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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

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Adaptive dynamic range shift (ADRIFT) quantitative phase imaging

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Light(Science & Applications) 2021年第1期10卷 19-28页

作者： Keiichiro Toda Miu Tamamitsu takuro Ideguchi Department of Physics The University of TokyoTokyo 113-0033Japan Institute for Photon Science and Technology The University of TokyoTokyo 113-0033Japan PRESTO Japan Science and Technology AgencySaitama 332-0012Japan

Quantitative phase imaging(QPI)with its high-contrast images of optical phase delay(OPD)maps is often used for label-free single-cell *** to other imaging methods,sensitivity improvement has not been intensively explored because conventional QPI is sensitive enough to observe the surface roughness of a substrate that restricts the minimum measurable ***,emerging QPI techniques that utilize,for example,differential image analysis of consecutive temporal frames,such as mid-infrared photothermal QPI,mitigate the minimum OPD limit by decoupling the static OPD contribution and allow measurement of much smaller ***,we propose and demonstrate supersensitive QPI with an expanded dynamic *** is enabled by adaptive dynamic range shift through a combination of wavefront shaping and dark-field QPI *** a proof-of-concept demonstration,we show dynamic range expansion(sensitivity improvement)of QPI by a factor of 6.6 and its utility in improving the sensitivity of mid-infrared photothermal *** technique can also be applied for wide-field scattering imaging of dynamically changing nanoscale objects inside and outside a biological cell without losing global cellular morphological image information.

关键词： scattering dynamic phase

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Improved image denoising via RAISR with fewer filters

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Computational Visual Media 2021年第4期7卷 499-511页

作者： Theingi Zin Yusuke Nakahara takuro Yamaguchi Masaaki Ikehara Department of Electronics and Electrical Engineering Keio UniversityYokohama-shi223-8522Japan

In recent years,accurate Gaussian noise removal has attracted considerable attention for mobile applications,as in smart *** conventional denoising methods have the potential ability to improve denoising performance with no additional ***,we propose a rapid post-processing method for Gaussian noise removal in this *** matching and 3D filtering and weighted nuclear norm minimization are utilized to suppress *** these nonlocal image denoising methods have quantitatively high performance,some fine image details are lacking due to the loss of high frequency *** tackle this problem,an improvement to the pioneering RAISR approach(rapid and accurate image super-resolution),is applied to rapidly post-process the denoised *** gives performance comparable to state-of-the-art super-resolution techniques at low computational cost,preserving important image structures *** modification is to reduce the hash classes for the patches extracted from the denoised image and the pixels from the ground truth to 18 filters by two improvements:geometric conversion and reduction of the strength *** addition,following RAISR,the census transform is exploited by blending the image processed by noise removal methods with the filtered one to achieve artifact-free *** results demonstrate that higher quality and more pleasant visual results can be achieved than by other methods,efficiently and with low memory requirements.

关键词： block matching and 3D filtering weighted nuclear norm minimization super-resolution geometric conversion census transform

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Interaction between Topographic Conditions and Entrainment Rate in Numerical Simulations of Debris Flow

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Journal of Mountain Science 2015年第6期12卷 1383-1394页

作者： Norifumi HOTTA Haruka TSUNETAKA takuro SUZUKI Faculty of Life and Environmental Sciences University of Tsukuba Forestry and Forest Products Research Institute

Debris flow simulations are useful for predicting the sediment supplied to watersheds from upstream areas. However, the topographic conditions upstream are more complicated than those downstream and the relationship between the topographic conditions and debris flow initiation is not well understood. This study compared the use of several entrainment rate equations in numerical simulations of debris flows to examine the effect of topographic conditions on the flow. One-dimensional numerical simulations were performed based on the shallow water equations and three entrainment rate equations were tested. These entrainment rate equations were based on the same idea that erosion and the deposition of debris flows occur via the difference between the equilibrium and current conditions of debris flows, while they differed in the expression of the concentration, channel angle, and sediment amount. The comparison was performed using a straight channel with various channel angles and a channel with a periodically undulating surface. The three entrainment rate equations gave different amounts of channel bed degradation and hydrographs for a straight channel with a channel angle greater than 21° when water was supplied from upstream at a steady rate. The difference was caused by the expression of the entrainment rate equations. For channels with little undulation, the numerical simulations gave results almost identical to those for straight channels with the same channel angle. However, for channels with large undulations, the hydrographs differed from those for straight channels with the same channel angle when the channel angle was less than 21°. Rapid erosion occurred and the hydrograph showed a significant peak, especially in cases using the entrainment equation expressed by channel angle. This was caused by the effects of the steep undulating sections, since the effect increased with the magnitude of the undulation, suggesting that a debris flow in an upstream area develo

