side chains corresponding to Manα1-3Manα1-2Manα1-2Manα1-2Man and Manα1-3Manα1-2Manα1-2Manα1-2Manα1-2Man, respectively, which have previously also been found in Candida albicans serotype A strain mannans. These findings indicate that C. tropicalis and C. albicans serotype A have no significant difference in the chemical structure of these cell wall mannans. Therefore, it can be interpreted that it is extremely difficult to distinguish both species by targeting the antigenic group in these mannans.

关键词： Candida tropicalis Pathogenic Yeast Cell Wall Mannan Antigenic Oligomannosyl Side Chain Acetolysis α-1 3-Linked Mannose Residue

Mechanism of Pb Removal from Brass Scrap by Compound Separation Using Ca and NaF

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International Journal of Nonferrous Metallurgy 2018年第1期7卷 1-7页

作者： Hidekazu Sueyoshi Kousaku yamada Masashi Miyazaki takuya Okada Nobuyuki Ashie Yoshiharu Kousaka Graduate School of Science and Engineering Kagoshima University Kagoshima Japan Kyushu Tabuchi Co. Ltd. Kirishima Japan San-Etsu Metals Co. Ltd. Tonami Japan

The Mechanism of Pb removal from brass scrap by compound separation using Ca and NaF addition was investigated. Because large Ca-Pb compound particles formed by Ca addition rise to the surface of the molten brass, they can be skimmed off from the molten brass. However, fine Ca-Pb compound particles remain in the molten brass because of low buoyancy. By subsequent NaF addition, the reaction between Ca-Pb compound and NaF takes place at their contact regions, resulting in the formation of solid CaF2, liquid Pb and Na gas. Pb is mainly present at the Ca-Pb compound-CaF2 interface. CaF2 acts as a binder for aggregation of fine Ca-Pb compound particles, resulting in the formation of light and large composite compounds, which rise to the surface of the molten brass. A high Pb removal rate is achieved by skimming off.

关键词： Lead Removal Brass Scrap Calcium Sodium Fluoride Compound Separation

Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren yamada Masatsugu Ohara takuya Sho Goki Suda Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation

Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda Takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics