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Savonius风力机叶片重叠比的风洞实验研究

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太阳能学报 2009年第2期30卷 226-231页

作者：李岩原丰林农东北农业大学工程学院哈尔滨150030 鸟取大学工学部日本鸟取6808552

为了探明其最佳重叠比,首先对具有3种典型重叠比(OL=0,0.2和0.5)的Savonius风力机进行了风洞实验,确认了OL=0.2的风力机具有较佳的性能。之后将OL设定在0.15～0.30之间,以0.025为间隔细分为7个模式,每一模式中又分为带有中心转轴和无转... 详细信息

为了探明其最佳重叠比,首先对具有3种典型重叠比(OL=0,0.2和0.5)的Savonius风力机进行了风洞实验,确认了OL=0.2的风力机具有较佳的性能。之后将OL设定在0.15～0.30之间,以0.025为间隔细分为7个模式,每一模式中又分为带有中心转轴和无转轴两种类型,分别进行了详细的风洞实验,对叶片重叠比以及转轴轴径对Savonius风力机的静态起动特性和动态功率输出特性的影响进行了研究。

关键词： Savonius风力机叶片重叠比风洞实验风力机转轴功率力矩

Linking uric acid metabolism to diabetic complications

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World Journal of Diabetes 2014年第6期5卷 787-795页

作者： Akifumi Kushiyama Kentaro Tanaka Shigeko hara Shoji Kawazu Division of Diabetes and Metabolism The Institute for Adult DiseasesAsahi Life Foundation2-2-6

Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase(XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid(UA) generation inhibitor in the 1950 s and has been routinely used for gout prevention since then. Serum UA levels are an important risk factor of disease progression for various diseases, including those related to lifestyle. Recently, other UA generation inhibitors such as febuxostat and topiroxostat were launched. The emergence of these novel medications has promoted new research in the field. Lifestyle-related diseases, such as metabolic syndrome or type 2 diabetes mellitus, often have a common pathological foundation. As such, hyperuricemia is often present among these patients. Many in vitro and animal studies have implicated inflammation and oxidative stress in UA metabolism and vascular injury because XDH/XO act as one of the major source of reactive oxygen species Many studies on UA levels and associated diseases implicate involvement of UA generation in disease onset and/or progression. Interventional studies for UA generation, not UA excretion revealed XDH/XO can be the therapeutic target forvascular injury and renal dysfunction. In this review, the relationship between UA metabolism and diabetic complications is highlighted.

关键词： Uric acid Xanthine dehydrogenase/xanthine oxidase Diabetes mellitus Diabetic complications Xanthine oxidase inhibitor Metabolism

Characteristics of Geriatric Health Service Facilities Designated as Sites of Death

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Health 2015年第10期7卷 1275-1282页

作者： Mitsumi Ono Hideyuki Kanda Yuko Takeda Sachiko hara Department of Community Health and Gerontological Nursing Faculty of Medicine Shimane University Izumo Japan Department of Environmental Medicine and Public Health Faculty of Medicine Shimane University Izumo Japan

There are many deaths occurring among the aged population in Japan. Geriatric Health Service Facilities (GHSFs) are highlighted as some of the chosen facilities designated as sites of death. The aim of our study was to clarify the characteristics and related factors, including physical signs first noticed by staff at the end-of-life period, in GHSFs designated as sites of death, using a nationwide survey in Japan. We administered a questionnaire to 3971 GHSFs in Japan. Eligible responses for the study were obtained from 854 GHSFs. We found that GHSFs designated as sites of death were more likely to have basic policies and documented preferences regarding end-of-life care. We also found that staff members in GHSFs designated as sites of death were less likely to first notice physical signs of pain. We found that GHSFs designated as sites of death tended to identify earlier symptoms, such as reduced oral intake and less vigor. Our results would enable elderly persons, their families, and staff in GHSFs to prepare for the elderly’s death more efficiently though earlier identification of the end-of-life period. We hope that GHSFs have an important role to play in end-of-life care provision to elderly persons in Japan, through the strengthening of these intermediate facilities.

关键词： Geriatric Health Service Facility End-of-Life Care Basic Policy Preference Documented Physical Signs

Improvement of Countrywide Vegetation Mapping over Japan and Comparison to Existing Maps

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Advances in Remote Sensing 2018年第3期7卷 163-170页

作者： Ram C. Sharma Keitarou hara Hidetake Hirayama Department of Informatics Tokyo University of Information Sciences Chiba Japan Graduate School of Informatics Tokyo University of Information Sciences Chiba Japan

This paper presents an improved classification and mapping of vegetation types for all of Japan by utilizing the Moderate-resolution Imaging Spectroradiometer (MODIS) data. The Nadir BRDF-Adjusted Reflectance (MCD43A4 product) data were compared to the conventional Surface Reflectance (MOD09A1/MOY09A1 products) data for the classification of vegetation types: evergreen coniferous forest, evergreen broadleaf forest, deciduous coniferous forest, deciduous broadleaf forest, shrubs, herbaceous, arable;and non-vegetation. Very rich spectral and temporal features were prepared from MCD43A4 and MOD09A1/MOY09A1 products. Random Forests classifier was employed for the classification of vegetation types with the support of ground truth data prepared in the research. Accuracy metrics—confusion matrix, overall accuracy, and kappa coefficient calculated through 10-fold cross-validation approach—were used for quantitative comparison of MCD43A4 and MOD09A1/MOY09A1 products. The cross-validation results indicated better performance of the MCD43A4 (Overall accuracy = 0.73;Kappa coefficient = 0.69) product than conventional MOD09A1/MOY09A1 products (Overall accuracy = 0.70;Kappa coefficient = 0.66) for the classification. McNemar’s test was also used to confirm a significant difference (p-value = 0.0003) between MCD43A4 and MOD09A1/MOY09A1 products. Based on these results, by utilizing the MCD43A4 features, a new vegetation map was produced for all of Japan. The newly produced map showed better accuracy than the extant, MODIS Land Cover Type product (MCD12Q1) and Global Land Cover by National Mapping Organizations (GLCNMO) product in Japan.

关键词： Vegetation Classification MODIS Random Forests Mapping Japan

Effect of Nutrition Education Using Self-Monitoring of Blood Glucose (SMBG) on Glycemic Control in Non-Insulin-Treated Obese Type 2 Diabetes Patients

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Food and Nutrition Sciences 2012年第9期3卷 1202-1208页

作者： Miyo Hasegawa Hideo Sasaki Masao hara Nobuko Murayama Department of Community Health and Welfare Center Niigata Medical Center Niigata Japan Department of Diabetes Center Niigata Medical Center Niigata Japan Graduate School of Health and Welfare Niigata University of Health and Welfare Niigata Japan

The effect of nutrition education using self-monitoring of blood glucose on glycemic control was investigated in the present study. Of 36 males and 25 females aged 30 - 69 years under outpatient treatment at 3 hospitals in Niigata prefecture, Japan, 61 non-insulin-treated obese type 2 diabetes patients with HbA1c of 6.9% - 9.3% and body mass index of 25 kg/m2 or higher were randomly allocated. Thirty and 31 patients were analyzed in intervention and control groups, respectively. The intervention group performed self-monitoring of blood glucose 2 hours after supper twice a week for 6 months and underwent nutrition education on the association between meals and postprandial blood glucose once every 2 months. The primary outcome was glycated hemoglobin, with the secondary outcome of body mass index. Stages of change for eating the appropriate supper amount were investigated to verify the process of the educational effect, and satisfaction with diabetes treatment and well-being were investigated to verify the continuity of treatment. On intention-to-treat analysis, glycated hemoglobin (mean ± SD) decreased from 7.9% ± 0.6% to 7.7% ± 0.6% in the intervention group but increased from 7.9% ± 0.6% to 8.1% ± 0.6% in the control group, showing a significant difference in the change after intervention between the groups (p = 0.027). In the intervention group, body mass index decreased from 28.9 ± 3.8 to 28.4 ± 3.7 kg/m2 (p = 0.019), the stages of change to learn the appropriate amount of supper progressed (p = 0.026), and satisfaction with diabetes treatment increased (p = 0.031).

关键词： SMBG Glycemic Control Nutrition Education Satisfaction with Diabetes Non-Insulin-Treated Type 2 Diabetes

Cancer chemoprevention through the induction of apoptosis by natural compounds

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Journal of Biophysical Chemistry 2012年第2期3卷 156-173页

作者： Toshiya Kuno Testuya Tsukamoto Akira hara Takuji Tanaka Department of Pathology Fujita Health University School of Medicine Dengakugakubo Kutsukake-cho Toyoake Japan Department of Tumor Pathology Graduate School of Medicine Gifu University Gifu Japan

As cell and tissue homeostasis are mediated by the balance between proliferation and apoptosis, controlling this balance is important for cancer chemoprevention. Cancer chemoprevention can be achieved by the use of natural, synthetic or biologic compounds that reverse, suppress or prevent the development of epithelial malignancies. Natural compounds including flavonoids are able to reduce oxidative stress, which is the most likely mechanism mediating the protective effects against cancer development. In addition, in vitro and in vivo studies have suggested that flavonoids, such as (-)-epigallocatechin-3-gallete (EGCG), quercetin, and curcumin, act by induction of apoptosis. Several natural compounds inhibit cell proliferation and angiogenesis. Certain natural products have been shown to inhibit the activation of nuclear factor kappa B (NF-κB) and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Understanding the mechanism of these natural products will contribute to the development of more specific preventive strategies against cancer development. Here we focus on the ability of natural cancer chemopreventive agents to induce apoptosis, and attempt to provide evidence for the preventive and therapeutic effects of natural compounds, EGCG, quercetin, and curcumin, in a succinct manner highlightingκand Akt signaling pathways in vivo.

关键词： Cancer Chemoprevention Apoptosis Natural Compounds

Activation without Proteolysis of Anti-σFactor RsiV of the Extracytoplasmic Function σFactor σVin a Glucolipid-Deficient Mutant of Bacillus subtilis

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Advances in Microbiology 2017年第4期7卷 315-327页

作者： Takahiro Seki Kouji Matsumoto Satoshi Matsuoka Hiroshi hara Department of Biochemistry and Molecular Biology Graduate School of Science and EngineeringSaitama UniversitySaitamaJapan

Extracytoplasmic function (ECF) σ factors are a crucial link in the process of bacterial response to environmental stresses, in which bacteria transmit information across the cytoplasmic membrane. Among the seven ECF σ factors of Bacillus subtilis σV, which is sequestered by transmembrane anti-σ factor RsiV under normal growth conditions, responds to lysozyme. When B. subtilis cells are challenged by lysozyme, the lysozyme-bound RsiV undergoes two successive proteolysis steps, by a signal peptidase and RasP protease, and releases σV. An unchallenged B. subtilis ugtP mutant lacking glucolipids exhibited higher σV activity than wild type. However, the activation occurred in the absence of RasP, and no proteolysis of RsiV was observed. It is likely that a conformational change, not proteolysis, of RsiV leads to this activation of σV in the absence of glucolipids. Replacement of the C-terminal region of RsiV with that of RsiW, the cognate σ factor of which, σW, is not activated in the ugtP mutant, indicated that the C-terminal extracytoplasmic region of RsiV was necessary for the response to glucolipid deficiency.

关键词： Anti-σ Factor Bacillus subtilis ECF σ Factor Glucolipid RsiV σV UgtP

Design Consideration for High Power Density GaN Buck-Rectifier in ISOP-IPOS Converter based dc Distribution, System

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Journal of Energy and Power Engineering 2015年第6期9卷 574-584页

作者： Yusuke Hayashi Hiroshi Iso Daisuke hara Akira Matsumoto Division of Electrical Electronic and Information Engineering Graduate School of Engineering Osaka University Osaka5650871 Japan Research and Department Headquarters NTT (Nippon Telegraph and Telephone) Facilities lnc. (Incorporated) Tokyo 1700004Japan

GaN （gallium nitride） buck-rectifier has been proposed to realize high power density ISOP （input series and output parallel）-IPOS （input parallel and output series） converter-based dc distribution system. The ultra-low loss bi-directional switch can be developed by the GaN power device because of the low on-resistance, the high-speed switching behavior and its own device structure. The buck-rectifier using the GaN bi-directional switches has the potential to achieve higher power density than the commonly utilized boost-rectifier. Availability of the GaN-HEMT （high electron mobility transistor） for the buck rectifier has been verified taking the theoretical limit of the on-resistance and the switching loss energy into account. Design consideration for a high power density buck-rectifier has been also conducted and the application effect of the GaN bidirectional switches has been evaluated quantitatively. The ISOP-IPOS converter-based dc （direct current） distribution system takes full advantage of the buck-rectifier and the rectifier using GaN devices contributes to realizing higher power density dc distribution system.

关键词： ac (alternate current)-dc converter GaN (gallium nitride) power device power density dc distribution ISOP-IPOStopology.

Autonomous Self-Oscillating Behavior of a Novel Nonthermoresponsive Polymer Chain

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Autonomous Self-Oscillating Behavior of a Novel Nonthermores...