关键词： Debris flow Entrainment rate equation Numerical simulation Topographic condition

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Specific targeting of lung ILC2s via NRP1 in pulmonary fibrosis

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Cellular & Molecular Immunology 2022年第8期19卷 869-871页

作者： takuro Nii Kiyoharu Fukushima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka UniversityOsaka565-0871Japan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

Innate lymphoid cells are predominantly tissue-resident immune cells that have diverse functions similar to T-cell subsets and regulate tissue homeostasis and innate immunity without specific antigen recognition. Prev... 详细信息

关键词： ILC2s immunity homeostasis

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铬镍亚稳奥氏体钢的疲劳性能

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水钢科技 2019年第1期 49-61页

作者： takuro ogawa Motomichi KOYAMA Yuri NISHIKURA Kaneaki TSUZAKI Hiroshi NOGUCHI 高长益(译) 叶雅妮(译) 张东升(译) 吴学林(译) 刘立德(译) 日本九州大学首钢水钢制造管理部贵州六盘水553028

采用旋转弯曲疲劳试验机测试了Fe-19Cr-8Ni-0.05C钢和Fe-19Cr-8Ni-0.14C钢的疲劳性能。两种钢的疲劳极限取决于裂纹萌生临界应力幅值。由于奥氏体的稳定性,Fe-19Cr-8Ni-0.05C钢的疲劳极限达到了200MPa,这比Fe-19Cr-8Ni-0.14C钢的疲劳极... 详细信息

采用旋转弯曲疲劳试验机测试了Fe-19Cr-8Ni-0.05C钢和Fe-19Cr-8Ni-0.14C钢的疲劳性能。两种钢的疲劳极限取决于裂纹萌生临界应力幅值。由于奥氏体的稳定性,Fe-19Cr-8Ni-0.05C钢的疲劳极限达到了200MPa,这比Fe-19Cr-8Ni-0.14C钢的疲劳极限要高。虽然Fe-19Cr-8Ni-0.14C钢的动态应变时效有望提高疲劳极限,但是,由于相稳定性的显著增大,抵消了相变诱发塑性和相变诱发裂纹闭合效应,没有出现动态应变时效提高疲劳极限的现象。

关键词：固溶碳奥氏体不锈钢相稳定动态应变时效疲劳

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Effects of salinity on the nail-holding power of dimension lumber used in light-frame wood building

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Journal of Forestry Research 2015年第3期26卷 765-770页

作者： Zeli Que LingYang FeibinWang Xuna Zhu Yongbing Wang takuro Mori College of Materials Science and Engineering NanjingForestry University Nanjing 210037 China College of Landscape Architecture Nanjing ForestryUniversity Nanjing 210037 China Suzhou Crownhomes Co. LTD. Suzhou 215105 China Research Institute for Sustainable Humanosphere (RISH) Kyoto University Kyoto 6110011 Japan

We studied the effect of salinity on nail-hold- ing power in wood construction. In saline solution, the holding power of nails was less than in purified water. With the increase of salt concentration, the surface and side nail- holding power of the wood specimens both declined, but the differences between salinity treatments were not sig- nificant. However, compared to the surface and side nail- holding power, the power on the edge was generally less and the difference was not obvious in different salt con- centrations. In the same salt concentration, with the extension of the processing cycle, the performance of holding power of nails showed a downward trend, expect the temporary rise in the middle.

关键词： Nail-holding power Salinity Mechanicalproperties Dimension lumber Joints

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Degradation rates and products of fluticasone propionate in alkaline solutions

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Journal of Pharmaceutical Analysis 2017年第5期7卷 297-302页

作者： Tadakazu Tokumura Naoko Yoshida Kanami Mori-Yasumoto Osamu Shirota takuro Kurita Laboratory of Pharmaceutics Kagawa School of Pharmaceutical Sciences Tokushima Bunri University Department of Pharmaceutical Sciences School of Pharmacy International University of Health and Welfare Laboratory of Pharmacognosy and Natural Products Chemistry Kagawa School of Pharmaceutical Sciences Tokushima Bunri University

The apparent degradation rate constant of fluticasone propionate(FLT) in 0.1 M NaOH:methanol=1:1 at 37 °C was previously reported to be 0.169 ± 0.003 h^(-1), and four degradation products(products 1–4) were observed in the solution. The aims of the present study were to assess the degradation rates of FLT in other alkaline solutions and clarify the chemical structures of the four degradation products in order to obtain basic data for designing an enema for inflammatory bowel disease. The apparent degradation rate constants in 0.05 M NaOH and 0.1 M NaOH:CH_3CN=1:1 were 0.472 ± 0.013 h^(-1) and 0.154 ± 0.000 h^(-1)(n=3), respectively. The chemical structures of products 1–4 in 0.1 M NaOH:methanol=1:1 were revealed by nuclear magnetic resonance(NMR)and mass spectrometry data. The chemical structure of products 2 was that the 17-position of the thioester moiety of FLT was substituted by a carboxylic acid. The degradation product in 0.1 M NaOH:CH_3CN=1:1 was found to be product 2 based on ~1H NMR data. The degradation product in 0.05 M NaOH was considered to be product 2 based on the retention time of HPLC. These results are useful for detecting the degradation products of FLT by enzymes of the intestinal bacterial flora in the large intestine after dosing FLT as an enema.

关键词： Fluticasone propionate Degradation rate Degradation products Chemical structure Alkaline solution

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In-situ observation of twinning and detwinning in AZ31 alloy

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Journal of Magnesium and Alloys 2022年第12期10卷 3418-3432页

作者： Wu Gong Ruixiao Zheng Stefanus Harjo takuro Kawasaki Kazuya Aizawa Nobuhiro Tsuji J-PARC Center Japan Atomic Energy Agency2-4 Shirane ShirakataTokaiNakaIbaraki 319-1195Japan Center for Elements Strategy Initiative for Structural Materials Kyoto UniversityYoshidahonmachiSakyo-kuKyoto 606-8501Japan Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto 606-8501Japan School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Twinning and detwinning behavior of a commercial AZ31 magnesium alloy during cyclic compression–tension deformation with a total strain amplitude of 4%(±2%) was evaluated using the complementary techniques of in-situ neutron diffraction, identical area electron backscatter diffraction, and transmission electron microscopy. In-situ neutron diffraction demonstrates that the compressive deformation was dominated by twin nucleation, twin growth, and basal slip, while detwinning dominated the unloading of compressive stresses and subsequent tension stage. With increasing number of cycles from one to eight: the volume fraction of twins at-2% strain gradually increased from 26.3% to 43.5%;the residual twins were present after 2% tension stage and their volume fraction increased from zero to 3.7% as well as a significant increase in their number;and the twinning spread from coarse grains to fine grains involving more grains for twinning. The increase in volume fraction and number of residual twins led to a transition from twin nucleation to twin growth, resulting in a decrease in yield strength of compression deformation with increasing cycles. A large number of-component dislocations observed in twins and the detwinned regions were attributed to the dislocation transmutation during the twinning and detwinning. The accumulation of barriers including twin boundaries and various types of dislocations enhanced the interactions of migrating twin boundary with these barriers during twinning and detwinning, which is considered to be the origin for increasing the work hardening rate in cyclic deformation of the AZ31 alloy.

关键词： Magnesium Neutron diffraction Twinning Detwinning Dislocation transmutation

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Strengthening of high-entropy alloys via modulation of cryo-pre-straining-induced defects

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Journal of Materials Science & Technology 2022年第34期129卷 251-260页

作者： Daixiu Wei Wu Gong Liqiang Wang Bowen Tang takuro Kawasaki Stefanus Harjo Hidemi Kato Institute for Materials Research Tohoku University2-1-1 KatahiraSendaiMiyagi 980-8577Japan J-PARC Center Japan Atomic Energy Agency2-4ShirakataTokaiNaka-gunIbaraki 319-1195Japan State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Graduate School of Materials Science Tohoku University6-6Aramaki Aza AobaAoba-kuSendaiMiyagi 980-8579Japan

Owing to their attractive structure and mechanical properties,high-entropy alloys(HEAs) and mediumentropy alloys(MEAs) have attracted considerable research *** strength of HEAs/MEAs with a single face-centered cubic(FCC) phase,on the other hand,requires ***,in this study,we demonstrate a strategy for increasing the room-temperature strength of FCC-phase HEAs/MEAs by tuning cryo-pre-straining-induced crystal defects via the temperature-dependent stacking fault energyregulated plasticity *** neutron diffraction line profile analysis and electron microscope observation,the effect of the tuned defects on the tensile strength was *** to the cryorolling-induced high dislocation density,mechanical twins,and stacking faults,the room-temperature yield strength of an equiatomic CoCrFeNi HEA was increased by ~290%,from 243 MPa(as-recrystallized)to 941.6 MPa(30% cryo-rolled),while maintaining a tensile elongation of 18%.After partial recovery via heat treatment,the yield strength and ultimate tensile strength decreased slightly to 869 and 936 MPa,***,the elongation increased to 25.6%,The dislocation density and distribution of the dislocations were found to contribute to the strengthening caused by forest dislocations,which warrants further *** study discussed the possibility of developing single-phase high-performance HEAs by tuning pre-straining-induced crystal defects.

关键词： High-entropy alloys Cryo-pre-straining Crystal defects Neutron diffraction Mechanical property

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